The DOI matches its Crossref record; 102 of the 104 references it cites were found in a registry or an index.
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Abstract
Neural circuits are assembled with remarkable precision during embryonic development, and the selectivity inherent in their formation helps to define the behavioural repertoire of the mature organism. In the vertebrate central nervous system, this developmental program begins with the differentiation of distinct classes of neurons from progenitor cells located at defined positions within the neural tube. The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules.
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In the citing paper
“the MGE can be further subdivided into dorsal, intermediate and ventrocaudal domains”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Jessell, 2000
In the citing paper
“Second, driven by the transcription factor network, each type of neural progenitors generates a series of neuronal cell types.”
From What is a cell type and how to define it? (2022) · cites this paper as Jessell, 2000
In the citing paper
“The generation and patterning of mouse cortex and spinal cord cell types are two example systems where extensive historical studies have uncovered several common principles (Cadwell et al., 2019; Catela et al., 2015; Jessell, 2000; O’Leary et al., 2007; Osseward and Pfaff, 2019; Sagner and Briscoe, 2019).”
From What is a cell type and how to define it? (2022) · cites this paper as Jessell, 2000
In the citing paper
“The set of cell type-defining transcription factors in a progenitor or a daughter cell can change with time, such that different neuronal types emanate from the same progenitor in a precisely timed “birth order”.”
From What is a cell type and how to define it? (2022) · cites this paper as Jessell, 2000
In the citing paper
“Third, specific sets of cell adhesion molecules provide guidance cues for axon path finding and synapse formation, leading to the assembly of region- and cell type-specific local and global circuit networks.”
From What is a cell type and how to define it? (2022) · cites this paper as Jessell, 2000
In the citing paper
“Later in development, the same neural progenitors also generate non-neuronal cell types such as astrocytes and oligodendrocytes.”
From What is a cell type and how to define it? (2022) · cites this paper as Jessell, 2000
In the citing paper
“First, opposing morphogen gradients establish the basic plan for cortex (anterior-posterior) or spinal cord (dorsal-ventral) patterning and provide instructive signals for the expression of complementary sets of transcription factor activators and repressors, which in turn define distinct neural progenitor domains within cortex or spinal cord.”
From What is a cell type and how to define it? (2022) · cites this paper as Jessell, 2000
In the citing paper
“Specification of the progenitor domains in the hindbrain and spinal cord relies on signaling molecules like WNT and retinoic acid (RA) secreted along the rostro-caudal axis, and sonic hedgehog (SHH) along the dorso-ventral axis”
From Generation of Functional Human 3D Cortico-Motor Assembloids (2020) · cites this paper as Jessell, 2000
In the citing paper
“The gene expression programme of each progenitor domain determines the neuronal cell type it generates”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Jessell, 2000
In the citing paper
“This is directed by signals that emanate from the dorsal and ventral poles of the neural tube that partition progenitors into 13 transcriptionally distinct domains that are ordered along the dorsal ventral axis”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Jessell, 2000
In the citing paper
“After their generation, MNs diversify and organise into distinct columns and pools along the anterior-posterior axis of the spinal cord”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Jessell, 2000
Citations
Cites
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Chiang, C. C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062
Patterning the Vertebrate Neuraxis
Lumsden, A., & Krumlauf, R. K. (1996) · Science · doi:10.1126/science.274.5290.1109 · Cited by 1,142
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
Niederreither, K., Subbarayan, V., Dollé, P., & Chambon, P. (1999) · Nature Genetics · doi:10.1038/7788 · Cited by 1,111
Briscoe, J., Pierani, A., Jessell, T. M., & Ericson, J. (2000) · Cell · doi:10.1016/s0092-8674(00)80853-3 · Cited by 1,111
Self-citationThe tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
Stone, D. M., Hynes, M., Armanini, M. P., Swanson, T. A., Gu, Q., Johnson, R. L., Scott, M. P., Pennica, D., Goddard, A. D., PHILLIPS, H. S., et al. (1996) · Nature · doi:10.1038/384129a0 · Cited by 1,104
Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling
Ericson, J., Rashbass, P., Schedl, A., Brenner‐Morton, S., Kawakami, A., van Heyningen, V., Jessell, T. M., & Briscoe, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80323-2 · Cited by 1,044
Self-citationWang, B., Fallon, J. F., & Beachy, P. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80678-9 · Cited by 1,014
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
Tsuchida, T., Ensini, M., Brenner‐Morton, S., Baldassare, M., Edlund, H., Jessell, T. M., & Pfaff, S. L. (1994) · Cell · doi:10.1016/0092-8674(94)90027-2 · Cited by 997
Self-citationRoelink, H., Porter, J. A., Chiang, C. C., Tanabe, Y., Chang, D. T., Beachy, P. A., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90397-6 · Cited by 888
Self-citationEricson, J., Brenner‐Morton, S., Kawakami, A., Roelink, H., & Jessell, T. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81386-0 · Cited by 870
Self-citation
Cited by
Sorted by citations
Hedgehog signaling in animal development: paradigms and principlesPreprint
Ingham, P. W., & McMahon, A. P. (2001) · Genes & Development · doi:10.1101/gad.938601 · Cited by 3,025
McDonald, J. W., & Sadowsky, C. L. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07603-1 · Cited by 1,858
The mechanisms of Hedgehog signalling and its roles in development and disease
Briscoe, J., & Thérond, P. P. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3598 · Cited by 1,751
Directed differentiation of embryonic stem cells into motor neurons.
Wichterle, H., Lieberam, I., Porter, J. A., & Jessell, T. (2002) · Cell · doi:10.1016/s0092-8674(02)00835-8 · Cited by 1,792
Self-citationNeuronal subtype specification in the cerebral cortex
Molyneaux, B. J., Arlotta, P., Menezes, J. R. L., & Macklis, J. D. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2151 · Cited by 1,704
Metadata
- Authors
- Jessell, T. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jessell, Thomas M.
- Venue
- Nature Reviews Genetics
- Published
- 2000-10
- Volume
- 1
- Issue
- 1
- Pages
- 20-29
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2081235375
- Cited by
- 2,089
- References
- 104
- Citations by year
- 2026: 36 · 2025: 46 · 2024: 41 · 2023: 45 · 2022: 64 · 2021: 57 · 2020: 88 · 2019: 64 · 2018: 64 · 2017: 62 · 2016: 76 · 2015: 80 · 2014: 80 · 2013: 103 · 2012: 100
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- neuronal specification, spinal cord development, neural tube, cell fate determination, transcriptional regulation, neural progenitor cells, neural circuit formation, signaling molecules, vertebrate central nervous system
- MeSH terms
- Animals, Neurons, Spinal Cord, Transcription, Genetic, Cell Lineage
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