Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
Shimomura, Iichiro, Hammer, Robert E., Ikemoto, Shinji, Brown, Michael S., Goldstein, Joseph L.·1999·Nature
DOI 10.1038/43448
Cited by (997)
Items 801–900 of 997
- Associations Between Serum Leptin Levels and Transaminase Activities and the Status of Lifestyle in Japanese WorkersHirokazu Yokoyama, Hiroshi Hirose, Hideki Ohgo, Ikuo Saito · 2004 · Alcoholism Clinical and Experimental Research
- Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesityChandramohan Chitraju, Alexander W. Fischer, Yohannes Abere Ambaw, Kun Wang, Bo Yuan, Sheng Tony Hui, Tobias C. Walther, Robert V. Farese · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- The inflammasome: Friend or foe in Chlamydia infection?Emma Louise Walton · 2016 · Biomedical Journal
- Adipose transplantation improves metabolism and atherosclerosis but not perivascular adipose tissue abnormality or vascular dysfunction in lipodystrophic Seipin/Apoe null miceZhe Meng, Chuangxing Liu, Mengke Xu, Ye-Qing Tao, Haiyu Li, Xijia Wang, Jiawei Liao, Mengyu Wang · 2024 · American Journal of Physiology-Cell Physiology
- Precision medicine: toward restoring fat with gene therapy in inherited lipodystrophyXavier Prieur, Lei Cao · 2024 · Gene Therapy
- Low Birth Weight and Insulin Resistance Associated with Lean Body Adiposity in an Adolescent Onset Diabetic PatientNaoya Igaki, Maki Tanaka, Takeo Goto · 2006 · Internal Medicine
- The Sick Adipocyte Theory: The Forces of Clustering at GlanceValmore Bermúdez, Joselyn Rojas, Miguel Aguirre, Clímaco Cano, Nailet Arráiz, Carlos Silva, Marcos Antônio Martins Lima, Raquel Cano, Eneida Fonseca, Manuel Velasco · 2011 · InTech eBooks
- How adipocytes integrate surplus caloric intake with caloric storage: lessons from Morgan Spurlock and some French geeseRoger H. Unger · 2004 · Current Opinion in Endocrinology & Diabetes
- Relation of Trp64Arg Polymorphism of β3-Adrenoreceptor Gene with Cardiovascular Risk Factors in Presurgical Morbidly Obese PatientsDaniel Antonio de Luis, R. Aller, Olatz Izaola, Manuel Gonzalez Sagrado, Rosa Conde · 2008 · Archives of Medical Research
- Serum Leptin Levels in Patients with Alzheimer’s DiseaseAlexandros Papadimitriou, Katerina A. Rizouli, Sokratis E. Karaoulanis, Katerina A Rizouli · 2012 · DOAJ (DOAJ: Directory of Open Access Journals)
- The Central Question of Type 2 DiabetesThaïs Rouquet, Marion S. Bonnet, Pierre Clément, Michel Dallaporta, Jean‐Denis Troadec, Julien Roux, Bruno Bariohay · 2013 · Pharmaceutical Patent Analyst
- Relationship of insulin resistance and adipocytokines on serum alanine aminotransferase in presurgical morbid obese patients.Daniel Antonio de Luis, R. Aller, Olatz Izaola, Manuel Gonzalez Sagrado, Rosa Conde, de la Fuente B, Pérez Castrillón Jl · 2009 · PubMed
- Metabolic Syndrome and AdipokinesToshimasa Yamauchi, Takashi Kadowaki · 2005 · Elsevier eBooks
- Comparative effects of different loads of aerobic exercise on lipid metabolism in MASLD rats: a perspective from the gut-liver axisDeng Dongkun, Qingfeng Jiang, Li Chang, Lin Yunhua, Jiaming Shi, Yufei Liu, Xu Lin · 2025 · Frontiers in Medicine
- Obesity and liver diseaseAyman A. Koteish, Anna Mae Diehl · 2001 · Current Treatment Options in Gastroenterology
- LipodystrophieKonstanze Miehle, Michael Stümvoll, Mathias Faßhauer · 2011 · Der Internist
- Regulated regeneration of adipose tissue in lipodystrophic Agpat2-null mice partially ameliorates hepatic steatosisAnil K. Agarwal, Katie Tunison, Jay D. Horton, Abhimanyu Garg · 2024 · iScience
- Lipodistrofias: bases moleculares y manifestaciones clínicasDavid Araujo Vilar · 2003 · Endocrinología y Nutrición
- Cell transplantation therapy for diabetes mellitus: endocrine pancreas and adipocyte [Review]Junji Fujikura, Kiminori Hosoda, Kazuwa Nakao · 2013 · Endocrine Journal
- MECHANISMS OF ENDOCRINE DISEASE Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic ApproachHarold Edward Bays, Lawrence J. Mandarino, Ralph Anthony DeFronzo · 2004
- HOT TOPIC Adipocytokines and Insulin ResistanceAnastassios G. Pittas, Nandini A. Joseph, Andrew S. Greenberg, Jean Mayer-USDA · 2004
- Jejunal Insulin Signalling Is Increased in Morbidly Obese Subjects with High Insulin Resistance and Is Regulated by Insulin and LeptinCarolina Gutiérrez‐Repiso, Ailec Ho‐Plagaro, Concepción Santiago‐Fernández, Sara García‐Serrano, Francisca Rodríguez‐Pacheco, Sergio Valdés, Lourdes Garrido‐Sánchez, Cristina Rodriguez, Carlos Lopez Gomez, Francisco J. Moreno‐Ruiz et al. · 2020 · Journal of Clinical Medicine
- PPARγ fundamental role in adipogenesisTerrie‐Anne Cock, Johan H. Auwerx · 2004 · International Congress Series
- Mice lacking triglyceride synthesis enzymes in adipose tissue are resistant to diet-induced obesityChandramohan Chitraju, Alexander W. Fischer, Yohannes Abere Ambaw, Kun Wang, Bo Yuan, Sheng Tony Hui, Tobias C. Walther, Robert V. Farese · 2023 · eLife
- Body Mass Index - Overweight, Normal Weight, UnderweightHülya Çakmur · 2022 · IntechOpen eBooks
- Leptin and Acute Lung DisordersAlice Huertas, Jahar Bhattacharya · 2025 · Comprehensive physiology
- Across-species benefits of adrenalectomy on congenital generalized lipoatrophic diabetes: a reviewPatricio H. Contreras, Pilar Vigil P · 2024 · Frontiers in Endocrinology
- Les lipodystrophies génétiquesCamille Vatier, Guillaume Bidault, Caroline Le Dour, Véronique Béréziat, Olivier Lascols, Jacqueline Capeau, Corinne Vigouroux · 2011 · Médecine et Nutrition
- The Importance of the Adiponectin and Leptin Relationship in In Utero and Infant GrowthAnne Lenz, Frank Diamond · 2011 · Springer eBooks
- A highly sensitive enzyme-linked immunosorbent assay for quantification of adipocytokines secreted by mouse adipocytesMinori Mimura, Risako Nabeshima, Miwako Maeda, Naofumi Shiomi · 2008 · Biochemical Engineering Journal
- Leaping for leptin: the 2010 Albert Lasker Basic Medical Research Award goes to Douglas Coleman and Jeffrey M. FriedmanUshma S. Neill · 2010 · Journal of Clinical Investigation
- Metabolic Disorders in HIV-infected Children Metabolic Disorders in HIVinfected ChildrenSpagnuolo M Liguoro · 2014 · Journal of Metabolic Syndrome
- Adipokines and MetabolismRexford S. Ahima, Laura M. Scolaro, Hyeong-Kyu Park · 2015 · Springer eBooks
- Significance of Organ Crosstalk in Insulin Resistance and Type 2 DiabetesS. Bhatt, Rohit Kulkarni · 2012 · Elsevier eBooks
- Role of Adipokines in Controlling Insulin Signaling Pathways in Type-2 Diabetes and Obesity. Current and Future PerspectivesTasneem Bouzid, Frederick G. Hamel, Jung Yul Lim · 2016
- Neuroendocrine Control of Energy StoresRoger D. Cone, Joel Keith Elmquist · 2016 · Elsevier eBooks
- Berardinelli-Seip Syndrome: Report of an Old Case Successfully Treated with Anti-Glucocorticoid Therapy Followed by Bilateral AdrenalectomyPatricio H. Contreras · 2022 · IntechOpen eBooks
- Syndromes of Extreme Insulin ResistanceGeorge Grunberger, Hisham Alrefai · 2004 · Springer eBooks
- Effect of Cannabidiol Oil on Weight Loss in Diet-Induced Obese Mice: Validation StudySae Saem Han, Shinn‐Won Lim, Sook‐Young Woo, Su Jin Lee, Doh Kwan Kim · 2022 · 신경정신의학
- Metabolic Mechanisms of Muscle Insulin ResistanceDeborah M. Muoio, Timothy R. Koves, Jie An, Christopher B. Newgard · 2008 · Humana Press eBooks
- Mediators of Insulin ResistanceRocio I. Pereira, David M. Maahs · 2009 · Humana Press eBooks
- Protein pieces of adipose tissue secretory puzzleFatma Töre, Neşe Tunçel · 2007 · Biomedical Reviews
- Obesity and InflammationJohn Alan Farmer · 2007 · Oxidative stress and disease
- Soy Protein Isolate Suppresses Lipodystrophy-induced Hepatic Lipid Accumulation in Model MiceKoji Nagao, Akiko Matsumoto, Shunichi Kai, Tomoko Kayashima, Teruyoshi Yanagita · 2017 · Journal of Oleo Science
- Protective effects of dietary restriction and physical exercise on intrahepatic fat accumulationYuka Kurosaka, Hideki Yamauchi, Shigeru Takemori, Kumiko Minato · 2018 · The Journal of Physical Fitness and Sports Medicine
- THE RELATIONSHIP THE LEPTIN HORMONE, OBESITY AND DIABETESAysel Sarı, Mateen Bahjat Sadeq · 2020 · NWSA Academic Journals
- Correction of Insulin Resistance and the Metabolic SyndromeDirk Müller‐Wieland, Jörg Kotzka · 2005 · Handbook of experimental pharmacology
- reply: Leptin and diabetes in lipoatrophic miceIichiro Shimomura, Robert E. Hammer, Shinji Ikemoto, Michael S. Brown, Joseph L. Goldstein · 2000 · Nature
- Sterol-regulatory element binding proteins (SREBPs): gene-regulatory target of statin actionJörg Kotzka, Wilhelm Krone, Dirk Müller‐Wieland · 2002 · Birkhäuser Basel eBooks
- The emerging clinical significance of leptin in humans with absolute or relative leptin deficiencyStergios J. Moschos, Christos Socrates Mantzoros · 2005 · Current Opinion in Internal Medicine
- Adipocyte-derived adiponectin is cardioprotective: fat cells can be our friendsVincent Gerard DeMarco, Kevin C. Dellsperger · 2006 · American Journal of Physiology-Heart and Circulatory Physiology
- The role of Ad-36 and its E4orf-1 protein in modulating glycemic controlEmily Jane Dhurandhar · 2011 · Louisiana State University
- LeptinMartin Grosvenor Myers · 2003 · Elsevier eBooks
- HIV Infection and DiabetesSwaytha Yalamanchi, Todd Tarquin Brown, Adrian Sandra Dobs · 2016 · Springer eBooks
- Neurophysiology of the endocrine systemKiran Prakash, Manpreet Kaur, Shival Srivastav, Mahesh Arjundan Gadhvi, Renuka Sharma · 2024 · Elsevier eBooks
- Le tissue adipeux: Son rôle dans les maladies métaboliquesJ P Pégorier · 2007 · Springer eBooks
- Effect of exogenous leptin on thrombotic and metabolic profiles of FVB/B6 lipodystrophic miceHoda C. Kadouh, Soo Jin Yang, Heidi B. IglayReger, Peter F. Bodary · 2013 · The FASEB Journal
- Local Macrophage Proliferation in Adipose Tissue Is a Characteristic of Obesity-Associated Inflammation: A DissertationAmano, Shinya U. · 2013 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
- Genetic Variation of PPARsMarie‐Claude Vohl, Mostafa Z. Badr, Stefan Wieczorek · 2009 · PPAR Research
- Obesidad y enfermedad hepáticaMaría E. Miquilena-Colina, Carmelo García Monzón · 2010 · Gastroenterología y Hepatología
- Lipin Deficiency Impairs Diurnal Metabolic FuelSwitching Xu, Jack Phan, Mohammed F. Saad, Karen Reue, Irwin J. Kurland · 2006
- Novel Combinatorial Therapies Involving Leptin: Opportunities for Mechanistic Advances and Therapeutic Translation in Human DiseasesTimo D. Müller, Christoffer Clemmensen, Brian Finan, Richard D. DiMarchi, Matthias H. Tschöp · 2014 · Springer eBooks
- A causal role of ATM- and NEMO-dependent NF-κB activation in DNA damage-induced senescence and agingJing Zhao · 2016 · D-Scholarship@Pitt (University of Pittsburgh)
- Synthetic gene circuits: Insulin self-regulationNobuhiro Shojima, Takashi Kadowaki · 2017 · Nature Biomedical Engineering
- Hypothalamic control of glucose and lipid metabolism in skeletal muscleYasuhiko Minokoshi · 2017 · The Journal of Physical Fitness and Sports Medicine
- The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesityGiuseppina Rosaria Umano, Grazia Cirillo, Gianmaria Sanchez, Giulia Rondinelli, Maria Vittoria Foderini, Serena Ferrara, Anna Di Sessa, Pierluigi Marzuillo, Alfonso Papparella, Nicola Santoro et al. · 2023 · Obesity
- Effects of microvascular complications on structural changes in visceral and subcutaneous adiposity among type 2 diabetes patientsShuhei Nakanishi, Rui Kishimoto, Aya Hamaoka, Chihiro Nagano, Mitsue Miyahara, Fumio Sawano · 2016 · Obesity Medicine
- Insulin Resistance and Diabetes Associated with LipodystrophiesSarah M. Leiter, Robert K. Semple · 2017 · Frontiers in diabetes
- Exploring Role of Adipose Organ and Dysmetabolic Effects of Adiposity: Over-Nutrition, Nutrient Overload, Insulin Resistance, T2DM and Other FalloutsVinod Nikhra · 2018 · Research in Medical & Engineering Sciences
- Molecular identification, characterization and structure analysis of house musk shrew (Suncus murinus) leptinSayaka Saga, Noriyasu Sasaki, Toshiro Arai · 2018 · Journal of Advanced Veterinary and Animal Research
- La vie sans tissu adipeux : les lipodystrophies généralisées congénitales ; causes, physiopathologie et prise en charge thérapeutiqueXavier Prieur, Bertrand Cariou, Jocelyne Magré · 2021 · Médecine des Maladies Métaboliques
- Cloning, Characterization and Bioinformatics Analysis of the Sequences of miR-10a and miR-10b in Sheep (Hu sheep)Zhibo Wu, Zhenhan Zhai, Mengyao Wang, Hongxiang Ding, Huibin Shi, Zhilong Tian, Xiaohui Zhang, Yuqin Wang, Caihong Wei, Chong Li · 2021 · Indian Journal of Animal Research
- Adipokines and MetabolismRexford S. Ahima, Hyeong Kyu Park · 2023 · Springer eBooks
- Toward a Mechanistic Understanding of Hepatic Insulin Action and ResistanceJoshua R. Cook · 2014
- Leptin — Signals and Secretions from White Adipose TissuePaul Trayhurn, John H. Beattie, D. Vernon Rayner · 2000 · Springer eBooks
- P287 RELATION OF TRP64ARG POLYMORPHISM OF BETA3ADRENORECEPTOR GENE WITH CARDIOVASCULAR RISK FACTORS IN PRESURGICAL MORBID OBESE PATIENTSDaniel Antonio de Luis, R. Aller, Olatz Izaola, Manuel Gonzalez Sagrado, E.R. Conde · 2009 · Clinical Nutrition Supplements
- Transgenic Approach toward Leptin Biology: The Clinical Implications of Leptin for the Treatment of Obesity-Associated Diabetes and Obesity-Related Hypertension.Hiroaki Masuzaki, Yoshihiro Ogawa, Megumi Aizawa‐Abe, Kazuwa Nakao · 2002 · Endocrine Journal
- Nutrigenomics, β-Cell Function and Type 2 DiabetesRodolfo Nino‐Fong, T. Collins, Catherine B. Chan · 2007 · Current Genomics
- [Leptine participation in the development of liver steatosis and biliar lithiasis].Nahúm Méndez‐Sánchez, Guadalupe Ponciano‐Rodríguez, Norberto Carlos Chávez-Tapia, Misael Uribe · 2005 · PubMed
- Phosphorylation of fetuin-A, a physiological inhibitor of insulin action, regulated by insulin and leptinJames B. Papizan · 2007
- Re: Lovastatin for reduction of leptin in nondialysis patients with type 2 diabetic nephropathy.Farrokhlagha Ahmadi, Azin Mohebi-Nejad · 2014 · Iranian Journal of Kidney Diseases
- HIV Infection and DiabetesMadhu N. Rao, Kathleen M. Mulligan, Morris Schambelan · 2009 · Springer eBooks
- Platelet aggregation inhibitors in prevention and treatment of coronary thrombosis.Marc E.R. Gomes, Freek W.A. Verheugt · 2003 · PubMed
- The molecular and genetic basis of type 2 diabetes mellitusNancy Wei, José C. Florez · 2009 · Dialnet (Universidad de la Rioja)
- Mouse Models of LipodystrophyJimmy Donkor, Karen Reue · 2010 · Wiley eBooks
- Leptin regulates glucose homeostasis via the canonical WNT pathwayKaj Kamstra, Mohammed Z. Rizwan, Julia A. Horsfield, Dominik Pretz, Peter Robin Shepherd, David Ross Grattan, Alexander Tups · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Syndromes of Extreme Insulin ResistanceGeorge Grunberger, Anjana Myneni, Bianca Alfonso · 2017 · Springer eBooks
- Role of the Adipocyte in Metabolism and Endocrine FunctionÉric Ravussin, Steven R. Smith · 2010 · Elsevier eBooks
- The Liver and Insulin Resistance: The Important Convergence of Endocrinology and HepatologyCharissa Chang, Kerry N. Whitt, Zhenqi Liu, Stephen Hugh Caldwell · 2009 · Humana Press eBooks
- Leptin and Intermediary Metabolism: Focus on Glucoregulation and LipidsRachel C. Morgan, Robert V. Considine · 2014 · Springer eBooks
- Insulin Sensitivity and the Onset of Hyperphagia in Fatty RatsHoliday A. Durham · 2004
- MOLECULAR MECHANISMS OF INSULIN RESISTANCE IN HUMAN SKELETAL MUSCLE AND LIPODYSTROPHIC ADIPOSE TISSUEElena Korsheninnikova · 2003 · Työväentutkimus Vuosikirja
- Clinical Applications of LeptinElif A Oral, Alex M. DePaoli · 2006 · Springer eBooks
- Role for Stearoyl-CoA Desaturase-1 in the Metabolic Effects of LeptinPaul Cohen · 2013 · Springer eBooks
- The Molecular Basis of Insulin Action and Insulin ResistanceJoseph Avruch · 2001 · Endocrine updates
- Central Regulation of Insulin SensitivitySilvana Obici, Luciano Rossetti · 2007 · Springer eBooks
- Mapping the Neural Mechanisms by which Leptin Regulates Distinct Physiological Functions.Gwendolyn W. Louis · 2010 · Deep Blue (University of Michigan)
- Lipoatrophic Diabetes MellitusElif A Oral, Stephanie Ann Moran · 2003 · Springer eBooks
- Leptin Secretion and ActionRobert V. Considine · 2010 · Wiley eBooks
- Multiple loci of intra- and extra-hypothalamic leptin receptor expression and action in the mouseRebecca L. Leshan · 2009 · Deep Blue (University of Michigan)