The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Crystal structure of SIV matrix antigen and implications for virus assembly
Abstract
Simian immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of Pr55Gag, the sole protein required for assembly of the virion shell. MA targets Pr55 to the plasma membrane, and facilitates incorporation of the virus envelope protein and assembly of the Pr55Gag shell. Cleavage of Pr55 by the viral protease produces the mature protein of relative molecular mass 17-18K, which underlies the host-derived membrane and is important in both virus entry and nuclear localization of the virion core. Here we report the crystal structure of SIV MA. The molecule forms a trimer consistent with oligomerization in vitro, the observed virion architecture, and various biological properties of MA.
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“Many other retroviruses, including SIV, EIAV, HTLV-2, BLV, and MPMV, exhibit MA trimers despite their highly varied sequences.”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Rao et al. 1995
In the citing paper
“Mutations in the trimer interface, at least in the case of MPMV, have been shown to compromise CA assembly”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Rao et al. 1995
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Metadata
- Authors
- Rao, Z., Belyaev, A. S., Fry, E., Roy, P., Jones, I. M., & Stuart, D. I.
- Affiliations
- University of Oxford (GB)
- University of Alabama at Birmingham (US)
- Natural Environment Research Council (GB)
- Venue
- Nature
- Published
- 1995-12
- Volume
- 378
- Issue
- 6558
- Pages
- 743-747
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2068340726
- Cited by
- 183
- References
- 27
- Citations by year
- 2025: 1 · 2024: 3 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 5
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Keywords
- simian immunodeficiency virus, matrix protein, Pr55gag, protein crystal structure, trimers, viral assembly, primate retroviruses
- MeSH terms
- Amino Acid Sequence, Antigens, Viral, Computer Graphics, Models, Molecular, Molecular Sequence Data, Protein Conformation, Viral Matrix Proteins, Virus Replication, Simian Immunodeficiency Virus, Gene Products, gag, Crystallography, X-Ray
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