Impaired immune and acute-phase responses in interleukin-6-deficient mice

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3. Concepts of Fever: Recent Advances and Lingering Dogma
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4. Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
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5. Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation.
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6. The Tetraspanin Protein CD37 Regulates IgA Responses and Anti-Fungal Immunity
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7. Resistance to Experimental Autoimmune Myasthenia Gravis in IL-6-Deficient Mice Is Associated with Reduced Germinal Center Formation and C3 Production1
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8. Impaired IgG Production in Mice Deficient for Heat Shock Transcription Factor 1*
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9. Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response
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10. Impact of Interleukin-6 in Hematological Malignancies
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11. Inflammatory and Angiogenic Factors in the Aqueous Humor and the Relationship to Diabetic Retinopathy
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12. Interleukin-6 Is Crucial for Recall of Influenza-Specific Memory CD4+ T Cells
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13. Both Th1 and Th2 Cytokines Affect the Ability of Monoclonal Antibodies To Protect Mice against Cryptococcus neoformans
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14. Estrogen augments glucose transporter and IGF1 expression in primate cerebral cortex
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15. Robust Antigen Specific Th17 T Cell Response to Group A Streptococcus Is Dependent on IL-6 and Intranasal Route of Infection
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16. Contributions of the Measles Virus Nucleocapsid Gene and the SQSTM1/p62P392L Mutation to Paget's Disease
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17. Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature
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18. Interleukin-6 and Interleukin-12 Participate in Induction of a Type 1 Protective T-Cell Response during Vaccination with a Tuberculosis Subunit Vaccine
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19. Recent Advances in Immunopathophysiology of Interleukin-6: An Innovative Therapeutic Drug, Tocilizumab (Recombinant Humanized Anti-human Interleukin-6 Receptor Antibody), Unveils The Mysterious Etiology of Immune-Mediated Inflammatory Diseases
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20. The Role of Interleukin-1, Interleukin-6, and Glia in Inducing Growth of Neuronal Terminal Arbors in Mice
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21. Interleukin‐6 (IL6) and cellular response to facial nerve injury: effects on lymphocyte recruitment, early microglial activation and axonal outgrowth in IL6‐deficient mice
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22. Pathogenesis of Kupffer Cells in Cholestatic Liver Injury
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23. Resistin and interleukin-6 exhibit racially-disparate expression in breast cancer patients, display molecular association and promote growth and aggressiveness of tumor cells through STAT3 activation
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25. Intrathymic IL-7: The where, when, and why of IL-7 signaling during T cell development
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26. Reciprocal actions of interleukin‐6 and brain‐derived neurotrophic factor on rat and mouse primary sensory neurons
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27. Interleukin‐6 Induces Expression of Peripherin and Cooperates with Trk Receptor Signaling to Promote Neuronal Differentiation in PC12 Cells
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28. IL-6 Activities in the Tumour Microenvironment. Part 1
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29. Interleukin-1 Receptor Signaling Protects Mice from Lethal Intestinal Damage Caused by the Attaching and Effacing Pathogen Citrobacter rodentium
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30. XIAP Regulates Cytosol-Specific Innate Immunity to Listeria Infection
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31. Interleukin-6 regulates hepatic transporters during acute-phase response.
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32. Biomimetic Nanoparticles Carrying a Repolarization Agent of Tumor-Associated Macrophages for Remodeling of the Inflammatory Microenvironment Following Photothermal Therapy.
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33. IL-6 promoter polymorphisms in rheumatoid arthritis
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34. Cytokine production and requirements during T-cell development.
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35. Induced illness in interleukin-6 (IL-6) knock-out mice: a causal role of IL-6 in the development of the low 3,5,3'-triiodothyronine syndrome.
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36. Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication
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37. IL6 Trans-signaling Promotes KRAS-Driven Lung Carcinogenesis.
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38. IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.
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39. Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus
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40. Interferon-driven deletion of antiviral B cells at the onset of chronic infection
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41. Interleukin 6 promotes vasculogenesis of murine brain microvessel endothelial cells.
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43. IL-6 Promotes T Cell Proliferation and Expansion under Inflammatory Conditions in Association with Low-Level RORγt Expression
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44. Skeletal Muscle Mass Recovery from Atrophy in IL-6 Knockout Mice
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45. Sustained High Levels of Interleukin-6 Contribute to the Pathogenesis of Enterovirus 71 in a Neonate Mouse Model
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46. Local activation of STAT‐1 and STAT‐3 in the inflamed synovium during zymosan‐induced arthritis: Exacerbation of joint inflammation in STAT‐1 gene–knockout mice
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49. Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tocilizumab therapy
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53. Analytic Review: Interleukin-6 in Surgery, Trauma, and Critical Care: Part I: Basic Science
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54. Mice, microbes and models of infection
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55. Regulation and Function of T1/ST2 Expression on CD4+ T Cells: Induction of Type 2 Cytokine Production by T1/ST2 Cross-Linking1
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56. Mechanisms of Liver Damage
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57. Uncoupling of interleukin-6 from its signalling pathway by dietary n-3-polyunsaturated fatty acid deprivation alters sickness behaviour in mice
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58. The transcription factor NFATc2 controls IL-6–dependent T cell activation in experimental colitis
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59. Genome amplification and cellular senescence are hallmarks of human placenta development
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61. Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice
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62. A protective role for IL‐6 during early infection with Toxoplasma gondii
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65. Pleiotropic Defects of IL‐6—deficient Mice Including Early Hematopoiesis, T and B Cell Function, and Acute Phase Responses
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66. Anti-Inflammatory Effect of Muscle-Derived Interleukin-6 and Its Involvement in Lipid Metabolism
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67. Interleukin-6: a potential target for post-thrombotic syndrome.
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68. Estrogen mediates the sex difference in post-burn immunosuppression.
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69. Diurnal variation of lipopolysaccharide-induced alterations in sleep and body temperature of interleukin-6-deficient mice
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70. ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer
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71. LXR/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling
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72. Tocilizumab for the treatment of rheumatoid arthritis
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73. Heat Shock Transcription Factor 1 Inhibits Expression of IL-6 through Activating Transcription Factor 3
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74. Dendritic Cells and Monocyte/Macrophages That Create the IL-6/APRIL-Rich Lymph Node Microenvironments Where Plasmablasts Mature
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75. Inflammatory arthritis can be reined in by CpG-induced DC–NK cell cross talk
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76. Endogenous Pro- and Anti-Inflammatory Cytokines Differentially Regulate an In Vivo Humoral Response to Streptococcus pneumoniae
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77. Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behavior
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78. Interleukin-6 in atherosclerosis: atherogenic or atheroprotective?
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79. Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-in-human study.
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80. Gene expression profiles during human CD4+ T cell differentiation
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82. The Correlation between Increased Serum Concentrations of Interleukin-6 Family Cytokines and Disease Activity in Rheumatoid Arthritis Patients
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84. Accelerated healing by topical administration of Salvia officinalis essential oil on Pseudomonas aeruginosa and Staphylococcus aureus infected wound model.
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85. Transient Maternal IL-6 Mediates Long-Lasting Changes in Neural Stem Cell Pools by Deregulating an Endogenous Self-Renewal Pathway
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89. Requirements for the Induction of Interleukin-6 by Herpes Simplex Virus-Infected Leukocytes
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92. Increased vulnerability of dopaminergic neurons in MPTP‐lesioned interleukin‐6 deficient mice
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93. Histamine induces IL‐6 production by human endothelial cells
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94. Lack of gp130 expression in hepatocytes promotes liver injury1 1K.L.S. and T.W. contributed equally to this work.
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95. Interleukin-6 in renal disease and therapy
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96. Autoimmune Disease in Lyn-Deficient Mice Is Dependent on an Inflammatory Environment Established by IL-6
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97. In Vivo Interleukin-6 Protects Neutrophils from Apoptosis in Osteomyelitis
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98. The biology of interleukin-27 reveals unique pro- and anti-inflammatory functions in immunity
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99. Interleukin-6 is a Marker of Inflammation with No Direct Role in Inflammasome-Mediated Mouse Models
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