Cited by 615Immunotherapy and Immune Responsesvaccines and immunoinformatics approachesT-cell and B-cell Immunology

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

Pfeifer, John D., Wick, Mary Jo, Roberts, Richard L., Findlay, Kirk, Normark, Staffan J., Harding, Clifford V.·1993·Nature

DOI 10.1038/361359a0

Open this paper in CoChat — free account

Abstract

Class I major histocompatibility complex (MHC) molecules present antigens that are produced within the presenting cell or penetrate from the vacuolar system into the cytosol for processing. Most studies of exogenous antigen processing have used soluble antigens, which are not efficiently presented by class I MHC molecules and do not elicit CD8 T-cell responses in vivo. But particulate antigen preparations with no known mechanism for cytosolic penetration can also elicit CD8 T-cell responses in vivo. We report here that phagocytosis of bacteria with no mechanism for cytosolic penetration also results in presentation of bacterial antigens by class I MHC molecules. Moreover, this mechanism is resistant to cycloheximide and Brefeldin A, which block the classical class I processing pathway. These results suggest a novel vacuolar class I processing pathway for exogenous phagocytic antigens.

Integrity signals

Registry

Crossref · 10.1038/361359a0

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
Falk, K., Rötzschke, O., Stevanovié, S., Jung, G., & Rammensee, H. (1991) · Nature · doi:10.1038/351290a0 · Cited by 2,421
Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.
Bevan, M. J. (1976) · The Journal of Experimental Medicine · doi:10.1084/jem.143.5.1283 · Cited by 984
Fibronectin binding mediated by a novel class of surface organelles on Escherichia coll
Olsén, A., Jonsson, A., & Normark, S. J. (1989) · Nature · doi:10.1038/338652a0 · Cited by 614
Self-citation
Sequence of chicken ovalbumin mRNA
McReynolds, L. A., O’Malley, B. W., Nisbet, A. D., Fothergill, J. E., Givol, D., Fields, S., Robertson, M., & Brownlee, G. G. (1978) · Nature · doi:10.1038/273723a0 · Cited by 435
Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.
Carbone, F., & Bevan, M. J. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.171.2.377 · Cited by 400
Promoters largely determine the efficiency of repressor action.
Lanzer, M., & Bujard, H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.8973 · Cited by 362
Presentation of Exogenous Antigen with Class I Major Histocompatibility Complex Molecules
Rock, K. L., Gamble, S., & Rothstein, L. (1990) · Science · doi:10.1126/science.2392683 · Cited by 335
Antigen Presentation Pathways to Class I and Class II MHC‐Restricted T Lymphocytes
Braciale, T. J., Morrison, L. A., Sweetser, M. T., Sambrook, J., Gething, M.-J. H., & Braciale, V. L. (1987) · Immunological Reviews · doi:10.1111/j.1600-065x.1987.tb00521.x · Cited by 320
Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization.
Carbone, F., & Bevan, M. J. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.3.603 · Cited by 220
Cloned T Lymphocytes and Monoclonal Antibodies as Probes for Cell Surface Molecules Active in T Cell‐Mediated Cytolysis
Sarmiento, M., Dialynas, D. P., Lancki, D. W., Wall, K. A., Lorber, M. I., Loken, M. R., & Fitch, F. W. (1982) · Immunological Reviews · doi:10.1111/j.1600-065x.1982.tb01063.x · Cited by 210

Flagged first, then by citations

Show all 31 references

Sorted by citations

Items 301–400 of 611

TAP‐dependent major histocompatibility complex class I presentation of soluble proteins using listeriolysin
Darji, A., Chakraborty, T., Wehland, J., & Weiß, S. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270609 · Cited by 38
CpG-B ODNs potently induce low levels of IFN-αβ and induce IFN-αβ-dependent MHC-I cross-presentation in DCs as effectively as CpG-A and CpG-C ODNs
Gray, R. C., Kuchtey, J., & Harding, C. V. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1006606 · Cited by 37
“3 T hybridoma cells, which detect OVA257–264:K b complexes [26].”
BackgroundSelf-citation
Involvement of an ATP-Dependent Peptide Chaperone in Cross-Presentation After DNA Immunization
Kumaraguru, U., Rouse, R. J. D., Nair, S. K., Bruce, B. D., & Rouse, B. T. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.750 · Cited by 37
“Candidate mechanisms include the cell to cell transfer of MHC-binding peptides perhaps regurgitated from phagocytic cells (15) or alternatively molecular chaperones, such as hsp70 or gp96, may bind the peptides and mediate their transfer between cells (14).”
Background
Cytotoxic T Lymphocytes in Resistance to Tuberculosis
Mazzaccaro, R. J., Stenger, S., Rock, K. L., Porcelli, S. A., Brenner, M. B., Modlin, R. L., & Bloom, B. R. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5355-7_11 · Cited by 37
Phosphoantigen Presentation by Macrophages toMycobacterium tuberculosis-Reactive Vγ9Vδ2+T Cells: Modulation by Chloroquine
Rojas, R. E., Torres, M., Fournié, J., Harding, C. V., & Boom, W. H. (2002) · Infection and Immunity · doi:10.1128/iai.70.8.4019-4027.2002 · Cited by 37
“BFA blocks the supply of nascent MHC-I and MHC-II molecules to the endogenous and endocytic pathways, respectively, and inhibits the formation of most peptideMHC complexes in the endoplasmic reticulum or in late endocytic compartment (2, 38).”
BackgroundSelf-citation
Stimulation of protective CD8+ T lymphocytes by vaccination with nonliving bacteria.
Szalay, G., Ladel, C. H., & Kaufmann, S. H. E. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.26.12389 · Cited by 37
Recombinant Listeria monocytogenes as a live vaccine vehicle and a probe for studying cell‐mediated immunity
Jensen, E. R., Shen, H., Wettstein, F. O., Ahmed, R., & Miller, J. F. (1997) · Immunological Reviews · doi:10.1111/j.1600-065x.1997.tb01001.x · Cited by 37
Presentation of an exogenous antigen by major histocompatibility complex class I molecules
Ulmer, J. B., Donnelly, J., & Liu, M. A. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240721 · Cited by 37
Biodegradable nanoparticles containing TLR3 or TLR9 agonists together with antigen enhance MHC-restricted presentation of the antigen
Lee, Y.-R., Lee, Y., Im, S., Yang, I. H., Ahn, G. W., Kim, K., & Lee, C. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-1119-z · Cited by 37
“DOBW and CD8 OVA T cells were provided by Dr. Clifford V. Harding (Case Western Reserve University) (Harding et al., 1991; Pfeifer et al., 1993).”
Method
Dendritic Cell Cross-Priming Is Essential for Immune Responses to Listeria monocytogenes
Reinicke, A. T., Omilusik, K. D., Basha, G., & Jefferies, W. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007210 · Cited by 36
“Cross-presentation of bacterial antigens on MHC I has been demonstrated in vitro [17] and several groups have provided data for a mechanism whereby apoptosis of infected cells would provide the source of antigen and result in uptake of bacteria-encoded”
Background
Antigen processing and CD24 expression determine antigen presentation by splenic CD4+ and CD8+ dendritic cells
Askew, D. S., & Harding, C. V. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02711.x · Cited by 36
Self-citation
Immunosuppression of thyroiditis.
Guimarães, V. C., Quintáns, J., Fisfalen, M. E., Straus, F. H., Fields, P. E., Medeiros-Neto, G. A., & DeGroot, L. J. (1996) · Endocrinology · doi:10.1210/endo.137.6.8641166 · Cited by 36
Breakdown of CTL Tolerance to Self HLA-B*2705 Induced by Exposure to Chlamydia trachomatis
Popov, I., Cruz, C. S. D., Barber, B. H., Chiu, B., & Inman, R. D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.4033 · Cited by 36
“It is known that Ag derived from intracellular bacteria may lead to activation of CD8 lymphocytes via class I-mediated pathways (7), thereby invoking CD8 CTL in a central role in resistance to these bacteria (8).”
Background
Peyer's patch CD8+ memory T cells secrete T helper type 1 and type 2 cytokines and provide help for immunoglobulin secretion
Lagoo, A. S., Eldridge, J. H., Lagoo‐Deenadaylan, S., Black, C. A., Ridwan, B. U., Hardy, K. J., McGhee, J. R., & Beagley, K. W. (1994) · European Journal of Immunology · doi:10.1002/eji.1830241226 · Cited by 36
Vaccine Efficacy of Fusogenic Liposomes Containing Tumor Cell-Lysate against Murine B16BL6 Melanoma
Yoshikawa, T., Okada, N., Tsujino, M., Gao, J., Hayashi, A., Tsutsumi, Y. M., Mayumi, T., Yamamoto, A., & Nakagawa, S. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.100 · Cited by 35
Induction of Endoplasmic Reticulum–Endosome Fusion for Antigen Cross-Presentation Induced by Poly (γ-Glutamic Acid) Nanoparticles
Mukai, Y., Yoshinaga, T., Yoshikawa, M., Matsuo, K., Yoshikawa, T., Matsuo, K., Niki, K., Yoshioka, Y., Okada, N., & Nakagawa, S. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1001093 · Cited by 35
“3 cells, a T–T hybridoma against OVA257–264/H-2K b complex (15, 16), were kindly provided by Dr.”
Method
Identification of Salmonella typhimurium genes responsible for interference with peptide presentation on MHC class I molecules: Deltayej Salmonella mutants induce superior CD8+ T-cell responses
Qimron, U., Kela-Madar, N., Mittrücker, H., Zilka, A., Yosef, I., Bloushtain, N., Kaufmann, S. H. E., Rosenshine, I., Apte, R. N., & Porgador, A. (2004) · Cellular Microbiology · doi:10.1111/j.1462-5822.2004.00418.x · Cited by 36
“© 2004 Blackwell Publishing Ltd, Cellular Microbiology, 6, 1057–1070 from the pQE-OVA8, we tested the well-studied pJLP-2H plasmid encoding the fusion protein Crl-OVA, which contains residues 257–277 of OVA including the OVA8 epitope (Pfeifer et al., 1993).”
Method
Antigen presentation in vaccine development
Takahashi, H. (2003) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/s0147-9571(03)00017-1 · Cited by 36
Interleukin-15 as an Immune Adjuvant To Increase the Efficacy of Mycobacterium bovis Bacillus Calmette-Guerin Vaccination
Umemura, M., Nishimura, H., Saito, K., Yajima, T., Matsuzaki, G., Mizuno, S., Sugawara, I., & Yoshikai, Y. (2003) · Infection and Immunity · doi:10.1128/iai.71.10.6045-6048.2003 · Cited by 35
“Although exogenous particulate Ags such as PPD are usually present in association with MHC class II, Ags in the extracellular milieu can also be processed and presented in association with MHC class I (10), which is usually required for activation of CD8 T cells.”
Differentiation of antigen-presenting cells (dendritic cells and macrophages) for therapeutic application in patients with lymphoma
Chaperot, L., Chokri, M. A., Jacob, M.-C., Drillat, P., Garban, F., Egelhofer, H., Molens, J.-P., Sotto, J., Bensa, J.-C., & Plumas, J. (2000) · Leukemia · doi:10.1038/sj.leu.2401888 · Cited by 35
A species-specific nucleotide sequence of Mycobacterium tuberculosis encodes a protein that exhibits hemolytic activity when expressed in Escherichia coli
Leão, S. C., Rocha, C. L., Murillo, L. A., Parra, C. A., & Patarroyo, M. E. (1995) · Infection and Immunity · doi:10.1128/iai.63.11.4301-4306.1995 · Cited by 35
“Although an alternative pathway for the presentation of class I-restricted antigens has been recently suggested to explain the antigen processing of pathogens that live inside the vacuole (27), the explanation for presentation of class I-restricted antigens in tuberculosis could be that the bacilli escape from the vac…”
Background
Phagocyte‐induced antigen‐specific activation of unprimed CD8+ T cells in vitro
Bruijn, M. L. H. D., Jackson, M. R., & Peterson, P. A. (1995) · European Journal of Immunology · doi:10.1002/eji.1830250522 · Cited by 35
H2-M3wt-restricted, Listeria monocytogenes-specific CD8 T cells recognize a novel, hydrophobic, protease-resistant, periodate-sensitive antigen
Nataraj, C., Brown, M. L., Poston, R. M., Shawar, S. M., Rich, R. R., Lindahl, K. F., & Kurlander, R. J. (1996) · International Immunology · doi:10.1093/intimm/8.3.367 · Cited by 35
The evolving biology of cross-presentation
Ohara, R. A., & MURPHY, K. M. M. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101711 · Cited by 37
MHC Class I Stability is Modulated by Cell Surface Sialylation in Human Dendritic Cells
Silva, Z., Ferro, T., Almeida, D. S., Soares, H., Ferreira, J. A., Deschepper, F. M., Hensbergen, P. J., Pirro, M., van Vliet, S. J., Springer, S., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12030249 · Cited by 34
Exogenous antigens and the stimulation of MHC class I restricted cell-mediated cytotoxicity: possible strategies for fish vaccines
Dijkstra, J. M., Fischer, U., Sawamoto, Y., Ototake, M., & Nakanishi, T. (2001) · Fish & Shellfish Immunology · doi:10.1006/fsim.2001.0351 · Cited by 34
Polyomavirus-Infected Dendritic Cells Induce Antiviral CD8+T Lymphocytes
Drake, D. R., Moser, J. M., Hadley, A., Altman, J. D., Maliszewski, C. R., Butz, E. A., & Lukacher, A. E. (2000) · Journal of Virology · doi:10.1128/jvi.74.9.4093-4101.2000 · Cited by 34
“Several studies also suggest that Mf are as efficient as DC in inducing primary CD8(1) T-cell responses (19, 59), while others suggest that DC and Mf may interact to generate CTL-mediated immune responses (20, 46).”
Background
The role of cytotoxic T-lymphocytes in the prevention and immune surveillance of tumors— lessons from normal and immunodeficient mice
Svane, I. M., Boesen, M., & ENGEL, A. ‐. (1999) · Medical Oncology · doi:10.1007/bf02785868 · Cited by 34
Interleukin‐3 and granulocyte–macrophage colony‐stimulating factor enhance the generation and function of dendritic cells
STOROZYNSKY, WOODWARD, Frelinger, & LORD (1999) · Immunology · doi:10.1046/j.1365-2567.1999.00741.x · Cited by 34
Advances in the development of bacterial vector technology
Kochi, S. K., Killeen, K., & Ryan, U. S. (2003) · Expert Review of Vaccines · doi:10.1586/14760584.2.1.31 · Cited by 34
Cross-Presentation of Cell-Associated Antigens by Dendritic Cells
Larsson, M., Fonteneau, J., & Bhardwaj, N. (2003) · Current topics in microbiology and immunology · doi:10.1007/978-3-662-06508-2_12 · Cited by 34
Detection of CD4+ T cells harboring human immunodeficiency virus type 1 DNA by flow cytometry using simultaneous immunophenotyping and PCR-driven in situ hybridization: evidence of epitope masking of the CD4 cell surface molecule in vivo
Patterson, B. K., Goolsby, C., Hodara, V. L., Lohman, K. L., & Wolinsky, S. M. (1995) · Journal of Virology · doi:10.1128/jvi.69.7.4316-4322.1995 · Cited by 34
Linkage of a fusion peptide to a CTL epitope from the nucleoprotein of measles virus enables incorporation into ISCOMs and induction of CTL responses following intranasal immunization
Hsu, S. (1996) · Vaccine · doi:10.1016/0264-410x(95)00241-r · Cited by 34
Activation of CD8 T cells with specificity for mycobacterial heat shock protein 60 in Mycobacterium bovis bacillus Calmette-Guérin-vaccinated mice
Zügel, U., & Kaufmann, S. H. E. (1997) · Infection and Immunity · doi:10.1128/iai.65.9.3947-3950.1997 · Cited by 34
“These studies favor an alternative pathway capable of translocating antigens from pathogenic microbes which stay in the endosome (14).”
Background
The GTPase Rab39a promotes phagosome maturation into MHC‐I antigen‐presenting compartments
Cruz, F. M., Colbert, J. D., & Rock, K. L. (2019) · The EMBO Journal · doi:10.15252/embj.2019102020 · Cited by 33
“Antigens internalized by phagocytosis are cross-presented 10 3 – 10 4 -fold more efficiently than ones acquired by fluid-phase endocytosis (Kovacsovics-Bankowski et al , 1993; Pfeifer et al , 1993; Hard-ing & Song, 1994).”
Phage display particles expressing tumor‐specific antigens induce preventive and therapeutic anti‐tumor immunity in murine p815 model
Wu, Y., Wan, Y., Bian, J., Zhao, J., Jia, Z., Zhou, L., Zhou, W., & Tan, Y. (2002) · International Journal of Cancer · doi:10.1002/ijc.10260 · Cited by 33
BPI–ANCA in transporter associated with antigen presentation (TAP) deficiency: possible role in susceptibility to Gram-negative bacterial infections
Schultz, H., Schinke, S., Weiss, J. P., Cerundolo, V., Gross, W. L., & Gadola, S. D. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02197.x · Cited by 32
Infection-Induced Expansion of a MHC Class Ib-Dependent Intestinal Intraepithelial γδ T Cell Subset
Davies, A., López-Briones, S., Ong, H., O’Neil-Marshall, C., Lemonnier, F. A., Nagaraju, K., Metcalf, E. S., & Soloski, M. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6828 · Cited by 32
Cellular immunity to intracellular bacteria
Pamer, E. G. (1993) · Current Opinion in Immunology · doi:10.1016/0952-7915(93)90028-q · Cited by 32
Specificity of CD8+ T cells from subunit-vaccinated and infected H-2b mice recognizing the 38 kDa antigen of Mycobacterium tuberculosis
Zhu, X. W. (1997) · International Immunology · doi:10.1093/intimm/9.11.1669 · Cited by 32
Compartmentalization of defined epitopes expressed in Escherichia coli has only a minor influence on efficiency of phagocytic processing for presentation by class I and class II major histocompatibility complex molecules to T cells
Wick, M. J., Pfeifer, J. D., Findlay, K. A., Harding, C. V., & Normark, S. J. (1993) · Infection and Immunity · doi:10.1128/iai.61.11.4848-4856.1993 · Cited by 32
“This is a likely result on the basis of the high copy number of the pUC18 vector of the Crl fusion proteins and the constitutive expression from the native crl promoter (42, 43).”
BackgroundMethodInfluentialSelf-citation
Bacterial infection and microbiota in carcinogenesis and tumor development
Li, Q. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1294082 · Cited by 32
Intracellular events regulating cross-presentation
Wagner, C., Grotzke, J. E., & Cresswell, P. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00138 · Cited by 35
Induction of Specific Immune Responses by Polycation-Based Vaccines
Lührs, P., SCHMIDT, W. A., Kutil, R., Buschle, M., Wagner, S. N., Stingl, G., & Schneeberger, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.5217 · Cited by 31
Induction of Potent Antigen-specific Cytotoxic T Cell Response by PLGA-nanoparticles Containing Antigen and TLR Agonist
Lee, Y.-R., Lee, Y., Kim, K., Im, S., & Lee, C. (2013) · Immune Network · doi:10.4110/in.2013.13.1.30 · Cited by 31
Processing ofMycobacterium tuberculosisBacilli by Human Monocytes for CD4+αβ and γδ T Cells: Role of Particulate Antigen
Balaji, K. N., & Boom, W. H. (1998) · Infection and Immunity · doi:10.1128/iai.66.1.98-106.1998 · Cited by 31
“For inhibition of ongoing antigen processing, monocytes were preincubated for 8 to 12 h with the antigens indicated in the figures before addition of chloroquine (400 mM) or Brefeldin A (5 mg/ml) according to published procedures (3, 14, 30).”
Method
Closely Related Mycobacterial Strains Demonstrate Contrasting Levels of Efficacy as Antitumor Vaccines and Are Processed for Major Histocompatibility Complex Class I Presentation by Multiple Routes in Dendritic Cells
Cheadle, E. J., O’Donnell, D., Selby, P. J., & Jackson, A. M. (2005) · Infection and Immunity · doi:10.1128/iai.73.2.784-794.2005 · Cited by 31
“coli and Salmonella enterica serovar Typhimurium, is presented on cell surface MHC class I in macrophages (41), dendritic cells (45, 50) and neutrophils (44).”
Background
Macrophages present exogenous antigens by class I major histocompatibility complex molecules via a secretory pathway as a consequence of interferon‐γ activation
Martín‐Orozco, N., Isibasi, A., & Ortiz-Navarrete, V. F. (2001) · Immunology · doi:10.1046/j.0019-2805.2001.01226.x · Cited by 31
Type-1 and type-2 CD8+ T-cell subsets isolated from chronic adult periodontitis tissue differ in surface phenotype and biological functions.
Wassenaar, A., Reinhardus, C., Abraham-Inpijn, L., & Kievits, F. (1996) · PubMed Central · Cited by 31
The Vacuolar Pathway in Macrophages Plays a Major Role in Antigen Cross-Presentation Induced by the Pore-Forming Protein Sticholysin II Encapsulated Into Liposomes
Cruz‐Leal, Y., Grubaugh, D., Nogueira, C. V., Lopetegui-Gonzalez, I., del Valle, A., Escalona, F., Laborde, R. J., Álvarez, C., Fernandez, L. E., Starnbach, M. N., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02473 · Cited by 30
“These observations are consistent with the phagocytic antigen processing pathway for presenting bacterial antigens in MHC class I molecules (43).”
Result
Suppressive dendritic cells as a tool for controlling allograft rejection in organ transplantation: Promises and difficulties
Ehser, S., Chuang, J. J., Kleist, C., Șandra-Petrescu, F., Iancu, M., Wang, D., Opelz, G., & Terness, P. (2008) · Human Immunology · doi:10.1016/j.humimm.2008.01.018 · Cited by 30
Immunology of psoriasis and psoriatic arthritis
Panayi, G. S. (1994) · Baillière s Clinical Rheumatology · doi:10.1016/s0950-3579(94)80026-x · Cited by 30
Identification of New Cytotoxic T-Cell Epitopes on the 38-Kilodalton Lipoglycoprotein ofMycobacterium tuberculosisby Using Lipopeptides
Fonseca, D. P. A. J., Joosten, D., van der Zee, R., Jue, D. L., Singh, M., Vordermeier, H. M., Snippe, H., & Verheul, A. F. M. (1998) · Infection and Immunity · doi:10.1128/iai.66.7.3190-3197.1998 · Cited by 30
“, phagosomes or phagolysosomes) or on the cell surface following peptide regurgitation (21, 29).”
Background
Structural features of MHC class I molecules that might facilitate alternative pathways of presentation
Hansen, T. H., Balendiran, G. K., Solheim, J. C., Ostrov, D. A., & Nathenson, S. G. (2000) · Immunology Today · doi:10.1016/s0167-5699(98)01426-1 · Cited by 30
Partially TAP-Independent Protection Against Listeria monocytogenes by H2-M3-Restricted CD8+ T Cells
Rolph, M. S., & Kaufmann, S. H. E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.8.4575 · Cited by 30
“(29) for MHC class Ia, is not likely as bystander cells are not loaded with peptide when cultured together with HKLpulsed macrophages (30).”
Background
In vitro induction of HLA-A2402-restricted and carcinoembryonic-antigen-specific cytotoxic T lymphocytes on fixed autologous peripheral blood cells
Kim, C., Matsumura, M., Saijo, K., & Ohno, T. (1998) · Cancer Immunology Immunotherapy · doi:10.1007/s002620050508 · Cited by 29
“It has been shown that phagocytic processing of exogenous antigens occurs in macrophages in which the processed antigenic peptides bind to MHC class I molecules [ 19 ].”
Background
Salmonella typhimurium infection triggers dendritic cells and macrophages to adopt distinct migration patterns in vivo
Zhao, C., Wood, M. W., Galyov, E. E., Höpken, U. E., Lipp, M., Bodmer, H. C., Tough, D. F., & Carter, R. W. (2006) · European Journal of Immunology · doi:10.1002/eji.200636179 · Cited by 29
Selective release of peptides from lysosomes.
Isenman, L. D., & Dice, J. F. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80464-5 · Cited by 29
Epitope cleavage byLeishmaniaendopeptidase(s) limits the efficiency of the exogenous pathway of major histocompatibility complex class I‐associated antigen presentation
Garcia, M. R., Graham, S., Harris, R. A., Beverley, S. M., & Kaye, P. M. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270430 · Cited by 29
Brucella abortus conjugated with a peptide derived from the V3 loop of human immunodeficiency virus (HIV) type 1 induces HIV-specific cytotoxic T-cell responses in normal and in CD4+ cell-depleted BALB/c mice
Lapham, C. K., Golding, B., Inman, J. K., Blackburn, R. J., Manischewitz, J. F., Highet, P. F., & Golding, H. (1996) · Journal of Virology · doi:10.1128/jvi.70.5.3084-3092.1996 · Cited by 29
“macrophages will process external particulate antigens (bacterial antigens, viruses, or proteins bound to silica beads) for presentation by preexisting MHC class I molecules (12, 13, 16, 27).”
Background
Course of Leishmania infection in β2-microglobulin-deficient mice
Overath, P., & Harbecke, D. (1993) · Immunology Letters · doi:10.1016/0165-2478(93)90126-m · Cited by 28
Recognition of chlamydial antigen by HLA‐B27‐restricted cytotoxic T cells in HLA‐B*2705 transgenic CBA (H‐2k) mice
Kuon, W., Lauster, R., Böttcher, U., Koroknay, A., Ulbrecht, M., Hartmann, M., Grolms, M., Ugrinović, S., Braun, J., Weiss, E. H., et al. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400524 · Cited by 28
Cross-presentation of phage particle antigen in MHC class II and endoplasmic reticulum marker-positive compartments
Wan, Y., Wu, Y., Zhou, J., Zou, L., Liang, Y., Zhao, J., Jia, Z., Engberg, J., Bian, J., & Zhou, W. (2005) · European Journal of Immunology · doi:10.1002/eji.200425322 · Cited by 27
Optimization of live oral Salmonella-HIV-l vaccine vectors for the induction of HIV-specific mucosal and systemic immune responses
Hone, D. M., Wu, S., Powell, R. J., Pascual, D. W., Cott, J. V., McGhee, J. R., FOUTS, T. R., Tuskan, R. G., & Lewis, G. K. (1996) · Journal of Biotechnology · doi:10.1016/0168-1656(95)00151-4 · Cited by 27
Heat shock proteins and the antitumor T cell response
Harada, M., Kimura, G., & Nomoto, K. (1998) · Biotherapy · doi:10.1007/bf02678301 · Cited by 27
“In addition, there have also been an increasing number of reports indicating that macrophages have the potential to present exogenous antigens in association with MHC class I molecules [ 24 - 26 ].”
Background
Induction of Lyt-2+ cytotoxic T lymphocytes following primary and secondary Salmonella infection.
Pope, M., Kotlarski, I., & Doherty, K. (1994) · PubMed Central · Cited by 27
Antigen expressed by Salmonella typhimurium is processed for class I major histocompatibility complex presentation by macrophages but not infected epithelial cells.
Harding, C. V., & Pfeifer, J. D. (1994) · PubMed Central · Cited by 27
Self-citation
A strategy for efficient cross-presentation of CTL-epitope peptides leading to enhanced induction of in vivo tumor immunity
Hayashi, A., Wakita, H., Yoshikawa, T., Nakanishi, T., Tsutsumi, Y. M., Mayumi, T., Mukai, Y., Yoshioka, Y., Okada, N., & Nakagawa, S. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.10.011 · Cited by 26
Differential Metabolite Accumulation May Be the Cause of Strain Differences in Sensitivity to Streptozotocin-Induced β Cell Death in Inbred Mice*
Cardinal, J. W., Allan, D. J., & Cameron, D. P. (1998) · Endocrinology · doi:10.1210/endo.139.6.6048 · Cited by 26
Extending the CD4+T-Cell Epitope Specificity of the Th1 Immune Response to an Antigen Using aSalmonella entericaSerovar Typhimurium Delivery Vehicle
Lo‐Man, R., Langeveld, J., Dériaud, E., Jéhanno, M., Rojas, M., Clément, J.-M., Meloen, R. H., Hofnung, M. J., & Leclerc, C. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3079-3089.2000 · Cited by 26
“However, in vitro, Salmonella can deliver Ag in either the MHC class I or class II pathway of Mf and DC (38, 53).”
Background
Peptide‐receptive class I major histocompatibility complex molecules on TAP‐deficient and wild‐type cells and their roles in the processing of exogenous antigens
Song, Porgador, A., & Harding (1999) · Immunology · doi:10.1046/j.1365-2567.1999.00759.x · Cited by 26
H2‐M3 Restricted Presentation of Listeria monocytogenes Antigens
Lenz, L. L., & Bevan, M. J. (1996) · Immunological Reviews · doi:10.1111/j.1600-065x.1996.tb00705.x · Cited by 26
Salmonella Modulates B Cell Biology to Evade CD8+ T Cell-Mediated Immune Responses
López‐Medina, M., Pérez-López, A., Alpuche-Aranda, C. M., & Ortiz-Navarrete, V. F. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00586 · Cited by 25
“MHC-I molecules (17); (3) the antigen is cross-processed through a phagosome-cytosol-phagosome alternating pathway (18); and (4) peptides are processed in a previously non-characterized endocytic compartment, secreted into the cytosol, and loaded onto empty MHC-I molecules on the surfaces of macrophages and bystander…”
Background
Activation Outcomes Induced in Naïve CD8 T-Cells by Macrophages Primed via “Phagocytic” and Nonphagocytic Pathways
Olazabal, I. M., Martin-Cofreces, N. B., Mittelbrunn, M., del Hoyo, G. M., Alarcón, B., & Sánchez‐Madrid, F. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-07-0650 · Cited by 25
“…studied for their ability to cross-present antigens from phagocytosed pathogens through the major histocompatibility complex (MHC)-class I pathway (Pfeifer et al., 1993; Oliveira and Splitter, 1995; Reis e Sousa and Germain, 1995; Turner and Dockrell, 1996; Oh et al., 1997; Belkaid et al., 2002;…”
Background
Distribution of endosomal, lysosomal, and major histocompatability complex markers in a monocytic cell line infected with Chlamydia psittaci
Ojcius, D. M., Hellio, R., & Dautry‐Varsat, A. (1997) · Infection and Immunity · doi:10.1128/iai.65.6.2437-2442.1997 · Cited by 25
“Along similar lines, a novel pathway linking phagosomes with the cytosol of antigenpresenting cells has recently been described (21, 28), and it is conceivable that Chlamydia could exploit this pathway.”
Background
In Vitro Human Memory CD8 T Cell Expansion in Response to Cytomegalovirus Requires CD4+T Cell Help
Salkowitz, J. R., Sieg, S. F., Harding, C. V., & Lederman, M. M. (2004) · The Journal of Infectious Diseases · doi:10.1086/382032 · Cited by 24
Self-citation
DNA Vaccines and Immunity to Herpes Simplex Virus
Rouse, B. T., Nair, S. K., Rouse, R. J. D., Yu, Z., Kuklin, N. A., Karem, K. L., & Manickan, E. (1998) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-80475-5_5 · Cited by 25
Neutrophils: Neglected Players in Viral Diseases
Gabriel, C., Her, Z., & Ng, L. F. P. (2013) · DNA and Cell Biology · doi:10.1089/dna.2013.2211 · Cited by 23
“…derived from a common hematopoietic cell progenitor (Inaba et al. , 1993) and share several common features in phagocytosis, antigen presentation (Pfeifer et al. , 1993; Berg et al. , 1994; Kovacsovics-Bankowski and Rock, 1995; Beauvillain et al. , 2007; Abi Abdallah et al. , 2011; Ostanin et…”
Reduced CD8+ peripheral blood T lymphocytes in rapidly progressive periodontitis
Nagasawa, T., Nitta, H., Watanabe, H., & Ishikawa, I. (1995) · Archives of Oral Biology · doi:10.1016/0003-9969(95)00025-k · Cited by 24
Cross-Presentation of Listeria -Derived CD8 T Cell Epitopes Requires Unstable Bacterial Translation Products
Janda, J., Schöneberger, P., Škoberne, M., Messerle, M., Rüssmann, H., & Geginat, G. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5644 · Cited by 24
“The strict requirement for proteasome-mediated Ag processing by DC also ruled out peptide regurgitation (5), a scenario that is also highly unlikely, because in our system the Ag donor cell and the APC did not share MHC class I molecules.”
Background
Dendritic Cell–Dead Cell Interactions: Implications and Relevance for Immunotherapy
Fonteneau, J., Larsson, M., & Bhardwaj, N. (2001) · Journal of Immunotherapy · doi:10.1097/00002371-200107000-00005 · Cited by 24
“After the original description of cross-presentation of minor histocompatibility antigens by Bevan (2), the phenomenon that CTLs could be activated through exogenous pathways was extended to other antigens, including self-antigens (20), viruses (11, 21,22), bacteria (14,23), parasites (24), and tumor antigens (25).”
Background
Enhanced Endoplasmic Reticulum Entry of Tumor Antigen Is Crucial for Cross-Presentation Induced by Dendritic Cell–Targeted Vaccination
Wang, H., Yu, X., Guo, C., Zuo, D., Fisher, P. B., Subjeck, J. R., & Wang, X. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1302312 · Cited by 23
Choosing and Preparing Antigen‐Presenting Cells
Harding, C. V., Canaday, D. H., & Ramachandra, L. (2010) · Current Protocols in Immunology · doi:10.1002/0471142735.im1601s88 · Cited by 23
Self-citation
The influence of curli, a MHC-I-binding bacterial surface structure, on macrophage–T cell interactions
Johansson, C., Nilsson, T., OlsÃ©n, A., & Wick, M. J. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(00)00228-5 · Cited by 23
Self-citation
PATHOGENESIS OF HUMAN LEUKOCYTE ANTIGEN B27–POSITIVE ARTHRITIS
Märker‐Hermann, E., & Höhler, T. (1998) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70046-6 · Cited by 23
Delivery of Exogenous Protein Antigens to Major Histocompatibility Complex Class I Pathway in Cytosol
Cao, H., Agrawal, D., Kushner, N. N., Touzjian, N., Essex, M., & Lu, Y. (2002) · The Journal of Infectious Diseases · doi:10.1086/338448 · Cited by 23
“The presentation of many exogenous antigens on MHC-I molecules involves proteolysis in the endocytic compartment [36–38], and the peptides subsequently gain access to the cytosol where they enter the MHC class I pathway.”
Background
Identification of HLA-B27–restricted peptides in reactive arthritis and other spondyloarthropathies
Kuon, W., & Sieper, J. (2003) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(03)00050-4 · Cited by 23
Carrier‐mediated uptake and presentation of a major histocompatibility complex class I‐restricted peptide
Brander, C., Wyss‐Coray, T., Mauri, D. N., Bettens, F., & Pichler, W. J. (1993) · European Journal of Immunology · doi:10.1002/eji.1830231226 · Cited by 23
Spontaneous transgenesis of human B lymphocytes
Filaci, G., Gerloni, M., Rizzi, M., Castiglioni, P., Chang, H.-D., Wheeler, M., Fiocca, R., & Zanetti, M. (2003) · Gene Therapy · doi:10.1038/sj.gt.3302132 · Cited by 23
Intracellular processing of hapten-modified protein for MHC class I presentation: cytoplasmic delivery by pH-sensitive liposomes
Martin, S. F., Niedermann, G., Leipner, C., Eichmann, K., & Weltzien, H. U. (1993) · Immunology Letters · doi:10.1016/0165-2478(93)90017-v · Cited by 23
Antigen Secreted from Noncytosolic Listeria monocytogenes Is Processed by the Classical MHC Class I Processing Pathway
Zwickey, H. L., & Potter, T. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6341 · Cited by 23
Secretion of different listeriolysin cognates by recombinant attenuated : superior efficacy of haemolytic over non-haemolytic constructs after oral vaccination
Hess, J., Grode, L., Gentschev, I., Fensterle, J., Dietrich, G., Goebel, W., & Kaufmann, S. H. E. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)01333-2 · Cited by 23
Intracellular Transport of Molecules Engaged in the Presentation of Exogenous Antigens
Nordeng, T. W., Gorvel, J., & Bakke, O. (1998) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-72045-1_9 · Cited by 22
Immunogenicity of hybrid DNA vaccines expressing hepatitis B core particles carrying human and simian immunodeficiency virus epitopes in mice and rhesus macaques
FULLER, D. H., Shipley, T., Allen, T. M., Fuller, J. T., Wu, M. S., Horton, H., Wilson, N. A., Widera, G., & Watkins, D. I. (2007) · Virology · doi:10.1016/j.virol.2007.02.024 · Cited by 22
“Phagocytic macrophages can process particulate antigens via the exogenous class I pathway (Kovacsovics-Bankowski et al., 1993; Pfeifer et al., 1993), and particulate protein-based vaccines induce CD8+ T cell responses via this mechanism (Griffiths et al., 1993; Layton et al., 1993; Schirmbeck et…”
Background
Peptides Bound to Major Histocompatibility Complex Molecules
Maffei, A., & Harris, P. E. (1998) · Peptides · doi:10.1016/s0196-9781(97)00277-5 · Cited by 22
Bacterial modulation of antigen processing and presentation
Maksymowych, W. P., & Kane, K. P. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00268-9 · Cited by 22
Modulation of T cell function and survival by the tumor microenvironment
Mani, N. L., Andrews, D., & Obeng, R. C. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1191774 · Cited by 22
“Although macrophages (Pfeifer et al., 1993; Rock et al., 1993), neutrophils (Tvinnereim et al.”
Progress in the Development of Multivalent Oral Vaccines Based on Live Attenuated Salmonella
Chatfield, S. N., Gordon Dougan, B., & Roberts, M. (1994) · Springer eBooks · doi:10.1007/978-1-4899-1450-7_5 · Cited by 21
Characterization of TAP‐Independent and Brefeldin A‐Resistant Presentation of Sendai Virus Antigen to CD8+ Cytotoxic T Lymphocytes
Zhou, X., Liu, T., Franksson, L., Lederer, E., Ljunggren, H., & Jondal, M. (1995) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1995.tb03627.x · Cited by 21
Bacterial Systems for the Delivery of Eukaryotic Antigen Expression Vectors
DIETRICH, G., Spreng, S., Gentschev, I., & Goebel, W. (2000) · Antisense and Nucleic Acid Drug Development · doi:10.1089/oli.1.2000.10.391 · Cited by 21
“Nevertheless, infection of primary macrophages with S. typhimurium results in the presentation of phagosomal proteins together with MHC class I molecules (Pfeifer et al., 1993).”

Authors: Pfeifer, J. D., Wick, M. J., Roberts, R. L., Findlay, K., Normark, S. J., & Harding, C. V.
Affiliations: Washington University in St. Louis (US)
ORCID: Pfeifer, John D.
Wick, Mary Jo
Normark, Staffan J.
Harding, Clifford V.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1993-01
Volume: 361
Issue: 6410
Pages: 359-362
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/361359a0
OpenAlex: W2042470561
Cited by: 615
References: 31
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 9 · 2015: 4 · 2014: 8 · 2013: 10 · 2012: 10
FWCI: 22.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: MHC class I, antigen processing, phagocytosis, bacterial antigens, CD8+ T cells, exogenous antigen presentation, cycloheximide resistance, particulate antigen
MeSH terms: Amino Acid Sequence, Animals, Epitopes, Antigens, Bacterial, Bacterial Proteins, Escherichia coli, Macrophages, Mice, Inbred CBA, Mice, Inbred C57BL, Microscopy, Electron, Molecular Sequence Data, Ovalbumin, Phagocytosis, Recombinant Fusion Proteins, Salmonella typhimurium, T-Lymphocytes, Vacuoles, Histocompatibility Antigens Class I, T-Lymphocyte Subsets, CD8 Antigens, Escherichia coli Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks