Leptin and diabetes in lipoatrophic mice
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The diabetes phenotype of lipodystrophic mice is ameliorated by leptin administration via a mechanism at least in part independent of food intake and body weight.
“the diabetes phenotype of these lipodystrophic mice is also ameliorated by leptin administration via a mechanism that is, at least in part, independent of its effect on food intake and body weight (64, 168).”
From Leptin and the Central Nervous System Control of Glucose Metabolism (2011) · cites this paper as [64]
Cites
Harrison's Principles of Internal Medicine.
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Congenital leptin deficiency is associated with severe early-onset obesity in humans
Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936 · see citing works
Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998 · see citing works
A leptin missense mutation associated with hypogonadism and morbid obesity
Strobel, A., Issad, T., Camoin, L., Ozata, M., & Strosberg, A. D. (1998) · Nature Genetics · doi:10.1038/ng0398-213 · Cited by 1,158 · see citing works
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038 · see citing works
Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., & Brown, M. S. (1998) · Genes & Development · doi:10.1101/gad.12.20.3182 · Cited by 790 · see citing works
Life without white fat: a transgenic mousePreprint
Moitra, J., Mason, M. M., Olive, M., Krylov, D. Y., Gavrilova, O., Marcus‐Samuels, B., Feigenbaum, L., Lee, E., Aoyama, T., Eckhaus, M., et al. (1998) · Genes & Development · doi:10.1101/gad.12.20.3168 · Cited by 776 · see citing works
Self-citationTroglitazone action is independent of adipose tissue.
Burant, C., Sreenan, S., Hirano, K., Tai, T. A., Lohmiller, J. J., Lukens, J. N., Davidson, N. O., Ross, S. R., & Graves, R. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119839 · Cited by 333 · see citing works
Torpor in mice is induced by both leptin-dependent and -independent mechanisms
Gavrilova, O., Leon, L. R., Marcus‐Samuels, B., Mason, M. M., Castle, A. L., Refetoff, S., Vinson, C., & Reitman, M. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14623 · Cited by 210 · see citing works
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Adipose Tissue as an Endocrine Organ
Ahima, R. S., & Flier, J. S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00301-5 · Cited by 1,608 · see citing works
Leptin in Human Physiology and Pathophysiology
Mantzoros, C. S., Magkos, F., Brinkoetter, M., Sienkiewicz, E., Dardeno, T. A., Kim, S.-Y., Hamnvik, O.-P. R., & Koniaris, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00315.2011 · Cited by 593 · see citing works
Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice
Kim, J. K., Gavrilova, O., Chen, Y., Reitman, M. L., & Shulman, G. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8456 · Cited by 443 · see citing works
Self-citationLeptin and the Central Nervous System Control of Glucose Metabolism
Morton, G. J., & Schwartz, M. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00007.2010 · Cited by 338 · see citing works
Reitman, M. L., Arioglu, E., Gavrilova, O., & Taylor, S. I. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00309-x · Cited by 193 · see citing works
Self-citationColombo, C., Cutson, J. J., Yamauchi, T., Vinson, C., Kadowaki, T., Gavrilova, O., & Reitman, M. L. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2727 · Cited by 147 · see citing works
Self-citationM<scp>ETABOLIC</scp> L<scp>ESSONS FROM</scp> G<scp>ENETICALLY</scp> L<scp>EAN</scp> M<scp>ICE</scp>
Reitman, M. L. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.010402.102849 · Cited by 75 · see citing works
Self-citationLeptin as a Potential Treatment for Obesity: Progress to Date
Bell-Anderson, K. S., & Bryson, J. M. (2004) · Treatments in Endocrinology · doi:10.2165/00024677-200403010-00002 · Cited by 36 · see citing works
- Authors
- Gavrilova, O., Marcus-Samuels, B., Leon, L. R., Vinson, C., & Reitman, M. L.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Reitman, Marc L.
- Venue
- Nature
- Published
- 2000-02-24
- Volume
- 403
- Issue
- 6772
- Pages
- 850-850
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2769269356
- Cited by
- 88
- References
- 9
- Citations by year
- 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 6 · 2012: 7
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- leptin, lipoatrophic diabetes, lipodystrophy, insulin resistance, hyperglycemia, leptin deficiency, fat loss, transgenic mouse model
- MeSH terms
- Animals, Diabetes Mellitus, Lipoatrophic, Disease Models, Animal, Humans, Leptin, Mice
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