Cited by 3,529Helicobacter pylori-related gastroenterology studiesBacterial Genetics and BiotechnologyGenomics and Phylogenetic Studies

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The complete genome sequence of the gastric pathogen Helicobacter pylori

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Tomb, Jean-F., White, Owen, Kerlavage, Anthony R., Clayton, Rebecca A., Sutton, Granger G., Fleischmann, Robert D., Ketchum, Karen A., Klenk, Hans Peter, Gill, Steven, Dougherty, Brian A., Nelson, Karen, Quackenbush, John, Zhou, Lixin, Kirkness, Ewen F., Peterson, Scott, Loftus, Brendan, Richardson, Delwood, Dodson, Robert, Khalak, Hanif G., Glodek, Anna, McKenney, Keith, Fitzegerald, Lisa M., Lee, Norman, Adams, Mark D., Hickey, Erin K., Berg, Douglas E., Gocayne, Jeanine D., Utterback, Teresa R., Peterson, Jeremy D., Kelley, Jenny M., Cotton, Matthew D., Weidman, Janice M., Fujii, Claire, Bowman, Cheryl, Watthey, Larry, Wallin, Erik, Hayes, William S., Borodovsky, Mark, Karp, Peter D., Smith, Hamilton O., Fraser, Claire M., Venter, J. Craig·1997·Nature

DOI 10.1038/41483

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Abstract

Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.

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Authors: Tomb, J.-F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S., Dougherty, B. A., Nelson, K., Quackenbush, J., Zhou, L., Kirkness, E. F., Peterson, S., Loftus, B., Richardson, D., Dodson, R., Khalak, H. G., Glodek, A., McKenney, K., Fitzegerald, L. M., Lee, N., Adams, M. D., Hickey, E. K., Berg, D. E., Gocayne, J. D., Utterback, T. R., Peterson, J. D., Kelley, J. M., Cotton, M. D., Weidman, J. M., Fujii, C., Bowman, C., Watthey, L., Wallin, E., Hayes, W. S., Borodovsky, M., Karp, P. D., Smith, H. O., Fraser, C. M., & Venter, J. C.
Affiliations: Washington University in St. Louis (US)
Stockholm University (SE)
Georgia Institute of Technology (US)
SRI International (US)
Johns Hopkins University (US)
Corresponding author: Tomb, Jean-F.
ORCID: White, Owen
Kerlavage, Anthony R.
Ketchum, Karen A.
Gill, Steven
Dougherty, Brian A.
Quackenbush, John
Zhou, Lixin
Loftus, Brendan
Adams, Mark D.
Wallin, Erik
Borodovsky, Mark
Karp, Peter D.
Fraser, Claire M.
Venter, J. Craig
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-08-07
Volume: 388
Issue: 6642
Pages: 539-547
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/41483
OpenAlex: W2110132014
Cited by: 3,529
References: 45
Citations by year: 2026: 23 · 2025: 41 · 2024: 36 · 2023: 45 · 2022: 36 · 2021: 60 · 2020: 43 · 2019: 50 · 2018: 71 · 2017: 66 · 2016: 92 · 2015: 82 · 2014: 148 · 2013: 101 · 2012: 102
FWCI: 324.03
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: European Synchrotron Radiation Facility
National Institutes of Health
National Center for Research Resources
Topics: Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
Keywords: Helicobacter pylori, complete genome sequence, motility genes, iron acquisition, adhesins, outer membrane proteins, lipoproteins, host-pathogen interaction, antigenic variation, slipped-strand mispairing, recombination, regulatory networks, acid resistance, membrane potential, strain 26695
MeSH terms: Antigenic Variation, Bacterial Adhesion, Bacterial Proteins, Base Sequence, Cell Division, DNA Repair, DNA, Bacterial, Biological Evolution, Hydrogen-Ion Concentration, Molecular Sequence Data, Recombination, Genetic, Transcription, Genetic, Protein Biosynthesis, Virulence, Gene Expression Regulation, Bacterial, Helicobacter pylori, Genome, Bacterial

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