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Cited by 662T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmune Response and Inflammation

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

Ferrick, David A., Schrenzel, Mark D., Mulvania, Thera, Hsieh, Beryl, Ferlin, Walter G., Lepper, Heather·1995·Nature
DOI 10.1038/373255a0
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Abstract

Exposure to various pathogens can stimulate at least two patterns of cytokine production by CD4-positive T cells. Responses that result in secretion of interferon-gamma (IFN-gamma), lymphotoxin and interleukin-2 (IL-2) are classified as T-helper-1 (Th1); CD4+ T-cell production of IL-4, IL-5, IL-9, IL-10 and IL-13 is called a T-helper-2 response (Th2). Differentiation of CD4+ T cells into either Th1 or Th2 cells is influenced by the cytokine milieu in which the initial antigen priming occurs. Here we use flow cytometry to identify the presence of intracellular cytokines (cytoflow) and analyse T-cell production of IFN-gamma and IL-4 from mice infected with Listeria monocytogenes or Nippostrongylus brasiliensis. We show that T cells bearing gamma delta receptors discriminate early in infection between these two pathogens by producing cytokines associated with the appropriate T-helper response. Our results demonstrate that gamma delta T cells are involved in establishing primary immune responses.

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Crossref · 10.1038/373255a0

Cites

30 of 30 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 1

  1. Moser, R. et al. J. Lab. clin. Med. 122, 567–575 (1993).

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Metadata

Authors
Ferrick, D. A., Schrenzel, M. D., Mulvania, T., Hsieh, B., Ferlin, W. G., & Lepper, H.
Affiliations
University of California, Davis (US)
ORCID
Ferlin, Walter G.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
1995-01
Volume
373
Issue
6511
Pages
255-257
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
DOI
10.1038/373255a0
OpenAlex
W1895680870
Cited by
662
References
30
Citations by year
2026: 2 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 12 · 2013: 12 · 2012: 14
FWCI
29.29
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
γδ T cells, interferon-gamma, IL-4, Th1 response, Th2 immune response, Listeria monocytogenes, Nippostrongylus brasiliensis, primary immune response, intracellular cytokine production, CD4+ T cells, pathogen discrimination, cytokine milieu
MeSH terms
Animals, Flow Cytometry, Interferon-gamma, Listeriosis, Mice, Inbred C3H, Nippostrongylus, Peritoneum, Spleen, Interleukin-4, Receptors, Antigen, T-Cell, gamma-delta, Strongylida Infections, Th1 Cells, Th2 Cells, Mice

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