The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Abstract
Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“evidence from non‐human primates (Sawaguchi & Goldman‐Rakic, 1991, 1994; Williams & Goldmanrakic, 1995) and in healthy humans (Fischer et al., 2010) showed that dopamine depletion or antagonism impairs visuospatial WM.”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Williams & Goldmanrakic, 1995
In the citing paper
“Third, dopamine exerts a significant influence over prefrontal cortical functions such as working memory (Williams and Goldman-Rakic, 1995), in a manner that depends on initial levels or efficacy of this neuromodulator (Cools and D’Esposito, 2011).”
From Goals and Habits in the Brain (2013) · cites this paper as Williams and Goldman-Rakic, 1995
In the citing paper
“Dopaminergic signalling has a role in the top-down regulation of spatial attention, and D1 dopaminergic receptors modulate response amplitude and selectivity in the dorsolateral prefrontal cortex for preferred spatial locations during working memory tasks204,205.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [205]
In the citing paper
“Dopaminergic signalling has a role in the top-down regulation of spatial attention, and D1 dopaminergic receptors modulate response amplitude and selectivity in the dorsolateral prefrontal cortex for preferred spatial locations during working memory tasks204,205.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [205]
In the citing paper
“It is also consistent with a growing literature documenting baseline performance-dependent effects of stimulants and related drugs, which have been explained by a hypothesized inverted U-shaped function, whereby optimal catecholamine levels determine optimal performance, and levels along the curve at either side of the optimum are associated with impaired performance (Robbins and Sahakian, 1979; N”
From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Williams and Goldman-Rakic, 1995
Citations
Cites
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685
Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey
Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979) · Science · doi:10.1126/science.112679 · Cited by 1,500
Self-citationD1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Sawaguchi, T., & Goldman-Rakic, P. S. (1991) · Science · doi:10.1126/science.1825731 · Cited by 1,364
Schizophrenics Show Spatial Working Memory Deficits
Park, S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120063009 · Cited by 953
Dopamine receptors and the dopamine hypothesis of schizophrenia
Seeman, P. M. (1987) · Synapse · doi:10.1002/syn.890010203 · Cited by 880
Molecular cloning and expression of the gene for a human D1 dopamine receptor
Dearry, A., Gingrich, J. A., Falardeau, P., Fremeau, R. T., Bates, M. D., & Caron, M. G. (1990) · Nature · doi:10.1038/347072a0 · Cited by 674
Lange, K. W., Robbins, T. W., MARSDEN, C. D., James-Galton, M., Owen, A. M., & Paul, G. M. (1992) · Psychopharmacology · doi:10.1007/bf02245167 · Cited by 624
Molecular Diversity of the Dopamine Receptors
Civelli, O., Bunzow, J. R., & Grandy, D. K. (1993) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.33.040193.001433 · Cited by 623
Dopaminergic innervation of the cerebral cortex: unexpected differences between rodents and primates
Berger, B., Gaspar, P., & Verney, C. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90179-x · Cited by 588
Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys
Arnsten, A. F. T., Cai, J. X., Murphy, B. L., & Goldman-Rakic, P. S. (1994) · Psychopharmacology · doi:10.1007/bf02245056 · Cited by 566
Cepeda, C., Buchwald, N. A., & Levine, M. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9576 · Cited by 559
Molecular Diversity of the Dopamine Receptors
Civelli, O. (1993) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.33.1.281 · Cited by 510
Visuospatial coding in primate prefrontal neurons revealed by oculomotor paradigms
Funahashi, S., Bruce, C. J., & Goldman‐Rakic, P. S. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.63.4.814 · Cited by 443
Self-citationCellular and circuit basis of working memory in prefrontal cortex of nonhuman primates.
Goldman-Rakic, P. (1990) · Progress in Brain Research · doi:10.1016/s0079-6123(08)62688-6 · Cited by 443
Self-citationDopamine synaptic complex with pyramidal neurons in primate cerebral cortex.
Goldman-Rakic, P. S., Leranth, C., Williams, S. M., Mons, N. E., & Geffard, M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.22.9015 · Cited by 429
Self-citationLidow, M. S., Goldman-Rakic, P. S., Gallager, D. W., & Rakic, P. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90003-7 · Cited by 394
Smiley, J. F., Levey, A. I., Ciliax, B. J., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.12.5720 · Cited by 383
Self-citationAltered striatal function in a mutant mouse lacking D1A dopamine receptors.
Drago, J., Gerfen, C. R., Lachowicz, J. E., Steiner, H., Hollon, T. R., Love, P. E., Ooi, G. T., Grinberg, A., Lee, E. J. K., & Huang, S.-P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12564 · Cited by 343
Xu, M., Hu, X., Cooper, D., Moratalla, R., Graybiel, A. M., White, F. J., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90026-4 · Cited by 333
Benson, D. F. (1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.10.1400-a · Cited by 328
Wilson, F. A. W., ÓScalaidhe, S. P., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4009 · Cited by 303
Self-citationCarroll, B. J., & Barrett, J. E. (1991) · Medical Entomology and Zoology · Cited by 278
Daniel, D., Weinberger, D. R., Jones, D. W., Zigun, J. R., Coppola, R., Handel, S. F., Bigelow, L. B., Goldberg, T., Berman, K. F., & Kleinman, J. E. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-07-01907.1991 · Cited by 276
Facilitation of Working Memory in Humans by a D2 Dopamine Receptor Agonist
Luciana, M. M., Depue, R. A., Arbisi, P. A., & Leon, A. S. (1992) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1992.4.1.58 · Cited by 273
van Eden, C. G., Hoorneman, E. M. D., Buijs, R. M., Matthijssen, M. A. H., Geffard, M., & Uylings, H. B. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)92964-2 · Cited by 272
Calabresi, P., Mercuri, N. B., Stanzione, P., Stefani, A., & Bernardi, G. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90239-9 · Cited by 261
Arnsten, A. F. T., Cai, J., Steere, J. C., & Goldman-Rakic, P. S. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-05-03429.1995 · Cited by 252
Self-citationSawaguchi, T., Matsumura, M., & Kubota, K. (1990) · Journal of Neurophysiology · doi:10.1152/jn.1990.63.6.1401 · Cited by 193
Chipkin, R. E., Iorio, L. C., Coffin, V. L., McQuade, R. D., Berger, J. G., & Barnett, A. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13263-1 · Cited by 182
Differential modulation by dopamine of responses evoked by excitatory amino acids in human cortex
Cepeda, C., Radisavljevic, Z., Peacock, W. J., Levine, M. S., & Buchwald, N. A. (1992) · Synapse · doi:10.1002/syn.890110408 · Cited by 172
Séguéla, P., Watkins, K. C., & Descarries, L. (1988) · Brain Research · doi:10.1016/0006-8993(88)91427-8 · Cited by 155
Visuospatial working memory in Parkinson's disease.
Bradley, V. A., Welch, J. L., & Dick, D. J. (1989) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.52.11.1228 · Cited by 147
Tyrosine reverses a cold-induced working memory deficit in humans
Shurtleff, D., Thomas, J. R., Schrot, J., Kowalski, K., & Harford, R. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90299-2 · Cited by 142
Godbout, R., Mantz, J., Pirot, S., Glowinski, J., & Thierry, A. M. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20466-9 · Cited by 97
Effects of dopaminergic drugs on working and reference memory in rats
Bushnell, P. J., & Levin, E. D. (1993) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(93)90119-e · Cited by 71
Goldstein, L. E., Rasmusson, A. M., Bunney, B., & Rh, R. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04937.1994 · Cited by 64
Millar, J., & Williams, G. V. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902870109 · Cited by 53
Self-citationEffects of d-Amphetamine and prefrontal cortical cooling on delayed matching-to-sample behavior
Bauer, R. H., & Fuster, J. M. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90311-8 · Cited by 39
Influence of the Mesocortical/Prefrontal Dopamine Neurons on Their Target Cellsa
Thierry, A. M., Mantz, J., Milla, C., & Glowinski, J. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb42099.x · Cited by 32
The binding of SCH 39166 and SCH 23390 to 5-HT1C receptors in porcine choroid plexus
Taylor, L. A., Tedford, C. E., & McQuade, R. D. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90051-c · Cited by 20
Ultra-low noise silver-plated carbon fibre microelectrodes
Millar, J., & Williams, G. V. (1988) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(88)90120-3 · Cited by 20
Self-citationSCH 23390 decreases self-stimulation of the medial prefrontal cortex in the rat
Sabater, R., Saez, J., & Jm, F. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90082-s · Cited by 6
Flagged first, then by citations
Research works printed but not linked: 6
- O'Scalaidhe, S. P. & Goldman-Rakic, P. S. Soc. Neurosci. Abstr. 19, 800 (1993).
- Chipkin, R. E. et al. J. Pharmac. exp. Ther. 247, 1093–1102 (1988).
- Fuster, J. M. in The Prefrontal Cortex 2nd edn 51–82 (Raven, New York, 1989).
- Malmberg, A., Jackson, D. M., Eriksson, A. & Mohell, N. Molec. Pharmac. 43, 749–754 (1993).
- Bergson, C. et al. Soc. Neurosci. Abstr. 20, 275 (1994).
- Godbout, R., Mantz, J., Pirot, S., Glowinski, J. & Thierry, A. M. J. Pharmac. exp. Ther. 258, 728–738 (1991).
Cited by
Sorted by citations
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388
Barkley, R. A. (1997) · Psychological Bulletin · doi:10.1037//0033-2909.121.1.65 · Cited by 580
Holroyd, C. B., & Coles, M. G. H. (2002) · Psychological Review · doi:10.1037/0033-295x.109.4.679 · Cited by 4,027
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379
“The mPFC is broadly associated with working memory and attentional function”
BackgroundEffect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., Goldman, D. A., & Weinberger, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111134598 · Cited by 2,416
Metadata
- Authors
- Williams, G. V., & Goldman-Rakic, P. S.
- Affiliations
- Yale University (US)
- ORCID
- Williams, Graham V.
- Venue
- Nature
- Published
- 1995-08
- Volume
- 376
- Issue
- 6541
- Pages
- 572-575
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2084007108
- Cited by
- 1,593
- References
- 42
- Citations by year
- 2026: 17 · 2025: 13 · 2024: 29 · 2023: 26 · 2022: 36 · 2021: 30 · 2020: 27 · 2019: 27 · 2018: 37 · 2017: 33 · 2016: 48 · 2015: 63 · 2014: 45 · 2013: 78 · 2012: 74
- FWCI
- 16.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- dopamine D1 receptor, working memory, prefrontal cortex, memory field, dopamine D1 receptor antagonist, synaptic modulation, excitatory synaptic input, iontophoresis, single-unit recording
- MeSH terms
- Animals, Haplorhini, Dose-Response Relationship, Drug, Iontophoresis, Memory, Neurons, Psychomotor Performance, Prefrontal Cortex, Receptors, Dopamine D1, Receptors, Dopamine D2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
