Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

Shimomura, Iichiro, Hammer, Robert E., Ikemoto, Shinji, Brown, Michael S., Goldstein, Joseph L.·1999·Nature

DOI 10.1038/43448

Cited by (1,000)

Items 301–400 of 1,000

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Acute effects of brain-derived neurotrophic factor on energy expenditure in obese diabetic mice
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Anil K. Agarwal, Suja Sukumaran, Vı́ctor Cortés, Katie Tunison, Dario Mizrachi, Shireesha Sankella, Robert D. Gerard, Jay D. Horton, Abhimanyu Garg · 2011 · Journal of Biological Chemistry
Protein Tyrosine Phosphatase 1B
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Shangang Zhao, Na Li, Yi Zhu, Leon G. Straub, Zhuzhen Zhang, May-Yun Wang, Qingzhang Zhu, Christine M. Kusminski, Joel Keith Elmquist, Philipp E. Scherer · 2020 · Molecular Metabolism
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Perumal Nagarajan · 2012 · World Journal of Gastroenterology
Leptin alters energy intake and fat mass but not energy expenditure in lean subjects
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Plasma leptin levels and cardiac sympathetic function in patients with obstructive sleep apnoea-hypopnoea syndrome
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Alexander J. Knights, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley, Kim S. Bell-Anderson · 2014 · Adipocyte
Development of conjugated linoleic acid (CLA)-mediated lipoatrophic syndrome in the mouse
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