Sex bias in trials and treatment must end
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Women were historically excluded from research partly because ovarian hormone fluctuations were assumed to induce variability, especially in emotion, that could not be experimentally controlled.
“Women were historically excluded from research participation partly due to the assumption that ovarian hormone fluctuations lead to variation, especially in emotion, that could not be experimentally controlled.”
From Little evidence for sex or ovarian hormone influences on affective variability (2021) · cites this paper as [2]
Cites
National Study of Physician Awareness and Adherence to Cardiovascular Disease Prevention Guidelines
Mosca, L., Linfante, A. H., Benjamin, E. J., Berra, K., Hayes, S. N., Walsh, B. W., Fabunmi, R. P., Kwan, J., Mills, T., & Simpson, S. L. (2005) · Circulation · doi:10.1161/01.cir.0000154568.43333.82 · Cited by 757 · see citing works
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Cancer immunotherapy efficacy and patients' sex: a systematic review and meta-analysis
Conforti, F., Pala, L., Bagnardi, V., De Pas, T., Martinetti, M., Viale, G., Gelber, R. D., & Goldhirsch, A. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30261-4 · Cited by 973 · see citing works
Sex differences in human fatigability: mechanisms and insight to physiological responses
Hunter, S. K. (2014) · Acta Physiologica · doi:10.1111/apha.12234 · Cited by 595 · see citing works
Sex and gender differences in health: Science & Society Series on Sex and Science
Regitz‐Zagrosek, V. (2012) · The EMBO Reports · doi:10.1038/embor.2012.87 · Cited by 572 · see citing works
Sex differences in circadian timing systems: implications for disease
Bailey, M., & Silver, R. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.11.003 · Cited by 348 · see citing works
Sex bias exists in basic science and translational surgical research
Yoon, D. Y., Mansukhani, N. A., Stubbs, V. C., Helenowski, I. B., Woodruff, T. K., & Kibbe, M. R. (2014) · Surgery · doi:10.1016/j.surg.2014.07.001 · Cited by 270 · see citing works
Self-citationDrugCentral 2021 supports drug discovery and repositioning
Avram, S., Bologa, C. G., Holmes, J., Bocci, G., Wilson, T. B., Nguyen, D.-T., Curpan, R., Halip, L., Bora, A., Yang, J. J., et al. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkaa997 · Cited by 189 · see citing works
Sex Differences in Brain Epigenetics
Menger, Y., Bettscheider, M., Murgatroyd, C., & Spengler, D. (2010) · Epigenomics · doi:10.2217/epi.10.60 · Cited by 82 · see citing works
Sabatello, M., & Appelbaum, P. S. (2017) · Hastings Center Report · doi:10.1002/hast.736 · Cited by 79 · see citing works
Towards the inclusion of gender and sex in health research and funding: An institutional perspective
Sharman, Z., & Johnson, J. (2012) · Social Science & Medicine · doi:10.1016/j.socscimed.2011.08.039 · Cited by 50 · see citing works
Little evidence for sex or ovarian hormone influences on affective variability
Weigard, A., Loviska, A. M., & Beltz, A. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-00143-7 · Cited by 32 · see citing works
Autistic People Do Enhance Their Selves
Gernsbacher, M. A., Stevenson, J. L., & Dern, S. (2020) · Social Psychological and Personality Science · doi:10.1177/1948550619865057 · Cited by 21 · see citing works
- Authors
- Kim, A. M., Tingen, C. M., & Woodruff, T. K.
- Affiliations
- Northwestern University (US)
- Venue
- Nature
- Published
- 2010-06
- Volume
- 465
- Issue
- 7299
- Pages
- 688-689
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2045902115
- Cited by
- 254
- References
- 1
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 16 · 2023: 12 · 2022: 18 · 2021: 16 · 2020: 14 · 2019: 9 · 2018: 18 · 2017: 14 · 2016: 17 · 2015: 17 · 2014: 23 · 2013: 17 · 2012: 17
- FWCI
- 19.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Social Sciences › Gender Studies › Diversity and Career in Medicine
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Keywords
- sex bias, gender inequality, women in clinical trials, underrepresentation of women, sex differences in medicine, women's health research, research funding, scholarly publishing, gender equity in medicine
- MeSH terms
- Clinical Trials as Topic, Female, Humans, Male, Sex Characteristics, Sex Factors, Bias, Sex Distribution, Genomic Imprinting, Biomedical Research, Drug Dosage Calculations, Precision Medicine
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