Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

Goedert, M., Jakes, R., Spillantini, M. G., Hasegawa, M., Smith, M. J., Crowther, R. A.·1996·Nature
DOI 10.1038/383550a0

Cited by (1,000)

Items 901–1,000 of 1,000

  1. Distinct sets of lysosomal genes define synucleinopathy and tauopathy
    Kyu Won Oh, Dong‐Kyu Kim, Ao‐Lin Hsu, Seung‐Jae Lee · 2023 · BMB Reports
  2. Sedimentation and Laser Light Scattering Methods for Quantifying Synthetic Tau Aggregation Propensity
    Dmitry Malyshka, Daniela Jimenez-Harrison, Jeff Kuret · 2024 · Methods in molecular biology
  3. dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments
    Kristīne Kitoka, Alons Lends, Gytis Kučinskas, Anna L. Bula, Lukas Krasauskas, Vytautas Smirnovas, Monika Žilková, Branislav Kováčech, Rostislav Škrabana, Jozef Hritz et al. · 2024 · Angewandte Chemie
  4. Drug Discovery and Screening Tool Development for Tauopathies by Focusing on Pathogenic Tau Repeat 3 Oligomers
    Soljee Yoon, Hye Yun Kim, Sohui Park, Minhae Cha, Kyeonghwan Kim, Songmin Lee, Jimin Kim, Saeyun Bhang, Young Soo Kim · 2024 · Angewandte Chemie
  5. Experimental Models of Tau Aggregation
    Kerstin Buck, Thomas Robert Jahn, Laura Gasparini · 2018 · Elsevier eBooks
  6. Tau, Tangles and Tauopathies: Insights from Drosophila Disease Models
    Nisha Nisha, Pragati, Shweta Tandon, Aqsa Aqsa, Prerna Aggarwal, Surajit Sarkar · 2019 · Springer eBooks
  7. Elongation of Fibrils Formed by a Tau Fragment is Inhibited by a Transient Dimeric Intermediate
    Harish Kumar, Jayant B. Udgaonkar · 2022 · The Journal of Physical Chemistry B
  8. Kinase Activity of PAR1b, Which Mediates Nuclear Translocation of the BRCA1 Tumor Suppressor, Is Potentiated by Nucleic Acid-Mediated PAR1b Multimerization
    Hiroko Nishikawa, Priscillia Christiany, Takeru Hayashi, Hisashi Iizasa, Hironori Yoshiyama, Masanori Hatakeyama · 2022 · International Journal of Molecular Sciences
  9. Aggregation kinetics and influencing factors of phosphorylated Tau proteins
    Yange Chen, Ningning Teng, Yingying Wu, Sen Li · 2022 · Scientia Sinica Vitae
  10. Historical Overview of Glycosaminoglycans (GAGs) and their Potential Value in the Treatment of Alzheimer’s Disease
    Umberto Cornelli, Israel Hanin, Stanley A. Lorens, Jawed Fareed, Phillip Lee, Ronald F. Mervis, Pietro Piccolo, M. Cornelli · 2002 · Advances in behavioral biology
  11. Tau and α-Synuclein in Neurodegenerative Diseases
    Benoit I. Giasson, Clare Wilson, John Q. Trojanowski, Virginia M.‐Y. Lee · 2001 · Humana Press eBooks
  12. Distinct Tau Gene Mutations Induce Specific Dysfunctions/Toxic Properties in Tau Proteins Associated With Specific FTDP-17 Phenotypes
    V. M.- Y. Lee, John Q. Trojanowski · 2000 · Research and perspectives in Alzheimer's disease
  13. BIOPHYSICAL STUDIES OF THE ALPHA-SYNUCLEIN PROTEIN ASSOCIATED WITH PARKINSON’S DISEASE AND OTHER SYNUCLEINOPATHIES
    Mihaela M. Apetri · 2006 · OhioLink ETD Center (Ohio Library and Information Network)
  14. Doxycycline interferes with tau amyloid aggregation abolishing its associated neuronal toxicity
    Luciana Medina, Florencia González‐Lizárraga, Antonio Dominguez‐Meijide, Diego Ploper, Valeria Parrales, Sabrina Sequeira, Maria Sol Cima-Omori, Markus Zweckstetter, Elaine Del Bel, Patrick Pierre Michel et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  15. Local Nucleation of Microtubule Bundles Through Tubulin Concentration Into a Condensed Tau Phase
    Amayra Hernnndez-Vega, Marcus Braun, Lara Scharrel, Marcus Jahnel, Susanne Wegmann, Bradley T. Hyman, Simon Albert, Stefan Diez, Anthony A. Hyman · 2018 · SSRN Electronic Journal
  16. Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy
    Morrie Lam, Szu-Yu Kuo, Surya A. Reis, Jason E. Gestwicki, M. Catarina Silva, Stephen J. Haggarty · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  17. DnaJB1 chaperone inhibits tau aggregation by recognizing its N-terminus
    Paweł M. Wydorski, Paulina Macierzyńska, Sofia Bali, Jaime Vaquer‐Alicea, Łukasz A. Joachimiak · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  18. Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments
    Sofia Lövestam, Jane L. Wagstaff, Taxiarchis Katsinelos, Jenny Shi, Stefan M.V. Freund, Michel Goedert, Sjors H. W. Scheres · 2025 · eLife
  19. Glycosaminoglycans as Potential Future Treatment of Alzheimer’s Disease
    Umberto Cornelli · 2004 · Humana Press eBooks
  20. Alzheimer's disease neurotoxic peptides : towards a comprehension of their modes of action on model membranes.
    Mehdi Azouz · 2019 · theses.fr (ABES)
  21. tRNA-derived fragments elevated in Alzheimer’s disease promote Tau aggregation
    Ami Kobayashi, Chung-Ta Han, Lien Nguyen, Karen Tsay, M Martins, Prakash Kharel, Yanhong Zhang, M. Inmaculada Barrasa, Allison M. Williams, Nana Kunii et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Untitled work
    Kordower · 1999 · 10.1002/1531-8249(199909)46:3
  23. Molecular Genetics and Molecular Biology of Alzheimer’s Disease
    Rupert Sandbrink, Konrad T. Beyreuther · 2001 · Springer eBooks
  24. Análisis de imagen in vivo, a partir de Resonancia Magnética, de los Procesos Neurodegenerativos que acontecen en ratones knock out para la proteína sustrato del receptor insulínico IRS-2
    Manuel Carretero González · 2013 · Gredos (University of Salamanca)
  25. Novel Proteins in α-Synucleinopathies
    Christine Lund Kragh, Poul Henning Jensen · 2008 · Focus on structural biology
  26. Whole Exome Analysis of Early Onset Alzheimer's Disease
    Margaret Ann Pericak‐Vance · 2013 · Defense Technical Information Center (DTIC)
  27. Molekulare Grundlagen Tau-Protein-vermittelter Toxizität
    Anja Schneider, Peter Falkai, Andreas Papassotiropoulos · 2010 · Der Nervenarzt
  28. Conformation of Human Microtubule Associated Protein-Tau
    Sadasivam Jeganathan� · 2008 · Max Planck Institute for Plasma Physics
  29. Intraneuronal Aβ and Alzheimer’s Disease
    Lauren M. Billings, Frank M. LaFerla · 2007 · Springer eBooks
  30. Chapter 4 Tau Protein and the Dementias
    Michel Goedert, Maria Grazia Spillantini · 2007 · Blue books of neurology
  31. Animal models of tau phosphorylation and tauopathy – what have they taught us?
    Lit‐Fui Lau, Joel B. Schachter · 2004 · Advances in cell aging and gerontology
  32. Chapter 3 Structural Changes in the Aged Brain
    Dennis W. Dickson · 1997 · Advances in cell aging and gerontology
  33. Regulation of the kinase MARK from Rattus norvegicus (Berkenhout, 1769): activation by MARKK and inhibition by PAK5
    Xiaoyu Li · 2006
  34. Neurodegeneration induced by clostridial neurotoxins in cerebellar granule neurons: a novel in vitro model for neurodegenerative disease
    Laura Berliocchi · 2000 · KOPS (University of Konstanz)
  35. Role of P70 S6 kinase in the formation of tau pathologies in Alzheimer´s disease
    Wenlin An · 2005 · Figshare
  36. Release of Brain Mitochondrial Hexokinase by Acidic Proteins and Macromolecular Polyanions
    F. Moller · 2005 · arXiv (Cornell University)
  37. Chapter 2 The Neuronal Cytoskeleton: Changes Associated with Age, Neurodegenerative Disease, and Neuronal Insult
    James W. Geddes, Andrew I. Matus · 1997 · Advances in cell aging and gerontology
  38. Genetic Basis of Resistance to Alzheimer’s Disease and Related Neurodegenerative Diseases
    Colin Louis Masters, Konrad T. Beyreuther · 2000 · Springer eBooks
  39. Transgenic Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease
    Philip C. Wong, David Borchelt, Michael K. Lee, Gopal Thinakaran, Sangram S. Sisodia, Donald L. Price · 1998 · Elsevier eBooks
  40. The implications of genetic studies on the pathogenesis of Alzheimer's disease
    Hidenao Sasaki · 1998 · Neuropathology
  41. Molecular Mechanisms of Tau Protein Aggregation Inhibition
    Elias Akoury · 2013 · eDiss (Georg-August-Universität Göttingen)
  42. Pseudophosphorylation of tau modulates its function and induces AD-like changes
    Qian Sun · 2009 · KU ScholarWorks (The University of Kansas)
  43. The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer Disease
    Zhi Tang · 2014 · Figshare
  44. Mouse and stem cell models of frontotemporal dementia
    Miranda E. Orr · 2012 · Montana State University ScholarWorks (Montana State University)
  45. Seeded propagation of Tau fibrils
    Paul D. Dinkel · 2013 · Digital Commons - DU (University of Denver)
  46. Medicinal ChemistryApproaches for theTreatment and Prevention of Alzheimer's Disease
    Сергей Олегович Бачурин · 2003
  47. Structural Polymorphism in Tau Filaments: An Implication for Neurodegenerative Diseases
    Ayisha Siddiqua · 2012 · Digital Commons - DU (University of Denver)
  48. Intraneuronal Ab and Alzheimer's Disease
    Lauren M. Billings, Frank M. LaFerla · 2008
  49. Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies
    Michel Goedert · 2017 · Neurodegeneration
  50. Detection and conformational characterization of misfolded proteins in neurodegenerative diseases
    Olga A. Morozova · 2016 · Library, Museums and Press - UDSpace (University of Delaware)
  51. Engineering antibody therapeutics and cell culture models for neurodegenerative diseases
    Kyle P. McHugh · 2024 · Library, Museums and Press - UDSpace (University of Delaware)
  52. Aging of cerebellar granule neurons in vitro
    Ana Pekanovic · 2006
  53. Development and characterization of cell models of tau aggregation
    Annalisa Cavallini · 2018 · UCL Discovery (University College London)
  54. Micro-fabricated super-hydrophobic substrate for amyloid fibers characterization
    Andrea Ricco · 2018 · King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology)
  55. Investigating the neuroprotective role of OGA inhibition by Thiamet-G against Alzheimer\'s disease
    Zenan Li · 2018 · Summit (Simon Fraser University)
  56. Methods for hybrid modeling of solution scattering data and their applications
    Alexander V. Shkumatov · 2011
  57. Identification of new proteins and biological processes in the apicomplexan Toxoplasma gondii
    Silvia Botero-Kleiven · 2006 · Figshare
  58. Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein
    Jaroslaw P. Majewski, Emmalee M. Jones, Crystal M. Vander Zanden, Jacek Biernat, Eckhard Mandelkow�, Eva Y. Chi · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  59. Einfluss des partialen Volumen Effekts auf die Positronenemissionstomographie bei Alzheimer Demenz
    Holger Jon Møller · 2008
  60. Tau AD fragment aggregates proliferate through autocatalytic secondary nucleation
    Diana C. Rodriguez Camargo, Eimantas Šileikis, Sean Chia, Emil Axell, Katja Bernfur, Rodrigo Cataldi, Samuel I. A. Cohen, Georg Meisl, Johnny Habchi, Tuomas P. J. Knowles et al. · 2021 · Research Square
  61. THE ROLE OF MICROTUBULE-ASSOCIATED PROTEIN TAU IN NEURONAL EXCITABILITY AND EPILEPTOGENESIS
    Ryan Cloyd · 2021 · UKnowledge (University of Kentucky)
  62. INVESTIGATION INTO THE FUNCTIONAL ROLES OF TAU AND ALPHA-SYNUCLEIN IN NEURODEGENERATIVE DISEASE
    Meaghan Morris · 2014
  63. Quantification and Analysis of Tau Protein Effects on Microtubule Dynamics in Mammalian (LLC-PK1) Cells
    Alexandra Doersch · 2020 · University of Minnesota Digital Conservancy (University of Minnesota)
  64. Heparan sulphate compounds regulate cholesterol metabolism in neurodegenerative disease models
    Rosemary W. Heathcott · 2015 · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare)
  65. Heparan sulphate compounds regulate cholesterol metabolism in neurodegenerative disease models
    Rosemary W. Heathcott · 2015
  66. Faculty Opinions recommendation of Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds.
    John Stephen Lazo · 2013 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  67. Faculty Opinions recommendation of Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tau versus α-synuclein and β-amyloid aggregates.
    John Stephen Lazo · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  68. Faculty Opinions recommendation of Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
    Berl R. Oakley · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  69. Preclinical Models
    Irene Cuadrado, Jesús Egido, José Luis Zamorano, Carlos Zaragoza · 2016 · Imaging in medical diagnosis and therapy
  70. Faculty Opinions recommendation of Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules.
    Berl R. Oakley · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  71. Extracellular Tau Oligomers Induce Disruption of Endogenous Tau Distribution, Invasion of Tau into the Somatodendritic Compartment and Axonal Transport Dysfunction
    Eric C Swanson · 2017
  72. FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation
    Dailu Chen, Aleksandra Wosztyl, Vishruth Mullapudi, Sofia Bali, Jaime Vaquer‐Alicea, Shamiram Melhem, Harro Seelaar, John Cornelis Van Swieten, Marc I. Diamond, Łukasz A. Joachimiak · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  73. Chemical Imaging of RNA‐Tau Amyloid Fibrils at the Nanoscale Using Tip‐Enhanced Raman Spectroscopy
    Gary Sean Cooney, David Talaga, Vicky Ury‐Thiery, Yann Fichou, Yuhan Huang, Sophie Lecomte, Sébastien Bonhommeau · 2023 · Angewandte Chemie
  74. To study the importance of pyrroloquinoline quinone in pet nutrition and health care
    Yongtong Liu, Fenglai Wang · 2023 · Highlights in Science Engineering and Technology
  75. Chronischer Streß auf der Ebene der Molekularbiologie und Neurobiochemie
    Kurt Mosetter · 2008 · VS Verlag für Sozialwissenschaften eBooks
  76. Two major culprits: Amyloidogenic Aβ and non-amyloidogenic tau
    Takaomi C. Saido · 2024 · Elsevier eBooks
  77. A charged tail on anti-α-Synuclein antibodies does not enhance their affinity to α-Synuclein fibrils
    Inga Petersen, Ana Godec, Farahnaz Ranjbarian, Anders Hofer, Claudio Mirabello, Greta Hultqvist · 2024 · PLoS ONE
  78. Structural insight of MODAG-005 on 𝛼-Synuclein aggregates as a novel PET tracer
    Kim, Myeongkyu · 2024 · eDiss (Georg-August-Universität Göttingen)
  79. Impact of Pre-analytical Factors on Fluid Biomarker Measurements in Alzheimer Disease
    Javier Torres‐Torronteras, Mariam Gouda, Charlotte Elisabeth Teunissen, Inge M.W. Verberk, Marta del Campo · 2025 · Springer eBooks
  80. Multifunctional Protein Tau Aggregation and Cytotoxicity
    Xiaping He, Yang Lü, Rong-Qiao He · 2025 · Springer eBooks
  81. Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients
    Preeti Sharma, Anuma Pallavi, Ananya Chatterjee, Vidya Mangala Prasad, Nikhil R. Gandasi, Sivaprakasam R. Saroja · 2025 · Autophagy
  82. Hindering tau fibrillization by disrupting transient precursor clusters
    Tomomi Takahashi, Takashi Nonaka, Reiko Ohtani, Masato Hasegawa, Yukiko Hori, Taisuke Tomita, Rei Kurita · 2025 · Neuroscience Research
  83. PKD1-tau disulfide linkage promotes tau phosphorylation and tau accumulation in a tauopathy mouse model
    Jinwang Ye, Rui-zhu Yue, Chengjia Li, Lijuan Wu, Xing Guo, Yuxi Zhao, Huali Wan, Jian-Zhi Wang, Bing Gu, Shifeng Xiao · 2025 · Research Square
  84. [11C]MODAG 005 – a PET tracer targeting alpha-synuclein aggregates in the brain
    Ran Sing Saw, Sabrina Buss, Felix Schmidt, Sergey Ryazanov, Andrei Leonov, Daniel Bleher, Ann-Kathrin Grotegerd, Laura Kuebler, Benjamin Röben, Fabian P. Schmidt et al. · 2025 · Research Square
  85. Additional file 1 of Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease
    Nora Bengoa‐Vergniory, Elisavet Velentza‐Almpani, Ana Maria Silva, Connor Scott, Mariana Vargas‐Caballero, Magdalena Sastre, Richard Wade‐Martins, Javier Alegre‐Abarrategui · 2021 · Figshare
  86. Additional file 4 of Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
    Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Ingelsson, Martin, Jinar Rostami, Maria Lindskog, Anna Erlandsson · 2024 · Figshare
  87. Additional file 10 of Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
    Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Ingelsson, Martin, Jinar Rostami, Maria Lindskog, Anna Erlandsson · 2024 · Figshare
  88. Additional file 9 of Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
    Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Ingelsson, Martin, Jinar Rostami, Maria Lindskog, Anna Erlandsson · 2024 · Figshare
  89. Additional file 3 of Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
    Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Ingelsson, Martin, Jinar Rostami, Maria Lindskog, Anna Erlandsson · 2024 · Figshare
  90. Additional file 1 of The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates
    Andreia Ferreira, Ines E. Royaux, Jian Liu, Wang, Zhangjie, Guowei Su, Diederik Moechars, Nico Callewaert, Louis De Muynck · 2024 · Figshare
  91. Additional file 1 of Tau seeding activity in various regions of down syndrome brain assessed by two novel assays
    Jin, Nana, 顾建兰, Ruozhen Wu, Dandan Chu, Tung, Yunn Chyn, Jerzy Węgiel, Wisniewski, Thomas, Gong, Cheng-Xin, Khalid Iqbal, Liu, Fei · 2022 · Figshare
  92. Additional file 7 of Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
    Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Ingelsson, Martin, Jinar Rostami, Maria Lindskog, Anna Erlandsson · 2024 · Figshare
  93. Additional file 8 of Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
    Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Ingelsson, Martin, Jinar Rostami, Maria Lindskog, Anna Erlandsson · 2024 · Figshare
  94. Additional file 5 of Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
    Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Ingelsson, Martin, Jinar Rostami, Maria Lindskog, Anna Erlandsson · 2024 · Figshare
  95. Additional file 2 of Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
    Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Ingelsson, Martin, Jinar Rostami, Maria Lindskog, Anna Erlandsson · 2024 · Figshare
  96. Additional file 1 of A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro
    Isabelle Aillaud, Kaniyappan, Senthilvelrajan, Chandupatla, Ram Reddy, Lisa Marie Ramirez, Sewar Alkhashrom, Jutta Eichler, Anselm H. C. Horn, Markus Zweckstetter, Eckhard Mandelkow, Heinrich Sticht et al. · 2022 · Figshare
  97. Additional file 6 of Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
    Tobias Mothes, Benjamin Portal, Evangelos Konstantinidis, Khalid Eltom, Sylwia Libard, Linn Streubel-Gallasch, Ingelsson, Martin, Jinar Rostami, Maria Lindskog, Anna Erlandsson · 2024 · Figshare
  98. Tau nucléaire : un acteur clé dans le stress neuronal
    Audrey Sultan · 2010 · theses.fr (ABES)
  99. Studies on the Role of Cellular Heparan Sulfate on Tau Pathology in Alzheimer's Disease and Related Tauopathies
    Julia Elisa Sepulveda-Diaz · 2013 · theses.fr (ABES)
  100. Étude de l’agrégation des protéines intrinsèquement désordonnées impliquées dans les maladies d’Alzheimer et de Parkinson
    Juan M. Lopez · 2015 · theses.fr (ABES)