D1 Dopamine Receptors in Prefrontal Cortex: Involvement in Working Memory
Abstract
The prefrontal cortex is involved in the cognitive process of working memory. Local injections of SCH23390 and SCH39166, selective antagonists of the D1 dopamine receptor, into the prefrontal cortex of rhesus monkeys induced errors and increased latency in performance on an oculomotor task that required memory-guided saccades. The deficit was dose-dependent and sensitive to the duration of the delay period. These D1 antagonists had no effect on performance in a control task requiring visually guided saccades, indicating that sensory and motor functions were unaltered. Thus, D1 dopamine receptors play a selective role in the mnemonic, predictive functions of the primate prefrontal cortex.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dopamine depletion or antagonism impairs visuospatial working memory.
“evidence from non‐human primates (Sawaguchi & Goldman‐Rakic, 1991, 1994; Williams & Goldmanrakic, 1995) and in healthy humans (Fischer et al., 2010) showed that dopamine depletion or antagonism impairs visuospatial WM.”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Sawaguchi & Goldman‐Rakic, 1991
Both blockade and excessive stimulation of D1 receptors impair spatial working memory.
“Both blockade and excessive stimulation of D1 receptors impair spatial working memory65–67.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [66]
Either blockade of D1/5 receptors or excessive stimulation of D1/5 receptors in the PFC impairs spatial working memory.
“Cognitive studies in animals have shown that either blockade of D1/5 receptors or excessive stimulation of D1/5 receptors in the PFC impairs spatial working memory (106–108).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [107]
Cites
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685 · see citing works
Gaspar, P., Berger, B., Febvret, A., Vigny, A., & Henry, J. P. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902790208 · Cited by 395 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564 · see citing works
Holroyd, C. B., & Coles, M. G. H. (2002) · Psychological Review · doi:10.1037/0033-295x.109.4.679 · Cited by 4,027 · see citing works
Dopamine receptors: from structure to function
MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.189 · Cited by 3,633 · see citing works
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299 · see citing works
Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574 · see citing works
A neuropsychological theory of positive affect and its influence on cognition.
Ashby, F. G., Isen, A. M., & Turken, A. U. (1999) · Psychological Review · doi:10.1037/0033-295x.106.3.529 · Cited by 2,270 · see citing works
A framework for mesencephalic dopamine systems based on predictive Hebbian learning
Montague, P., Dayan, P., & Sejnowski, T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-05-01936.1996 · Cited by 2,066 · see citing works
Inverted-U–Shaped Dopamine Actions on Human Working Memory and Cognitive Control
Cools, R., & D'Esposito, M. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.028 · Cited by 1,673 · see citing works
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592 · see citing works
Modulation of memory fields by dopamine Dl receptors in prefrontal cortex
Williams, G. V., & Goldman-Rakic, P. S. (1995) · Nature · doi:10.1038/376572a0 · Cited by 1,593 · see citing works
Jentsch, J. D., & Taylor, J. R. (1999) · Psychopharmacology · doi:10.1007/pl00005483 · Cited by 1,545 · see citing works
Multiple dopamine functions at different time courses
Schultz, W. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135722 · Cited by 1,415 · see citing works
Schultz, W., Apicella, P., & Ljungberg, T. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-03-00900.1993 · Cited by 1,291 · see citing works
Compte, A. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.9.910 · Cited by 1,143 · see citing works
Neuronal Reward and Decision Signals: From Theories to Data
Schultz, W. (2015) · Physiological Reviews · doi:10.1152/physrev.00023.2014 · Cited by 1,126 · see citing works
Rogers, R. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00091-8 · Cited by 1,101 · see citing works
Goldman-Rakic, P. S. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0129 · Cited by 1,072 · see citing works
Self-citationNeural mechanisms for visual memory and their role in attention
Desimone, R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13494 · Cited by 1,028 · see citing works
The Neuropsychopharmacology of Fronto-Executive Function: Monoaminergic Modulation
Robbins, T. W., & Arnsten, A. F. T. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135535 · Cited by 957 · see citing works
Friston, K. J. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00140-0 · Cited by 882 · see citing works
Prefrontal Dopamine D<sub>1</sub>Receptors and Working Memory in Schizophrenia
Abi-Dargham, A., Mawlawi, O., Lombardo, I., Gil, R., Martinez, D., Huang, Y., Hwang, D.-R., Keilp, J., Kochan, L., Van Heertum, R., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03708.2002 · Cited by 724 · see citing works
Modafinil: a review of neurochemical actions and effects on cognition
Minzenberg, M. J., & Carter, C. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301534 · Cited by 713 · see citing works
Visual attention mediated by biased competition in extrastriate visual cortex
Desimone, R. (1998) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1998.0280 · Cited by 696 · see citing works
Brunel, N., & Wang, X.-J. (2001) · Journal of Computational Neuroscience · doi:10.1023/a:1011204814320 · Cited by 620 · see citing works
Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys
Arnsten, A. F. T., Cai, J. X., Murphy, B. L., & Goldman-Rakic, P. S. (1994) · Psychopharmacology · doi:10.1007/bf02245056 · Cited by 566 · see citing works
Self-citationThe neuroscience of working memory capacity and training
Constantinidis, C., & Klingberg, T. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.43 · Cited by 533 · see citing works
Dopamine and Cognitive Control in Prefrontal Cortex
Ott, T., & Nieder, A. (2019) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.12.006 · Cited by 530 · see citing works
Granon, S., Passetti, F., Thomas, K. L., Dalley, J. W., Everitt, B. J., & Robbins, T. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01208.2000 · Cited by 546 · see citing works
Changes in cortical dopamine D1 receptor binding associated with cognitive training
McNab, F., Varrone, A., Farde, L., Jucaite, A., Bystritsky, P., Forssberg, H., & Klingberg, T. (2009) · Science · doi:10.1126/science.1166102 · Cited by 545 · see citing works
Bench, C. J., Friston, K. J., Brown, R. G., Frackowiak, R. S. J., & Dolan, R. J. (1993) · Psychological Medicine · doi:10.1017/s0033291700025368 · Cited by 530 · see citing works
The Drosophila learning and memory gene rutabaga encodes a - adenylyl cyclase
Levin, L. R., Han, P.-L., Hwang, P. M., Feinstein, P. G., Davis, R. L., & Reed, R. R. (1992) · Cell · doi:10.1016/0092-8674(92)90185-f · Cited by 517 · see citing works
Cognition and control in schizophrenia: a computational model of dopamine and prefrontal function
Braver, T. S., Barch, D. M., & Cohen, J. D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00116-x · Cited by 507 · see citing works
Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks
Arnsten, A. F. T. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.01.027 · Cited by 493 · see citing works
Cognitive dysfunction in Parkinson's disease: the role of frontostriatal circuitry
Owen, A. M. (2004) · The Neuroscientist · doi:10.1177/1073858404266776 · Cited by 496 · see citing works
Frank, M. J., & O'Reilly, R. C. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.3.497 · Cited by 472 · see citing works
Chudasama, Y., & Robbins, T. W. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.005 · Cited by 484 · see citing works
Mizoguchi, K., Yuzurihara, M., Ishige, A., Sasaki, H., Chui, D.-H., & Tabira, T. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01568.2000 · Cited by 481 · see citing works
Pharmacology and behavioral pharmacology of the mesocortical dopamine system
Tzschentke, T. M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00033-2 · Cited by 481 · see citing works
The endophenotype concept in psychiatric genetics
FLINT, J., & MUNAFÒ, M. R. (2007) · Psychological Medicine · doi:10.1017/s0033291706008750 · Cited by 477 · see citing works
Mesocortical dopamine modulation of executive functions: beyond working memory
Floresco, S. B., & Magyar, O. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0404-5 · Cited by 426 · see citing works
Bäckman, L., Lindenberger, U., Li, S.-C., & Nyberg, L. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.12.008 · Cited by 414 · see citing works
Roozendaal, B., & McGaugh, J. L. (2011) · Behavioral Neuroscience · doi:10.1037/a0026187 · Cited by 445 · see citing works
Roberts, A., De Salvia, M., Wilkinson, L., Collins, P., Muir, J., Everitt, B., & Robbins, T. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-05-02531.1994 · Cited by 415 · see citing works
Slifstein, M., van de Giessen, E., Van Snellenberg, J., Thompson, J. L., Narendran, R., Gil, R., Hackett, E., Girgis, R., Ojeil, N., Moore, H., et al. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2414 · Cited by 398 · see citing works
Lewis, D. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00277-1 · Cited by 388 · see citing works
Genetic and neurochemical modulation of prefrontal cognitive functions in children
Diamond, A., Briand, L., Fossella, J., & Gehlbach, L. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.1.125 · Cited by 381 · see citing works
Differential roles of monkey striatum in learning of sequential hand movement
Miyachi, S., Hikosaka, O., Miyashita, K., Kárádi, Z., & Rand, M. K. (1997) · Experimental Brain Research · doi:10.1007/pl00005669 · Cited by 374 · see citing works
Arnsten, A. F., & Dudley, A. G. (2005) · Behavioral and Brain Functions · doi:10.1186/1744-9081-1-2 · Cited by 363 · see citing works
Toward a Neurodevelopmental Model of Obsessive–Compulsive Disorder
Rosenberg, D. R., & Keshavan, M. S. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00443-5 · Cited by 355 · see citing works
Role of dopamine in the motivational and cognitive control of behavior
Cools, R. (2008) · The Neuroscientist · doi:10.1177/1073858408317009 · Cited by 352 · see citing works
Lewis, D. A., Melchitzky, D. S., Sesack, S. R., Whitehead, R. E., Auh, S., & Sampson, A. (2001) · Journal of Comparative Neurology · doi:10.1002/cne.1092 · Cited by 352 · see citing works
Thiele, A., & Bellgrove, M. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.008 · Cited by 350 · see citing works
Dopamine Modulation of Prefrontal Cortical Interneurons Changes during Adolescence
Tseng, K.-Y., & O'Donnell, P. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl034 · Cited by 339 · see citing works
Gaspar, P., Bloch, B., & Le Moine, C. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01092.x · Cited by 323 · see citing works
Rosenberg, D. R., & Lewis, D. A. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903580306 · Cited by 319 · see citing works
Krystal, J. H., Perry, E. B., Gueorguieva, R., Belger, A., Madonick, S. H., Abi-Dargham, A., Cooper, T. B., MacDougall, L., Abi-Saab, W., & D’Souza, D. C. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.9.985 · Cited by 317 · see citing works
Bussey, T. J., Holmes, A., Lyon, L., Mar, A. C., McAllister, K. A. L., Nithianantharajah, J., Oomen, C. A., & Saksida, L. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.011 · Cited by 299 · see citing works
Sun, X., Zhao, Y., & Wolf, M. E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4603-04.2005 · Cited by 299 · see citing works
Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum
Cools, R., Gibbs, S. E., Miyakawa, A., Jagust, W., & D'Esposito, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4475-07.2008 · Cited by 302 · see citing works
Gorelova, N., Seamans, J. K., & Yang, C. R. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00335.2002 · Cited by 302 · see citing works
Effects of dextroamphetamine on cognitive performance and cortical activation
Mattay, V. S., Callicott, J. H., Bertolino, A., Heaton, I., Frank, J. A., Coppola, R., Berman, K. F., Goldberg, T. E., & Weinberger, D. R. (2000) · NeuroImage · doi:10.1006/nimg.2000.0610 · Cited by 296 · see citing works
Rogers, R. D., Blackshaw, A. J., Middleton, H. C., Matthews, K., Hawtin, K., Crowley, C., Hopwood, A., Wallace, C., Deakin, J. F. W., Sahakian, B. J., et al. (1999) · Psychopharmacology · doi:10.1007/pl00005494 · Cited by 289 · see citing works
Birnbaum, S., Gobeske, K. T., Auerbach, J., Taylor, J. R., & Arnsten, A. F. T. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00138-9 · Cited by 281 · see citing works
Tan, H.-Y., Callicott, J. H., & Weinberger, D. R. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm069 · Cited by 266 · see citing works
D1 and D2 dopamine receptor mRNA expression in whole hemisphere sections of the human brain
Hurd, Y. L., Suzuki, M., & Sedvall, G. C. (2001) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(01)00122-3 · Cited by 262 · see citing works
Mehta, M. A., Swainson, R., Ogilvie, A. D., Sahakian, B., & Robbins, T. W. (2001) · Psychopharmacology · doi:10.1007/s002130100851 · Cited by 235 · see citing works
Huang, Y.-Y., Simpson, E., Kellendonk, C., & Kandel, E. R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308280101 · Cited by 231 · see citing works
Mehta, M. A., Sahakian, B. J., McKenna, P. J., & Robbins, T. W. (1999) · Psychopharmacology · doi:10.1007/s002130051102 · Cited by 223 · see citing works
Modulators in concert for cognition: Modulator interactions in the prefrontal cortex
Briand, L. A., Gritton, H., Howe, W. M., Young, D. A., & Sarter, M. (2007) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2007.06.007 · Cited by 216 · see citing works
ADHD and the Prefrontal Cortex
Arnsten, A. F. T. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.01.018 · Cited by 220 · see citing works
Stress-induced cognitive dysfunction: hormone-neurotransmitter interactions in the prefrontal cortex
Shansky, R. M., & Lipps, J. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00123 · Cited by 205 · see citing works
“Pharmacological blockade of D1 receptors in both monkeys and rodents impairs performance on working memory tasks (Sawaguchi and Goldman-Rakic, 1991; Izquierdo et al., 1998), indicating a key role for D1 signaling in normal PFC function.”
BackgroundA perceptual inference mechanism for hallucinations linked to striatal dopamine
Cassidy, C. M., Balsam, P. D., Weinstein, J. J., Rosengard, R. J., Slifstein, M., Daw, N. D., Abi-Dargham, A., & Horga, G. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.059 · Cited by 176 · see citing works
Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function
Mizoguchi, K., Ishige, A., Takeda, S., Aburada, M., & Tabira, T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0086-04.2004 · Cited by 192 · see citing works
Nagai, T., Takuma, K., Kamei, H., Ito, Y., Nakamichi, N., Ibi, D., Nakanishi, Y., Murai, M., Mizoguchi, H., Nabeshima, T., et al. (2007) · Learning & Memory · doi:10.1101/lm.461407 · Cited by 184 · see citing works
Personality predicts working-memory-related activation in the caudal anterior cingulate cortex
GRAY, J. R., & BRAVER, T. S. (2002) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.2.1.64 · Cited by 175 · see citing works
Zhang, T. Y., Chrétien, P., Meaney, M. J., & Gratton, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3293-04.2005 · Cited by 174 · see citing works
Ragozzino, M. E. (2002) · Learning & Memory · doi:10.1101/lm.45802 · Cited by 174 · see citing works
Rosenberg, D. R., & Lewis, D. A. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90610-6 · Cited by 174 · see citing works
A Dynamical Systems Hypothesis of Schizophrenia
Loh, M., Rolls, E. T., & Deco, G. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030228 · Cited by 164 · see citing works
Understanding Obsessive–Compulsive Disorder: Focus on Decision Making
Cavedini, P., Gorini, A., & Bellodi, L. (2006) · Neuropsychology Review · doi:10.1007/s11065-006-9001-y · Cited by 161 · see citing works
Chapter 19 Dopamine, cognitive control, and schizophrenia: the gating model
Braver, T. S., & Cohen, J. D. (1999) · Progress in Brain Research · doi:10.1016/s0079-6123(08)63082-4 · Cited by 159 · see citing works
Sanchez, C. J., Bailie, T. M., Wu, W.-R., Li, N., & Sorg, B. A. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00078-2 · Cited by 160 · see citing works
Krawczyk, D. C., Gazzaley, A., & D'Esposito, M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.052 · Cited by 156 · see citing works
Wang, X., Zhong, P., & Yan, Z. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09185.2002 · Cited by 155 · see citing works
Lee, B., Groman, S., London, E. D., & Jentsch, J. D. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301337 · Cited by 148 · see citing works
Mattay, V. S., Berman, K. F., Ostrem, J. L., Esposito, G., Van Horn, J. D., Bigelow, L. B., & Weinberger, D. R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-15-04816.1996 · Cited by 151 · see citing works
Dopamine’s Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders
Arnsten, A. F. T., Wang, M., & Paspalas, C. D. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010512 · Cited by 149 · see citing works
Tyrosine reverses a cold-induced working memory deficit in humans
Shurtleff, D., Thomas, J. R., Schrot, J., Kowalski, K., & Harford, R. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90299-2 · Cited by 142 · see citing works
Tan, H.-Y., Chen, Q., Goldberg, T. E., Mattay, V. S., Meyer-Lindenberg, A., Weinberger, D. R., & Callicott, J. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4041-07.2007 · Cited by 144 · see citing works
An in vivo assay of synaptic function mediating human cognition
Moran, R. J., Symmonds, M., Stephan, K. E., Friston, K. J., & Dolan, R. J. (2011) · Current Biology · doi:10.1016/j.cub.2011.06.053 · Cited by 137 · see citing works
Schweitzer, J. B., Lee, D. O., Hanford, R. B., Zink, C. F., Ely, T. D., Tagamets, M. A., Hoffman, J. M., Grafton, S. T., & Kilts, C. D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.07.011 · Cited by 135 · see citing works
Amphetamine-induced displacement of [18F] fallypride in striatum and extrastriatal regions in humans
Riccardi, P., Li, R., Ansari, M. S., Zald, D., Park, S., Dawant, B., Anderson, S., Doop, M., Woodward, N., Schoenberg, E., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300916 · Cited by 134 · see citing works
Kaalund, S. S., Newburn, E. N., Ye, T., Tao, R., Li, C., Deep-Soboslay, A., Herman, M. M., Hyde, T. M., Weinberger, D. R., Lipska, B. K., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.165 · Cited by 132 · see citing works
Responses of monkey midbrain dopamine neurons during delayed alternation performance
Ljungberg, T., Apicella, P., & Schultz, W. (1991) · Brain Research · doi:10.1016/0006-8993(91)90816-e · Cited by 128 · see citing works
Hains, A. B., & Arnsten, A. F. T. (2008) · Learning & Memory · doi:10.1101/lm.921708 · Cited by 127 · see citing works
Passetti, F., Dalley, J. W., & Robbins, T. W. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1227-7 · Cited by 121 · see citing works
Levodopa ameliorates learning and memory deficits in a murine model of Alzheimer’s disease
Ambrée, O., Richter, H., Sachser, N., Lewejohann, L., Dere, E., de Souza Silva, M. A., Herring, A., Keyvani, K., Paulus, W., & Schäbitz, W.-R. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.010 · Cited by 115 · see citing works
Adolescent Maturation of Cortical Dopamine
O’Donnell, P. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9157-3 · Cited by 107 · see citing works
The Neurobiology of Thought: The Groundbreaking Discoveries of Patricia Goldman-Rakic 1937-2003
Arnsten, A. F. T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht195 · Cited by 94 · see citing works
- Authors
- Sawaguchi, T., & Goldman-Rakic, P. S.
- Affiliations
- Yale University (US)
- Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.
- Venue
- Science
- Published
- 1991-02-22
- Volume
- 251
- Issue
- 4996
- Pages
- 947-950
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2058396154
- Cited by
- 1,364
- References
- 2
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 24 · 2023: 22 · 2022: 31 · 2021: 30 · 2020: 28 · 2019: 31 · 2018: 33 · 2017: 27 · 2016: 40 · 2015: 54 · 2014: 53 · 2013: 34 · 2012: 41
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 44866, MH38546, P50MH044866)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine D1 receptor, prefrontal cortex, working memory, memory-guided saccades, oculomotor tasks, SCH 23390, delay period, rhesus monkeys, memory function
- MeSH terms
- Animals, Benzazepines, Cerebral Cortex, Macaca mulatta, Memory, Receptors, Dopamine, Salicylamides, Visual Perception, Receptors, Dopamine D1, Dopamine Antagonists, Raclopride
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
