Specification of neuroblast identity in the Drosophila embryonic central nervous system by gooseberry-distal
Abstract
The Drosophila central nervous system develops from a segmentally reiterated array of 30 unique neural precursors, called neuroblasts. Each neuroblast goes through a stereotyped cell lineage to produce an invariant clone of neural progeny. It is critical to identify the genes that specify neuroblast identity as these genes control the time of formation, gene expression profile, and cell lineage characteristics of each neuroblast. Here we show that the Pax-type gooseberry-distal gene specifies row 5 neuroblast identity. Initially, four rows of neuroblasts form per segment (1, 3, 5, 7) and gooseberry-distal is expressed in row 5 neuroblasts. By using 10 molecular markers, and by following the number and orientation of neuroblast divisions, we show that lack of gooseberry-distal transforms row 5 neuroblasts into row 3 neuroblasts, whereas ubiquitous gooseberry-distal generates the reciprocal transformation. Thus, gooseberry-distal is necessary and sufficient to specify row 5 neuroblast identity autonomously. The 10 genes coordinately regulated by gooseberry-distal are prime candidates for controlling specific aspects of neuroblast identity.
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The molecular basis for metameric pattern in the Drosophila embryo
Akam, M. E. (1987) · Development · doi:10.1242/dev.101.1.1 · Cited by 1,022 · see citing works
Bopp, D., Burri, M., Baumgartner, S., Frigerio, G., & Noll, M. (1986) · Cell · doi:10.1016/0092-8674(86)90818-4 · Cited by 486 · see citing works
Expression and Function of the Segmentation Gene fushi tarazu During Drosophila Neurogenesis
Doe, C. Q., Hiromi, Y., Gehring, W. J., & Goodman, C. S. (1988) · Science · doi:10.1126/science.2892267 · Cited by 340 · see citing works
Self-citationCabrera, C. V., Martínez-Arias, A., & Bate, M. (1987) · Cell · doi:10.1016/0092-8674(87)90496-x · Cited by 263 · see citing works
Boundaries and fields in early embryos
Ingham, P. W., & Arias, A. M. (1992) · Cell · doi:10.1016/0092-8674(92)90467-q · Cited by 234 · see citing works
The role of segment polarity genes during Drosophila neurogenesis.Preprint
Patel, N. H., Schäfer, B., Goodman, C. S., & Holmgren, R. A. (1989) · Genes & Development · doi:10.1101/gad.3.6.890 · Cited by 232 · see citing works
Self-citationSkeath, J. B., & Carroll, S. B. (1992) · Development · doi:10.1242/dev.114.4.939 · Cited by 218 · see citing works
Self-citationEllis, M. C., O’Neill, E., & Rubin, G. M. (1993) · Development · doi:10.1242/dev.119.3.855 · Cited by 217 · see citing works
Baumgartner, S., Bopp, D., Burri, M., & Noll, M. (1987) · Genes & Development · doi:10.1101/gad.1.10.1247 · Cited by 211 · see citing works
Pax: Gene regulators in the developing nervous system
Chalepakis, G., Stoykova, A., Wijnholds, J., Tremblay, P. J., & Gruß, P. (1993) · Journal of Neurobiology · doi:10.1002/neu.480241009 · Cited by 195 · see citing works
Jiménez, F., & Campos‐Ortega, J. A. (1990) · Neuron · doi:10.1016/0896-6273(90)90036-f · Cited by 172 · see citing works
Neuroblast Specification and Formation Regulated by wingless in the Drosophila CNS
Chu‐LaGraff, Q., & Doe, C. Q. (1993) · Science · doi:10.1126/science.8372355 · Cited by 169 · see citing works
Self-citationSkeath, J. B., Panganiban, G. E. F., Selegue, J. E., & Carroll, S. B. (1992) · Genes & Development · doi:10.1101/gad.6.12b.2606 · Cited by 133 · see citing works
Self-citationCôté, S., Preiss, A., Haller, J., Schuh, R., Kienlin, A., Seifert, E., & Jäckle, H. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02575.x · Cited by 87 · see citing works
Gutjahr, T., Patel, N. H., Li, X., Goodman, C. S., & Noll, M. (1993) · Development · doi:10.1242/dev.118.1.21 · Cited by 85 · see citing works
Antagonistic Adrenergic-Muscarinic Regulation of M Current in Smooth Muscle Cells
Sims, S. M., Singer, J. J., & Walsh, J. V. (1988) · Science · doi:10.1126/science.2827305 · Cited by 72 · see citing works
Zhang, Y., Ungar, A., Fresquez, C., & Holmgren, R. (1994) · Development · doi:10.1242/dev.120.5.1151 · Cited by 71 · see citing works
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The Embryonic Central Nervous System Lineages ofDrosophila melanogaster
Bossing, T., Udolph, G., Doe, C. Q., & Technau, G. M. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0240 · Cited by 524 · see citing works
Self-citationThe Embryonic Central Nervous System Lineages ofDrosophila melanogaster
Schmidt, H., Rickert, C., Bossing, T., Vef, O., Urban, J., & Technau, G. M. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8660 · Cited by 429 · see citing works
Schmid, A. T., Chiba, A., & Doe, C. Q. (1999) · Development · doi:10.1242/dev.126.21.4653 · Cited by 419 · see citing works
Self-citationPax genes and their roles in cell differentiation and development
Mansouri, A., Hallonet, M. E. R., & Gruß, P. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80087-1 · Cited by 331 · see citing works
Genetic control of Drosophila nerve cord development
Skeath, J. B., & Thor, S. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00007-2 · Cited by 279 · see citing works
Self-citationTemporal Patterning in the Drosophila CNS
Doe, C. Q. (2017) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125210 · Cited by 270 · see citing works
Self-citationWeiss, J. B., Von Ohlen, T., Mellerick, D. M., Dressler, G., Doe, C. Q., & Scott, M. P. (1998) · Genes & Development · doi:10.1101/gad.12.22.3591 · Cited by 250 · see citing works
“Embryos lacking gooseberry function have a transformation of row 5 into row 3 neuroectoderm and neuroblast identity, whereas misexpression of gooseberry results in the converse row 3 to row 5 transformation (Zhang et al. 1994; Skeath et al. 1995).”
BackgroundSelf-citationComparison of early nerve cord development in insects and vertebrates
Arendt, D., & Nübler-Jung, K. (1999) · Development · doi:10.1242/dev.126.11.2309 · Cited by 258 · see citing works
Broadus, J., Skeath, J. B., Spana, E. P., Bossing, T., Technau, G. M., & Doe, C. Q. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(95)00454-8 · Cited by 213 · see citing works
Self-citationBurrill, J. D., Moran, L., Goulding, M., & Saueressig, H. (1997) · Development · doi:10.1242/dev.124.22.4493 · Cited by 210 · see citing works
Neuronal Subtype Specification within a Lineage by Opposing Temporal Feed-Forward Loops
Baumgardt, M., Karlsson, D., Terriente, J., Díaz‐Benjumea, F. J., & Thor, S. (2009) · Cell · doi:10.1016/j.cell.2009.10.032 · Cited by 173 · see citing works
Embryonic Origins of a Motor System: Motor Dendrites Form a Myotopic Map in Drosophila
Landgraf, M., Jeffrey, V., Fujioka, M., Jaynes, J. B., & Bate, M. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000041 · Cited by 173 · see citing works
McDonald, J. A., Holbrook, S., Isshiki, T., Weiss, J., Doe, C. Q., & Mellerick, D. M. (1998) · Genes & Development · doi:10.1101/gad.12.22.3603 · Cited by 162 · see citing works
Self-citationThe hybridoma revolution: an offshoot of basic research
Milstein, C. (1999) · BioEssays · doi:10.1002/(sici)1521-1878(199911)21:11 · Cited by 9 · see citing works
Self-citationCharacterization of a novel subset of cardiac cells and their progenitors in theDrosophilaembryo
Ward, E. J., & Skeath, J. B. (2000) · Development · doi:10.1242/dev.127.22.4959 · Cited by 155 · see citing works
Self-citationIntegration of temporal and spatial patterning generates neural diversity
Erclik, T., Li, X., Courgeon, M., Bertet, C., Chen, Z., Baumert, R., Ng, J., Koo, C., Arain, U., Behnia, R., et al. (2017) · Nature · doi:10.1038/nature20794 · Cited by 153 · see citing works
Isshiki, T., Takeichi, M., & Nose, A. (1997) · Development · doi:10.1242/dev.124.16.3099 · Cited by 148 · see citing works
Mansouri, A., & Gruss, P. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00168-3 · Cited by 148 · see citing works
Homeostatic plasticity at the Drosophila neuromuscular junction
Frank, C. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.06.015 · Cited by 140 · see citing works
floating head and masterblind Regulate Neuronal Patterning in the Roof of the Forebrain
Masai, I., Heisenberg, C., Barth, K., MacDonald, R. E., Adamek, S., & Wilson, S. W. (1997) · Neuron · doi:10.1016/s0896-6273(01)80045-3 · Cited by 136 · see citing works
Technau, G. M., Berger, C., & Urbach, R. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20566 · Cited by 123 · see citing works
Does the immune system of a mouse age faster than the immune system of a human?
Aspinall, R. (1999) · BioEssays · doi:10.1002/(sici)1521-1878(199906)21:6 · Cited by 11 · see citing works
Dittrich, R., Bossing, T., Gould, A. P., Technau, G. M., & Urban, J. (1997) · Development · doi:10.1242/dev.124.13.2515 · Cited by 117 · see citing works
Formation and specification of ventral neuroblasts is controlled by vnd in Drosophila neurogenesisPreprint
Chu, H., Parras, C. M., White, K., & Jiménez, F. (1998) · Genes & Development · doi:10.1101/gad.12.22.3613 · Cited by 113 · see citing works
Neurogenesis in the insect central nervous system
Doe, C. Q., & Skeath, J. B. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80004-3 · Cited by 113 · see citing works
Self-citationSkeath, J. B. (1998) · Development · doi:10.1242/dev.125.17.3301 · Cited by 111 · see citing works
Self-citationWada, H., Holland, P. W. H., Sato, S., Yamamoto, H., & Satoh, N. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8626 · Cited by 110 · see citing works
Urbach, R., & Technau, G. M. (2003) · Development · doi:10.1242/dev.00532 · Cited by 110 · see citing works
Walsh, K. T., & Doe, C. Q. (2017) · Development · doi:10.1242/dev.157826 · Cited by 94 · see citing works
Self-citationPdm and Castor close successive temporal identity windows in the NB3-1 lineage
Tran, K. D., & Doe, C. Q. (2008) · Development · doi:10.1242/dev.024349 · Cited by 89 · see citing works
Self-citationNeural stem cells: From fly to vertebrates
Doe, C. Q., Fuerstenberg, S., & Peng, C. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199808)36:2 · Cited by 85 · see citing works
Self-citationVertebrate neural progenitor cells: subtypes and regulation
Temple, S., & Qian, X. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80003-1 · Cited by 84 · see citing works
Regulation of vertebrate neural cell fate by transcription factors
Bang, A. G., & Goulding, M. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80005-5 · Cited by 80 · see citing works
Sen, S., Chanchani, S., Southall, T. D., & Doe, C. Q. (2019) · eLife · doi:10.7554/elife.44036 · Cited by 79 · see citing works
Self-citationZhao, G., & Skeath, J. B. (2002) · Development · doi:10.1242/dev.129.5.1165 · Cited by 76 · see citing works
Self-citationNakanishi, N., Yuan, D., Jacobs, D. K., & Hartenstein, V. (2008) · Development Genes and Evolution · doi:10.1007/s00427-008-0239-7 · Cited by 71 · see citing works
Wheeler, S. R., Kearney, J. B., Guardiola, A. R., & Crews, S. T. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.03.016 · Cited by 72 · see citing works
Bhat, K. M. (1996) · Development · doi:10.1242/dev.122.9.2921 · Cited by 68 · see citing works
Bhat, K. M., & Schedl, P. D. (1997) · Development · doi:10.1242/dev.124.9.1675 · Cited by 68 · see citing works
Birkholz, O., Rickert, C., Berger, C., Urbach, R., & Technau, G. M. (2013) · Development · doi:10.1242/dev.090043 · Cited by 61 · see citing works
Skeath, J. B., & Doe, C. Q. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70681-7 · Cited by 61 · see citing works
Self-citationMcDonald, J. A., & Doe, C. Q. (1997) · Development · doi:10.1242/dev.124.5.1079 · Cited by 60 · see citing works
Self-citationThe ladybird homeobox genes are essential for the specification of a subpopulation of neural cells
Graeve, F. D., Jagla, T., Daponte, J.-P., Rickert, C., Dastugue, B., Urban, J., & Jagla, K. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.02.014 · Cited by 59 · see citing works
huckebein specifies aspects of CNS precursor identity required for motoneuron axon pathfinding
Chu‐LaGraff, Q., Schmid, A. T., Leidel, J., Brönner, G., ̈ckle, H. J., & Doe, C. Q. (1995) · Neuron · doi:10.1016/0896-6273(95)90093-4 · Cited by 57 · see citing works
Self-citationGene expression patterns in primary neuronal clusters of the Drosophila embryonic brain
Sprecher, S. G., Reichert, H., & Hartenstein, V. (2007) · Gene Expression Patterns · doi:10.1016/j.modgep.2007.01.004 · Cited by 58 · see citing works
Control of neural precursor specification by proneural proteins in the CNS of Drosophila.
Parras, C. M., García‐Alonso, L., Rodríguez, I., & Jiménez, F. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01030.x · Cited by 54 · see citing works
Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations
Guo, Q., Fu, W., Holtsberg, F. W., Steiner, S. M., & Mattson, M. P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990601)56:5 · Cited by 69 · see citing works
odd-skipped is expressed in multiple tissues during Drosophila embryogenesis
Ward, E. J., & Coulter, D. E. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00389-0 · Cited by 46 · see citing works
Udolph, G., Urban, J., Rüsing, G., Lüer, K., & Technau, G. M. (1998) · Development · doi:10.1242/dev.125.17.3291 · Cited by 46 · see citing works
Seven up acts as a temporal factor during two different stages of neuroblast 5-6 development
Benito‐Sipos, J., Ulvklo, C., Gabilondo, H., Baumgardt, M., Angel, A., Torroja, L., & Thor, S. (2011) · Development · doi:10.1242/dev.070946 · Cited by 44 · see citing works
Runt determines cell fates in the Drosophila embryonic CNS
Dormand, E.-L., & Brand, A. H. (1998) · Development · doi:10.1242/dev.125.9.1659 · Cited by 44 · see citing works
Yang, X., Bahri, S. M., Klein, T., & Chia, W. (1997) · Genes & Development · doi:10.1101/gad.11.11.1396 · Cited by 44 · see citing works
Synaptic Homeostasis Is Consolidated by the Cell Fate Gene gooseberry, a Drosophila pax3/7 Homolog
Marie, B., Pym, E. C. G., Bergquist, S. H., & Davis, G. W. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5467-09.2010 · Cited by 43 · see citing works
Stollewerk, A., Tautz, D., & Weller, M. (2003) · Arthropod Structure & Development · doi:10.1016/s1467-8039(03)00041-0 · Cited by 40 · see citing works
Genetic separation of the neural and cuticular patterning functions of gooseberry
Duman‐Scheel, M., Li, X., Orlov, I., Noll, M., & Patel, N. H. (1997) · Development · doi:10.1242/dev.124.15.2855 · Cited by 39 · see citing works
Integration of Spatial and Temporal Patterning in the Invertebrate and Vertebrate Nervous System
Chen, Y., & Konstantinides, N. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.854422 · Cited by 35 · see citing works
Romani, S., Jiménez, F., Hoch, M., Patel, N. H., Taubert, H., & Jäckle, H. (1996) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00603-x · Cited by 36 · see citing works
Matsuzaki, M., & Saigo, K. (1996) · Development · doi:10.1242/dev.122.11.3567 · Cited by 35 · see citing works
Hodgson, J. W., Cheng, N. N., Sinclair, D. A. R., Kyba, M., Randsholt, N. B., & Brock, H. W. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00091-9 · Cited by 34 · see citing works
Rossi, A. M., Jafari, S., & Desplan, C. (2021) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-102120-014813 · Cited by 30 · see citing works
Buescher, M., & Chia, W. N. (1997) · Development · doi:10.1242/dev.124.3.673 · Cited by 30 · see citing works
Bossing, T., Technau, G. M., & Doe, C. Q. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(95)00490-4 · Cited by 29 · see citing works
Self-citationGenerating neural diversity through spatial and temporal patterning
Sen, S. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.06.002 · Cited by 28 · see citing works
Deshpande, N., Dittrich, R., Technau, G. M., & Urban, J. (2001) · Development · doi:10.1242/dev.128.17.3253 · Cited by 26 · see citing works
He, H., & Noll, M. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.05.017 · Cited by 23 · see citing works
Meng, J. L., & Heckscher, E. S. (2020) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2020.11.010 · Cited by 24 · see citing works
Regulated vnd expression is required for both neural and glial specification in Drosophila
Mellerick, D. M., & Modica, V. (2002) · Journal of Neurobiology · doi:10.1002/neu.10022 · Cited by 22 · see citing works
Regulatory DNA required for vnd/NK-2 homeobox gene expression pattern in neuroblasts
Shao, X., Koizumi, K., Nosworthy, N. J., Tan, D.-P., Odenwald, W. F., & Nirenberg, M. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012584599 · Cited by 20 · see citing works
Zhao, G., Boekhoff‐Falk, G., Wilson, B. A., & Skeath, J. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611700104 · Cited by 20 · see citing works
Self-citationFunctions of the segment polarity genes midline and H15 in Drosophila melanogaster neurogenesis
Buescher, M., Tio, M., Tear, G., Overton, P. M., Brook, W. J., & Chia, W. N. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.01.016 · Cited by 19 · see citing works
Seibert, J., & Urbach, R. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.07.024 · Cited by 17 · see citing works
Becker, H., Renner, S., Technau, G. M., & Berger, C. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005961 · Cited by 17 · see citing works
Combinatorial Activity of Pair-Rule Proteins on the Drosophila gooseberry Early Enhancer
Bouchard, M., St-Amand, J., & Côté, S. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9702 · Cited by 16 · see citing works
Imp and Syp mediated temporal patterning of neural stem cells in the developing Drosophila CNS
Islam, I. M., & Erclik, T. (2022) · Genetics · doi:10.1093/genetics/iyac103 · Cited by 13 · see citing works
Decoding neuronal diversity: Mechanisms governing neural cell fate in Drosophila
Bakshi, A., Kadhi, K. B. E., & Desplan, C. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103061 · Cited by 12 · see citing works
40 years of homeodomain transcription factors in the Drosophila nervous system
Doe, C. Q., & Thor, S. (2024) · Development · doi:10.1242/dev.202910 · Cited by 10 · see citing works
Self-citationLosada‐Pérez, M., Gabilondo, H., del Saz, D., Baumgardt, M., Molina, I., León, Y., Monedero, I., Díaz‐Benjumea, F. J., Torroja, L., & Benito‐Sipos, J. (2010) · Mechanisms of Development · doi:10.1016/j.mod.2010.08.003 · Cited by 10 · see citing works
Anderson, N. L. Q., Lai, S.-L., & Doe, C. Q. (2026) · Developmental Biology · doi:10.1016/j.ydbio.2026.01.008 · Cited by 7 · see citing works
Self-citationUnfolding the ventral nerve center of chaetognaths
Ordoñez, J. F. F., & Wollesen, T. (2024) · Neural Development · doi:10.1186/s13064-024-00182-6 · Cited by 7 · see citing works
Local inhibition of Drosophila homeobox‐containing neural dorsoventral patterning genes by Dpp
Oh, C. T., Kwon, S., Jeon, K. J., Han, P., Kim, S. H., & Jeon, S. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03573-1 · Cited by 8 · see citing works
The RED domain of Paired is specifically required forDrosophilaaccessory gland maturation
Li, L., Li, P., & Xue, L. (2015) · Open Biology · doi:10.1098/rsob.140179 · Cited by 6 · see citing works
Concurrent temporal patterning of neural stem cells in the fly visual systemPreprint
Arain, U., Islam, I. M., Valentino, P., & Erclik, T. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.13.512100 · Cited by 6 · see citing works
Cellular reprogramming processes in Drosophila and C. elegans
Tursun, B. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.09.005 · Cited by 5 · see citing works
Progressive derivation of serially homologous neuroblast lineages in the gnathal CNS of Drosophila
Rickert, C., Lüer, K., Vef, O., & Technau, G. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191453 · Cited by 4 · see citing works
Fer3 is uniquely expressed in NotchOFF hemilineages, where it promotes interneuron identity
Drake, K., Lai, S.-L., & Doe, C. Q. (2025) · Development · doi:10.1242/dev.205118 · Cited by 3 · see citing works
Self-citationBoyan, G., & Ehrhardt, E. (2022) · Development Genes and Evolution · doi:10.1007/s00427-022-00695-2 · Cited by 3 · see citing works
Lai, S.-L., & Doe, C. Q. (2026) · eLife · doi:10.7554/elife.109188.3 · Cited by 2 · see citing works
Self-citationKlumpfuss controls FMRFamide expression by enabling BMP signaling within the NB5-6 lineage
Losada‐Pérez, M., Gabilondo, H., Molina, I., Turiégano, E., Torroja, L., Thor, S., & Benito‐Sipos, J. (2013) · Development · doi:10.1242/dev.089748 · Cited by 2 · see citing works
Asymmetric Cell Division and Fate Specification in the Drosophila Central Nervous System
Broadus, J., & Spana, E. P. (1999) · Elsevier eBooks · doi:10.1016/b978-012505255-9/50019-5 · Cited by 2 · see citing works
Sen, S., Chanchani, S., Southall, T. D., & Doe, C. Q. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/485193 · Cited by 2 · see citing works
Self-citationLai, S.-L., & Doe, C. Q. (2025) · eLife · doi:10.7554/elife.109188.1 · Cited by 1 · see citing works
Self-citationBhattacharya, A., Rao, H., & Sen, S. (2026) · eLife · doi:10.7554/elife.110150.1 · Cited by 1 · see citing works
Chen, Y., Nielsen, S., Choi, B. J., Bakshi, A., Coyne, R., Özel, M. N., & Desplan, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.09.743789 · Cited by 1 · see citing works
Neural Stem and Progenitor Cells: Lineage and Cell Fate Determination
Sansom, S. N., Rahman, S., Thammongkol, U., & Livesey, F. J. (2003) · Springer eBooks · doi:10.1007/0-306-48356-4_2
Sprecher, S. G. (2005) · edoc (University of Basel) · doi:10.5451/unibas-003675493
Brunet, J. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1158750.619978
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Irene, R.-F., Clarembaux‐Badell, L., Baladrón‐de‐Juan, P., Berrocal-Rubio, M. Á., Thor, S., Cobeta, I., & Benito‐Sipos, J. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03721-x
Bhattacharya, A., Rao, H., & Sen, S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.25.690435
Lai, S.-L., & Doe, C. Q. (2025) · eLife · doi:10.7554/elife.109188
Self-citationGenetic mechanisms controlling cell specification and cell numbers in the Drosophila CNS
Ulvklo, C. (2012) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
- Authors
- Skeath, J. B., Zhang, Y., Holmgren, R., Carroll, S. B., & Doe, C. Q.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Nature
- Published
- 1995-08
- Volume
- 376
- Issue
- 6539
- Pages
- 427-430
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2029265468
- Cited by
- 111
- References
- 17
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 11 · 2022: 6 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2013: 4 · 2012: 2
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- neuroblast lineage, Pax genes
- MeSH terms
- Animals, Cell Differentiation, Drosophila, Ectoderm, Mutation, Neurons, Transcription Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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