Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

Molecular and cellular mechanisms of general anaesthesia

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The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

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Binding of Xenon to Sperm Whale Myoglobin

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Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects

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Enhancement of homomeric glycine receptor function by longchain alcohols and anaesthetics

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Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.

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Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons

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Positive modulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane.

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GABAA-R α1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice

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Neuroanesthesiology Update 2010

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Anesthetic effects on synaptic transmission and gain control in respiratory control

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Structural features of phenol derivatives determining potency for activation of chloride currents via α1 homomeric and α1β heteromeric glycine receptors

Haeseler, G., Ahrens, J., Krampfl, K., Bufler, J., Dengler, R., Hecker, H., Aronson, J. K., & Leuwer, M. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706254 · Cited by 14

In vivo and in vitro hyperbaric studies in mice suggest novel sites of action for ethanol

Davies, D. L., Bolger, M. B., Brinton, R. D., Finn, D. A., & Alkana, R. L. (1999) · Psychopharmacology · doi:10.1007/s002130050843 · Cited by 14

Molecular and Cellular Mechanisms of Anesthesia

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Insights into the Nature of Anesthetic–Protein Interactions: An ONIOM Study

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Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC

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Identification of an Inhibitory Alcohol Binding Site in GABAAρ1 Receptors

Borghese, C. M., Ruiz, C. I., Lee, U. S., Cullins, M. A., Bertaccini, E. J., Trudell, J. R., & Harris, R. A. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00246 · Cited by 13

Structural basis for the ethanol action on G-protein–activated inwardly rectifying potassium channel 1 revealed by NMR spectroscopy

Toyama, Y., Kano, H., Mase, Y., Yokogawa, M., Osawa, M., & Shimada, I. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722257115 · Cited by 13

Modulation of Glycine Receptor-Mediated Pain Signaling in vitro and in vivo by Glucose

Hussein, R. A., Ahmed, M., Breitinger, H., & Breitinger, U. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00280 · Cited by 13

Decreased GABAA benzodiazepine binding site densities in postmortem brains of Cloninger type 1 and 2 alcoholics

Laukkanen, V., Storvik, M., Häkkinen, M. R., Akamine, Y., Tupala, E., Virkkunen, M. E., & Tiihonen, J. (2013) · Alcohol · doi:10.1016/j.alcohol.2012.12.008 · Cited by 13

Little Evidence of a Role for theα1 GABAA Subunit‐Containing Receptor in a Rhesus Monkey Model of Alcohol Drinking

Sawyer, E. K., Moran, C. A., Sirbu, M. H., Szafir, M., Linn, M., Namjoshi, O. A., Tiruveedhula, V. V. N. P. B., Cook, J. M., & Platt, D. M. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12320 · Cited by 13

Differential Effects of Methylmercury on γ-Aminobutyric Acid Type A Receptor Currents in Rat Cerebellar Granule and Cerebral Cortical Neurons in Culture

Herden, C., Pardo, N. E., Hajela, R. K., Yuan, Y., & Atchison, W. D. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.123976 · Cited by 13

Probing the molecular basis for signal transduction through the Zinc-Activated Channel (ZAC)

Madjroh, N., Mellou, E., Æbelø, L., Davies, P. A., Söderhielm, P. C., & Jensen, A. A. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114781 · Cited by 13

GABAA receptors in GtoPdb v.2021.3

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Strychnine-Sensitive Glycine Receptors Mediate the Analgesic but Not Hypnotic Effects of Emulsified Volatile Anesthetics

Chen, Y., Ti-jun, D., & Yin-ming, Z. (2007) · Pharmacology · doi:10.1159/000103255 · Cited by 13

Partitioning of four modern volatile general anesthetics into solvents that model buried amino acid side-chains

Johansson, J. S., & Zou, H. Y. (1999) · Biophysical Chemistry · doi:10.1016/s0301-4622(99)00046-0 · Cited by 13

Selective GABAA circuits for novel CNS drugs

Möhler, H., & Rudolph, U. (2004) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2004.08.019 · Cited by 13

Binding of the General Anesthetics Chloroform and 2,2,2-Trichloroethanol to the Hydrophobic Core of a Four-α-Helix Bundle Protein¶

Johansson, J. S., Solt, K., & Reddy, K. S. (2003) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2003)0770089botgac2.0.co2 · Cited by 13

GABAergic Neuroactive Steroids Modulate Selective Ethanol Actions

McDaniel, J. R., Tokunaga, S., Matthews, D. B., Khisti, R. T., & Morrow, A. L. (2003) · Frontiers in neuroscience · doi:10.1201/9780203508169.ch10 · Cited by 13

Alcohol Actions on GABAA Receptors: From Protein Structure to Mouse Behavior

Ueno, S., Harris, R. A., Messing, R. O., Sánchez‐Pérez, A. M., Hodge, C. W., McMahon, T., Wang, D., Mehmert, K. K., Kelley, S., Haywood, A., et al. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200105051-00014 · Cited by 13

Neurotoxicology and Behavior

Boyes, W. K. (2012) · Patty's Toxicology · doi:10.1002/0471435139.tox025.pub2 · Cited by 13

Schisandrin B, a dual positive allosteric modulator of GABAA and glycine receptors, alleviates seizures in multiple mouse models

Wu, J., Zhao, M., Jin, Y., Li, M., Yu, K.-X., & Yu, H. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01195-3 · Cited by 12

Physiological concentrations of zinc reduce taurine-activated GlyR responses to drugs of abuse

Kirson, D., Cornelison, G. L., Philpo, A. E., Todorović, J., & Mihic, S. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.07.025 · Cited by 12

Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice

Ito, J., Otsuki, N., Zhang, X., Konno, T., Kurahashi, T., Takahashi, M., Yamato, M., Matsuoka, Y., Yamada, K., Miyata, S., et al. (2013) · Life Sciences · doi:10.1016/j.lfs.2013.12.004 · Cited by 12

Sensitization of Nociceptive Ion Channels by Inhaled Anesthetics—A Pain in the Gas?

Harrison, N. L., & Nau, C. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.051615 · Cited by 12

Alcohol reduces muscle fatigue through atomistic interactions with nicotinic receptors

Noori, H. R., Mücksch, C., Vengeliene, V., Schönig, K., Takahashi, T. T., Mukhtasimova, N., Oskouei, M. B., Mosqueira, M., Bartsch, D., Fink, R., et al. (2018) · Communications Biology · doi:10.1038/s42003-018-0157-9 · Cited by 12

Intravenous Anesthetics

García, P. S., Whalin, M. K., & Sebel, P. S. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-1679-5.00009-0 · Cited by 12

Study of the potential oxidative stress induced by six solvents in the rat brain

Chalansonnet, M., Carabin, N., Boucard, S., Cosnier, F., Nunge, H., & Gagnaire, F. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.12.002 · Cited by 12

Mutation in neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes blocks ethanol action

Borghese, C. M., WANG, L., Bleck, V., & Harris, R. A. (2003) · Addiction Biology · doi:10.1080/13556210310001602220 · Cited by 12

Sites of Excitatory and Inhibitory Actions of Alcohols on Neuronal α2β4 Nicotinic Acetylcholine Receptors

Borghese, C. M., Henderson, L. A., Bleck, V., Trudell, J. R., & Harris, R. A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.053710 · Cited by 12

Mechanisms of anaesthesia: time to say farewell to the Meyer-Overton rule

Bovill, J. G. (2000) · Current Opinion in Anaesthesiology · doi:10.1097/00001503-200008000-00006 · Cited by 12

Mode of action of ICS 205,930, a novel type of potentiator of responses to glycine in rat spinal neurones

Chesnoy‐Marchais, D. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702384 · Cited by 12

Tiagabine does not attenuate alcohol-induced activation of the human reward system

Fehr, C., Hohmann, N., Gründer, G., Dielentheis, T. F., Buchholz, H., Chechko, N., Yakushev, I. Y., Landvogt, C., Bartenstein, P., Urban, R., et al. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0696-5 · Cited by 12

Effects of isoflurane on [Ca2+]i, SR Ca2+content, and twitch force in intact trabeculae

Jiang, Y., & Julian, F. J. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.275.4.h1360 · Cited by 12

Direct antagonism of ethanol's effects on GABA(A) receptors by increased atmospheric pressure.

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Pharmacology of the GABAAReceptor

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Molecular dynamics simulation of a synthetic four‐α‐helix bundle that binds the anesthetic halothane

Davies, L. A., Klein, M. L., & Scharf, D. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00890-x · Cited by 12

Alteration of lipid bilayer mechanics by volatile anesthetics: Insights from μs-long molecular dynamics simulations

Zizzi, E. A., Cavaglià, M., Tuszyński, J. A., & Deriu, M. A. (2022) · iScience · doi:10.1016/j.isci.2022.103946 · Cited by 11

MAC reduction after intrathecal coadministration of GABA A agonist and glutamate antagonist in rats

Sumikura, H., & Arendt‐Nielsen, L. (2003) · Journal of Anesthesia · doi:10.1007/s005400300023 · Cited by 11

Effects of ethanol on kinaesthetic perception

Tiplady, B., Baird, R., Lütcke, H., Drummond, G. B., & WRIGHT, P. D. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105056539 · Cited by 11

Effects ofGabra2Point Mutations on Alcohol Intake: Increased Binge‐Like and Blunted Chronic Drinking by Mice

Newman, E. L., Gunner, G., Huynh, P., Gachette, D., Moss, S. J., Smart, T. G., Rudolph, U., DeBold, J. F., & Miczek, K. A. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13215 · Cited by 11

Interactions between Zinc and Allosteric Modulators of the Glycine Receptor

Cornelison, G. L., Daszkowski, A. W., Pflanz, N. C., & Mihic, S. J. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.239152 · Cited by 11

Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes

Borghese, C. M., Herman, M. A., Snell, L. D., Lawrence, K. J., Lee, H. Y., Backos, D. S., Vanderlinden, L. A., Harris, R. A., Roberto, M., Hoffman, P. L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05966-x · Cited by 11

A chimeric prokaryotic-eukaryotic pentameric ligand gated ion channel reveals interactions between the extracellular and transmembrane domains shape neurosteroid modulation

Ghosh, B., Tsao, T.-W., & Czajkowski, C. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.007 · Cited by 12

Exon level machine learning analyses elucidate novel candidate miRNA targets in an avian model of fetal alcohol spectrum disorder

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Mutagenesis of the GABAA receptor α1 subunit reveals a domain that affects sensitivity to GABA and benzodiazepine‐site ligands

Davies, M., Newell, J. G., & Dunn, S. M. J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00527.x · Cited by 11

The discovery of new anesthetics by targeting GABAAreceptors

Krasowski, M. D., & Hopfinger, A. J. (2011) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2011.627324 · Cited by 11

Allosteric Modulation of GABAA Receptors

M�hler, H. (2006) · Informa Healthcare eBooks · doi:10.1201/9781420016185.sec2 · Cited by 11

Direct Evidence for a Cause‐Effect Link Between Ethanol Potentiation of GABAA Receptor Function and Intoxication From Hyperbaric Studies in C57, LS, and SS Mice

Davies, D. L., & Alkana, R. L. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02322.x · Cited by 11

Xenon in Anesthesia

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Protein kinase C regulates dopamine D4 receptor-mediated phospholipid methylation

Sharma, A. K., Waly, M. I., & Deth, R. C. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01242-0 · Cited by 11

The effects of a point mutation of the β2 subunit of GABAA receptor on direct and modulatory actions of general anesthetics

Fukami, S., Uchida, I., Takenoshita, M., Mashimo, T., & Yoshiya, I. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00033-3 · Cited by 11

Mutating the Highly Conserved Second Membrane-Spanning Region 9′ Leucine Residue in the α1 or β1 Subunit Produces Subunit-Specific Changes in the Function of Human α1β1 γ-Aminobutyric AcidA Receptors

Dalziel, J. E., Cox, G. B., Gage, P. W., & Birnir, B. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)26495-6 · Cited by 11

HCN1 Channels as Targets for Volatile Anesthetics: Coming to the Fore

Goldstein, P. A. (2015) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000000871 · Cited by 10

The dorsal striatum expressing adenylyl cyclase-5 controls behavioral sensitivity of the righting reflex to high-dose ethanol

Kim, K.-S., Kim, H., Park, S.-K., & Han, P.-L. (2012) · Brain Research · doi:10.1016/j.brainres.2012.10.016 · Cited by 10

Site-specific microinjection of Gaboxadol into the infralimbic cortex modulates ethanol intake in male C57BL/6J mice

Fritz, B. M., & Boehm II, S. L. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.020 · Cited by 10

Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors

Mascia, M. P., Asproni, B., Busonero, F., Talani, G., Maciocco, E., Pau, A., Cerri, R., Sanna, E., & Biggio, G. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.05.006 · Cited by 10

GCY-35/GCY-36—TAX-2/TAX-4 Signalling in O2 Sensory Neurons Mediates Acute Functional Ethanol Tolerance in Caenorhabditis elegans

Chen, Y.-H., Ge, C.-L., Wang, H., Ge, M.-H., He, Q.-Q., Zhang, Y., Tian, W., & Wu, Z.-X. (2018) · Scientific Reports · doi:10.1038/s41598-018-20477-z · Cited by 10

Energy Aspects of Sodium Thiopental Action on Nervous Activity

Mednikova, Y. S., Козлов, М. К., & Makarenko, A. N. (2019) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2019.92004 · Cited by 10

Structural mechanism underlying the differential effects of ivermectin and moxidectin on the C. elegans glutamate-gated chloride channel GLC-2

Kaji, M. D., Noonan, J. D., Geary, T. G., & Beech, R. N. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112380 · Cited by 10

Modulatory Actions of the Glycine Receptor β Subunit on the Positive Allosteric Modulation of Ethanol in α2 Containing Receptors

Muñoz, B., Mariqueo, T. A., Murath, P., Peters, C., Yévenes, G. E., Moraga-Cid, G., Peoples, R., & Aguayo, L. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.763868 · Cited by 8

Thermodynamic Analysis for Synthesis of Advanced Materials

Liu, C., Ji, Y., Shao, Q., Feng, X. F., & Lü, X. (2008) · Structure and bonding · doi:10.1007/978-3-540-69116-7_5 · Cited by 10

Ecotoxicology of narcosis: Stereoselectivity and potential target sites

Sandermann, H. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.05.002 · Cited by 10

Activated G Protein αs Subunits Increase the Ethanol Sensitivity of Human Glycine Receptors

Yévenes, G. E., Moraga‐Cid, G., Romo, X., & Aguayo, L. G. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.184408 · Cited by 10

Identification and characterization of heptapeptide modulators of the glycine receptor

Cornelison, G. L., Pflanz, N. C., Tipps, M. E., & Mihic, S. J. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.03.058 · Cited by 10

Taurine Suppression of Central Amygdala GABAergic Inhibitory Signaling via Glycine Receptors Is Disrupted in Alcohol Dependence

Kirson, D., Oleata, C. S., & Roberto, M. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14252 · Cited by 9

Interaction of propofol with voltage-gated human Kv1.5 channel through specific amino acids within the pore region

Kojima, A., Ito, Y., Ding, W., Kitagawa, H., & Matsuura, H. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.08.007 · Cited by 10

Molecular Targets of General Anesthetics in the Nervous System

Hemmings, H. C. (2009) · Contemporary clinical neuroscience · doi:10.1007/978-1-60761-462-3_2 · Cited by 10

Die GABAA-Rezeptor-Familie

Drexler, B., Grasshoff, C., Rudolph, U., Unertl, K. E., & Antkowiak, B. (2005) · Der Anaesthesist · doi:10.1007/s00101-005-0950-y · Cited by 11

Ethanol-Induced Hypnotic Tolerance Is Absent in N-Methyl-d-Aspartate Receptor ε1 Subunit Knockout Mice

Sato, Y., Seo, N., & Kobayashi, E. (2006) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000220944.27963.b1 · Cited by 10

Kinetics of Anesthetic-Induced Conformational Transitions in a Four-α-Helix Bundle Protein

Solt, K., Johansson, J. S., & Raines, D. E. (2006) · Biochemistry · doi:10.1021/bi052206o · Cited by 10

Influence of oxygenated fuel additives and their metabolites on γ-aminobutyric acidA (GABAA) receptor function in rat brain synaptoneurosomes

Martin, J. V., Iyer, S. V., McIlroy, P. J., & Iba, M. M. (2003) · Toxicology Letters · doi:10.1016/j.toxlet.2003.10.024 · Cited by 10

The Basic Property of Lys385 Is Important for Potentiation of the Human α1 Glycine Receptor by Ethanol

Castro, P. A., Figueroa, M., Yévenes, G. E., Martín, L. S., & Aguayo, L. G. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.185140 · Cited by 10

Inhalants

Bowen, S. E., & Cruz, S. L. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-418679-8.00018-6 · Cited by 10

Complex formation of skeletal muscle Ca2+-regulatory membrane proteins by halothane

Froemming, G. R. A., Dillane, D., & Ohlendieck, K. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00854-1 · Cited by 10

Functional Relevance of GABAA-Receptor Subtypes

Möhler, H. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-465-0_2 · Cited by 10

Withdrawal Effects of a Neuroactive Steroid as a Model of PMS: Synaptic Physiology to Behavior

Smith, S. (2003) · Frontiers in neuroscience · doi:10.1201/9780203508169.ch7 · Cited by 10

The In Vitro Ethanol Sensitivity of Hippocampal Synaptic γ-Aminobutyric AcidA Responses Differs in Lines of Mice and Rats Genetically Selected for Behavioral Sensitivity or Insensitivity to Ethanol

Poelchen, W., Proctor, W. R., & Dunwiddie, T. V. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38963-3 · Cited by 10

Anaesthetics in a bind?

Peters, J. A., & Lambert, J. J. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01135-8 · Cited by 10

The Anesthetic Potency of Propanol and Butanol Versus Propanethiol and Butanethiol in α1 Wild Type and α1(S267Q) Glycine Receptors

Mascia, M. P., Gong, D., Eger, E. I., & Harris, R. A. (2000) · Anesthesia & Analgesia · doi:10.1097/00000539-200011000-00044 · Cited by 10

GABAA Receptor

Olsen, R. W., & Li, G.-D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-378630-2.00339-x · Cited by 11

Isoflurane does not aggregate inside POPC bilayers at high pressure: Implications for pressure reversal of general anaesthesia

Wieteska, J. R., Welche, P. R. L., Tu, K.-M., ElGamacy, M., Cśanyi, G., Payne, M. C., & Chau, P. ‐. (2015) · Chemical Physics Letters · doi:10.1016/j.cplett.2015.07.065 · Cited by 9

Intracerebroventricular or intrathecal injection of glycine produces analgesia in thermal nociception and chemical nociception via glycine receptors

Cheng, W., Yin, Q., Cheng, M.-Y., Chen, H.-S., Wang, S., Feng, T., Yin-ming, Z., & Liu, G. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.052 · Cited by 9

Volatile Anesthetic Binding to Proteins Is Influenced by Solvent and Aliphatic Residues

Streiff, J. H., & Jones, K. A. (2008) · Journal of Chemical Information and Modeling · doi:10.1021/ci800206a · Cited by 9

Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity

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Cryo-electron microscopy reveals informative details of GABAA receptor structural pharmacology: implications for drug discovery

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Use of Concatemers of Ligand-Gated Ion Channel Subunits to Study Mechanisms of Steroid Potentiation

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A Kinetic Model of Ion Channel Electrophysiology: Incorporating Bilayer-Mediated Effects of Agonists and Anesthetics on Protein Conformational Transitions

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Alcohol Withdrawal Seizures

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BK β1 subunit‐dependent facilitation of ethanol inhibition of BK current and cerebral artery constriction is mediated by the β1 transmembrane domain 2

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Structural analysis of pathogenic missense mutations in GABRA2 and identification of a novel de novo variant in the desensitization gate

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A kinetic model of ion channel electrophysiology: bilayer-mediated effects of agonists and anesthetics on protein conformational transitions

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The lipid/protein interface as a target site for general anesthetics: a multiple-site kinetic analysis of synaptosomal Ca2+-ATPase

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The exhaustive additivity displayed by nitrous oxide has implications for cognitive-energetical theory

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Is Anesthesia Caused by Potentiation of Synaptic or Intrinsic Inhibition? Recent Insights into the Mechanisms of Volatile Anesthetics

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Could do better: statistics in anaesthesia research

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Volatile and Local Anesthetics Interfere with Thromboxane A2 Receptors Recombinantly Expressed in Xenopus Oocytes

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Allosteric Modulation of GABAA Receptor Function by General Anesthetics and Alcohols

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Antagonism of Inhalant and Volatile Anesthetic Enhancement of Glycine Receptor Function

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The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations

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Anaesthetics set their sites on ion channels

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Inhibition of rho1 receptor GABAergic currents by alcohols and volatile anesthetics.

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