In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

Gorman, C., Moffat, L. F., & Howard, B. H. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.9.1044 · Cited by 7,674

Firefly Luciferase Gene: Structure and Expression in Mammalian Cells

de Wet, J. R., Wood, K. V., DeLuca, M., Helinski, D. R., & Subramani, S. E. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.725 · Cited by 3,088

A short amino acid sequence able to specify nuclear location

Kalderon, D., Roberts, B., Richardson, W. D., & Smith, A. E. (1984) · Cell · doi:10.1016/0092-8674(84)90457-4 · Cited by 2,511

Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes.

Miller, J., McLachlan, A., & Klug, A. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb03825.x · Cited by 2,476

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

Evan, G. I., Lewis, G. K., Ramsay, G. M., & Bishop, J. M. (1985) · Molecular and Cellular Biology · doi:10.1128/mcb.5.12.3610 · Cited by 2,412

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

Kadonaga, J. T., Carner, K., Masiarz, F. R., & Tjian, R. (1987) · Cell · doi:10.1016/0092-8674(87)90594-0 · Cited by 1,614

pEF-BOS, a powerful mammalian expression vector

Mizushima, S., & Nagata, S. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.17.5322 · Cited by 1,594

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

Shtivelman, E., Lifshitz, B., Gale, R. P., & Canaani, E. (1985) · Nature · doi:10.1038/315550a0 · Cited by 1,583

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

Groffen, J., Stephenson, J. R., Heisterkamp, N., DeKlein, A., Bartram, C., & Grosveld, G. C. (1984) · Cell · doi:10.1016/0092-8674(84)90077-1 · Cited by 1,578

Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?

Stein, C., & Cheng, Y. C. (1993) · Science · doi:10.1126/science.8351515 · Cited by 1,300

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

Konopka, J. B., Watanabe, S. M., & Witte, O. N. (1984) · Cell · doi:10.1016/0092-8674(84)90438-0 · Cited by 872

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

Bartram, C. R., de Klein, A., Hagemeijer, A., van Agthoven, T., van Kessel, A. G., Bootsma, D., Grosveld, G. C., Ferguson-Smith, M. A., Davies, T., Stone, M., et al. (1983) · Nature · doi:10.1038/306277a0 · Cited by 738

A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences.

Christy, B. A., Lau, L. F., & Nathans, D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.7857 · Cited by 734

IL3-dependent mouse clones that express B-220 surface antigen, contain ig genes in germ-line configuration, and generate B lymphocytes in vivo

Palacios, R., & Steinmetz, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80053-2 · Cited by 716

Acute leukaemia in bcr/abl transgenic mice

Heisterkamp, N., Jenster, G. W., ten Hoeve, J., Zovich, D., Pattengale, P. K., & Groffen, J. (1990) · Nature · doi:10.1038/344251a0 · Cited by 660

Three-Dimensional Solution Structure of a Single Zinc Finger DNA-Binding Domain

Lee, M. S., Gippert, G. P., Soman, K. V., Case, D. A., & Wright, P. E. (1989) · Science · doi:10.1126/science.2503871 · Cited by 627

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

Daley, G. Q., & Baltimore, D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9312 · Cited by 563

Selection of phage antibodies by binding affinity

Hawkins, R. E., Russell, S. J., & Winter, G. P. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90639-2 · Cited by 526

Zinc Finger Phage: Affinity Selection of Fingers with New DNA-Binding Specificities

Rebar, E. J., & Pabo, C. O. (1994) · Science · doi:10.1126/science.8303274 · Cited by 417

Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins.

Berg, J. M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.1.99 · Cited by 412

Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation

Maher, L. J., Wold, B. J., & Dervan, P. B. (1989) · Science · doi:10.1126/science.2549631 · Cited by 409

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

Hermans, A., Heisterkamp, N., Lindern, M. V., van Baal, S., Meijer, D., van der Plas, D., Wiedemann, L. M., Groffen, J., Bootsma, D., & Grosveld, G. C. (1987) · Cell · doi:10.1016/0092-8674(87)90007-9 · Cited by 378

Different activation domains stimulate transcription from remote (‘enhancer’) and proximal (‘promoter’) positions.

Seipel, K., Georgiev, O., & Schaffner, W. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05603.x · Cited by 359

Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage.

Choo, Y., & Klug, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11163 · Cited by 322

Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions.

Choo, Y., & Klug, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11168 · Cited by 287

A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia

Kurzrock, R., Shtalrid, M., Romero, P., Kloetzer, W. S., Talpas, M., Trujillo, J. M., Blick, M. B., Beran, M., & Gutterman, J. U. (1987) · Nature · doi:10.1038/325631a0 · Cited by 267

Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.Preprint

Lüscher, B., Mitchell, P. J., Williams, T., & Tjian, R. (1989) · Genes & Development · doi:10.1101/gad.3.10.1507 · Cited by 252

Toward rules relating zinc finger protein sequences and DNA binding site preferences.

Desjarlais, J. R., & Berg, J. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7345 · Cited by 220

In vitro selection of zinc fingers with altered DNA-binding specificity

Jamieson, A. C., Kim, S., & Wells, J. A. (1994) · Biochemistry · doi:10.1021/bi00185a004 · Cited by 214

GAL4 fusion vectors for expression in yeast or mammalian cells

Sadowski, I., Bell, B., Broad, P. M., & Hollis, M. (1992) · Gene · doi:10.1016/0378-1119(92)90261-m · Cited by 209

Transcriptional repression directed by the yeast α2 protein in vitro

Herschbach, B. M., Arnaud, M. B., & Johnson, A. D. (1994) · Nature · doi:10.1038/370309a0 · Cited by 115

A role in DNA binding for the linker sequences of the first three zinc fingers of TFIIIA

Choo, Y., & Klug, A. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.15.3341 · Cited by 109

The cysteine‐rich LIM domains inhibit DNA binding by the associated homeodomain in Isl‐1.

Sánchez-Garcı́a, I., Osada, H., Forster, A. M., & Rabbitts, T. H. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06108.x · Cited by 98

Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities.

Sánchez-Garcı́a, I., & Rabbitts, T. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.7869 · Cited by 93

The Two-Hybrid System to Detect Protein-Protein Interactions

Fields, S. (1993) · Methods · doi:10.1006/meth.1993.1016 · Cited by 92

Sequence-specific DNA binding by a two zinc-finger peptide from the Drosophila melanogaster tramtrack protein

Fairall, L., Harrison, S. D., TRAVERS, A. A., & Rhodes, D. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90952-g · Cited by 61

The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc

Berg, J. M., & Shi, Y. (1996) · Science · doi:10.1126/science.271.5252.1081 · Cited by 1,930

Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects

Li, H., Yang, Y., Hong, W., Huang, M., Wu, M., & Zhao, X. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0089-y · Cited by 1,829

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Urnov, F. D., Miller, J. C., Lee, Y.-L., Beausejour, C. M., Rock, J. M., Augustus, S., Jamieson, A. C., Porteus, M. H., Gregory, P. D., & Holmes, M. C. (2005) · Nature · doi:10.1038/nature03556 · Cited by 1,642

Phage Display

Smith, G. P., & Petrenko, V. A. (1997) · Chemical Reviews · doi:10.1021/cr960065d · Cited by 1,550

The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE).

Martínez‐Pastor, M. T., Marchler, G. H., Schüller, C., Marchler‐Bauer, A., Ruis, H., & Estruch, F. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00576.x · Cited by 1,077

Sequence‐specific DNA‐binding proteins within the Mbcr on the ph1 chromosome

Leibowitz, D. S., Young, K., & Cox, G. (1991) · Genes Chromosomes and Cancer · doi:10.1002/gcc.2870030410 · Cited by 4

Designed protein represses leukemia gene

BORMAN, S. (1994) · Chemical & Engineering News · doi:10.1021/cen-v072n051.p005 · Cited by 1

A peptide-based synthetic transcription factor selectively down-regulates the proto-oncogene CFOS in tumour cells and inhibits proliferation

Chakraborty, M., & Roy, S. (2016) · Chemical Communications · doi:10.1039/c6cc08086c · Cited by 9

Genetic selection for genes encoding sequence-specific DNA-binding proteins.

Elledge, S. J., Sugiono, P., Guarente, L., & Davis, R. W. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3689 · Cited by 43

Positive and negative regulation of endogenous genes by designed transcription factors

Beerli, R. R., Dreier, B., & Barbas, C. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040552697 · Cited by 305