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Potassium leak channels and the KCNK family of two-p-domain subunits
Open accessAbstract
With a bang, a new family of potassium channels has exploded into view. Although KCNK channels were discovered only five years ago, they already outnumber other channel types. KCNK channels are easy to identify because of their unique structure — they possess two pore-forming domains in each subunit. The new channels function in a most remarkable fashion: they are highly regulated, potassium-selective leak channels. Although leak currents are fundamental to the function of nerves and muscles, the molecular basis for this type of conductance had been a mystery. Here we review the discovery of KCNK channels, what has been learned about them and what lies ahead. Even though two-P-domain channels are widespread and essential, they were hidden from sight in plain view — our most basic questions remain to be answered.
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Sleep and arousal: thalamocortical mechanisms
McCormick, D. A., & Bal, T. (1997) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.20.1.185 · Cited by 1,267
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Bean, B. P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2148 · Cited by 1,785
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Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
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Cirelli, C., Gutierrez, C. M., & Tononi, G. (2004) · Neuron · doi:10.1016/s0896-6273(03)00814-6 · Cited by 627
Metadata
- Authors
- Goldstein, S. A. N., Bockenhauer, D., O'Kelly, I., & Zilberberg, N.
- Venue
- Nature Reviews Neuroscience
- Published
- 2001-03
- Volume
- 2
- Issue
- 3
- Pages
- 175-184
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W1993637697
- Cited by
- 718
- References
- 2
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Goldstein, S. A. N., Bockenhauer, D., O'Kelly, I., & Zilberberg, N. (2001). Potassium leak channels and the KCNK family of two-p-domain subunits. Nature Reviews Neuroscience. https://doi.org/10.1038/35058574
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