Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

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1. Bilateral Injections of Amyloid-β 25-35 into the Amygdala of Young Fischer Rats: Behavioral, Neurochemical, and Time Dependent Histopathological Effects
   Einar M. Sigurdsson, J.M Lee, Xin-W. Dong, Matthew J. Hejna, Stanley A. Lorens · 1997 · Neurobiology of Aging
2. Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components
   Elsdon Storey, Konrad T. Beyreuther, Colin Louis Masters · 1996 · Brain Research
3. Muscarinic m1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain
   D. Müller, Klaus D. Mendla, Steven Arthur Farber, Roger M. Nitsch · 1997 · Life Sciences
4. A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid β in the Brain in a Transgenic Model of Alzheimer Disease
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   Jessie Theuns, Els Marjaux, Mathieu Vandenbulcke, Koen Van Laere, Samir Kumar‐Singh, Guy M Bormans, Nathalie Brouwers, Marleen Van den Broeck, Kristel M. Vennekens, Ellen Corsmit et al. · 2006 · Human Mutation
6. Genetically augmenting tau levels does not modulate the onset or progression of Aβ pathology in transgenic mice
   Salvatore Oddo, Antonella Caccamo, David Cheng, Bahareh Jouleh, Reidun Torp, Frank M. LaFerla · 2007 · Journal of Neurochemistry
7. Secretion and Intracellular Generation of Truncated Aβ in β-Site Amyloid-β Precursor Protein-cleaving Enzyme Expressing Human Neurons
   Edward B. Lee, Daniel Skovronsky, Farhad Abtahian, Robert W. Doms, Virginia M.‐Y. Lee · 2003 · Journal of Biological Chemistry
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9. Alzheimer's and prion disease as disorders of protein conformation: implications for the design of novel therapeutic approaches
   Claudio A. Soto · 1999 · Journal of Molecular Medicine
10. β-Peptide Immunization
    Dale B. Schenk, Peter A. Seubert, Ivan M. Lieberburg, Jan Wallace · 2000 · Archives of Neurology
11. The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid
    Joshua H. K. Tam, Claudia Seah, Stephen Pasternak · 2014 · Molecular Brain
12. Toxic effect of a β-amyloid peptide (β22–35) on the hippocampal neuron and its prevention
    Takadera, Tsuneo, Sakura, Naoki, Mohri, Tetsuro, Hashimoto, Tadashi · 1993 · Neuroscience Letters
13. A Splice Variant of β-Secretase Deficient in the Amyloidogenic Processing of the Amyloid Precursor Protein
    Ursula Bodendorf, Frauke Fischer, Dale L. Bodian, Gerd Multhaup, Paolo Paganetti · 2001 · Journal of Biological Chemistry
14. hFE65L Influences Amyloid Precursor Protein Maturation and Secretion
    Suzanne Y. Guénette, Jing Chen, Amber Ferland, Christian Haass, Anja Capell, Rudolph E. Tanzi · 1999 · Journal of Neurochemistry
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    Yuan Luo · 2006 · Life Sciences
16. Cerebral amyloidosis: amyloid subunits, mutants and phenotypes
    Agueda A. Rostagno, Janice L. Holton, Tammaryn Lashley, Tamás Révész, Jorge A. Ghiso · 2009 · Cellular and Molecular Life Sciences
17. Death and survival of neuronal cells exposed to Alzheimer's insults
    Takako Niikura, Yuichi Hashimoto, Hirohisa Tajima, Ikuo Nishimoto · 2002 · Journal of Neuroscience Research
18. Towards Understanding the Roles of Heparan Sulfate Proteoglycans in Alzheimer’s Disease
    Gan-lin Zhang, Xiao Zhang, Xiaomin Wang, Jin‐Ping Li · 2014 · BioMed Research International
19. Insulin-Like Growth Factor I (IGF-I) Protects Cells from Apoptosis by Alzheimer's V642I Mutant Amyloid Precursor Protein through IGF-I Receptor in an IGF-Binding Protein-Sensitive Manner
    Takako Niikura, Yuichi Hashimoto, Takashi Okamoto, Yoichiro Abe, Takashi Yasukawa, Masaoki Kawasumi, Takako Hiraki, Yoshiko A. Kita, Kenzo Terashita, Keisuke Kouyama et al. · 2001 · Journal of Neuroscience
20. Effect of alkalizing agents on the processing of the β-amyloid precursor protein
    Gesine Schrader‐Fischer, Paolo Paganetti · 1996 · Brain Research
21. Comparison of Aβ levels in the brain of familial and sporadic Alzheimer's disease
    Ewa Hellström‐Lindahl, Matti H. Viitanen, Amelia Marutle · 2009 · Neurochemistry International
22. Neurodegenerative mechanisms in alzheimer disease
    Bryce L. Sopher, Ken‐ichiro Fukuchi, Terrance J. Kavanagh, Clement E. Furlong, George M. Martin · 1996 · Molecular and Chemical Neuropathology
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    Dema Najem, Michelle Bamji‐Mirza, Nina Chang, Qing Yan Liu, Wandong Zhang · 2014 · Reviews in the Neurosciences
24. Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes
    Cacquevel, Matthias, Aeschbach, Lorène, Houacine, Jemila, Fraering, Patrick C. · 2012 · PLoS ONE
25. Intracellular A-Beta Amyloid, A Sign for Worse Things to Come?
    Valentina Echeverrı́a, A. Claudio Cuello · 2002 · Molecular Neurobiology
26. Pharmacological modulation of Alzheimer's β-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions
    Vahram H. Haroutunian, Nigel H. Greig, Xue‐Feng Pei, Tada Utsuki, R Gluck, Larisa D. Acevedo, Kenneth L. Davis, William Wallace · 1997 · Molecular Brain Research
27. Neuronal Expression of β-Amyloid Precursor Protein Alzheimer Mutations Causes Intracellular Accumulation of a C-terminal Fragment Containing Both the Amyloid β and Cytoplasmic Domains
    Donna L. McPhie, Robert K. K. Lee, Christopher B. Eckman, Daniel H. Olstein, Stephanie P. Durham, Debra Yager, Steven G. Younkin, Richard Jay Wurtman, Rachael L. Neve · 1997 · Journal of Biological Chemistry
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    Fei Wang, Danqi Chen, Peipei Wu, Catherine B. Klein, Chunyuan Jin · 2019 · Chemical Research in Toxicology
29. Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1
    Johnson, Erik C. B., Ho, Kaitlyn, Yu, Gui-Qiu, Das, Melanie, Sanchez, Pascal E., Djukic, Biljana, Lopez, Isabel, Yu, Xinxing, Gill, Michael, Zhang, Weiping et al. · 2020 · Molecular Neurodegeneration
30. Oxidative stress induces macroautophagy of amyloid β-protein and ensuing apoptosis
    Lin Ping Zheng, Katarina Kågedal, Nodi Dehvari, Eiríkur Benedikz, Richard F. Cowburn, Jan O. Marcusson, Alexei Terman · 2008 · Free Radical Biology and Medicine
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    Sebastian Jäger, Stefanie Leuchtenberger, Anne Marie Martin, Eva Czirr, Johanna Wesselowski, Marco Dieckmann, Elaine Waldron, Carsten Korth, Edward H. Koo, Michael Thomas Heneka et al. · 2009 · Journal of Neurochemistry
32. Endogenous Aβ causes cell death via early tau hyperphosphorylation
    Giuseppina Amadoro, Veronica Corsetti, Maria Teresa Ciotti, Fulvio Florenzano, Simona Capsoni, G. Amato, Pietro Calissano · 2009 · Neurobiology of Aging
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    Robert J. Andrew, Celia G. Fernandez, Molly Stanley, Hong Jiang, Phuong Anh H. Nguyen, Richard C. Rice, Virginie Buggia-Prévot, Pierre De Rossi, Kulandaivelu S. Vetrivel, Raza Lamb et al. · 2017 · Proceedings of the National Academy of Sciences
34. Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer’s disease pathology
    Wojciech Michno, Sofie Nyström, Patrick M. Wehrli, Tammaryn Lashley, Gunnar Brinkmalm, Laurent Guérard, Stina Syvänen, Dag Sehlin, Ibrahim Kaya, Dimitri Brinet et al. · 2019 · Journal of Biological Chemistry
35. Dementia: Alzheimer pathology and vascular factors: From mutually exclusive to interaction
    Anouk G.W. van Norden, Ewoud J. van Dijk, Karlijn F. de Laat, Philip Scheltens, Marcel G.M. Olde-Rikkert, Frank‐Erik de Leeuw · 2011 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
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    Qiao‐Xin Li, Christa J. Maynard, Roberto Cappai, Catriona McLean, Robert A. Cherny, Toni Lynch, Janetta Gladys Culvenor, Jim Trevaskis, Jane E. Tanner, Karen A. Bailey et al. · 1999 · Journal of Neurochemistry
37. Delayed behavioral effects following intrahippocampal injection of aggregated Aβ(1–42)
    Eugene O‘Hare, Derik T. Weldon, Patrick W. Mantyh, Joseph R. Ghilardi, Matthew P. Finke, Mike Kuskowski, J.E. Maggio, Robert A. Shephard, James P. Cleary · 1999 · Brain Research
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    Zhongmin Zhou, Jonathan D. Smith, Paul Greengard, Sam Gandy · 1996 · Molecular Medicine
39. Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives
    Nikolaos K. R K Robakis · 2010 · Neurobiology of Aging
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    I‐Hsuan Liu, Vladimir Nikolaevich Uversky, Larissa A. Munishkina, Anthony L. Fink, Willi M. Halfter, Gregory J. Cole · 2005 · Glycobiology
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    Keun‐A Chang, Yoo‐Hun Suh · 2005 · Journal of Pharmacological Sciences
42. Reactive astrocytes as treatment targets in Alzheimer's disease—Systematic review of studies using the <scp>APPswePS1dE9</scp> mouse model
    Smit, Tamar, Deshayes, Natasja A. C., Borchelt, David R., Kamphuis, Willem, Middeldorp, Jinte, Hol, Elly M. · 2021 · Glia
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    VIVIAN Y. H. HOOK, Lydiane Funkelstein, Jill Wegrzyn, Steven J. Bark, Mark S. Kindy, Gregory Hook · 2011 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
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    José Rodrigo, P. Fernández‐Vizarra, Susana Castro‐Blanco, María Luisa Bentura, M. Nieto, Teresa Gómez‐Isla, Ricardo Martínez‐Murillo, Alfredo Martı́nez, Julia Serrano, Ana Patricia Fernández · 2004 · Neuroscience
45. The use of Seldi ProteinChip? Arrays to monitor production of Alzheimer's ?-amyloid in transfected cells
    Brian Austen, Emma R. Frears, Huw Davies · 2000 · Journal of Peptide Science
46. Intramembrane Proteolysis of β-Amyloid Precursor Protein by γ-Secretase Is an Unusually Slow Process
    Frits Kamp, Edith Winkler, Johannes Trambauer, Amelie Ebke, Regina Fluhrer, Harald Steiner · 2015 · Biophysical Journal
47. Alzheimer β-Amyloid Homodimers Facilitate Aβ Fibrillization and the Generation of Conformational Antibodies
    Ariane Schmechel, Hanswalter Zentgraf, Stefan Scheuermann, Günter Fritz, Rüdiger Pipkorn, Jennifer Reed, Konrad T. Beyreuther, Thomas A. Bayer, Gerd Multhaup · 2003 · Journal of Biological Chemistry
48. Molecular genetics of Alzheimer’s disease
    Pau Pástor, Alison Goate · 2004 · Current Psychiatry Reports
49. Full-length amyloid precursor protein regulates lipoprotein metabolism and amyloid-β clearance in human astrocytes
    Lauren K. Fong, Max M. Yang, Rodrigo dos Santos Chaves, Sol M. Reyna, Vanessa F. Langness, Grace Woodruff, Elizabeth A. Roberts, Jessica E. Young, Lawrence S.B. Goldstein · 2018 · Journal of Biological Chemistry
50. High levels of circulating beta-amyloid peptide do not cause cerebral beta-amyloidosis in transgenic mice.
    Ken‐ichiro Fukuchi, Libin Ho, Steven G. Younkin, Dennis D. Kunkel, Charles E. Ogburn, Renee C. LeBoeuf, Clement E. Furlong, Samir S. Deeb, David Nochlin, Jerzy Węgiel et al. · 1996 · Europe PMC (PubMed Central)
51. Neuroglial-Mediated Immunoinflammatory Responses in Alzheimer's Disease: Complement Activation and Therapeutic Approaches
    Suio Chen, Robert C.A. Frederickson, Kurt R. Brunden · 1996 · Neurobiology of Aging
52. Emerging Alzheimer’s disease therapies: inhibition of β-secretase
    Martin Citron · 2002 · Neurobiology of Aging
53. Comparison of memory, affective behavior, and neuropathology in APPNLGF knock-in mice to 5xFAD and APP/PS1 mice
    Andrea Locci, Hector Orellana, Guadalupe Rodríguez, Meredith Gottliebson, Bryan M. McClarty, Sky Dominguez, Rachel M. Keszycki, Hongxin Dong · 2021 · Behavioural Brain Research
54. Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice
    Masaoki Kawasumi, Tomohiro Chiba, Marina Yamada, Makiko Miyamae‐Kaneko, Masaaki Matsuoka, Jin Nakahara, Taisuke Tomita, Takeshi Iwatsubo, Shigeaki Kato, Sadakazu Aiso et al. · 2004 · European Journal of Neuroscience
55. Intrinsically Disordered Proteins: Where Computation Meets Experiment
    Virginia Burger, Thomas Gurry, Collin M. Stultz · 2014 · Polymers
56. The 5XFAD Mouse Model of Alzheimer’s Disease Exhibits an Age-Dependent Increase in Anti-Ceramide IgG and Exogenous Administration of Ceramide Further Increases Anti-Ceramide Titers and Amyloid Plaque Burden
    Michael B. Dinkins, Somsankar Dasgupta, Guanghu Wang, Gu Zhu, Qian He, Ji Na Kong, Erhard Bieberich · 2015 · Journal of Alzheimer s Disease
57. Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease
    Benedikt Kretner, Johannes Trambauer, Akio Fukumori, Janina Mielke, Peer‐Hendrik Kuhn, Elisabeth Kremmer, Armin Giese, Stefan F. Lichtenthaler, Christian Haass, Thomas Arzberger et al. · 2016 · EMBO Molecular Medicine
58. Amyloid-β Metal Interaction and Metal Chelation
    Math P. Cuajungco, Christopher J. Frederickson, Ashley Ian Bush · 2006 · Springer eBooks
59. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists
    Christof Haffner, Mélanie Frauli, Stephanie D. Topp, Martin Irmler, Kay Hofmann, Jörg T. Regula, Laure Bally‐Cuif, Christian Haass · 2004 · The EMBO Journal
60. Intracellular Amyloidogenesis by Human Islet Amyloid Polypeptide Induces Apoptosis in COS-1 Cells
    Henry J. Hiddinga, Norman L. Eberhardt · 1999 · American Journal Of Pathology
61. β-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer’s disease mutations
    Donna L. McPhie, Todd Eliot Golde, Christopher B. Eckman, Debra Yager, Justin B Brant, Rachael L. Neve · 2001 · Molecular Brain Research
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    Ana Marta de Matos, Maria Paula Macedo, Amélia P. Rauter · 2017 · Medicinal Research Reviews
63. Mutations of beta-amyloid precursor protein alter the consequence of Alzheimer’s disease pathogenesis
    Nuo-Min Li, Nuomin Li, Kefu Liu, Huan-Huan Zhang, Hiroshi Nakanishi, Hong Qing · 2019 · Neural Regeneration Research
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    Ursula Quitterer, Said AbdAlla · 2019 · Pharmacological Research
65. γ-Secretase Inhibition and Modulation for Alzheimers Disease
    Michael S. Wolfe · 2008 · Current Alzheimer Research
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    N. Ertekin-Taner, James Ronald, L. Feuk, J. Prince, Michael Tucker, L. Younkin, Maria Hella, S. Jain, Alyssa M. Hackett, Leah Scanlin et al. · 2005 · Human Molecular Genetics
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    Amelia Marutle, Ulrika Warpman, Nenad Bogdanović, Lars Lannfelt, Agneta K. Nordberg · 2000 · Journal of Neurochemistry
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    Takeshi Kawarabayashi, Mikio Shoji, Masahiro Sato, Atsushi Sasaki, Libin Ho, Christopher B. Eckman, C.-M. Prada, Steven G. Younkin, Takashi Kobayashi, Norihiro Tada et al. · 1996 · Neurobiology of Aging
69. APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression
    Marcus O.W. Grimm, Janine Mett, Christoph P. Stahlmann, Sven Grösgen, Viola J. Haupenthal, Tamara Blümel, Benjamin Hundsdörfer, Valerie C. Zimmer, Nadine T. Mylonas, Heikki Tanila et al. · 2015 · Frontiers in Aging Neuroscience
70. Activation of PKR Causes Amyloid ß-Peptide Accumulation via De-Repression of BACE1 Expression
    Gerard ILL‐Raga, Ernest Palomer, Matthew A. Wozniak, Eva Ramos‐Fernández, Mònica Bosch-Morató, Marta Tajes, Francesc Xavier Guix, José Jorge Galán, Jordi Clarimón, Carmen Antúnez et al. · 2011 · PLoS ONE
71. The Interaction of Amyloid-β with ApoE
    Donald B. Carter · 2005 · Sub-cellular biochemistry/Subcellular biochemistry
72. Entorhinal Cortical Deep Brain Stimulation Rescues Memory Deficits in Both Young and Old Mice Genetically Engineered to Model Alzheimer’s Disease
    Frances Xia, Adelaide P. Yiu, Scellig S. D. Stone, Soo Jin Oh, Andrés M. Lozano, Sheena A. Josselyn, Paul W. Frankland · 2017 · Neuropsychopharmacology
73. The Ras-related GTP-binding Protein, Rab1B, Regulates Early Steps in Exocytic Transport and Processing of β-Amyloid Precursor Protein
    Jan M. Dugan, Christina deWit, Lisa McConlogue, William A. Maltese · 1995 · Journal of Biological Chemistry
74. Copper(II) complexation by human and mouse fragments (11–16) of β-amyloid peptide
    Teresa Kowalik‐Jankowska, Monika Ruta-Dolejsz, Kornelia Wiśniewska, Leszek Łankiewicz, Henryk Kozłowski · 2000 · Journal of the Chemical Society Dalton Transactions
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    Robert N. Dreyer, Kathryn M. Bausch, Paul Fracasso, Lisa J. Hammond, David A. Wunderlich, Dana O. Wirak, Gary L. Davis, Carla M. Brini, Thomas M. Buckholz, Gerhard König et al. · 1994 · European Journal of Biochemistry
76. Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells
    Boyu Zhao, Francis J. Chrest, Walter E. Horton, Sangram S. Sisodia, John W. Kusiak · 1997 · Journal of Neuroscience Research
77. CRISPR-Cas9: A Promising Genome Editing Therapeutic Tool for Alzheimer’s Disease—A Narrative Review
    Nirmal Chandra Barman, Md. Niuz Morshed Khan, Maidul Islam, Zulkar Nain, Rajib Kanti Roy, Anwarul Haque, Shital Kumar BARMAN · 2020 · Neurology and Therapy
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    Warren E. Hochfeld, Shirley Huan Fang Lee, David Chaim Rubinsztein · 2013 · Acta Pharmacologica Sinica
79. Insights on altered mitochondrial function and dynamics in the pathogenesis of neurodegeneration
    Joseph McInnes · 2013 · Translational Neurodegeneration
80. Differential Effects of a Rab6 Mutant on Secretory Versus Amyloidogenic Processing of Alzheimer's β-Amyloid Precursor Protein
    Lisa McConlogue, Flavia Castellano, Christina deWit, Dale Schenk, William A. Maltese · 1996 · Journal of Biological Chemistry
81. Multiple Mechanisms Underlie Neurotoxicity by Different Types of Alzheimer's Disease Mutations of Amyloid Precursor Protein
    Yuichi Hashimoto, Takako Niikura, Yuko Ito, Ikuo Nishimoto · 2000 · Journal of Biological Chemistry
82. The neurotoxicity of amyloid beta protein in aged primates
    Ann Carolyn McKee, N. W. Kawall, J. S. Schumacher, M. Flint Beal · 1998 · Amyloid
83. Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways
    Christopher Böhm, F. Chen, Jean Sévalle, Seema Qamar, Roger B. Dodd, Y. Li, Gerold Schmitt‐Ulms, Paul E. Fraser, Peter St George‐Hyslop · 2015 · Molecular and Cellular Neuroscience
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    Cristina Guardia‐Laguarta, Marta Pera, Jordi Clarimón, José Luís Molinuevo, Raquel Sánchez‐Valle, Albert Lladó, Mireia Coma, Teresa Gómez‐Isla, Rafael Blesa, Isidró Ferrer et al. · 2009 · Journal of Neuropathology & Experimental Neurology
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    Sang‐Moon Yun, Sun-Jung Cho, Jae Chun Song, Sung Yeon Song, Sangmee Ahn Jo, Chulman Jo, Keejung Yoon, Rudolph E. Tanzi, Eui‐Ju Choi, Young Ho Koh · 2012 · Neurobiology of Aging
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    Vo Van Giau, Vorapun Senanarong, Eva Bagyinszky, Seong Soo A. An, SangYun Kim · 2019 · International Journal of Molecular Sciences
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    Victoria Burchell, Sonia Gandhi, Emma Deas, Nicholas William Wood, Andrey Y. Abramov, Hélène Plun‐Favreau · 2010 · Expert Opinion on Therapeutic Targets
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    Hiroshi Takuma, Takami Tomiyama, Keisuke Kuida, Hiroshi Mori · 2004 · Journal of Neuropathology & Experimental Neurology
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    Bart De Strooper, Katleen Craessaerts, Ilse Dewachter, Dieder Moechars, Barry Greenberg, Fred VAN LEUVEN, Herman VAN DEN BERGHE · 1995 · Journal of Biological Chemistry
90. Identification of NEEP21 as a β-Amyloid Precursor Protein-Interacting ProteinIn VivoThat Modulates Amyloidogenic ProcessingIn Vitro
    Eric M. Norstrom, Can Martin Zhang, Rudolph E. Tanzi, Sangram S. Sisodia · 2010 · Journal of Neuroscience
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    Jung Keun Cho, Young Bae Ryu, Marcus J. C. Long, Ji Young Kim, Doman Kim, Sun Lee, Woo Song Lee, Ki Hun Park · 2011 · Bioorganic & Medicinal Chemistry Letters
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    Kei Sakamoto, Shunji Matsuki, Kyoko Matsuguma, Tatsuya Yoshihara, Naoki Uchida, Fumihiko Azuma, Muir Russell, Glen Hughes, Samantha Budd Haeberlein, Robert Alexander et al. · 2017 · The Journal of Clinical Pharmacology
93. βAPP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family
    Henry W. Querfurth, Ellen M. Wijsman, Peter St George‐Hyslop, Dennis J. Selkoe · 1995 · Molecular Brain Research
94. Enhanced Release of Secreted Form of Alzheimer’s Amyloid Precursor Protein from PC12 Cells by Nicotine
    Seonghun Kim, Young Kyung Kim, Sung‐Jin Jeong, Christian Haass, Young-Hoon Kim, Yoo‐Hun Suh · 1997 · Molecular Pharmacology
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    Kumar Sambamurti, Nigel H. Greig, Tadanobu Utsuki, Eliza Barnwell, Ekta Sharma, Cheryl Mazell, Narayan R. Bhat, Mark S. Kindy, Debomoy K. Lahiri, Miguel A. Pappolla · 2011 · Journal of Neurochemistry
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    Charlotte Sahlin, Anna Lord, Kristina Magnusson, Hillevi Englund, Cláudia Guimas Almeida, Paul Greengard, Fred Nyberg, Gunnar K. Gouras, Lars Lannfelt, Lars N. G. Nilsson · 2007 · Journal of Neurochemistry
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    Lisa Marie Munter, Anne Botev, Luise Richter, Peter Werner Hildebrand, Veit Althoff, Christoph Weise, Daniela Kaden, Gerd Multhaup · 2010 · Journal of Biological Chemistry
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    Adriana Ferreira · 2012 · ISRN Biochemistry
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     Frédéric Checler, Elissa Afram, Raphaëlle Pardossi‐Piquard, Inger Lauritzen · 2021 · Journal of Biological Chemistry