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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Abstract
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
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“There were also age-dependent expression of genes encoding secreted proteins (Figure 3H, S3H, Table S3), including the “anti-aging” gene Klotho (Kuro-o et al., 1997; Zhu et al., 2018), which increased with age (Figure 3H).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Kuro-o et al., 1997
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Metadata
- Authors
- Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., Iwasaki, H., Iida, A., Shiraki-Iida, T., Nishikawa, S., Nagai, R., & Nabeshima, Y.-I.
- Affiliations
- Gunma University (JP)
- The University of Tokyo (JP)
- Institute of Molecular Embryology and Genetics, Kumamoto University (JP)
- National Center of Neurology and Psychiatry (JP)
- Corresponding author
- Nabeshima, Yo-ichi
- ORCID
- Venue
- Nature
- Published
- 1997-11-06
- Volume
- 390
- Issue
- 6655
- Pages
- 45-51
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2114360920
- Cited by
- 3,837
- References
- 26
- Citations by year
- 2026: 117 · 2025: 194 · 2024: 234 · 2023: 195 · 2022: 213 · 2021: 220 · 2020: 239 · 2019: 212 · 2018: 225 · 2017: 178 · 2016: 208 · 2015: 194 · 2014: 167 · 2013: 170 · 2012: 154
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- Klotho gene, aging, lifespan, mouse mutations, infertility, arteriosclerosis, osteoporosis, emphysema, skin atrophy, β-glucosidase, membrane proteins, age-related diseases
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