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Molekulare Medizin der Alzheimer-Krankheit

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Jumping mode atomic force microscopy obtains reproducible images of Alzheimer paired helical filaments in liquids

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Preservation of hippocampal pyramidal cells in paraphrenia

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Introduction to the Tauopathies

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Inert and seed-competent tau monomers suggest structural origins of aggregationPreprint

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[11C]MODAG 005 – a novel PET tracer targeting alpha-synuclein aggregates in the brainPreprint

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Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filamentsPreprint

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Protein Phosphatase 5-Recruiting Chimeras for Accelerating Tau Dephosphorylation

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Uric Acid, the End-Product of Purine Metabolism, Mitigates Tau-Related Abnormalities: Comparison with DOT, a Non-Antibiotic Oxytetracycline Derivative

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Protein Coaggregation in Caribbean Atypical Parkinsonism: The Contribution of Annonacin

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Making tau amyloid models in vitro: a crucial and underestimated challenge

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Measuring Interactions Between Tau and Aggregation Inducers with Single-Molecule Förster Resonance Energy Transfer

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Molecular Mechanism of Tau Misfolding and Aggregation: Insights from Molecular Dynamics Simulation

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NMR Relaxation Experiments Probe Monomer–Fibril Interaction and Identify Critical Interacting Residues Responsible for Distinct Tau Fibril Morphologies

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Protein Degradation in Alzheimer’s Disease and Aging of the Brain

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Development of a Fluorescent High Throughput Assay for Tau Aggregation

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HSPG2 Gene C/A Polymorphism Does Not Confer Susceptibility to Alzheimer’s Disease in Chinese

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Chaperone-Like Manner of Human Neuronal Tau Towards Lactate Dehydrogenase

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Effect of Tau Fragment and Membrane Interactions on Membrane Permeabilization and Peptide Aggregation

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Reversibility and β-sheet formation are decoupled in tau condensate aging

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Amyloid Hypothesis and Alzheimer's Disease

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Cryo-EM structural analyses reveal diverse porous structures in brain-derived tau oligomers

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Insights into neurodegeneration from electron microscopy studies

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Molecular polymorphism of tau aggregates in Pick's disease

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Tau Fibrillogenesis

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Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models

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The protein–surfactant stoichiometry governs the conformational switching and amyloid nucleation kinetics of tau K18

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Types of Age-Related Brain Lesions and Relationship to Neuropathologic Diagnostic Systems of Alzheimer's Disease

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Minimalistic in vitro systems for investigating tau pathology

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Polyserine peptides are toxic and exacerbate tau pathology in micePreprint

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Structures of ΔD421 Truncated Tau Fibrils

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Development of a robust, physiologically relevant neuronal tau aggregation assay for tau-related drug discovery

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Solubility and Metastability of the Amyloidogenic Core of Tau

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Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

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The Cellular Environment Guides Self‐Assembly and Structural Conformations of Microtubule‐Associated Protein Tau (MAPT)

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Polymerization of recombinant tau core fragments in vitro and seeding studies in cultured cells

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Investigation on the Aggregation Behaviors and Filament Morphology of Tau Protein by a Simple 90° Angle Light‐Scattering Assay

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Structural Studies of Specific Intermolecular Interactions and Self-Aggregation of Biomolecules and Their Application to Drug Design

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Small-molecule compound from AlphaScreen disrupts tau-glycan interface

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Quantitative Prediction of Protein–Polyelectrolyte Binding Thermodynamics: Adsorption of Heparin-Analog Polysulfates to the SARS-CoV-2 Spike Protein RBD

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Yeast surface display of full‐length human microtubule‐associated protein tau

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Commercial and Instant Coffees Effectively Lower Aβ1-40 and Aβ1-42 in N2a/APPswe Cells

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Tau Protein Expression in Adult Bovine Oligodendrocytes: Functional and Pathological Significance

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What is the Link Between Protein Aggregation and Interneuronal Lesion Propagation in Neurodegenerative Disease?

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Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer’s Disease

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Parkinsonism-Plus Syndromes and Secondary Parkinsonian Disorders

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A novel gene therapy for methamphetamine- induced cognitive disorder with a hyper-acidified fusion variant of DnaJB1

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Tau and Axonal Transport

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Heparin injection into the adult rat hippocampus induces seizures in the absence of macroscopic abnormalities

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NMR metabolomics techniques and mathematical tools as an aid in neurological diagnosis

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Progressive Supranuclear Palsy and Corticobasal Degeneration

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Aluminum, Tau and Neurofibrillary Degeneration

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Fibril formation rewires interactome of the Alzheimer protein Tau by π-stackingPreprint

Ferrari, L., Stucchi, R., Konstantoulea, A., van de Kamp, G., Kos, R., Geerts, W. J. C., Förster, F. G., Altelaar, M. A. F., Hoogenraad, C. C., & Rüdiger, S. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/522284 · Cited by 3

The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular modelPreprint

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Biomolecular Tau condensation is linked to Tau accumulation at the nuclear envelopePreprint

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Central and peripheral tau retention modulated by an anti-tau antibodyPreprint

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A high-throughput drug screening assay for anti-tau aggregation using split GFP and flow cytometry

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Structural and mechanistic characterization of heparin interactions with tau fibrils

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Electric Double Layer Phenomena Near Surfaces Irreversibly Trigger Assembly of Tau Protein

Masquelier, E., Hicks, M. H., Watkins, N. B., Lim, N., Yi, J., Morse, D. E., Sepunaru, L., & Gordon, M. J. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.5c23171 · Cited by 2

Cinnamon Bud Extract Is a Source of Biomolecules Active against the Aggregation and Condensation of Alzheimer′s-Associated Tau Protein

Viola, G., Sperotto, A., Palmioli, A., Tira, R., Munari, F., Assfalg, M., Airoldi, C., & D’Onofrio, M. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c17659 · Cited by 2

C. elegans and Neurodegeneration In Caenorhabditis Elegans: Anatomy, Life Cycles and Biological Functions.

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A half‐century of tau

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EFhd2 co-aggregates with monomeric and filamentous tau in vitro

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Structure and function of Full-length Tau

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Glycosaminoglycans, Proteoglycans, and Conformational Disorders

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Progress in Familial Parkinson's Disease.

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Localization microscopy for the study of amyloid fibril formation

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Atypical parkinsonism, parkinsonism-plus syndromes, and secondary parkinsonian disorders

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Effects of Formaldehyde on Protein (Tau) Aggregation and Cytotoxicity

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Neurodegeneration and the Ordered Assembly of Tau

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Tau Pathology and Neurodegenerative Disorders

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Binding of Tau Protein to the Ends of ex vivo Paired Helical Filaments

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Gene-environment interactions in considering physical activity for the prevention of dementia

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Formation of a new fluorescence of human neuronal tau protein

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Neurotransmitter Receptor—G-Protein-Mediated Signal Transduction in Alzheimer’s Disease

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dGAE(297-391) tau fragment promotes formation of CTE-like full-length tau filamentsPreprint

Kitoka, K., Lends, A., Kučinskas, G., Bula, A. L., Krasauskas, L., Smirnovas, V., Žilková, M., Kováčech, B., Škrabana, R., Hritz, J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.01.526268 · Cited by 2

Structures of AT8 and PHF1 Phospho-Mimetic Tau: Insights Into the Posttranslational Modification Code of Tau Amyloid FormationPreprint

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Phosphatidylinositol (PI) Lipids Modulate the Binding of Tau Fibrils on Lipid BilayersPreprint

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Tau-Centric Therapies for Treating Alzheimer’s Disease

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Expanded Conformations of Monomeric Tau Initiate Its Amyloidogenesis**

Fernández‐Ramírez, M. D. C., Ng, K. K., Menéndez, M., Laurents, D. V., Hervás, R., & Carrión‐Vázquez, M. (2022) · Angewandte Chemie · doi:10.1002/ange.202209252 · Cited by 1

Biophysical Studies of Amyloid-Binding Fluorophores to Tau AD Core Fibrils Formed without Cofactors

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Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments

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4-Amino-3′,4′-dihydroxychalcone Increases Tau Dynamics in Phase-Separated Droplets and Inhibits Tau Aggregation

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Impact of Lysine Acetylation Mutations on the Structure of Full-Length Tau Fibrils

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