In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

Gorman, C., Moffat, L. F., & Howard, B. H. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.9.1044 · Cited by 7,673 · see citing works

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

de Wet, J. R., Wood, K. V., DeLuca, M., Helinski, D. R., & Subramani, S. E. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.725 · Cited by 3,088 · see citing works

A short amino acid sequence able to specify nuclear location

Kalderon, D., Roberts, B., Richardson, W. D., & Smith, A. E. (1984) · Cell · doi:10.1016/0092-8674(84)90457-4 · Cited by 2,511 · see citing works

Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes.

Miller, J., McLachlan, A., & Klug, A. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03825.x · Cited by 2,476 · see citing works

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

Evan, G. I., Lewis, G. K., Ramsay, G. M., & Bishop, J. M. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.12.3610 · Cited by 2,412 · see citing works

pEF-BOS, a powerful mammalian expression vector

Mizushima, S., & Nagata, S. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.17.5322 · Cited by 1,632 · see citing works

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

Kadonaga, J. T., Carner, K., Masiarz, F. R., & Tjian, R. (1987) · Cell · doi:10.1016/0092-8674(87)90594-0 · Cited by 1,614 · see citing works

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

Shtivelman, E., Lifshitz, B., Gale, R. P., & Canaani, E. (1985) · Nature · doi:10.1038/315550a0 · Cited by 1,583 · see citing works

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

Groffen, J., Stephenson, J. R., Heisterkamp, N., DeKlein, A., Bartram, C., & Grosveld, G. C. (1984) · Cell · doi:10.1016/0092-8674(84)90077-1 · Cited by 1,578 · see citing works

Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?

Stein, C., & Cheng, Y. C. (1993) · Science · doi:10.1126/science.8351515 · Cited by 1,303 · see citing works

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

Konopka, J. B., Watanabe, S. M., & Witte, O. N. (1984) · Cell · doi:10.1016/0092-8674(84)90438-0 · Cited by 872 · see citing works

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

Bartram, C. R., de Klein, A., Hagemeijer, A., van Agthoven, T., van Kessel, A. G., Bootsma, D., Grosveld, G. C., Ferguson-Smith, M. A., Davies, T., Stone, M., et al. (1983) · Nature · doi:10.1038/306277a0 · Cited by 738 · see citing works

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

Christy, B. A., Lau, L. F., & Nathans, D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.7857 · Cited by 734 · see citing works

IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo

Palacios, R., & Steinmetz, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80053-2 · Cited by 716 · see citing works

Acute leukaemia in bcr/abl transgenic mice

Heisterkamp, N., Jenster, G. W., ten Hoeve, J., Zovich, D., Pattengale, P. K., & Groffen, J. (1990) · Nature · doi:10.1038/344251a0 · Cited by 660 · see citing works

Three-Dimensional Solution Structure of a Single Zinc Finger DNA-Binding Domain

Lee, M. S., Gippert, G. P., Soman, K. V., Case, D. A., & Wright, P. E. (1989) · Science · doi:10.1126/science.2503871 · Cited by 627 · see citing works

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

Daley, G. Q., & Baltimore, D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9312 · Cited by 563 · see citing works

Selection of phage antibodies by binding affinity

Hawkins, R. E., Russell, S. J., & Winter, G. P. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90639-2 · Cited by 522 · see citing works

Zinc Finger Phage: Affinity Selection of Fingers with New DNA-Binding Specificities

Rebar, E. J., & Pabo, C. O. (1994) · Science · doi:10.1126/science.8303274 · Cited by 417 · see citing works

Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation

Maher, L. J., Wold, B. J., & Dervan, P. B. (1989) · Science · doi:10.1126/science.2549631 · Cited by 414 · see citing works

Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins.

Berg, J. M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.1.99 · Cited by 412 · see citing works

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

Hermans, A., Heisterkamp, N., Lindern, M. V., van Baal, S., Meijer, D., van der Plas, D., Wiedemann, L. M., Groffen, J., Bootsma, D., & Grosveld, G. C. (1987) · Cell · doi:10.1016/0092-8674(87)90007-9 · Cited by 378 · see citing works

Different activation domains stimulate transcription from remote (‘enhancer’) and proximal (‘promoter’) positions.

Seipel, K., Georgiev, O., & Schaffner, W. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05603.x · Cited by 359 · see citing works

Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage.

Choo, Y., & Klug, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11163 · Cited by 322 · see citing works

Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions.

Choo, Y., & Klug, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11168 · Cited by 287 · see citing works

A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia

Kurzrock, R., Shtalrid, M., Romero, P., Kloetzer, W. S., Talpas, M., Trujillo, J. M., Blick, M. B., Beran, M., & Gutterman, J. U. (1987) · Nature · doi:10.1038/325631a0 · Cited by 267 · see citing works

Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.Preprint

Lüscher, B., Mitchell, P. J., Williams, T., & Tjian, R. (1989) · Genes & Development · doi:10.1101/gad.3.10.1507 · Cited by 252 · see citing works

Toward rules relating zinc finger protein sequences and DNA binding site preferences.

Desjarlais, J. R., & Berg, J. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7345 · Cited by 220 · see citing works

In vitro selection of zinc fingers with altered DNA-binding specificity

Jamieson, A. C., Kim, S., & Wells, J. A. (1994) · Biochemistry · doi:10.1021/bi00185a004 · Cited by 214 · see citing works

GAL4 fusion vectors for expression in yeast or mammalian cells

Sadowski, I., Bell, B., Broad, P. M., & Hollis, M. (1992) · Gene · doi:10.1016/0378-1119(92)90261-m · Cited by 209 · see citing works

Transcriptional repression directed by the yeast α2 protein in vitro

Herschbach, B. M., Arnaud, M. B., & Johnson, A. D. (1994) · Nature · doi:10.1038/370309a0 · Cited by 116 · see citing works

A role in DNA binding for the linker sequences of the first three zinc fingers of TFIIIA

Choo, Y., & Klug, A. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.15.3341 · Cited by 109 · see citing works

The cysteine‐rich LIM domains inhibit DNA binding by the associated homeodomain in Isl‐1.

Sánchez-Garcı́a, I., Osada, H., Forster, A. M., & Rabbitts, T. H. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06108.x · Cited by 98 · see citing works

Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities.

Sánchez-Garcı́a, I., & Rabbitts, T. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.7869 · Cited by 93 · see citing works

The Two-Hybrid System to Detect Protein-Protein Interactions

Fields, S. (1993) · Methods · doi:10.1006/meth.1993.1016 · Cited by 93 · see citing works

Sequence-specific DNA binding by a two zinc-finger peptide from the Drosophila melanogaster tramtrack protein

Fairall, L., Harrison, S. D., TRAVERS, A. A., & Rhodes, D. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90952-g · Cited by 61 · see citing works

The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc

Berg, J. M., & Shi, Y. (1996) · Science · doi:10.1126/science.271.5252.1081 · Cited by 1,930 · see citing works

Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects

Li, H., Yang, Y., Hong, W., Huang, M., Wu, M., & Zhao, X. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0089-y · Cited by 1,771 · see citing works

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Urnov, F. D., Miller, J. C., Lee, Y.-L., Beausejour, C. M., Rock, J. M., Augustus, S., Jamieson, A. C., Porteus, M. H., Gregory, P. D., & Holmes, M. C. (2005) · Nature · doi:10.1038/nature03556 · Cited by 1,642 · see citing works

Phage Display

Smith, G. P., & Petrenko, V. A. (1997) · Chemical Reviews · doi:10.1021/cr960065d · Cited by 1,550 · see citing works

The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE).

Martínez‐Pastor, M. T., Marchler, G. H., Schüller, C., Marchler‐Bauer, A., Ruis, H., & Estruch, F. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00576.x · Cited by 1,077 · see citing works

DNA Recognition by Cys₂His₂ Zinc Finger Proteins

Wolfe, S. A., Nekludova, L., & Pabo, C. O. (2000) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.29.1.183 · Cited by 1,053 · see citing works

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

Doyon, Y., McCammon, J. M., Miller, J. C., Faraji, F., Ngo, C., Katibah, G. E., Amora, R., Hocking, T. D., Zhang, L., Rebar, E. J., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1409 · Cited by 896 · see citing works

Targeted Chromosomal Cleavage and Mutagenesis in Drosophila Using Zinc-Finger Nucleases

Bibikova, M., Golic, M., Golic, K. G., & Carroll, D. (2002) · Genetics · doi:10.1093/genetics/161.3.1169 · Cited by 860 · see citing works

The Discovery of Zinc Fingers and Their Applications in Gene Regulation and Genome Manipulation

Klug, A. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-010909-095056 · Cited by 710 · see citing works

Design and Selection of Novel Cys2His2 Zinc Finger Proteins

Pabo, C. O., Peisach, E., & Grant, R. A. (2001) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.70.1.313 · Cited by 715 · see citing works

Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases

Bibikova, M. V., Carroll, D., Segal, D. J., Trautman, J. K., Smith, J., Kim, Y., & Chandrasegaran, S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.289-297.2001 · Cited by 614 · see citing works

Toward controlling gene expression at will: Specific regulation of the erbB - 2 / HER - 2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

Beerli, R. R., Segal, D. J., Dreier, B., & Barbas, C. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14628 · Cited by 539 · see citing works

Protein Design: A Hierarchic Approach

Bryson, J. W., Betz, S. F., Lu, H. S. M., Suich, D. J., Zhou, H. X., O’Neil, K. T., & DeGrado, W. F. (1995) · Science · doi:10.1126/science.270.5238.935 · Cited by 530 · see citing works

Engineering polydactyl zinc-finger transcription factors

Beerli, R. R., & Barbas, C. F. (2002) · Nature Biotechnology · doi:10.1038/nbt0202-135 · Cited by 495 · see citing works

Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility

Chevalier, B. S. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.18.3757 · Cited by 483 · see citing works

Editing the epigenome: technologies for programmable transcription and epigenetic modulation

Thakore, P. I., Black, J. B., Hilton, I. B., & Gersbach, C. A. (2016) · Nature Methods · doi:10.1038/nmeth.3733 · Cited by 451 · see citing works

Activation of the MHC Class II Transactivator CIITA by Interferon-γ Requires Cooperative Interaction between Stat1 and USF-1

Mühlethaler‐Mottet, A., Berardino, W. D., Otten, L., & Mach, B. (1998) · Immunity · doi:10.1016/s1074-7613(00)80468-9 · Cited by 376 · see citing works

Engineering Novel Metalloproteins: Design of Metal-Binding Sites into Native Protein Scaffolds

Lu, Y., Berry, S. M., & Pfister, T. D. (2001) · Chemical Reviews · doi:10.1021/cr0000574 · Cited by 375 · see citing works

Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

Moehle, E. A., Rock, J. M., Lee, Y.-L., Jouvenot, Y., DeKelver, R. C., Gregory, P. D., Urnov, F. D., & Holmes, M. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611478104 · Cited by 371 · see citing works

A General Strategy for Selecting High-Affinity Zinc Finger Proteins for Diverse DNA Target Sites

Greisman, H. A., & Pabo, C. O. (1997) · Science · doi:10.1126/science.275.5300.657 · Cited by 331 · see citing works

Origins of Programmable Nucleases for Genome Engineering

Chandrasegaran, S., & Carroll, D. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.10.014 · Cited by 327 · see citing works

Design of polydactyl zinc-finger proteins for unique addressing within complex genomes

Liu, Q., Segal, D. J., Ghiara, J. B., & Barbas, C. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5525 · Cited by 327 · see citing works

Cloning and characterization of mCtBP2, a co‐repressor that associates with basic Krüppel‐like factor and other mammalian transcriptional regulators

Turner, J., & Crossley, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.5129 · Cited by 315 · see citing works

Mechanisms of inhibitors of mutagenesis and carcinogenesis

Flora, S. D. (1998) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(97)00292-3 · Cited by 304 · see citing works

A Fluorescent Intercalator Displacement Assay for Establishing DNA Binding Selectivity and Affinity

Tse, W. C., & Boger, D. L. (2003) · Accounts of Chemical Research · doi:10.1021/ar030113y · Cited by 290 · see citing works

Meganucleases and DNA Double-Strand Break-Induced Recombination: Perspectives for Gene Therapy

Pâques, F., & Duchateau, P. N. (2007) · Current Gene Therapy · doi:10.2174/156652307779940216 · Cited by 274 · see citing works

The discovery of zinc fingers and their development for practical applications in gene regulation and genome manipulation

Klug, A. (2010) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583510000089 · Cited by 269 · see citing works

Foundations for the design and implementation of synthetic genetic circuits

Slusarczyk, A. L., Lin, A. Y., & Weiss, R. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3227 · Cited by 270 · see citing works

Protein-DNA interactions: amino acid conservation and the effects of mutations on binding specificity.

Luscombe, N., & Thornton, J. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00571-5 · Cited by 272 · see citing works

A primitive hematopoietic cell is the target for the leukemic transformation in human Philadelphia-positive acute lymphoblastic leukemia

Cobaleda, C., Gutiérrez-Cianca, N., Pérez‐Losada, J., Flores, T., García‐Sánz, R., González, M., & Sánchez-Garcı́a, I. (2000) · Blood · doi:10.1182/blood.v95.3.1007.003k35_1007_1013 · Cited by 249 · see citing works

Physical basis of a protein-DNA recognition code

Choo, Y., & Klug, A. (1997) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(97)80015-2 · Cited by 248 · see citing works

LESSONS FROM ZINC-BINDING PEPTIDES

Berg, J. M., & Godwin, H. A. (1997) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.26.1.357 · Cited by 227 · see citing works

Zinc finger peptides for the regulation of gene expression

Klug, A. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3007 · Cited by 223 · see citing works

Phage display: practicalities and prospects

Willats, W. G. T. (2002) · Plant Molecular Biology · doi:10.1023/a:1021215516430 · Cited by 220 · see citing works

Assembly requirements of PU.1–Pip (IRF‐4) activator complexes: inhibiting function in vivo using fused dimers

Brass, A. L., Zhu, A. Q., & Singh, H. (1999) · The EMBO Journal · doi:10.1093/emboj/18.4.977 · Cited by 207 · see citing works

Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice

Garriga-Canut, M., Agustín‐Pavón, C., Herrmann, F., Sánchez, A., Dierssen, M., Fillat, C., & Isalan, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206506109 · Cited by 196 · see citing works

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

Isalan, M., Klug, A., & Choo, Y. (2001) · Nature Biotechnology · doi:10.1038/90264 · Cited by 191 · see citing works

Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2.

Sánchez-Garcı́a, I., & Grütz, G. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5287 · Cited by 193 · see citing works

Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology

Orlando, S. J., Santiago, Y., Dekelver, R., Freyvert, Y., Boydston, E. A., Moehle, E. A., Choi, V. M., Gopalan, S. M., Lou, J., Li, J., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq512 · Cited by 207 · see citing works

α-Helical Protein Assembly Motifs

Kohn, W. D., Mant, C. T., & Hodges, R. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.5.2583 · Cited by 185 · see citing works

Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway

Pérez‐Losada, J., Sánchez‐Martín, M., Rodrı́guez-Garcı́a, A., Sánchez, M. L., Órfão, A., Flores, T., & Sánchez-Garcı́a, I. (2002) · Blood · doi:10.1182/blood.v100.4.1274.h81602001274_1274_1286 · Cited by 182 · see citing works

Synthetic Zinc Finger Transcription Factor Action at an Endogenous Chromosomal Site

Zhang, L., Spratt, S. K., Liu, Q., Johnstone, B. H., Qi, H., Raschke, E. E., Jamieson, A. C., Rebar, E. J., Wolffe, A. P., & Case, C. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005341200 · Cited by 180 · see citing works

A 2.2 Å resolution crystal structure of a designed zinc finger protein bound to DNA

Kim, C. A., & Berg, J. M. (1996) · Nature Structural Biology · doi:10.1038/nsb1196-940 · Cited by 178 · see citing works

FlbC is a putative nuclear C2H2 transcription factor regulating development in Aspergillus nidulans

Kwon, N., Garzia, A., Espeso, E. A., Ugalde, U., & Yu, J. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07282.x · Cited by 177 · see citing works

Multidimensional control of therapeutic human cell function with synthetic gene circuits

Li, H.-S., Israni, D. V., Gagnon, K. A., Gan, K. A., Raymond, M. H., Sander, J. D., Roybal, K. T., Joung, J. K., Wong, W. W., & Khalil, A. S. (2022) · Science · doi:10.1126/science.ade0156 · Cited by 176 · see citing works

Analysis of zinc fingers optimized via phage display: evaluating the utility of a recognition code 1 1Edited by P. E. Wright

Wolfe, S. A., Greisman, H. A., Ramm, E. I., & Pabo, C. O. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2421 · Cited by 177 · see citing works

Function of the Zinc-Finger Transcription FactorSNAI2in Cancer and Development

Cobaleda, C., Pérez-Caro, M., Vicente‐Dueñas, C., & Sánchez-Garcı́a, I. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130146 · Cited by 175 · see citing works

Solution‐Phase Combinatorial Libraries: Modulating Cellular Signaling by Targeting Protein–Protein or Protein–DNA Interactions

Boger, D. L., Desharnais, J., & Capps, K. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200300574 · Cited by 171 · see citing works

Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase

Minczuk, M., Papworth, M. A., Kolasinska, P., Murphy, M. P., & Klug, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609502103 · Cited by 166 · see citing works

Validated Zinc Finger Protein Designs for All 16 GNN DNA Triplet Targets

Liu, Q., Xia, Z., & Case, C. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110669200 · Cited by 164 · see citing works

Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection

Hurt, J. A., Thibodeau, S. A., Hirsh, A. S., Pabo, C. O., & Joung, J. K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135381100 · Cited by 146 · see citing works

Designer zinc-finger proteins and their applications

Papworth, M. A., Kolasinska-Zwierz, P., & Minczuk, M. A. (2005) · Gene · doi:10.1016/j.gene.2005.09.011 · Cited by 146 · see citing works

Homologous DNA Pairing Promoted by a 20-Amino Acid Peptide Derived from RecA

Voloshin, O. N., Wang, L., & Camerini‐Otero, R. D. (1996) · Science · doi:10.1126/science.272.5263.868 · Cited by 139 · see citing works

Transcription-Factor Mutations and Disease

Latchman, D. S. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601043340108 · Cited by 133 · see citing works

Targeting signal transduction for disease therapy

Levitzki, A. (1996) · Medical Oncology · doi:10.1007/bf02990952 · Cited by 133 · see citing works

The Design of Functional DNA-Binding Proteins Based on Zinc Finger Domains

Jantz, D., Amann, B. T., Gatto, G. J. J., & Berg, J. M. (2003) · Chemical Reviews · doi:10.1021/cr020603o · Cited by 131 · see citing works

Cancer induction by restriction of oncogene expression to the stem cell compartment

Pérez-Caro, M., Cobaleda, C., González‐Herrero, I., Vicente‐Dueñas, C., Bermejo‐Rodríguez, C., Sánchez‐Beato, M., Órfão, A., Pintado, B., Flores, T., Sánchez‐Martín, M., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.253 · Cited by 128 · see citing works

A Novel Allosterically trans-Activated Ribozyme, the Maxizyme, with Exceptional Specificity In Vitro and In Vivo

Kuwabara, T., Warashina, M., Tanabe, T., Tani, K., Asano, S., & Taira, K. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80160-4 · Cited by 127 · see citing works

Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA

Foster, M. P., Wuttke, D. S., Radhakrishnan, I., Case, D. A., Gottesfeld, J. M., & Wright, P. E. (1997) · Nature Structural Biology · doi:10.1038/nsb0897-605 · Cited by 122 · see citing works

Quantitative Analyses of Core Promoters Enable Precise Engineering of Regulated Gene Expression in Mammalian Cells

Ede, C., Chen, X., Lin, M.-Y., & Chen, Y. Y. (2016) · ACS Synthetic Biology · doi:10.1021/acssynbio.5b00266 · Cited by 113 · see citing works

Optimizing the affinity and specificity of proteins with molecular display

Levin, A. M., & Weiss, G. A. (2005) · Molecular BioSystems · doi:10.1039/b511782h · Cited by 114 · see citing works

Zinc-finger-based artificial transcription factors and their applications

Sera, T. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.03.012 · Cited by 112 · see citing works

A detailed study of the substrate specificity of a chimeric restriction enzyme

Smith, J., Berg, J. M., & Chandrasegaran, S. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.2.674 · Cited by 107 · see citing works

dCas9: A Versatile Tool for Epigenome Editing

Brocken, D. J. W., Tark‐Dame, M., & Dame, R. T. (2017) · Current Issues in Molecular Biology · doi:10.21775/cimb.026.015 · Cited by 106 · see citing works

A systematic survey of the Cys2His2 zinc finger DNA-binding landscape

Persikov, A. V., Wetzel, J. L., Rowland, E. F., Oakes, B. L., Xu, D. J., Singh, M., & Noyes, M. B. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1395 · Cited by 104 · see citing works

Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules

Boger, D. L. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(01)00243-7 · Cited by 101 · see citing works

Key Residues Characteristic of GATA N-fingers Are Recognized By FOG

Fox, A. H., Kowalski, K., King, G. F., Mackay, J. P., & Crossley, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33595 · Cited by 96 · see citing works

Regulation of the MDR1 Gene by Transcriptional Repressors Selected Using Peptide Combinatorial Libraries

Bartsevich, V. V., & Juliano, R. L. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.1.1 · Cited by 96 · see citing works

Advances in zinc finger engineering

Choo, Y., & Isalan, M. (2000) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00107-x · Cited by 95 · see citing works

Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer

Stolzenburg, S., Beltrán, A. S., Swift‐Scanlan, T., Rivenbark, A. G., Rashwan, R., & Blancafort, P. (2015) · Oncogene · doi:10.1038/onc.2014.470 · Cited by 94 · see citing works

Finite-difference solution of the Poisson-Boltzmann equation: Complete elimination of self-energy

Zhou, Z., Payne, P. W., Vásquez, M., Kuhn, N., & Levitt, M. (1996) · Journal of Computational Chemistry · doi:10.1002/(sici)1096-987x(199608)17:11 · Cited by 94 · see citing works

A molecular code dictates sequence‐specific DNA recognition by homeodomains.

Damante, G., Pellizzari, L., Esposito, G., Fogolari, F., Viglino, P., Fabbro, D., Tell, G., Formisano, S., & Lauro, R. D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00879.x · Cited by 93 · see citing works

Phage display: protein engineering by directed evolution

O’Neil, K. T., & Hoess, R. H. (1995) · Current Opinion in Structural Biology · doi:10.1016/0959-440x(95)80027-1 · Cited by 93 · see citing works

Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities

Uil, T. G. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg815 · Cited by 92 · see citing works

Synthesis at the Interface of Chemistry and Biology

Wu, X., & Schultz, P. G. (2009) · Journal of the American Chemical Society · doi:10.1021/ja9026067 · Cited by 90 · see citing works

Fusion Proteins Consisting of Human Immunodeficiency Virus Type 1 Integrase and the Designed Polydactyl Zinc Finger Protein E2C Direct Integration of Viral DNA into Specific Sites

Tan, W., Zhu, K., Segal, D., Barbas, C., & Chow, S. A. (2004) · Journal of Virology · doi:10.1128/jvi.78.3.1301-1313.2004 · Cited by 90 · see citing works

MDR1 Promoter Hypermethylation in MCF-7 Human Breast Cancer Cells: Changes in Chromatin Structure Induced by Treatment with 5-Aza-Cytidine

David, G. L., Yegnasubramanian, S., Kumar, A., Marchi, V. L., Marzo, A. M. D., Lin, X., & Nelson, W. G. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.6.845 · Cited by 88 · see citing works

Sequence specificity is obtained from the majority of modular C2H2 zinc-finger arrays

Lam, K. N., van Bakel, H., Coté, A. G., van der Ven, A., & Hughes, T. R. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1303 · Cited by 87 · see citing works

In vivo inhibition by a site-specific catalytic RNA subunit of RNase P designed against the BCR-ABL oncogenic products: a novel approach for cancer treatment

Cobaleda, C., & Sánchez-Garcı́a, I. (2000) · Blood · doi:10.1182/blood.v95.3.731.003k28_731_737 · Cited by 86 · see citing works

The rise of DNA methylation and the importance of chromatin on multidrug resistance in cancer

Baker, E. K., & El‐Osta, A. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00342-2 · Cited by 85 · see citing works

Targeting CCR5 as a Component of an HIV-1 Therapeutic Strategy

Mohamed, H., Gurrola, T., Berman, R., Collins, M., Sariyer, I. K., Nonnemacher, M. R., & Wigdahl, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.816515 · Cited by 81 · see citing works

Recent developments in the engineering of zinc finger proteins

Moore, M., & Ullman, C. G. (2003) · Briefings in Functional Genomics · doi:10.1093/bfgp/1.4.342 · Cited by 81 · see citing works

Arresting Cancer Proliferation by Small-Molecule Gene Regulation

Dickinson, L. A., Burnett, R., Melander, C., Edelson, B. S., Arora, P. S., Dervan, P. B., & Gottesfeld, J. M. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.09.004 · Cited by 81 · see citing works

Imaging Specific Genomic DNA in Living Cells

Chen, B., Guan, J., & Huang, B. (2016) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-062215-010830 · Cited by 77 · see citing works

Chemical Approaches to Control Gene Expression

Gottesfeld, J. M., Turner, J. M., & Dervan, P. B. (2001) · Gene Expression · doi:10.3727/000000001783992696 · Cited by 80 · see citing works

Overlap of Nuclear Localisation Signal and Specific DNA-binding Residues Within the Zinc Finger Domain of PacC

Fernández-Martı́nez, J., Brown, C. V., Dı́ez, E., Tilburn, J., Arst, H. N., Peñalva, M. A., & Espeso, E. A. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.09.072 · Cited by 76 · see citing works

Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors

Papworth, M. A., Moore, M., Isalan, M., Minczuk, M. A., Choo, Y., & Klug, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252773399 · Cited by 76 · see citing works

Characterisation of site-biased DNA methyltransferases: specificity, affinity and subsite relationships

McNamara, A. R. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf501 · Cited by 74 · see citing works

Towards therapeutic applications of engineered zinc finger proteins

Klug, A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.10.104 · Cited by 74 · see citing works

Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors.

Snowden, A. W., Zhang, L., Urnov, F. D., Dent, C. L., Jouvenot, Y., Zhong, X., Rebar, E. J., Jamieson, A. C., Zhang, H. S., Tan, S., et al. (2003) · PubMed · Cited by 71 · see citing works

Determining the Specificities of TALENs, Cas9, and Other Genome-Editing Enzymes

Pattanayak, V., Guilinger, J. P., & Liu, D. R. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-801185-0.00003-9 · Cited by 70 · see citing works

Phase display of proteins

Dunn, I. S. (1996) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(96)80060-7 · Cited by 70 · see citing works

Design of polyzinc finger peptides with structured linkers

Moore, M., Choo, Y., & Klug, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1432 · Cited by 69 · see citing works

Towards an understanding of protein-DNA recognition

Rhodes, D., Schwabe, J. W. R., Chapman, A. C., & Fairall, L. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0048 · Cited by 69 · see citing works

Gene editing and its applications in biomedicine

Li, G., Li, X., Zhuang, S., Wang, L., Zhu, Y., Chen, Y., Sun, W. C., Wu, Z., Zhou, Z. L., Chen, J., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2057-0 · Cited by 65 · see citing works

Changing the Structural Context of a Functional β-Hairpin

Drakopoulou, E., Zinn‐Justin, S., Guenneugues, M., Gilquin, B., Ménèz, A., & Vita, C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.11979 · Cited by 68 · see citing works

Designing DNA-binding proteins on the surface of filamentous phage

Choo, Y., & Klug, A. (1995) · Current Opinion in Biotechnology · doi:10.1016/0958-1669(95)80073-5 · Cited by 68 · see citing works

Targeted Methylation of the Epithelial Cell Adhesion Molecule (EpCAM) Promoter to Silence Its Expression in Ovarian Cancer Cells

Nunna, S., Reinhardt, R., Ragozin, S., & Jeltsch, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087703 · Cited by 65 · see citing works

Altered DNA-binding specificity mutants of EKLF and Sp1 show that EKLF is an activator of the β-globin locus control region in vivoPreprint

Gillemans, N., Tewari, R., Lindeboom, F., Rottier, R. J., de Wit, T., Wijgerde, M., Grosveld, F. G., & Philipsen, S. (1998) · Genes & Development · doi:10.1101/gad.12.18.2863 · Cited by 65 · see citing works

Epigenetic Editing: On the Verge of Reprogramming Gene Expression at Will

Cano-Rodríguez, D., & Rots, M. G. (2016) · Current Genetic Medicine Reports · doi:10.1007/s40142-016-0104-3 · Cited by 63 · see citing works

Sequence‐specific DNA‐binding proteins within the Mbcr on the ph1 chromosome

Leibowitz, D. S., Young, K., & Cox, G. (1991) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870030410 · Cited by 4 · see citing works

Designed protein represses leukemia gene

BORMAN, S. (1994) · Chemical & Engineering News · doi:10.1021/cen-v072n051.p005 · Cited by 1 · see citing works

A peptide-based synthetic transcription factor selectively down-regulates the proto-oncogene CFOS in tumour cells and inhibits proliferation

Chakraborty, M., & Roy, S. (2016) · Chemical Communications · doi:10.1039/c6cc08086c · Cited by 9 · see citing works

Genetic selection for genes encoding sequence-specific DNA-binding proteins.

Elledge, S. J., Sugiono, P., Guarente, L., & Davis, R. W. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3689 · Cited by 43 · see citing works

Positive and negative regulation of endogenous genes by designed transcription factors

Beerli, R. R., Dreier, B., & Barbas, C. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040552697 · Cited by 349 · see citing works