The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Toxic effect of a β-amyloid peptide (β22–35) on the hippocampal neuron and its prevention
Abstract
A synthetic truncated beta-amyloid peptide, beta 22-35, was shown to have a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. The peptide formed aggregates and typical amyloid fibrils resembling those of the beta-amyloid protein (AP) in neutral buffer solution and showed characteristic staining with Congo red and thioflavin-S. The neurotoxicity of beta 22-35 was suppressed by addition of calf serum, dibutyryl cAMP or insulin to culture medium, but not by addition of NGF or substance P. beta 22-35 had no effect on the glial cells. These results suggest that the AP can induce neurotoxicity in the hippocampal cells in vitro and the toxicity may involve a disorder in the intracellular signal transduction.
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Aβ(22-35) contains the biologically active portion of Aβ.
“This Aβ peptide fragment contains the biologically active portion of Aβ (Yanker et al., 1990; Takadera et al., 1993).”
From The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease (2011) · cites this paper as Takadera et al., 1993
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Cites
Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides
Yankner, B. A., Duffy, L. K., & Kirschner, D. A. (1990) · Science · doi:10.1126/science.2218531 · Cited by 1,975
Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., & Selkoe, D. J. (1992) · Nature · doi:10.1038/360672a0 · Cited by 1,757
Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor
Cai, X.-D., Golde, T. E., & Younkin, S. G. (1993) · Science · doi:10.1126/science.8424174 · Cited by 913
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Research works printed but not linked: 17
- Castano, 1986, In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease β-protein, Biochem. Biophys. Res. Commun., 141, 782, 10.1016/S0006-291X(86)80241-8 · DOI
- Glenner, 1984, Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein, Biochem. Biophys. Res. Commun., 120, 885, 10.1016/S0006-291X(84)80190-4 · DOI · Paper page
- Joslin, 1991, Amyloid-β peptide, substance P and bombesin bind to the serpin-enzyme complex receptor, J. Biol. Chem., 266, 21897, 10.1016/S0021-9258(18)54721-9 · DOI
- Koh, 1990, β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage, Brain Res., 533, 315, 10.1016/0006-8993(90)91355-K · DOI
- Kozlowski, 1992, The neurotoxic carboxy-terminal fragment of the Alzheimer amyloid precursor binds specifically to a neuronal cell surface molecule: pH dependence of the neurotoxicity and the binding, J. Neurosci., 12, 1679, 10.1523/JNEUROSCI.12-05-01679.1992 · DOI
- Maruyama, 1990, Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor, Nature, 347, 566, 10.1038/347566a0 · DOI
- Mattson, 1992, β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity, J. Neurosci., 12, 376, 10.1523/JNEUROSCI.12-02-00376.1992 · DOI
- Mitsuhashi, 1991, Amyloid β protein substituent peptides do not interact with the substance P receptor expressed in cultured cells, Mol. Brain Res., 11, 177, 10.1016/0169-328X(91)90120-M · DOI
- Ohkubo, 1991, Characterization of the uptake of adenosine by cultured rat hippocampal cells and inhibition of the uptake by xanthine derivatives, Neurosci. Lett., 133, 275, 10.1016/0304-3940(91)90587-J · DOI
- Pike, 1991, In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity, Brain Res., 563, 311, 10.1016/0006-8993(91)91553-D · DOI
- Pike, 1993, Neurodegeneration induced by β-amyloid peptide in vitro: the role of peptide assembly state, J. Neurosci., 13, 1676, 10.1523/JNEUROSCI.13-04-01676.1993 · DOI · Paper page
- Roher, 1991, β-Amyloid from Alzheimer disease brains inhibits sprouting and survival of sympathetic neurons, Biochem. Biophys. Res. Commun., 174, 572, 10.1016/0006-291X(91)91455-L · DOI
- Rukenstein, 1991, Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms, J. Neurosci., 11, 2552, 10.1523/JNEUROSCI.11-08-02552.1991 · DOI
- Selkoe, 1986, Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease, J. Neurochem., 46, 1820, 10.1111/j.1471-4159.1986.tb08501.x · DOI
- Whitson, 1989, Amyloid β protein enhances the survival of hippocampal neurons in vitro, Science, 243, 1488, 10.1126/science.2928783 · DOI
- Whitson, 1990, β-Amyloid protein promotes neuritic branching in hippocampal cultures, Neurosci. Lett., 110, 319, 10.1016/0304-3940(90)90867-9 · DOI
- Yoshikawa, 1992, Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor, Nature, 359, 64, 10.1038/359064a0 · DOI
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Luchsinger, J. A. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.7.635 · Cited by 682
McManus, M. J., Murphy, M. P., & Franklin, J. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0552-11.2011 · Cited by 432
Insulin rescues amyloid β-induced impairment of hippocampal long-term potentiation
Lee, C.-C., Kuo, Y.-M., Huang, C.-C., & Hsu, K.-S. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.06.014 · Cited by 81
Prevention of the Neurotoxicity of the Amyloid Beta Protein by Genipin
YAMAZAKI, M., SAKURA, N., CHIBA, K., & MOHRI, T. (2001) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.24.1454 · Cited by 62
Self-citationSantos, R. X., Correia, S. C., Alves, M. G., Oliveira, P. F., Cardoso, S., Carvalho, C., Duarte, A. I., Santos, M. S., & Moreira, P. I. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.04.011 · Cited by 61
Metadata
- Authors
- Takadera, T., Sakura, N., Mohri, T., & Hashimoto, T.
- Affiliations
- Hokuriku University (JP)
- Corresponding author
- Takadera, Tsuneo
- ORCID
- Takadera, Tsuneo
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1993-10
- Volume
- 161
- Issue
- 1
- Pages
- 41-44
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1983288425
- Cited by
- 77
- References
- 3
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- neurotoxicity, hippocampal neurons, amyloid fibril formation, Congo red staining, thioflavin S staining, neuroprotection, dibutyryl cyclic AMP, insulin, signal transduction, Alzheimer's disease
- MeSH terms
- Animals, Cells, Cultured, Bucladesine, Hippocampus, Insulin, Nerve Growth Factors, Neurons, Substance P, Amyloid beta-Peptides, Rats
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