Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

Molecular and cellular mechanisms of general anaesthesia

Franks, N. P., & Lieb, W. R. (1994) · Nature · doi:10.1038/367607a0 · Cited by 1,786

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

Ortells, M. O., & Lunt, G. G. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)93887-4 · Cited by 524

The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones

Hales, T. G., & Lambert, J. J. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12479.x · Cited by 345

Binding of Xenon to Sperm Whale Myoglobin

SCHOENBORN, B. P., WATSON, H. C., & Kendrew, J. C. (1965) · Nature · doi:10.1038/207028a0 · Cited by 241

Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects

Franks, N. P., & Lieb, W. R. (1985) · Nature · doi:10.1038/316349a0 · Cited by 240

A relationship between alcohol intoxication and the disordering of brain membranes by a series of short-chain alcohols.

Lyon, R. C., McComb, J. A., Schreurs, J., & Goldstein, D. B. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32727-8 · Cited by 209

Enhancement of homomeric glycine receptor function by longchain alcohols and anaesthetics

Mascia, M. P., Machu, T. K., & Harris, R. A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb16042.x · Cited by 198

Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit.

Xu, M., & Akabas, M. H. (1996) · The Journal of General Physiology · doi:10.1085/jgp.107.2.195 · Cited by 197

Effects of volatile anesthetics on the kinetics of inhibitory postsynaptic currents in cultured rat hippocampal neurons

Jones, M. V., & Harrison, N. L. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.4.1339 · Cited by 179

Positive modulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane.

Harrison, N. L., Kugler, J., Jones, M. V., Greenblatt, E. P., & Pritchett, D. B. (1993) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13234-3 · Cited by 167

Mutant human α1β1(T262Q) GABAA receptors are directly activated but not modulated by pentobarbital

Dalziel, J. E., Cox, G. B., Gage, P. W., & Birnir, B. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00710-4 · Cited by 27

The in vitro ethanol sensitivity of hippocampal synaptic gamma-aminobutyric acid(A) responses differs in lines of mice and rats genetically selected for behavioral sensitivity or insensitivity to ethanol.

Poelchen, W., Proctor, W. R., & Dunwiddie, T. V. (2000) · PubMed · Cited by 27

The effects of adolescent alcohol exposure on learning and related neurobiology in humans and rodents

Seemiller, L. R., & Gould, T. J. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107234 · Cited by 23

The TMEM132B-GABAA receptor complex controls alcohol actions in the brain

Wang, G., Peng, S.-X., Mendez, M. R., Keramidas, A., Castellano, D., Wu, K., Han, W., Tian, Q., Dong, L., Li, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.09.006 · Cited by 25

High-intensity binge drinking is associated with alterations in spontaneous neural oscillations in young adults

Affan, R. O., Huang, S., Cruz, S. M., Holcomb, L. A., Nguyen, E., & Marinković, K. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.01.002 · Cited by 27

Mutation of a Zinc-Binding Residue in the Glycine Receptor α1 Subunit Changes Ethanol Sensitivity In Vitro and Alcohol Consumption In Vivo

McCracken, L. M., Blednov, Y. A., Trudell, J. R., Benavidez, J. M., Betz, H., & Harris, R. A. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.197707 · Cited by 26

Attenuation of Gap-Junction-Mediated Signaling Facilitated Anesthetic Effect of Sevoflurane in the Central Nervous System of Rats

Masaki, E., Kawamura, M., & Kato, F. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000103259.72635.72 · Cited by 26

Modulation of GABAA Receptor Function by Nonhalogenated Alkane Anesthetics: The Effects on Agonist Enhancement, Direct Activation, and Inhibition

Raines, D. E., Claycomb, R., & Forman, S. A. (2003) · Anesthesia & Analgesia · doi:10.1097/00000539-200301000-00024 · Cited by 26

Lack of positive allosteric modulation of mutated α1S267I glycine receptors by cannabinoids

Foadi, N., Leuwer, M., Demir, R., Dengler, R., Buchholz, V., de la Roche, J., Karst, M., Haeseler, G., & Ahrens, J. (2010) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-010-0506-9 · Cited by 26

Evolutionarily Conserved Allosteric Network in the Cys Loop Family of Ligand-gated Ion Channels Revealed by Statistical Covariance Analyses

Chen, Y., Reilly, K. D., & Chang, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600349200 · Cited by 26

Identification of novel ethanol-sensitive genes by expression profiling

Rahman, S., & Miles, M. F. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00163-2 · Cited by 26

Low Brain Histamine Content Affects Ethanol-Induced Motor Impairment

Lintunen, M., Raatesalmi, K., Sallmén, T., Anichtchik, O. V., Karlstedt, K. A., Kaslin, J., Kiianmaa, K., Korpi, E. R., & Panula, P. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0453 · Cited by 26

Molecular modeling of ligand-gated ion channels: Progress and challenges

Bertaccini, E. J., & Trudell, J. R. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)48015-9 · Cited by 26

Inhibition versus Potentiation of Ligand-Gated Ion Channels Can Be Altered by a Single Mutation that Moves Ligands between Intra- and Intersubunit Sites

Broemstrup, T., Howard, R. J., Trudell, J. R., Harris, R. A., & Lindahl, E. R. (2013) · Structure · doi:10.1016/j.str.2013.06.018 · Cited by 25

Inhibition of the human intermediate conductance Ca2+-activated K+ channel, hIK1, by volatile anesthetics

Namba, T., Ishii, T. M., Ikeda, M., Hisano, T., Itoh, T., Hirota, K., Adelman, J. P., & Fukuda, K. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00254-5 · Cited by 26

Chapter 4 New concept to search for alternate insect control agents from plants

Kubo, I. (2006) · Advances in phytomedicine · doi:10.1016/s1572-557x(06)03004-2 · Cited by 25

Glycine receptor mutants of the mouse: what are possible routes of inhibitory compensation?

Schaefer, N., Vogel, N., & Villmann, C. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00098 · Cited by 25

p-Trifluoromethyldiazirinyl-etomidate: A Potent Photoreactive General Anesthetic Derivative of Etomidate That Is Selective for Ligand-Gated Cationic Ion Channels

Husain, S. S., Stewart, D. S., Desai, R., Hamouda, A. K., Li, S. G.-D., Kelly, E. W., Dostalova, Z., Zhou, X., Cotten, J. F., Raines, D. E., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100498u · Cited by 25

Impaired Glycinergic Synaptic Transmission and Enhanced Inflammatory Pain in Mice with Reduced Expression of Vesicular GABA Transporter (VGAT)

Yamada, M., Nishikawa, K., Kubo, K., Yanagawa, Y., & Saito, S. (2012) · Molecular Pharmacology · doi:10.1124/mol.111.076083 · Cited by 25

A Transmembrane Amino Acid in the GABAA Receptor β2 Subunit Critical for the Actions of Alcohols and Anesthetics

McCracken, M. L., Borghese, C. M., Trudell, J. R., & Harris, R. A. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.170472 · Cited by 26

GABAergic effect on resting-state functional connectivity: Dynamics under pharmacological antagonism

Nasrallah, F. A., Singh, K. K. D. O. R., Yeow, L. Y., & Chuang, K. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.01.040 · Cited by 27

Interaction of Anesthetics with Open and Closed Conformations of a Potassium Channel Studied via Molecular Dynamics and Normal Mode Analysis

Vemparala, S., Domene, C., & Klein, M. L. (2008) · Biophysical Journal · doi:10.1529/biophysj.107.119958 · Cited by 25

7,8-Dihydroxyflavone Alleviates Anxiety-Like Behavior Induced by Chronic Alcohol Exposure in Mice Involving Tropomyosin-Related Kinase B in the Amygdala

Wang, N., Liu, X., Li, X., Li, X., Ma, W., Xu, Y., Liu, Y. U., Gao, Q., Yang, T., Wang, H., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02111-0 · Cited by 24

Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs

Kumar, A., Kindig, K. J., Rao, S., Zaki, A. M., Basak, S., Sansom, M. S. P., Biggin, P. C., & Chakrapani, S. (2022) · Nature Communications · doi:10.1038/s41467-022-32594-5 · Cited by 24

Positive Allosteric Modulators of Glycine Receptors and Their Potential Use in Pain Therapies

Gallagher, C. I., Ha, D. A., Harvey, R. J., & Vandenberg, R. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000583 · Cited by 26

Alcohol and inhibitory receptors: Unexpected specificity from a nonspecific drug

Harris, R. A., & Mihic, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307281101 · Cited by 24

Reduced effect of propofol at human α1β2(N289M)γ2 and α2β3(N290M)γ2 mutant GABAA receptors

Fagerlund, M. J., Sjödin, J., Krupp, J., & Dabrowski, M. A. (2010) · British Journal of Anaesthesia · doi:10.1093/bja/aeq023 · Cited by 24

Dioxygen Transmembrane Distributions and Partitioning Thermodynamics in Lipid Bilayers and Micelles

Al-Abdul-Wahid, S., Evanics, F., & Prosser, R. S. (2011) · Biochemistry · doi:10.1021/bi200168n · Cited by 24

Monod-Wyman-Changeux Allosteric Shift Analysis in Mutant α1β3γ2L GABAA Receptors Indicates Selectivity and Crosstalk among Intersubunit Transmembrane Anesthetic Sites

Szabo, A., Nourmahnad, A., Halpin, E. S., & Forman, S. A. (2019) · Molecular Pharmacology · doi:10.1124/mol.118.115048 · Cited by 24

Relationship between dopamine‐stimulated phospholipid methylation and the single‐carbon folate pathway

Zhao, R., Chen, Y., Tan, W., Waly, M. I., Sharma, A. K., Stover, P. J., Rosowsky, A., Malewicz, B., & Deth, R. C. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00471.x · Cited by 24

Acetylcholine and Alcohol Sensitivity of Neuronal Nicotinic Acetylcholine Receptors: Mutations in Transmembrane Domains

Borghese, C. M., Ali, D. N., Bleck, V., & Harris, R. A. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-200212000-00002 · Cited by 24

2,6 Di-tert-butylphenol, a Nonanesthetic Propofol Analog, Modulates α1β Glycine Receptor Function in a Manner Distinct from Propofol

Ahrens, J., Haeseler, G., Leuwer, M., Mohammadi, B., Krampfl, K., Dengler, R., & Bufler, J. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000120083.10269.54 · Cited by 24

Toward Cost‐Benefit Analysis of Acute Behavioral Effects of Toluene in Humans

Benignus, V. A., Bushnell, P. J., & Boyes, W. K. (2005) · Risk Analysis · doi:10.1111/j.1539-6924.2005.00601.x · Cited by 24

Sites in TM2 and 3 are critical for alcohol‐induced conformational changes in GABA A receptors

Jung, S., & Harris, R. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03617.x · Cited by 24

A TM2 Residue in the β1 Subunit Determines Spontaneous Opening of Homomeric and Heteromeric γ-Aminobutyric Acid-gated Ion Channels

Miko, A., Werby, E., Sun, H., Healey, J., & Zhang, L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402577200 · Cited by 24

Etomidate revisited

Ostwald, P., & Doenicke, Α. (1998) · Current Opinion in Anaesthesiology · doi:10.1097/00001503-199808000-00003 · Cited by 24

Mutating the highly conserved second membrane-spanning region 9' leucine residue in the alpha(1) or beta(1) subunit produces subunit-specific changes in the function of human alpha(1)beta(1) gamma-aminobutyric Acid(A) receptors.

Dalziel, J. E., Cox, G. B., Gage, P. W., & Birnir, B. (2000) · PubMed · Cited by 24

Allosteric modulation in spontaneously active mutant γ-aminobutyric acidA receptors

Findlay, G. S., Ueno, S., Harrison, N. L., & Harris, R. A. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01646-9 · Cited by 24

Both Cerebral GABAA Receptors and Spinal GABAA Receptors Modulate the Capacity of Isoflurane to Produce Immobility

Zhang, Y., Stabernack, C. R., Sonner, J. M., Dutton, R. C., & Eger, E. I. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200106000-00047 · Cited by 24

A Mutation in Transmembrane Domain II of the 5-Hydroxytryptamine3A Receptor Stabilizes Channel Opening and Alters Alcohol Modulatory Actions

Sessoms-Sikes, J. S., Hamilton, M. E., Liu, L.-X., Lovinger, D. M., & Machu, T. K. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.050542 · Cited by 24

Identification and characterization of anesthetic targets by mouse molecular genetics approaches

Drexler, B., Antkowiak, B., Engin, E., & Rudolph, U. (2010) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-010-9414-1 · Cited by 25

Modeling Anesthetic Binding Sites within the Glycine Alpha One Receptor Based on Prokaryotic Ion Channel Templates: The Problem with TM4

Bertaccini, E. J., Wallner, B., Trudell, J. R., & Lindahl, E. R. (2010) · Journal of Chemical Information and Modeling · doi:10.1021/ci100266c · Cited by 23

A Transmembrane Residue Influences the Interaction of Propofol with the Strychnine-Sensitive Glycine α1 and α1β Receptor

Ahrens, J., Leuwer, M., Stachura, S., Krampfl, K., Belelli, D., Lambert, J. J., & Haeseler, G. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181875a31 · Cited by 23

The Effect of Sevoflurane on Neuronal Degeneration and GABAA Subunit Composition in a Developing Rat Model of Organotypic Hippocampal Slice Cultures

Piehl, E., Foley, L. S., Barron, M., D'Ardenne, C., Guillod, P., & Wise‐Faberowski, L. (2010) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0b013e3181e16c89 · Cited by 23

GABAA receptor transmembrane amino acids are critical for alcohol action: disulfide cross‐linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites

Borghese, C. M., Hicks, J. A., Lapid, D. J., Trudell, J. R., & Harris, R. A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12476 · Cited by 23

BK Channel Subunit Composition Modulates Molecular Tolerance to Ethanol

Feinberg‐Zadek, P. L., Martin, G. E., & Treistman, S. N. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00704.x · Cited by 23

Effect of anesthesia on motor responses evoked by spinal neural prostheses during intraoperative procedures

Toossi, A., Everaert, D. G., Uwiera, R. R. E., Hu, D. S., Robinson, K. D., Gragasin, F. S., & Mushahwar, V. K. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab0938 · Cited by 19

Computational Methods for the Identification of Molecular Targets of Toxic Food Additives. Butylated Hydroxytoluene as a Case Study

Tortosa, V., Pietropaolo, V., Brandi, V., Macari, G., Pasquadibisceglie, A., & Polticelli, F. (2020) · Molecules · doi:10.3390/molecules25092229 · Cited by 23

Kinetic Analyses of Alcohol-Induced Potentiation of the Response of GABAA Receptors Composed of 1 and 1 Subunits

Aoshima, H., Hossain, S. J., Hamamoto, K., Yokoyama, T., Yamada, M. C., & Shingai, R. (2001) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a003037 · Cited by 23

Synthesis, Structure−Activity Relationships at the GABAA Receptor in Rat Brain, and Differential Electrophysiological Profile at the Recombinant Human GABAA Receptor of a Series of Substituted 1,2-Diphenylimidazoles

Asproni, B., Talani, G., Busonero, F., Pau, A., Sanna, S., Cerri, R., Mascia, M. P., Sanna, E., & Biggio, G. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm049120y · Cited by 23

Molecular dynamics simulations of ethanol binding to the transmembrane domain of the glycine receptor: Implications for the channel potentiation mechanism

Cheng, M. H., Coalson, R. D., & Cascio, M. (2007) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.21784 · Cited by 23

The Effects of Isoflurane on Desensitized Wild-Type and ??1(S270H) ??-Aminobutyric Acid Type A Receptors

Hall, A. C., Rowan, K. C., Stevens, R. J. N., Kelley, J. C., & Harrison, N. L. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000111108.78745.ad · Cited by 23

Fine mapping of a sedative‐hypnotic drug withdrawal locus on mouse chromosome 11

Hood, H. M., Metten, P., Crabbe, J. C., & Buck, K. J. (2005) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2005.00122.x · Cited by 23

Halogenated Diazirines as Photolabel Mimics of the Inhaled Haloalkane Anesthetics

Eckenhoff, R. G., Knoll, F. J., Greenblatt, E. P., & Dailey, W. P. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm0104926 · Cited by 23

General Anesthetics Have Additive Actions on Three Ligand Gated Ion Channels

Jenkins, A., Lobo, I. A., Gong, D., Trudell, J. R., Solt, K., Harris, R. A., & Eger, E. I. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31817b70c1 · Cited by 23

Modulating inhibitory ligand-gated ion channels

Cascio, M. (2006) · The AAPS Journal · doi:10.1007/bf02854906 · Cited by 23

Residues in the first transmembrane domain of theCaenorhabditis elegansGABAAreceptor confer sensitivity to the neurosteroid pregnenolone sulfate

Wardell, B. B., Marik, P. S., Piper, D. R., Rutar, T., Jørgensen, E. M., & Bamber, B. A. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706719 · Cited by 23

Nonimmobilizers and Transitional Compounds May Produce Convulsions by Two Mechanisms

Eger, E. I., Koblin, D. D., Sonner, J. M., Gong, D., Laster, M. J., Ionescu, P., Halsey, M. J., & Hudlický, T. (1999) · Anesthesia & Analgesia · doi:10.1097/00000539-199904000-00037 · Cited by 23

GABA system as the cause and effect in early development

Topchiy, I., Mohbat, J., Folorunso, O. O., Wang, Z., Lazcano-Etchebarne, C., & Engin, E. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105651 · Cited by 26

Optical Reversal of Halothane-Induced Immobility in C. elegans

Singaram, V. K., Somerlot, B. H., Falk, S. A., Falk, M. J., Sedensky, M. M., & Morgan, P. G. (2011) · Current Biology · doi:10.1016/j.cub.2011.10.042 · Cited by 23

Alcohol‐Induced Tolerance and Physical Dependence in Mice With Ethanol Insensitive α1 GABAAReceptors

Werner, D. F., Swihart, A., Ferguson, C., Lariviere, W. R., Harrison, N. L., & Homanics, G. E. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00832.x · Cited by 22

Amphetamine Potentiates the Effects of β-Phenylethylamine through Activation of an Amine-Gated Chloride Channel

Safratowich, B. D., Hossain, M., Bianchi, L. K., & Carvelli, L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3100-13.2014 · Cited by 22

The tongue and its control by sleep state-dependent modulators.

Horner, R. L. (2011) · PubMed · doi:10.4449/aib.v149i4.1256 · Cited by 22

Etomidate and propofol-hyposensitive GABAA receptor β3(N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal

Sanchis‐Segura, C., Cline, B. H., Jurd, R., Rudolph, U., & Spanagel, R. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.024 · Cited by 22

Channel Opening by Anesthetics and GABA Induces Similar Changes in the GABAA Receptor M2 Segment

Rosen, A., Bali, M., Horenstein, J., & Akabas, M. H. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.094490 · Cited by 22

Volatile Aromatic Anesthetics Variably Impact Human γ-Aminobutyric Acid Type A Receptor Function

Kelly, E. W., Solt, K., & Raines, D. E. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000282829.21797.97 · Cited by 22

Molecular Dynamics Simulations of C2F6 Effects on Gramicidin A: Implications of the Mechanisms of General Anesthesia

Liu, Z., Xu, Y., & Tang, P. S. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.055566 · Cited by 22

Linear transformation of the encoding mechanism for light intensity underlies the paradoxical enhancement of cortical visual responses by sevoflurane

Arena, A., Lamanna, J., Gemma, M. F., Ripamonti, M., Ravasio, G., Zimarino, V., Vitis, A. D., Beretta, L., & Malgaroli, A. (2016) · The Journal of Physiology · doi:10.1113/jp272215 · Cited by 22

Chirality in Anesthesia II: Stereoselective Modulation of Ion Channel Function by Secondary Alcohol Enantiomers

Brosnan, R. J., Gong, D., Cotten, J. F., Keshavaprasad, B., Yost, C. S., Eger, E. I., & Sonner, J. M. (2006) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000221437.87338.af · Cited by 22

Rat brain DNA transcript profile of halothane and isoflurane exposure

Pan, J. Z., Wei, H., Hecker, J., Tobias, J., Eckenhoff, R., & Eckenhoff, M. (2006) · Pharmacogenetics & Genomics · doi:10.1097/01.fpc.0000189795.21770.08 · Cited by 27

Structures, Diversity and Pharmacology of Glycine Receptors and Transporters

Betz, H., Harvey, R. J., & Schloss, P. D. (2001) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-56833-6_16 · Cited by 22

Are Sobriety and Consciousness Determined by Water in Protein Cavities?

Trudell, J. R., & Harris, R. A. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000108648.32241.bd · Cited by 22

Amino acids in transmembrane domain two influence anesthetic enhancement of serotonin-3A receptor function

Lopreato, G. F., Banerjee, P., & Mihic, S. J. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(03)00332-2 · Cited by 22

Trichloroethanol Modulation of Recombinant GABAA, Glycine and GABA ρ1 Receptors

Krasowski, M. D., Finn, S. E., Ye, Q., & Harrison, N. L. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37323-9 · Cited by 22

Neurotoxicity of organic solvents: An update on mechanisms and effects

van Thriel, C., & Boyes, W. K. (2022) · Advances in neurotoxicology · doi:10.1016/bs.ant.2022.05.004 · Cited by 21

Gene specific modifications unravel ethanol and acetaldehyde actions

Israel, Y., Rivera‐Meza, M., Karahanian, E., Quintanilla, M. E., Tampier, L., Morales, P., & Herrera‐Marschitz, M. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00080 · Cited by 21

Discovery of a Novel General Anesthetic Chemotype Using High-throughput Screening

McKinstry-Wu, A. R., Bu, W., Rai, G., Lea, W., Weiser, B. P., Liang, D., Simeonov, A. M., Jadhav, A., Maloney, D. J., & Eckenhoff, R. G. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000505 · Cited by 21

Rodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research

Fritz, B. M., & Boehm, S. L. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.05.012 · Cited by 24

Differential actions of ethanol and trichloroethanol at sites in the M3 and M4 domains of the NMDA receptor GluN2A (NR2A) subunit

Salous, A. K., Ren, H., Lamb, K., Hu, X., Lipsky, R. H., & Peoples, R. W. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00397.x · Cited by 21

Glycine Receptors Contribute to Hypnosis Induced by Ethanol

Ye, J. H., Sokol, K. A., & Bhavsar, U. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00928.x · Cited by 21

Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit

Schofield, C. M., & Harrison, N. L. (2004) · Brain Research · doi:10.1016/j.brainres.2004.11.002 · Cited by 21

The Site of Action of General Anesthetics - A Chemical Approach

Sándorfy, C. (2005) · Collection of Czechoslovak Chemical Communications · doi:10.1135/cccc20050539 · Cited by 21

Differential effects of ethanol on glycine uptake mediated by the recombinant GLYT1 and GLYT2 glycine transporters

Núñez, E., López‐Corcuera, B., Maza, R. M., & Aragón, C. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703100 · Cited by 21

The Sensitivity of G Protein-activated K+ Channels toward Halothane Is Essentially Determined by the C Terminus

Milovic, S., Steinecker-Frohnwieser, B., Schreibmayer, W., & Weigl, L. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403448200 · Cited by 21

Volatile anesthetics modulate the binding of guanine nucleotides to the α subunits of heterotrimeric GTP binding proteins

Pentyala, S., Sung, K.-Y., Chowdhury, A., & Rebecchi, M. J. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00625-1 · Cited by 21

Point Mutation in the First Transmembrane Region of the β2 Subunit of the γ-Aminobutyric Acid Type A Receptor Alters Desensitization Kinetics of γ-Aminobutyric Acid- and Anesthetic-induced Channel Gating

Engblom, A. C., Carlson, B. X., Olsen, R. W., Schousboe, A., & Kristiansen, U. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111215200 · Cited by 21

Gating-induced Conformational Rearrangement of the γ-Aminobutyric Acid Type A Receptor β-α Subunit Interface in the Membrane-spanning Domain

Bali, M., & Akabas, M. H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.363341 · Cited by 20

The influence of manipulations to alter ambient GABA concentrations on the hypnotic and immobilizing actions produced by sevoflurane, propofol, and midazolam

Nishikawa, K., Kubo, K., Obata, H., Yanagawa, Y., & Saito, S. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.025 · Cited by 20

Opposing Actions of Sevoflurane on GABAergic and Glycinergic Synaptic Inhibition in the Spinal Ventral Horn

Eckle, V., Hauser, S., Drexler, B., Antkowiak, B., & Grasshoff, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060286 · Cited by 19

The Effects of Volatile Aromatic Anesthetics on Voltage-Gated Na+ Channels Expressed in Xenopus Oocytes

Horishita, T., Eger, E. I., & Harris, R. A. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318184b966 · Cited by 20

Prior social experience affects the behavioral and neural responses to acute alcohol in juvenile crayfish

Swierzbinski, M. E., Lazarchik, A. R., & Herberholz, J. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.154419 · Cited by 20

Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors

Sparling, B. A., & DiMauro, E. F. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.04.073 · Cited by 23

In Search of GABAA Receptor’s Neurosteroid Binding Sites

Álvarez, L. D., Pecci, A., & Estrin, D. A. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01400 · Cited by 20

Alcoholism and Alternative Splicing of Candidate Genes

Sasabe, T., & Ishiura, S. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041448 · Cited by 20

Ammonia Has Anesthetic Properties

Brosnan, R. J., Yang, L., Milutinovic, P. S., Zhao, J., Laster, M. J., Eger, E. I., & Sonner, J. M. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000264072.97705.0f · Cited by 20

Anesthetic Modulation of Protein Dynamics: Insight from an NMR Study

Canlas, C. G., Cui, T., Li, L., Xu, Y., & Tang, P. S. (2008) · The Journal of Physical Chemistry B · doi:10.1021/jp805952w · Cited by 20

Human glycine α1 receptor inhibition by quercetin is abolished or inversed by α267 mutations in transmembrane domain 2

Lee, B.-H., Lee, J., Yoon, I., Lee, J.-H., Choi, S.-H., Pyo, M. K., Jeong, S. M., Choi, W., Shin, T., Lee, S., et al. (2007) · Brain Research · doi:10.1016/j.brainres.2007.05.057 · Cited by 20

Control of Ethanol Sensitivity of the Glycine Receptor α3 Subunit by Transmembrane 2, the Intracellular Splice Cassette and C-Terminal Domain

Sánchez, A., Yévenes, G. E., Martín, L. S., Burgos, C. F., Moraga‐Cid, G., Harvey, R. J., & Aguayo, L. G. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.221143 · Cited by 20

Volatile An�sthetika

Loscar, M., & Conzen, P. (2004) · Der Anaesthesist · doi:10.1007/s00101-003-0632-6 · Cited by 20

NMR Studies of Drug Interaction with Membranes and Membrane-Associated Proteins

Xu, Y., Yushmanov, V. E., & Tang, P. S. (2002) · Bioscience Reports · doi:10.1023/a:1020182404940 · Cited by 20

Allosteric Modulation of GABAA Receptor Function by General Anesthetics and Alcohols

Krasowski, M. D., Harris, R. A., & Harrison, N. L. (2001) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-56833-6_5

Antagonism of Inhalant and Volatile Anesthetic Enhancement of Glycine Receptor Function

Beckstead, M. J., Phelan, R., & Mihic, S. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011627200 · Cited by 44

The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations

Krasowski, M. D., & Harrison, N. L. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703087 · Cited by 145

Anaesthetics set their sites on ion channels

Franks, N. P., & Lieb, W. R. (1997) · Nature · doi:10.1038/38614 · Cited by 88

Inhibition of rho1 receptor GABAergic currents by alcohols and volatile anesthetics.

Mihic, S. J., & Harris, R. A. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12838-3 · Cited by 101