The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence
Open accessAbstract
A DNA-binding peptide comprising three zinc-fingers has been engineered to bind specifically to a unique nine-base-pair region of a BCR-ABL fusion oncogene in preference to the parent genomic sequences. Binding to the target oncogene in chromosomal DNA is possible in transformed cells in culture, and results in blockage of transcription. Consequently, murine cells rendered independent of growth factors by the action of the oncogene revert to factor dependence upon transient transfection with a vector expressing the peptide.
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The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc
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Metadata
- Authors
- Choo, Y., Sánchez-García, I., & Klug, A.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- ORCID
- Choo, Yen
- Venue
- Nature
- Published
- 1994-12
- Volume
- 372
- Issue
- 6507
- Pages
- 642-645
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2019616754
- Cited by
- 292
- References
- 36
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 9 · 2019: 3 · 2018: 3 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 11 · 2013: 1 · 2012: 6
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- zinc finger DNA-binding protein, transcriptional repression, site-specific DNA binding, growth factor independence, transformed cells, transcriptional block
- MeSH terms
- Amino Acid Sequence, Animals, Cell Line, DNA, DNA-Binding Proteins, Feasibility Studies, Gene Expression Regulation, Humans, Molecular Sequence Data, Protein Binding, Recombinant Fusion Proteins, Transcription, Genetic, Transfection, Fusion Proteins, bcr-abl, Zinc Fingers, Mice
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