Nagai, Ryozo

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature

Genetics, Aging, and Longevity in Model OrganismsParathyroid Disorders and Treatments

Cited by 3,837

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

Yamauchi, T., Kamon, J., Ito, Y., Tsuchida, A., Yokomizo, T., Kita, S., Sugiyama, T., Miyagishi, M., Hara, K., Tsunoda, M., et al. (2003) · Nature

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 3,176

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 2,230

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

Yamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Okada-Iwabu, M., Kawamoto, S., Kubota, N., Kubota, T., et al. (2007) · Nature Medicine

Adipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

Cited by 1,396

Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis

Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., Matsui, J., et al. (2003) · Journal of Biological Chemistry

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 911

Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

Kubota, N., Yano, W., Kubota, T., Yamauchi, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Okamoto, S., Shiuchi, T., et al. (2007) · Cell Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 844

Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity

Tsuchida, A., Yamauchi, T., Ito, Y., Hada, Y., Maki, T., Takekawa, S., Kamon, J., Kobayashi, M., Suzuki, R., Hara, K., et al. (2004) · Journal of Biological Chemistry

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 550

Adipogenesis in Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels

Nishimura, S., Manabe, I., Nagasaki, M., Hosoya, Y., Yamashita, H., Fujita, H., Ohsugi, M., Tobe, K., Kadowaki, T., Nagai, R., et al. (2007) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 440

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle

Kubota, T., Kubota, N., Kumagai, H., Yamaguchi, S., Kozono, H., Takahashi, T., Inoue, M., Itoh, S., Takamoto, I., Sasako, T., et al. (2011) · Cell Metabolism

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 435

Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression

Sekiya, M., Yahagi, N., Matsuzaka, T., Najima, Y., Nakakuki, M., Nagai, R., Ishibashi, S., Osuga, J.-I., Yamada, N., & Shimano, H. (2003) · Hepatology

Liver Disease Diagnosis and TreatmentFatty Acid Research and Health

Cited by 415

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue

Nishimura, S., Manabe, I., Nagasaki, M., Seo, K., Yamashita, H., Hosoya, Y., Ohsugi, M., Tobe, K., Kadowaki, T., Nagai, R., et al. (2008) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

Cited by 277

Adipose natural regulatory B cells negatively control adipose tissue inflammation

Nishimura, S., Manabe, I., Takaki, S., Nagasaki, M., Otsu, M., Yamashita, H., Sugita, J., Yoshimura, K., Eto, K., Komuro, I., et al. (2013) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesT-cell and B-cell Immunology

Cited by 251

Dynamic Functional Relay between Insulin Receptor Substrate 1 and 2 in Hepatic Insulin Signaling during Fasting and Feeding

Kubota, N., Kubota, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Mineyama, T., Ogata, H., Tokuyama, K., Ohsugi, M., et al. (2008) · Cell Metabolism

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 244

Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus

Kubota, N., Terauchi, Y., Tobe, K., Yano, W., Suzuki, R., Ueki, K., Takamoto, I., Satoh, H., Maki, T., Kubota, T., et al. (2004) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 239

Association between cigarette smoking, metabolic syndrome, and carotid arteriosclerosis in Japanese individuals

Ishizaka, N., Ishizaka, Y., Toda, E.-I., Hashimoto, H., Nagai, R., & Yamakado, M. (2005) · Atherosclerosis

Smoking Behavior and CessationDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 113

Manganese superoxide dismutase polymorphism affects the oxidized low-density lipoprotein-induced apoptosis of macrophages and coronary artery disease

Fujimoto, H., Taguchi, J.-I., Imai, Y., Ayabe, S., Hashimoto, H., Kobayashi, H., Ogasawara, K., Aizawa, T., Yamakado, M., Nagai, R., et al. (2008) · European Heart Journal

Glutathione Transferases and PolymorphismsParaoxonase enzyme and polymorphisms

Cited by 84

Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation

Sahara, M., Ikutomi, M., Morita, T., Minami, Y., Nakajima, T., Hirata, Y., Nagai, R., & Sata, M. (2014) · Cardiovascular Research

Renin-Angiotensin System StudiesAtherosclerosis and Cardiovascular Diseases

Cited by 74

Circadian Rhythms in the CNS and Peripheral Clock Disorders: Role of the Biological Clock in Cardiovascular Diseases

Maemura, K., Takeda, N., & Nagai, R. (2007) · Journal of Pharmacological Sciences

Circadian rhythm and melatoninCardiac electrophysiology and arrhythmias

Cited by 73

Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: Results from 1-year outcomes in the Japanese REACH Registry

Uchiyama, S., Goto, S., Matsumoto, M., Nagai, R., Origasa, H., Yamazaki, T., Shigematsu, H., Shimada, K., Yamada, N., Bhatt, D. L., et al. (2009) · Journal of the Neurological Sciences

Acute Ischemic Stroke ManagementCerebrovascular and Carotid Artery Diseases

Cited by 59

Iron Chelation Suppresses Ferritin Upregulation and Attenuates Vascular Dysfunction in the Aorta of Angiotensin II–Infused Rats

Ishizaka, N., Saito, K., Mori, I., Matsuzaki, G., Ohno, M., & Nagai, R. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology

Renin-Angiotensin System StudiesNitric Oxide and Endothelin Effects

Cited by 55

Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways

Watanabe, T., Kubota, N., Ohsugi, M., Kubota, T., Takamoto, I., Iwabu, M., Awazawa, M., Katsuyama, H., Hasegawa, C., Tokuyama, K., et al. (2009) · Journal of Biological Chemistry

Adipokines, Inflammation, and Metabolic DiseasesPharmacology and Obesity Treatment

Cited by 53

Iron chelation and a free radical scavenger suppress angiotensin II-induced upregulation of TGF-β1 in the heart

Saito, K., Ishizaka, N., Aizawa, T., Sata, M., Iso-o, N., Noiri, E., Mori, I., Ohno, M., & Nagai, R. (2005) · American Journal of Physiology-Heart and Circulatory Physiology

Cardiac Fibrosis and RemodelingRenin-Angiotensin System Studies

Cited by 33

Regulation of Transforming Growth Factor-β-dependent Cyclooxygenase-2 Expression in Fibroblasts

Matsumura, T., Suzuki, T., Aizawa, K., Sawaki, D., Munemasa, Y., Ishida, J., & Nagai, R. (2009) · Journal of Biological Chemistry

TGF-β signaling in diseasesInflammatory mediators and NSAID effects

Cited by 28

Associations of variations in the MRF2/ARID5B gene with susceptibility to type 2 diabetes in the Japanese population

Wang, G., Watanabe, M., Imai, Y., Hara, K., Manabe, I., Maemura, K., Horikoshi, M., Ozeki, A., Itoh, C., Sugiyama, T., et al. (2012) · Journal of Human Genetics

Genetic Associations and EpidemiologyAdipokines, Inflammation, and Metabolic Diseases

Cited by 19