Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Citron, Martin, Oltersdorf, Tilman, Haass, Christian, McConlogue, Lisa, Hung, Albert Y., Seubert, Peter, Vigo-Pelfrey, Carmen, Lieberburg, Ivan +1 more·1992·Nature
DOI 10.1038/360672a0

Cited by (1,005)

Items 101–200 of 1,005

  1. The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain
    Megan M. Varnum, Tsuneya Ikezu · 2012 · Archivum Immunologiae et Therapiae Experimentalis
  2. Longer Forms of Amyloid β Protein: Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase
    Qi-Takahara, Yue, Morishima-Kawashima, Maho, Tanimura, Yu, Dolios, Georgia, Hirotani, Naoko, Horikoshi, Yuko, Kametani, Fuyuki, Maeda, Masahiro, Saido, Takaomi C., Wang, Rong et al. · 2005 · The Journal of Neuroscience
  3. Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease
    Martins, I J, Hone, E, Foster, J K, Sünram-Lea, S I, Gnjec, A, Fuller, S J, Nolan, D, Gandy, S E, Martins, R N · 2006 · Molecular Psychiatry
  4. Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42
    Ruth G. Perez, Salvador Soriano, Jay D. Hayes, Beth L. Ostaszewski, Weiming Xia, Dennis J. Selkoe, Xiaohua Chen, Gorazd Bernard Stokin, Edward H. Koo · 1999 · Journal of Biological Chemistry
  5. Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome
    Takeshi Iwatsubo, David M. A. Mann, Asano Odaka, Nobuhiro Suzuki, Yasuo Ihara · 1995 · Annals of Neurology
  6. An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease
    Du Yan, Shi, Fu, Jin, Soto, Claudio, Chen, Xi, Zhu, Huaijie, Al-Mohanna, Futwan, Collison, Kate, Zhu, Aiping, Stern, Eric, Saido, Takaomi et al. · 1997 · Nature
  7. Amyloid peptides are toxic via a common oxidative mechanism.
    David A. Schubert, Christian Behl, Robin Lesley, André Brack, Richard Dargusch, Yutaka Sagara, Hideo Kimura · 1995 · Proceedings of the National Academy of Sciences
  8. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
    Taisuke Tomita, Kei Maruyama, Takaomi C. Saido, Hideaki Kume, Kohki Shinozaki, Shinya Tokuhiro, Anja Capell, Jochen Walter, Jürgen Grünberg, Christian Haass et al. · 1997 · Proceedings of the National Academy of Sciences
  9. Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease
    Gomez‐Isla, Teresa, West, Howard L., Rebeck, G. William, Harr, Steven D., Growdon, John H., Locascio, Joseph J., Perls, Thomas T., Lipsitz, Lewis A., Hyman, Bradley T. · 1996 · Annals of Neurology
  10. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative
    Gabuzda, D., Busciglio, J., Chen, L.B., Matsudaira, P., Yankner, B.A. · 1994 · Journal of Biological Chemistry
  11. Early-onset and Robust Cerebral Microvascular Accumulation of Amyloid β-Protein in Transgenic Mice Expressing Low Levels of a Vasculotropic Dutch/Iowa Mutant Form of Amyloid β-Protein Precursor
    Davis, Judianne, Xu, Feng, Deane, Rashid, Romanov, Galina, Previti, Mary Lou, Zeigler, Kelly, Zlokovic, Berislav V., Van Nostrand, William E. · 2004 · Journal of Biological Chemistry
  12. Robust Central Reduction of Amyloid-β in Humans with an Orally Available, Non-Peptidic β-Secretase Inhibitor
    Patrick C. May, Robert A. Dean, Stephen Loucian Lowe, Ferenc Martényi, Scott M. Sheehan, Leonard N. Boggs, Scott A. Monk, Brian M. Mathes, Dustin J. Mergott, Brian M. Watson et al. · 2011 · Journal of Neuroscience
  13. Neuroprotection and neurorescue against Aβ toxicity and PKC‐dependent release of non‐amyloidogenic soluble precursor protein by green tea polyphenol (‐)‐epigallocatechin‐3‐gallate
    Yona Levites, Tamar Amit, Silvia A. Mandel, Moussa B. H. Youdim · 2003 · The FASEB Journal
  14. The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis
    Jie Janet Zhao, Tracy O’Connor, Robert J. Vassar · 2011 · Journal of Neuroinflammation
  15. Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
    Nilüfer Ertekin‐Taner, Neill Graff-Radford, Linda H. Younkin, Christopher B. Eckman, Matthew Baker, Jennifer L. Adamson, James Ronald, John Blangero, Michael L. Hutton, Steven G. Younkin · 2000 · Science
  16. Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.
    Citron, M, Vigo-Pelfrey, C, Teplow, D B, Miller, C, Schenk, D, Johnston, J, Winblad, B, Venizelos, N, Lannfelt, L, Selkoe, D J · 1994 · Proceedings of the National Academy of Sciences
  17. Therapeutic approaches to Alzheimer's disease
    Hans‐Wolfgang Klafki, Matthias Staufenbiel, Johannes Kornhuber, Jens Wiltfang · 2006 · Brain
  18. Evaluation of the safety and immunogenicity of synthetic Aβ42 (AN1792) in patients with AD
    Bayer, A. J., Bullock, R., Jones, R. W., Wilkinson, D., Paterson, K. R., Jenkins, L., Millais, S. B., Donoghue, S. · 2005 · Neurology
  19. Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease.
    1997 · Europe PMC (PubMed Central)
  20. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits
    Holcomb, Leigh A., Gordon, Marcia N., Jantzen, Paul, Hsiao, Karen, Duff, Karen, Morgan, Dave · 1999 · Behavior Genetics
  21. Amyloid-β Aggregation
    Verena H. Finder, Rudi Glockshuber · 2007 · Neurodegenerative Diseases
  22. Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
    Arendash, Gary W., King, David L., Gordon, Marcia N., Morgan, Dave, Hatcher, Jaime M., Hope, Caroline E., Diamond, David M. · 2001 · Brain Research
  23. Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNS<i>In Vivo</i>
    Weldon, Derik T., Rogers, Scott D., Ghilardi, Joseph R., Finke, Matthew P., Cleary, James P., O’Hare, Eugene, Esler, William P., Maggio, John E., Mantyh, Patrick W. · 1998 · The Journal of Neuroscience
  24. Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau
    John Hardy, Karen Duff, Katrina Gwinn Hardy, Jordi Pérez‐Tur, Mike Hutton · 1998 · Nature Neuroscience
  25. The molecular basis of genetic dominance.
    Andrew O.M. Wilkie · 1994 · Journal of Medical Genetics
  26. Longitudinal study of cerebrospinal fluid levels of tau, Aβ1–40, and Aβ1–42(43) in Alzheimer's disease: A study in Japan
    Kanai, M., Matsubara, E., Isoe, K., Urakami, K., Nakashima, K., Arai, H., Sasaki, H., Abe, K., Iwatsubo, T., Kosaka, T. et al. · 1998 · Annals of Neurology
  27. Brain-targeted drug delivery by manipulating protein corona functions
    Zhang, Zui, Guan, Juan, Jiang, Zhuxuan, Yang, Yang, Liu, Jican, Hua, Wei, Mao, Ying, Li, Cheng, Lu, Weiyue, Qian, Jun et al. · 2019 · Nature Communications
  28. Amyloid β-Peptide Is Transported on Lipoproteins and Albumin in Human Plasma
    Biere, Anja Leona, Ostaszewski, Beth, Stimson, Evelyn R., Hyman, Bradley T., Maggio, John E., Selkoe, Dennis J. · 1996 · Journal of Biological Chemistry
  29. Evidence that Aβ42 is the real culprit in alzheimer's disease
    Steven G. Younkin · 1995 · Annals of Neurology
  30. Amyloid β-Protein Is Degraded by Cellular Angiotensin-converting Enzyme (ACE) and Elevated by an ACE Inhibitor*
    Matthew L. Hemming, D. Selkoe · 2005 · Journal of Biological Chemistry
  31. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects
    Robert J. Vassar, Peer‐Hendrik Kuhn, Christian Haass, Matthew E Kennedy, Lawrence Rajendran, Philip C. Wong, Stefan F. Lichtenthaler · 2014 · Journal of Neurochemistry
  32. Copper-Dependent Inhibition of Human Cytochrome<i>c</i>Oxidase by a Dimeric Conformer of Amyloid-β<sub>1-</sub>42
    Crouch, Peter J., Blake, Rachel, Duce, James A., Ciccotosto, Giuseppe D., Li, Qiao-Xin, Barnham, Kevin J., Curtain, Cyril C., Cherny, Robert A., Cappai, Roberto, Dyrks, Thomas et al. · 2005 · The Journal of Neuroscience
  33. Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome
    Jan K. Teller, Claudio Russo, Laura M. DeBusk, Giovanna Angelini, D Zaccheo, Francesca Dagna-Bricarelli, Pietro Scartezzini, Stefano Bertolini, David M. A. Mann, Massimo Tabaton et al. · 1996 · Nature Medicine
  34. Protein Kinase C-dependent α-Secretase Competes with β-Secretase for Cleavage of Amyloid-β Precursor Protein in the Trans-Golgi Network
    Daniel Skovronsky, D.Blaine Moore, Marcos E. Milla, Robert W. Doms, Virginia M.‐Y. Lee · 2000 · Journal of Biological Chemistry
  35. Amyloid β Peptide of Alzheimer’s Disease Downregulates Bcl-2 and Upregulates Bax Expression in Human Neurons
    Eric Paradis, Hélène Douillard, Maria Koutroumanis, Cynthia G. Goodyer, Andrea Claire LeBlanc · 1996 · Journal of Neuroscience
  36. Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease
    Jadiya, Pooja, Kolmetzky, Devin W., Tomar, Dhanendra, Di Meco, Antonio, Lombardi, Alyssa A., Lambert, Jonathan P., Luongo, Timothy S., Ludtmann, Marthe H., Praticò, Domenico, Elrod, John W. · 2019 · Nature Communications
  37. The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex
    Anja Capell, Jürgen Grünberg, Brigitte Pesold, Anke Diehlmann, Martin Citron, Ralph A. Nixon, Konrad T. Beyreuther, Dennis J. Selkoe, Christian Haass · 1998 · Journal of Biological Chemistry
  38. Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
    Scott A. Small, Sam Gandy · 2006 · Neuron
  39. Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Aβ42 and decreased Aβ40
    Samir Kumar‐Singh, Jessie Theuns, Bianca Van Broeck, Daniel Nicolae Pirici, Krist’l Vennekens, Ellen Corsmit, Marc Cruts, Bart Dermaut, Rong Wang, Christine Van Broeckhoven · 2006 · Human Mutation
  40. Causative and susceptibility genes for Alzheimer’s disease: a review
    Anna Rocchi, Silvia Pellegrini, Gabriele Siciliano, Luigi Murri · 2003 · Brain Research Bulletin
  41. Metabolism of the “Swedish” Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells
    Thinakaran, Gopal, Teplow, David B., Siman, Robert, Greenberg, Barry, Sisodia, Sangram S. · 1996 · Journal of Biological Chemistry
  42. Mouse models of Alzheimer's disease
    Hall, Alicia M., Roberson, Erik D. · 2012 · Brain Research Bulletin
  43. A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ
    Dylan Kwart, Andrew Gregg, Claudia Scheckel, Elisabeth A. Murphy, Dominik Paquet, Michael D. Duffield, John J. Fak, Olav Olsen, Robert B. Darnell, Marc Tessier‐Lavigne · 2019 · Neuron
  44. Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß <sub>42</sub> by Inhibiting Rho
    Zhou, Yan, Su, Yuan, Li, Baolin, Liu, Feng, Ryder, John W., Wu, Xin, Gonzalez-DeWhitt, Patricia A., Gelfanova, Valentina, Hale, John E., May, Patrick C. et al. · 2003 · Science
  45. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor
    Christian Haass, Albert Y. Hung, Dennis J. Selkoe, David B. Teplow · 1994 · Journal of Biological Chemistry
  46. Behavioral and anatomical deficits in mice homozygous for a modified ?-amyloid precursor protein gene
    Ulrike Müller · 1994 · Cell
  47. Endogenous Neuroprotection Factors and Traumatic Brain Injury: Mechanisms of Action and Implications for Therapy
    Mark P. Mattson, Stephen W. Scheff · 1994 · Journal of Neurotrauma
  48. Amyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease
    Villegas, Sandra, Roda, AlejandroR, Serra-Mir, Gabriel, Montoliu-Gaya, Laia, Tiessler, Lidia · 2022 · Neural Regeneration Research
  49. β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
    Cummings, Brian J., Pike, Christian J., Shankle, Rodman, Cotman, Carl W. · 1996 · Neurobiology of Aging
  50. The cerebrospinal-fluid soluble form of Alzheimer's amyloid β is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex
    Ghiso, J, Matsubara, E, Koudinov, A, Choi-Miura, N H, Tomita, M, Wisniewski, T, Frangione, B · 1993 · Biochemical Journal
  51. A Loss of Function Mutation of Presenilin-2 Interferes with Amyloid β-Peptide Production and Notch Signaling
    Harald Steiner, Karen Duff, Anja Capell, Helmut Romig, Melissa G. Grim, Sarah Lincoln, John Hardy, Xin Yu, Melanie Picciano, Katja Fechteler et al. · 1999 · Journal of Biological Chemistry
  52. Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer’s disease
    Todd Eliot Golde, Christopher B. Eckman, Steven G. Younkin · 2000 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  53. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease
    Darin Jaturapatporn, Mokhtar Gad El Kareem Nasr Isaac, Jenny M. McCleery, Naji Tabet · 2012 · Cochrane Database of Systematic Reviews
  54. Evidence for glial-mediated inflammation in aged APPSW transgenic mice
    William C. Benzing, Jerome R. Wujek, Erin K. Ward, Daniel J. Shaffer, Karen H. Ashe, Steven G. Younkin, Kurt R. Brunden · 1999 · Neurobiology of Aging
  55. Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments
    Stefan F. Lichtenthaler, Marius K. Lemberg, Regina Fluhrer · 2018 · The EMBO Journal
  56. Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension.
    Stuart J. McKinnon, Donna M Lehman, Lisa A. Kerrigan, Carol A. Merges, Mary Ellen Pease, Danielle Kerrigan, Nancy L. Ransom, Nayyirih G. Tahzib, Herbert Anton Reitsamer, Hana Levkovitch-Verbin et al. · 2002 · PubMed
  57. The amyloid cascade hypothesis: an updated critical review
    Kasper P. Kepp, Nikolaos K. R K Robakis, Poul Flemming Høilund‐Carlsen, Stefano Luca Sensi, Bryce Vissel · 2023 · Brain
  58. Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies
    Tamás Révész, Janice L. Holton, Tammaryn Lashley, Gordon Terence Plant, Blas Frangione, Agueda A. Rostagno, Jorge A. Ghiso · 2009 · Acta Neuropathologica
  59. Deciphering the Genetic Basis of Alzheimer's Disease
    Dennis J. Selkoe, Marcia Berman Podlisny · 2002 · Annual Review of Genomics and Human Genetics
  60. The Profile of Soluble Amyloid β Protein in Cultured Cell Media
    Rong Wang, David A. Sweeney, Sam Gandy, Sangram S. Sisodia · 1996 · Journal of Biological Chemistry
  61. Axonal Transport and Alzheimer's Disease
    Gorazd Bernard Stokin, Lawrence S.B. Goldstein · 2006 · Annual Review of Biochemistry
  62. Inflammatory mechanisms in Alzheimer's disease
    Piet Eikelenboom, Shanshan Zhan, Willem A. van Gool, David Allsop · 1994 · Trends in Pharmacological Sciences
  63. Detection of a Novel Intraneuronal Pool of Insoluble Amyloid β Protein that Accumulates with Time in Culture
    Skovronsky, Daniel M., Doms, Robert W., Lee, Virginia M.-Y. · 1998 · The Journal of Cell Biology
  64. Translation of the Alzheimer Amyloid Precursor Protein mRNA Is Up-regulated by Interleukin-1 through 5′-Untranslated Region Sequences
    Rogers, Jack T., Leiter, Lorene M., McPhee, Jay, Cahill, Catherine M., Zhan, Shan-Shan, Potter, Huntington, Nilsson, Lars N.G. · 1999 · Journal of Biological Chemistry
  65. Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities
    Martin Citron, Thekla S. Diehl, Grace Gordon, Anja Leona Biere, Peter A. Seubert, Dennis J. Selkoe · 1996 · Proceedings of the National Academy of Sciences
  66. Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis
    Keil, Uta, Bonert, Astrid, Marques, Celio A., Scherping, Isabel, Weyermann, Jörg, Strosznajder, Joanna B., Müller-Spahn, Franz, Haass, Christian, Czech, Christian, Pradier, Laurent et al. · 2004 · Journal of Biological Chemistry
  67. The role of Aβ42 in Alzheimer's disease
    Younkin, Steven G. · 1998 · Journal of Physiology-Paris
  68. Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins
    Weiming Xia, Jimin Zhang, Dora Kholodenko, Martin Citron, Marcia Berman Podlisny, David B. Teplow, Christian Haass, Peter A. Seubert, Edward H. Koo, Dennis J. Selkoe · 1997 · Journal of Biological Chemistry
  69. PEN-2 Is an Integral Component of the γ-Secretase Complex Required for Coordinated Expression of Presenilin and Nicastrin
    Harald Steiner, Edith Winkler, Dieter Edbauer, Stefan Prokop, Gabriele Basset, Aya Yamasaki, Marcus Kostka, Christian Haass · 2002 · Journal of Biological Chemistry
  70. Serial propagation of distinct strains of Aβ prions from Alzheimer’s disease patients
    Joel C. Watts, Carlo Condello, Jan Stöhr, Abby Oehler, Joanne Lee, Stephen J. DeArmond, Lars Lannfelt, Martin Ingelsson, Kurt Giles, Stanley B. Prusiner · 2014 · Proceedings of the National Academy of Sciences
  71. C‐terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase‐3β expression
    Hye‐Sun Kim, Eun‐Mee Kim, Jean‐Pyo Lee, Cheol Hyoung Park, Seonghan Kim, Ji‐Heui Seo, Keun‐A Chang, Eunah Yu, Sung‐Jin Jeong, Young Hae Chong et al. · 2003 · The FASEB Journal
  72. Amyloid β-protein oligomers and Alzheimer’s disease
    Hayden, Eric Y, Teplow, David B · 2013 · Alzheimer's Research &amp; Therapy
  73. Molecular genetics of Alzheimer’s disease
    Peter St George‐Hyslop · 2000 · Biological Psychiatry
  74. Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice
    John Larson, GARY S. LYNCH, Dora Games, Peter A. Seubert · 1999 · Brain Research
  75. Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide.
    Joseph D. Buxbaum, Edward H. Koo, Paul Greengard · 1993 · Proceedings of the National Academy of Sciences
  76. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology
    Fiona E McAlpine, Jae‐Kyung Lee, Ashley S. Harms, Kelly A. Ruhn, Mathew M. Blurton-Jones, John J. Hong, Pritam Das, Todd Eliot Golde, Frank M. LaFerla, Salvatore Oddo et al. · 2009 · Neurobiology of Disease
  77. Slow Degradation of Aggregates of the Alzheimer's Disease Amyloid β-Protein by Microglial Cells
    Donata M. Paresce, Haeyong Chung, Frederick R. Maxfield · 1997 · Journal of Biological Chemistry
  78. Fibrillogenesis in Alzheimer's disease of amyloid <i>β</i> peptides and apolipoprotein E
    Castano, E M, Prelli, F, Wisniewski, T, Golabek, A, Kumar, R A, Soto, C, Frangione, B · 1995 · Biochemical Journal
  79. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ 42 production
    Tobias Moehlmann, Edith Winkler, Xuefeng Xia, Dieter Edbauer, Jill R. Murrell, Anja Capell, Christoph Kaether, Hui Zheng, Bernardino Francesco Ghetti, Christian Haass et al. · 2002 · Proceedings of the National Academy of Sciences
  80. Neuroprotective and neurotrophic actions of glucagon‐like peptide‐1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders
    Isidro Salcedo, David Tweedie, Yazhou Li, Nigel H. Greig · 2012 · British Journal of Pharmacology
  81. Oxidatively Modified Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and Alzheimer's Disease: Many Pathways to Neurodegeneration
    David Allan Butterfield, Sarita S. Hardas, Miranda L. Bader Lange · 2010 · Journal of Alzheimer s Disease
  82. Image analysis of β-amyloid load in Alzheimer's disease and relation to dementia severity
    Brian J Cummings, Carl W. Cotman · 1995 · The Lancet
  83. Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia
    Marsel M. Mesulam, Changiz Geula · 1994 · Annals of Neurology
  84. Astrocyte energy and neurotransmitter metabolism in Alzheimer’s disease: Integration of the glutamate/GABA-glutamine cycle
    Jens Velde Andersen, Arne Schousboe, Alexei Verkhratsky · 2022 · Progress in Neurobiology
  85. Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease
    Lorenzo, Alfredo, Yuan, Menglan, Zhang, Zhuohua, Paganetti, Paolo A., Sturchler-Pierrat, Christine, Staufenbiel, Matthias, Mautino, Jorge, Vigo, Francisco Sol, Sommer, Bernd, Yankner, Bruce A. · 2000 · Nature Neuroscience
  86. Sorting of the Alzheimer's Disease Amyloid Precursor Protein Mediated by the AP-4 Complex
    Burgos, Patricia V., Mardones, Gonzalo A., Rojas, Adriana L., daSilva, Luis L.P., Prabhu, Yogikala, Hurley, James H., Bonifacino, Juan S. · 2010 · Developmental Cell
  87. An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function
    Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F. Lichtenthaler, Harald Steiner, Christian Haass · 2017 · EMBO Molecular Medicine
  88. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases
    Harald Steiner, Marcus Kostka, Helmut Romig, Gabriele Basset, Brigitte Pesold, John Hardy, Anja Capell, Liane Meyn, Melissa L. Grim, Ralf Baumeister et al. · 2000 · Nature Cell Biology
  89. Genetic Neurodegenerative Diseases: The Human Illness and Transgenic Models
    Donald L. Price, Sangram S. Sisodia, David Borchelt · 1998 · Science
  90. Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research
    Asad Jan, Dean M. Hartley, Hilal Ahmed Lashuel · 2010 · Nature Protocols
  91. Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant “Apoptotic” Pattern of Gene Induction
    Steven Estus, H. Michael Tucker, Corlia van Rooyen, Sarah Wright, Elizabeth F. Brigham, Mark D. Wogulis, Russell E. Rydel · 1997 · Journal of Neuroscience
  92. Energy Inhibition Elevates β-Secretase Levels and Activity and Is Potentially Amyloidogenic in APP Transgenic Mice: Possible Early Events in Alzheimer's Disease Pathogenesis
    Velliquette, Rodney A., O'Connor, Tracy, Vassar, Robert · 2005 · The Journal of Neuroscience
  93. Modulation of Secreted β-Amyloid Precursor Protein and Amyloid β-Peptide in Brain by Cholesterol
    David Howland, Stephen P. Trusko, Mary J. Savage, Andrew G. Reaume, Diane M. Lang, James D. Hirsch, N. Maeda, Robert Siman, Barry Greenberg, Richard W. Scott et al. · 1998 · Journal of Biological Chemistry
  94. Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques.
    Takeshi Iwatsubo, Takaomi C. Saido, David M. A. Mann, Virginia M.-Y. Lee, John Q. Trojanowski · 1996 · Europe PMC (PubMed Central)
  95. Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests
    Bates, K A, Verdile, G, Li, Q-X, Ames, D, Hudson, P, Masters, C L, Martins, R N · 2009 · Molecular Psychiatry
  96. Maturation and Pro-peptide Cleavage of β-Secretase
    Anja Capell, Harald Steiner, Michael Willem, Hartmut Kaiser, Carmen Meyer, Jochen Walter, Sven Lammich, Gerd Multhaup, Christian Haass · 2000 · Journal of Biological Chemistry
  97. Cellular Functions of the Amyloid Precursor Protein from Development to Dementia
    Rik van der Kant, Lawrence S.B. Goldstein · 2015 · Developmental Cell
  98. The Role of APP Processing and Trafficking Pathways in the Formation of Amyloid β‐Proteina
    Dennis J. Selkoe, Tsuneo Yamazaki, Martin Citron, Marcia Berman Podlisny, Edward H. Koo, David B. Teplow, Christian Haass · 1996 · Annals of the New York Academy of Sciences
  99. Mechanisms of Aβ mediated neurodegeneration in Alzheimer's disease
    Peter John Crouch, Susan-Marie E. Harding, Anthony Robert White, James Camakaris, Ashley Ian Bush, Colin Louis Masters · 2007 · The International Journal of Biochemistry & Cell Biology
  100. Calcium Ionophore Increases Amyloid .beta. Peptide Production by Cultured Cells
    Henry W. Querfurth, Dennis J. Selkoe · 1994 · Biochemistry