Identity crisis
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The extent of cell line misidentification is estimated between one fifth and one third of all cell lines.
“Although no exact numbers are known, the extent of cell line misidentification is estimated between one fifth and one third of all cell lines [4, 14].”
From The ghosts of HeLa: How cell line misidentification contaminates the scientific literature (2017) · cites this paper as [14]
The opening section (S) estimates that between a fifth and a third of cell lines in common use may be misidentified, and reports misidentification in 18–36% of cultures examined. The cited estimate supports the fraction, but the claim extends it from lines in common use to all cell lines. (LLM, conf=0.82)
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Cited by
Sorted by citations
A resource for cell line authentication, annotation and quality control
Yu, M., Selvaraj, S. K., Liang-Chu, M. M. Y., Aghajani, S., Busse, M., Yuan, J., Lee, G., Peale, F., Klijn, C., Bourgon, R., et al. (2015) · Nature · doi:10.1038/nature14397 · Cited by 243 · see citing works
The ghosts of HeLa: How cell line misidentification contaminates the scientific literature
Horbach, S. P. J. M., & Halffman, W. (2017) · PLOS ONE · doi:10.1371/journal.pone.0186281 · Cited by 167 · see citing works
Ye, F., Chen, C., Qin, J., Liu, J., & Zheng, C. (2015) · The FASEB Journal · doi:10.1096/fj.14-266718 · Cited by 144 · see citing works
Gu, M., Yang, M., He, J., Xia, S., Zhang, Z., Wang, Y., Zheng, C., & Shen, C. (2022) · International Journal of Cancer · doi:10.1002/ijc.33789 · Cited by 11 · see citing works
The history, landscape, and outlook of human cell line authentication and security
Harbut, E., Makris, Y., Pertsemlidis, A., & Bleris, L. (2024) · SLAS Discovery · doi:10.1016/j.slasd.2024.100194 · Cited by 8 · see citing works
- Venue
- Nature
- Published
- 2009-02
- Volume
- 457
- Issue
- 7232
- Pages
- 935-936
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W4248123918
- Cited by
- 42
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 4 · 2012: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Biomedical Ethics and Regulation
- Social Sciences › Safety Research › Academic integrity and plagiarism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Keywords
- cell line contamination, research integrity, research funding, research misconduct, scientific fraud
- MeSH terms
- Cell Line, Humans, Quality Control, Research Design, Reproducibility of Results, DNA Fingerprinting, Biological Specimen Banks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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