Cited by 219Microtubule and mitosis dynamicsDNA Repair MechanismsGenomics and Chromatin Dynamics

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Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores

Chan, G. K. T., Jablonski, S. A., Starr, D. A., Goldberg, M. L., Yen, T. J.·2000·Nature Cell Biology

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Abstract

Here we show that human Zeste White 10 (Zw10) and Rough deal (Rod) are new components of the mitotic checkpoint, as cells lacking these proteins at kinetochores fail to arrest in mitosis when exposed to microtubule inhibitors. Checkpoint failure and premature mitotic exit may explain why cells defective for hZw10 and hRod divide with lagging chromosomes. As Zw10 and Rod are not conserved in yeast, our data, combined with an accompanying study of Drosophila Zw10 and Rod, indicate that metazoans may require an elaborate spindle checkpoint to monitor complex kinetochore functions.

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Authors: Chan, G. K. T., Jablonski, S. A., Starr, D. A., Goldberg, M. L., & Yen, T. J.
Affiliations: Fox Chase Cancer Center (US)
University of Colorado Boulder (US)
Cornell University (US)
Corresponding author: Yen, T. J.
ORCID: Chan, G. K. T.
Jablonski, S. A.
Starr, D. A.
Goldberg, M. L.
Yen, T. J.
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2000-11-14
Volume: 2
Issue: 12
Pages: 944-947
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/35046598
OpenAlex: W1540858422
Cited by: 217
References: 31
Citations by year: 2026: 5 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 10 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 2
FWCI: 5.28
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P30CA006927, CA06927)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: ZW10, rods, spindle assembly checkpoint, kinetochore, microtubule inhibitors, mitotic arrest, lagging chromosomes, chromosome segregation, Drosophila, animal evolution
MeSH terms: Binding Sites, Chromosomal Proteins, Non-Histone, HeLa Cells, Humans, Microscopy, Fluorescence, Microtubules, Mitosis, Spindle Apparatus, Protein Binding, Nocodazole, Kinetochores, Cell Cycle Proteins

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Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores

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