The DOI matches its Crossref record; 44 of the 45 references it cites were found in a registry or an index.
The complete genome sequence of the gastric pathogen Helicobacter pylori
Open accessAbstract
Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.
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“The complete genome sequences of two H. pylori strains, 26695 and J99 (1, 34), have been published elsewhere and demonstrate that this organism contains only two rRNA operons, increasing the likelihood that rRNA mutations could arise.”
From Mutations in the 16S rRNA Genes of Helicobacter pylori Mediate Resistance to Tetracycline (2002) · cites this paper as [34]
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“Analysis of the H. pylori genome sequences (1, 34) indicates that the smallest distances between rdxA and one of the 16S rRNA genes are 193 kb in strain 26695 and 205 kb in strain J99.”
From Mutations in the 16S rRNA Genes of Helicobacter pylori Mediate Resistance to Tetracycline (2002) · cites this paper as [34]
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Flagged first, then by citations
1 of the 45 references couldn’t be matched to a known paper.
Research works printed but not linked: 7
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Towards a Reconstruction of Ancestral Genomes by Gene Cluster Alignment
Wächtershäuser, G. (1998) · Systematic and Applied Microbiology · doi:10.1016/s0723-2020(98)80058-1 · Cited by 39
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Metadata
- Authors
- Tomb, J.-F., White, O., Kerlavage, A. R., Clayton, R. A., Sutton, G. G., Fleischmann, R. D., Ketchum, K. A., Klenk, H. P., Gill, S., Dougherty, B. A., Nelson, K., Quackenbush, J., Zhou, L., Kirkness, E. F., Peterson, S., Loftus, B., Richardson, D., Dodson, R., Khalak, H. G., Glodek, A., McKenney, K., Fitzegerald, L. M., Lee, N., Adams, M. D., Hickey, E. K., Berg, D. E., Gocayne, J. D., Utterback, T. R., Peterson, J. D., Kelley, J. M., Cotton, M. D., Weidman, J. M., Fujii, C., Bowman, C., Watthey, L., Wallin, E., Hayes, W. S., Borodovsky, M., Karp, P. D., Smith, H. O., Fraser, C. M., & Venter, J. C.
- Affiliations
- Washington University in St. Louis (US)
- Stockholm University (SE)
- Georgia Institute of Technology (US)
- SRI International (US)
- Johns Hopkins University (US)
- Corresponding author
- Tomb, Jean-F.
- ORCID
- Venue
- Nature
- Published
- 1997-08-07
- Volume
- 388
- Issue
- 6642
- Pages
- 539-547
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2110132014
- Cited by
- 3,529
- References
- 45
- Citations by year
- 2026: 23 · 2025: 41 · 2024: 36 · 2023: 45 · 2022: 36 · 2021: 60 · 2020: 43 · 2019: 50 · 2018: 71 · 2017: 66 · 2016: 92 · 2015: 82 · 2014: 148 · 2013: 101 · 2012: 102
- FWCI
- 324.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- European Synchrotron Radiation Facility
- National Institutes of Health
- National Center for Research Resources
- Topics
- Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- Helicobacter pylori, complete genome sequence, motility genes, iron acquisition, adhesins, outer membrane proteins, lipoproteins, host-pathogen interaction, antigenic variation, slipped-strand mispairing, recombination, regulatory networks, acid resistance, membrane potential, strain 26695
- MeSH terms
- Antigenic Variation, Bacterial Adhesion, Bacterial Proteins, Base Sequence, Cell Division, DNA Repair, DNA, Bacterial, Biological Evolution, Hydrogen-Ion Concentration, Molecular Sequence Data, Recombination, Genetic, Transcription, Genetic, Protein Biosynthesis, Virulence, Gene Expression Regulation, Bacterial, Helicobacter pylori, Genome, Bacterial
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