Sex Differences in Brain Epigenetics

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325 · see citing works

Epigenetic programming by maternal behavior

Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177 · see citing works

DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143 · see citing works

The emergence of gender differences in depression during adolescence.

Nolen–Hoeksema, S., & Girgus, J. S. (1994) · Psychological Bulletin · doi:10.1037/0033-2909.115.3.424 · Cited by 2,221 · see citing works

Stability and flexibility of epigenetic gene regulation in mammalian development

Reik, W. (2007) · Nature · doi:10.1038/nature05918 · Cited by 1,963 · see citing works

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,889 · see citing works

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action

Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works

Developmental plasticity and human health

Bateson, P., Barker, D., Clutton-Brock, T., Deb, D., D'Udine, B., Foley, R. A., Gluckman, P., Godfrey, K., Kirkwood, T., Lahr, M. M., et al. (2004) · Nature · doi:10.1038/nature02725 · Cited by 1,742 · see citing works

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

Eden, A., Gaudet, F., Waghmare, A., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083557 · Cited by 1,401 · see citing works

Dynamic DNA methylation programs persistent adverse effects of early-life stress

Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., & Spengler, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2436 · Cited by 1,162 · see citing works

Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics.

Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002 · see citing works

Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response

Rosenfeld, M. G., Lunyak, V. V., & Glass, C. K. (2006) · Genes & Development · doi:10.1101/gad.1424806 · Cited by 952 · see citing works

Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life

Weaver, I. C. G., Champagne, F. A., Brown, S. E., Dymov, S., Sharma, S., Meaney, M. J., & Szyf, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3652-05.2005 · Cited by 905 · see citing works

Plasma Testosterone and Progesterone Titers of Pregnant Rats, Their Male and Female Fetuses, and Neonatal Offspring*

WEISZ, J., & WARD, I. L. (1980) · Endocrinology · doi:10.1210/endo-106-1-306 · Cited by 830 · see citing works

Pubertal transition, stressful life events, and the emergence of gender differences in adolescent depressive symptoms.

Ge, X., Conger, R. D., & Elder, G. H. (2001) · Developmental Psychology · doi:10.1037//0012-1649.37.3.404 · Cited by 788 · see citing works

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

van Haaften, G., Dalgliesh, G. L., Davies, H., Chen, L., Bignell, G., Greenman, C., Edkins, S., Hardy, C., O'Meara, S., Teague, J., et al. (2009) · Nature Genetics · doi:10.1038/ng.349 · Cited by 784 · see citing works

Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis

Mill, J., Tang, T., Kaminsky, Z., Khare, T., Yazdanpanah, S., Bouchard, L., Jia, P., Assadzadeh, A., Flanagan, J., Schumacher, A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.01.008 · Cited by 773 · see citing works

Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood

Weaver, I. C. G., Meaney, M. J., & Szyf, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507526103 · Cited by 771 · see citing works

Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines

Gillies, G. E., & McArthur, S. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002071 · Cited by 733 · see citing works

Maternal Care Associated with Methylation of the Estrogen Receptor-α1b Promoter and Estrogen Receptor-α Expression in the Medial Preoptic Area of Female Offspring

Champagne, F. A., Weaver, I. C. G., Diorio, J., Dymov, S., Szyf, M., & Meaney, M. J. (2006) · Endocrinology · doi:10.1210/en.2005-1119 · Cited by 675 · see citing works

Antidepressant Actions of Histone Deacetylase Inhibitors

Covington, H. E., Maze, I., LaPlant, Q. C., Vialou, V. F., Ohnishi, Y. N., Berton, O., Fass, D. M., Renthal, W., Rush, A. J., Wu, E. Y., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1758-09.2009 · Cited by 624 · see citing works

CLINICAL DEVELOPMENT OF HISTONE DEACETYLASE INHIBITORS AS ANTICANCER AGENTS

Drummond, D. C., Noble, C. O., Kirpotin, D. B., Guo, Z., Scott, G. K., & Benz, C. C. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095825 · Cited by 598 · see citing works

Dnmt3a binds deacetylases and is recruited by a sequence‐specific repressor to silence transcription

Fuks, F., Burgers, W. A., Godin, N., Kasai, M., & Kouzarides, T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.10.2536 · Cited by 555 · see citing works

Epigenetic Reactivation of Tumor Suppressor Genes by a Novel Small-Molecule Inhibitor of Human DNA Methyltransferases

Brueckner, B., Boy, R. G., Siedlecki, P. S., Musch, T., Kliem, H., Zielenkiewicz, P., Suhai, S., Wießler, M., & Lyko, F. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2957 · Cited by 548 · see citing works

Psychopathology in Women and Men: Focus on Female Hormones

Seeman, M. V. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.12.1641 · Cited by 542 · see citing works

Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse

Schroeder, F. A., Lin, C. L., Crusio, W. E., & Akbarian, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.036 · Cited by 541 · see citing works

The Epigenetics of Sex Differences in the Brain: Figure 1.

McCarthy, M. M., Auger, A. P., Bale, T. L., Vries, G. J. D., Dunn, G. A., Forger, N. G., Murray, E. K., Nugent, B. M., Schwarz, J. M., & Wilson, M. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3331-09.2009 · Cited by 478 · see citing works

Sex differences in outcomes of very low birthweight infants: the newborn male disadvantage

Stevenson, D. K., Verter, J., Fanaroff, A. A., Oh, W., Ehrenkranz, R. A., Shankaran, S., Donovan, E. F., Wright, L. L., Lemons, J. A., Tyson, J. E., et al. (2000) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/fn.83.3.f182 · Cited by 474 · see citing works

Males still dominate animal studies

Zucker, I., & Beery, A. K. (2010) · Nature · doi:10.1038/465690a · Cited by 460 · see citing works

Towards a new developmental synthesis: adaptive developmental plasticity and human disease

Gluckman, P. D., Hanson, M. A., Bateson, P., Beedle, A. S., Law, C., Bhutta, Z. A., Anokhin, K. V., Bougneres, P. F., Chandak, G. R., Dasgupta, P. S., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60234-8 · Cited by 400 · see citing works

Treatment of depression: time to consider folic acid and vitamin B12

Coppen, A. J., & Bolander-Gouaille, C. (2005) · Journal of Psychopharmacology · doi:10.1177/0269881105048899 · Cited by 375 · see citing works

Mutations in the JARID1C Gene, Which Is Involved in Transcriptional Regulation and Chromatin Remodeling, Cause X-Linked Mental Retardation

Jensen, L. R., Amende, M., Gurok, U., Moser, B., Gimmel, V., Tzschach, A., Janecke, A. R., Tariverdian, G., Chelly, J., Fryns, J.-P., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/427563 · Cited by 373 · see citing works

Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

Zhou, L., Cheng, X., Connolly, B. A., Dickman, M. J., Hurd, P. J., & HORNBY, D. P. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)00676-9 · Cited by 363 · see citing works

Synergistic Enhancement of Nuclear Receptor Function by p160 Coactivators and Two Coactivators with Protein Methyltransferase Activities

Koh, S. S., Chen, D., Lee, Y., & Stallcup, M. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004228200 · Cited by 360 · see citing works

Prefrontal Dysfunction in Schizophrenia Involves Mixed-Lineage Leukemia 1-Regulated Histone Methylation at GABAergic Gene Promoters

Huang, H.-S., Matevossian, A., Whittle, C., Kim, S. Y., Schumacher, A., Baker, S. P., & Akbarian, S. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3272-07.2007 · Cited by 352 · see citing works

Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat

Szyf, M., Weaver, I. C. G., Champagne, F. A., Diorio, J., & Meaney, M. J. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.10.002 · Cited by 348 · see citing works

Differential Hippocampal Expression of Glutamic Acid Decarboxylase 65 and 67 Messenger RNA in Bipolar Disorder and Schizophrenia

Heckers, S., Stone, D., Walsh, J., Shick, J., Koul, P., & Benes, F. M. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.6.521 · Cited by 322 · see citing works

Sex and Racial Differences in Pharmacological Response: Where Is the Evidence? Pharmacogenetics, Pharmacokinetics, and Pharmacodynamics

Anderson, G. D. (2005) · Journal of Women s Health · doi:10.1089/jwh.2005.14.19 · Cited by 320 · see citing works

Brain masculinization requires androgen receptor function

Sato, T., Matsumoto, T., Kawano, H., Watanabe, T., Uematsu, Y., Sekine, K., Fukuda, T., Aihara, K.-I., Krust, A., Yamada, T., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305303101 · Cited by 303 · see citing works

Regulation of hippocampal H3 histone methylation by acute and chronic stress

Hunter, R. G., McCarthy, K. J., Milne, T. A., Pfaff, D. W., & McEwen, B. S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911143106 · Cited by 290 · see citing works

S-Adenosyl-l-methionine (SAMe): from the bench to the bedside—molecular basis of a pleiotrophic molecule,,

Bottiglieri, T. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.1151s · Cited by 286 · see citing works

Sex bias in trials and treatment must end

Kim, A. M., Tingen, C. M., & Woodruff, T. K. (2010) · Nature · doi:10.1038/465688a · Cited by 254 · see citing works

Brain Estradiol Content in Newborn Rats: Sex Differences, Regional Heterogeneity, and Possible de Novo Synthesis by the Female Telencephalon

Amateau, S. K., Alt, J., Stamps, C. L., & McCarthy, M. M. (2004) · Endocrinology · doi:10.1210/en.2003-1363 · Cited by 242 · see citing works

Distribution of estrogen receptor alpha and beta immunoreactive profiles in the postnatal rat brain

Pérez, S. E., Chen, E.-Y., & Mufson, E. J. (2003) · Developmental Brain Research · doi:10.1016/s0165-3806(03)00223-2 · Cited by 228 · see citing works

Chromatin remodeling in neural development and plasticity

Hsieh, J., & Gage, F. H. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.002 · Cited by 225 · see citing works

Diet and the epigenetic (re)programming of phenotypic differences in behavior

McGowan, P. O., Meaney, M. J., & Moshe Szyf, A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.07.074 · Cited by 212 · see citing works

Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation

Zhao, Z., Fan, L., & Frick, K. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910578107 · Cited by 205 · see citing works

Sex differences in histone modifications in the neonatal mouse brain

Tsai, H., Grant, P. A., & Rissman, E. F. (2009) · Epigenetics · doi:10.4161/epi.4.1.7288 · Cited by 201 · see citing works

Developmental and hormone-induced epigenetic changes to estrogen and progesterone receptor genes in brain are dynamic across the life span

Schwarz, J. M., Nugent, B. M., & McCarthy, M. M. (2010) · Endocrinology · doi:10.1210/en.2010-0142 · Cited by 198 · see citing works

Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior.

Auger, A. P., Tetel, M. J., & McCarthy, M. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7551 · Cited by 196 · see citing works

Fluoxetine and Cocaine Induce the Epigenetic Factors MeCP2 and MBD1 in Adult Rat Brain

Cassel, S. L., Carouge, D., Gensburger, C., Anglard, P., Burgun, C., Dietrich, J., Aunis, D., & Zwiller, J. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.022301 · Cited by 194 · see citing works

Roles of estrogen receptors α and β in differentiation of mouse sexual behavior

Kudwa, A. E., Michopoulos, V., Gatewood, J. D., & Rissman, E. F. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.10.018 · Cited by 190 · see citing works

Sex Differences in Epigenetic Regulation of the Estrogen Receptor-α Promoter within the Developing Preoptic Area

Kurian, J. R., Olesen, K. M., & Auger, A. P. (2010) · Endocrinology · doi:10.1210/en.2009-0649 · Cited by 185 · see citing works

DNA Methyltransferase Is Actively Retained in the Cytoplasm during Early Development

Cardoso, M. C., & Leonhardt, H. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.25 · Cited by 172 · see citing works

Longitudinal effects of adolescent girls' pubertal development, perceptions of pubertal timing, and parental relations on eating problems.

Swarr, A. E., & Richards, M. H. (1996) · Developmental Psychology · doi:10.1037/0012-1649.32.4.636 · Cited by 171 · see citing works

Sex-Specific Differences in Expression of Histone DemethylasesUtxandUtyin Mouse Brain and Neurons

Xu, J., Deng, X., Watkins, R., & Distèche, C. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5382-07.2008 · Cited by 168 · see citing works

Epigenetic Control of Sexual Differentiation of the Bed Nucleus of the Stria Terminalis

Murray, E. K., Hien, A., Vries, G. J. D., & Forger, N. G. (2009) · Endocrinology · doi:10.1210/en.2009-0458 · Cited by 166 · see citing works

Minireview: Sex Chromosomes and Brain Sexual Differentiation

Arnold, A. P., Xu, J., Grisham, W., Chen, X., Kim, Y., & Itoh, Y. (2003) · Endocrinology · doi:10.1210/en.2003-1491 · Cited by 164 · see citing works

Folate for Depressive Disorders: Systematic Review and Meta-Analysis of Randomized Controlled Trials

Taylor, M. J., Carney, S. M., Goodwin, G. M., & Geddes, J. R. (2004) · Journal of Psychopharmacology · doi:10.1177/0269881104042630 · Cited by 163 · see citing works

DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen

Yamagata, Y., Asada, H., Tamura, I., Lee, L., Maekawa, R., Taniguchi, K., Taketani, T., Matsuoka, A., Tamura, H., & Sugino, N. (2009) · Human Reproduction · doi:10.1093/humrep/dep015 · Cited by 151 · see citing works

Uteroplacental insufficiency affects epigenetic determinants of chromatin structure in brains of neonatal and juvenile IUGR rats

Ke, X., Lei, Q., James, S. J., Kelleher, S. L., Melnyk, S., Jernigan, S., Yu, X., Wang, L., Callaway, C. W., Gill, G., et al. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00093.2005 · Cited by 136 · see citing works

Valproate and Amitriptyline Exert Common and Divergent Influences on Global and Gene Promoter-Specific Chromatin Modifications in Rat Primary Astrocytes

Perišić, T., Zimmermann, N., Kirmeier, T., Asmus, M., Tuorto, F., Uhr, M., Holsboer, F., Rein, T., & Zschocke, J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.188 · Cited by 133 · see citing works

Age differentially influences estrogen receptor-α (ERα) and estrogen receptor-β (ERβ) gene expression in specific regions of the rat brain

Wilson, M. E., Rosewell, K. L., Kashon, M. L., Shughrue, P. J., Merchenthaler, I. J., & Wise, P. M. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00406-7 · Cited by 133 · see citing works

Case gender and severity in cerebral palsy varies with intrauterine growth

Jarvis, S. N. (2005) · Archives of Disease in Childhood · doi:10.1136/adc.2004.052670 · Cited by 130 · see citing works

Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues

Pogribny, I. P., James, S. J., Jernigan, S., & Pogribna, M. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.12.014 · Cited by 123 · see citing works

Sex Differences in Progesterone Receptor Expression: A Potential Mechanism for Estradiol-Mediated Sexual Differentiation

Quadros, P. S., Pfau, J. L., Goldstein, A. Y. N., De Vries, G. J., & Wagner, C. K. (2002) · Endocrinology · doi:10.1210/en.2002-211438 · Cited by 123 · see citing works

Epigenetic Regulation of Estrogen Receptor α Gene Expression in the Mouse Cortex during Early Postnatal Development

Westberry, J. M., Trout, A. L., & Wilson, M. E. (2009) · Endocrinology · doi:10.1210/en.2009-0955 · Cited by 118 · see citing works

HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients

Binder, E. B., Kunzel, H. E., Nickel, T., Kern, N., Pfennig, A., Majer, M., Uhr, M., Ising, M., & Holsboer, F. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.018 · Cited by 116 · see citing works

Regulation of Aromatase Gene Expression in the Adult Rat Brain

Roselli, C. E., Abdelgadir, S. E., & Resko, J. A. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00214-1 · Cited by 114 · see citing works

Evidence for S-Adenosyl- L -Methionine (SAM-e) for the Treatment of Major Depressive Disorder

Papakostas, G. I. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.8157su1c.04 · Cited by 113 · see citing works

Sex-related differences in methionine metabolism and plasma homocysteine concentrations

Fukagawa, N. K., Martin, J., Wurthmann, A., Prue, A. H., Ebenstein, D. B., & O’Rourke, B. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.1.22 · Cited by 103 · see citing works

Mecp2 organizes juvenile social behavior in a sex-specific manner

Kurian, J. R., Bychowski, M. E., Forbes-Lorman, R. M., Auger, C. J., & Auger, A. P. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1345-08.2008 · Cited by 100 · see citing works

Epigenetic regulation of the estrogen receptor alpha promoter in the cerebral cortex following ischemia in male and female rats

Westberry, J. M., Prewitt, A. K., & Wilson, M. E. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.048 · Cited by 98 · see citing works

Sex Difference in Mecp2 Expression During a Critical Period of Rat Brain Development

Kurian, J. R., Forbes‐Lorman, R. M., & Auger, A. P. (2007) · Epigenetics · doi:10.4161/epi.2.3.4841 · Cited by 91 · see citing works

Sex Differences in the Development of Estrogen Receptors in the Rat Brain

Kühnemann, S., Brown, T. J., Hochberg, R. B., & MacLusky, N. J. (1994) · Hormones and Behavior · doi:10.1006/hbeh.1994.1046 · Cited by 90 · see citing works

Expression of the nuclear receptor coactivator, cAMP response element-binding protein, is sexually dimorphic and modulates sexual differentiation of neonatal rat brain

Auger, A. P., Perrot-Sinal, T. S., Auger, C. J., Ekas, L. A., Tetel, M. J., & McCarthy, M. M. (2002) · Endocrinology · doi:10.1210/en.143.8.3009 · Cited by 89 · see citing works

Regulation of Progesterone Receptor Expression by Estradiol Is Dependent on Age, Sex and Region in the Rat Brain

Quadros, P. S., & Wagner, C. K. (2008) · Endocrinology · doi:10.1210/en.2007-1133 · Cited by 85 · see citing works

Metabolism of steroids in the brain: a new insight into the role of 5α-reductase and aromatase in brain differentiation and functions

Negri‐Cesi, P., Poletti, A., & Celotti, F. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(96)00083-0 · Cited by 81 · see citing works

Sex differences in progesterone receptor immunoreactivity in neonatal mouse brain depend on estrogen receptor α expression

Wagner, C. K., Pfau, J. L., Vries, G. J. D., & Merchenthaler, I. J. (2001) · Journal of Neurobiology · doi:10.1002/neu.1025 · Cited by 79 · see citing works

Hormonally-mediated Epigenetic Changes to Steroid Receptors in the Developing Brain: Implications for Sexual Differentiation

Nugent, B. M., Schwarz, J., & McCarthy, M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.08.009 · Cited by 76 · see citing works

Androgen receptor mRNA is inversely regulated by testosterone and estradiol in adult mouse brain

Kumar, R., & Thakur, M. K. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.10.011 · Cited by 70 · see citing works

MeCP2 and other methyl‐cpg binding proteins

Jørgensen, H. F., & Bird, A. P. (2002) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.10021 · Cited by 70 · see citing works

Age and gender affect DNMT3a and DNMT3b expression in human liver

Xiao, Y., Word, B. R., Starlard‐Davenport, A., Haefele, A., Lyn‐Cook, B. D., & Hammons, G. (2007) · Cell Biology and Toxicology · doi:10.1007/s10565-007-9035-9 · Cited by 64 · see citing works

Effects of gender and stress on the regulation of steroid receptor coactivator-1 expression in the rat brain and pituitary

Bousios, S., Karandrea, D., Kittas, C., & Kitraki, E. (2001) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(01)00123-6 · Cited by 55 · see citing works

Progesterone Receptors and Neural Development: A Gap between Bench and Bedside?

Wagner, C. K. (2008) · Endocrinology · doi:10.1210/en.2008-0049 · Cited by 55 · see citing works

The Nuclear Receptor Corepressor Has Organizational Effects within the Developing Amygdala on Juvenile Social Play and Anxiety-Like Behavior

Jessen, H. M., Kolodkin, M. H., Bychowski, M. E., Auger, C. J., & Auger, A. P. (2010) · Endocrinology · doi:10.1210/en.2009-0594 · Cited by 53 · see citing works

Sexual differentiation of the rodent hypothalamus: Hormonal and environmental influences

Negri-Cesi, P., Colciago, A., Pravettoni, A., Casati, L., Conti, L., & Celotti, F. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.03.003 · Cited by 50 · see citing works

Expression of Androgen‐Activating Enzymes in Cultured Cells of Developing Rat Brain

Poletti, A., Negri‐Cesi, P., Melcangi, R. C., Colciago, A., Martini, L., & Celotti, F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68031298.x · Cited by 47 · see citing works

Potential role of estrogen in regulation of the Insulin-like growth factor2–H19 locus in the rat testis

Pathak, S., D'Souza, R., Ankolkar, M., Gaonkar, R., & Balasinor, N. H. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.005 · Cited by 40 · see citing works

In the cerebral cortex of female and male mice, amyloid precursor protein (APP) promoter methylation is higher in females and differentially regulated by sex steroids

Mani, S. T., & Thakur, M. K. (2005) · Brain Research · doi:10.1016/j.brainres.2005.10.006 · Cited by 39 · see citing works

Reversible histone methylation regulates brain gene expression and behavior

Xu, J., & Andreassi, M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.08.019 · Cited by 30 · see citing works

Sex‐specific windows for high mRNA expression of DNA methyltransferases 1 and 3A and methyl‐CpG‐binding domain proteins 2 and 4 in human fetal gonads

Galetzka, D., Weis, E., Tralau, T., Seidmann, L., & Haaf, T. (2006) · Molecular Reproduction and Development · doi:10.1002/mrd.20615 · Cited by 28 · see citing works

Histone modifications proposed to regulate sexual differentiation of brain and behavior

Gagnidze, K., Weil, Z. M., & Pfaff, D. W. (2010) · BioEssays · doi:10.1002/bies.201000064 · Cited by 27 · see citing works

5alpha-reductase 2 inhibition impairs brain defeminization of male rats: Reproductive aspects

Ribeiro, C. M., & Pereira, O. C. M. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.08.015 · Cited by 26 · see citing works

EVALUATION OF GENERAL BEHAVIOR, MEMORY, LEARNING PERFORMANCE, AND BRAIN SEXUAL DIFFERENTIATION IN F1 OFFSPRING MALES OF RATS TREATED WITH FLUTAMIDE DURING LATE GESTATION

Goto, K., Koizumi, K., Yoshio, O. H. T. A., HASHI, M., FUJII, Y., Nanae, O. H. B. O., Saika, O., Suzuki, H., Saito, K., & Suzuki, K. (2005) · The Journal of Toxicological Sciences · doi:10.2131/jts.30.249 · Cited by 13 · see citing works

New Evidence that an Epigenetic Mechanism Mediates Testosterone-Dependent Brain Masculinization

Baum, M. J. (2009) · Endocrinology · doi:10.1210/en.2009-0664 · Cited by 8 · see citing works

Women Abound in NIH Trials

Holden, C. (2008) · Science · doi:10.1126/science.322.5899.219 · Cited by 7 · see citing works

Effects of the environmental estrogenic contaminants bisphenol A and 17α-ethinyl estradiol on sexual development and adult behaviors in aquatic wildlife species

Bhandari, R. K., Deem, S. L., Holliday, D. K., Jandegian, C. M., Kassotis, C. D., Nagel, S. C., Tillitt, D. E., Saal, F. S. V., & Rosenfeld, C. S. (2014) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2014.09.014 · Cited by 298 · see citing works

Cortisol in mother's milk across lactation reflects maternal life history and predicts infant temperament

Hinde, K., Skibiel, A. L., Foster, A. B., Rosso, L. A. D., Mendoza, S. P., & Capitanio, J. P. (2014) · Behavioral Ecology · doi:10.1093/beheco/aru186 · Cited by 254 · see citing works

Sex-Biased Gene Expression

Grath, S., & Parsch, J. (2016) · Annual Review of Genetics · doi:10.1146/annurev-genet-120215-035429 · Cited by 239 · see citing works

Epigenetics of sex determination and gonadogenesis

Piferrer, F. (2013) · Developmental Dynamics · doi:10.1002/dvdy.23924 · Cited by 218 · see citing works

Epigenetics of Early Child Development

Murgatroyd, C., & Spengler, D. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00016 · Cited by 195 · see citing works

Encyclopedia of Psychopharmacology

Stolerman, I. P. (2010) · Springer eBooks · doi:10.1007/978-3-540-68706-1 · Cited by 172 · see citing works

The puzzle of sex, gender and Alzheimer’s disease: Why are women more often affected than men?

Andrew, M. K., & Tierney, M. C. (2018) · Women s Health · doi:10.1177/1745506518817995 · Cited by 113 · see citing works

Neuroactive steroids, neurosteroidogenesis and sex

Giatti, S., García‐Segura, L. M., Barreto, G. E., & Melcangi, R. C. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.06.007 · Cited by 105 · see citing works

Epigenetic Contributions to Hormonally‐Mediated Sexual Differentiation of the Brain

McCarthy, M. M., & Nugent, B. M. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12072 · Cited by 96 · see citing works

Epigenetic Risk Factors in PTSD and Depression

Raabe, F. J., & Spengler, D. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00080 · Cited by 94 · see citing works

Opening up the DNA methylome of dementia

Delgado‐Morales, R., & Esteller, M. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.242 · Cited by 74 · see citing works

Sex‐specific expression of estrogen receptors α and β and Kiss1 in the postnatal rat amygdala

Cao, J., & Patisaul, H. B. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23185 · Cited by 67 · see citing works

Genetic and epigenetic architecture of sex-biased expression in the jewel wasps Nasonia vitripennis and giraulti

Wang, X., Werren, J. H., & Clark, A. G. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510338112 · Cited by 63 · see citing works

Sex-specific DNA methylation differences in Alzheimer’s disease pathology

Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01177-8 · Cited by 58 · see citing works

Role of epigenetic factors in the development of mental illness throughout life

Guintivano, J., & Kaminsky, Z. A. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.08.003 · Cited by 54 · see citing works

New knockout model confirms a role for androgen receptors in regulating anxiety-like behaviors and HPA response in mice

Chen, C. V., Brummet, J. L., Lonstein, J. S., Jordan, C. L., & Breedlove, S. M. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.01.001 · Cited by 55 · see citing works

Epigenetic modifications associated with pathophysiological effects of lead exposure

Khalid, M., & Abdollahi, M. R. (2019) · Journal of Environmental Science and Health Part C · doi:10.1080/10590501.2019.1640581 · Cited by 53 · see citing works

Role of Mecp2 in Experience-Dependent Epigenetic Programming

Zimmermann, C. A., Hoffmann, A., Raabe, F. J., & Spengler, D. (2015) · Genes · doi:10.3390/genes6010060 · Cited by 48 · see citing works

Unraveling the Role of Sex in Endothelial Cell Dysfunction: Evidence From Lineage Tracing Mice and Cultured Cells

Shin, J., Hong, J., Edwards, J. M., Krukovets, I., Tkachenko, S., Adelus, M. L., Romanoski, C. E., Rajagopalan, S., Podrez, E. A., Byzova, T. V., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319833 · Cited by 48 · see citing works

Epigenetic modifications associated with in utero exposure to endocrine disrupting chemicals BPA, DDT and Pb

Onuzulu, C. D., Rotimi, O. A., & Rotimi, S. O. (2019) · Reviews on Environmental Health · doi:10.1515/reveh-2018-0059 · Cited by 47 · see citing works

Understanding the role of steroids in typical and atypical brain development: Advantages of using a “brain in a dish” approach

Adhya, D., Annuario, E., Lancaster, M. A., Price, J., Baron‐Cohen, S., & Srivastava, D. P. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12547 · Cited by 45 · see citing works

Sex- and tissue-specific methylome changes in brains of mice perinatally exposed to lead

Sánchez-Martín, F. J., Lindquist, D. M., Landero-Figueroa, J., Zhang, X., Chen, J., Cecil, K. M., Medvedovic, M., & Puga, A. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2014.12.004 · Cited by 43 · see citing works

Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring

Schrott, R., Modliszewski, J. L., Hawkey, A. B., Grenier, C., Holloway, Z., Evans, J., Pippen, E., Corcoran, D. L., Levin, E. D., & Murphy, S. K. (2022) · Epigenetics & Chromatin · doi:10.1186/s13072-022-00466-3 · Cited by 42 · see citing works

Neonatal maternal separation stress elicits lasting DNA methylation changes in the hippocampus of stress‐reactive Wistar Kyoto rats

McCoy, C. R., Rana, S., Stringfellow, S. A., Day, J. J., Wyss, J. M., Clinton, S. M., & Kerman, I. A. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13404 · Cited by 42 · see citing works

Genetic Variation in the Epigenetic Machinery and Mental Health

Murgatroyd, C., & Spengler, D. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0255-1 · Cited by 41 · see citing works

Chromatin Remodeler CHD8 in Autism and Brain Development

Hoffmann, A., & Spengler, D. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10020366 · Cited by 41 · see citing works

Genetic predisposition to high anxiety- and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala

McCoy, C. R., Jackson, N. L., Day, J. J., & Clinton, S. M. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.12.008 · Cited by 39 · see citing works

Altered DNA Methylation in the Developing Brains of Rats Genetically Prone to High versus Low Anxiety

McCoy, C. R., Glover, M. E., Flynn, L. T., Simmons, R. K., Cohen, J. L., Ptacek, T., Lefkowitz, E. J., Jackson, N. L., Akil, H., Wu, X., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1157-15.2019 · Cited by 38 · see citing works

Early life stress and sex-specific sensitivity of the catecholaminergic systems in prefrontal and limbic regions of Octodon degus

Kunzler, J., Braun, K., & Bock, J. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0688-2 · Cited by 38 · see citing works

The Lasting Legacy of Social Stress on the Epigenome of the Hypothalamic–Pituitary–Adrenal Axis

Hoffmann, A., & Spengler, D. (2012) · Epigenomics · doi:10.2217/epi.12.34 · Cited by 37 · see citing works

Heritability of brain volumes in older adults: the Older Australian Twins Study

Batouli, S. A. H., Sachdev, P. S., Wen, W. X., Wright, M. J., Ames, D. J., & Trollor, J. N. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.10.079 · Cited by 35 · see citing works

Epigenetic regulation of neurodevelopmental genes in response to in utero exposure to phthalate plastic chemicals: How can we delineate causal effects?

Ponsonby, A., Symeonides, C., Vuillermin, P., Mueller, J. F., Sly, P. D., & Saffery, R. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.05.011 · Cited by 35 · see citing works

Brain Sexual Differentiation and Requirement of SRY: Why or Why Not?

Rosenfeld, C. S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00632 · Cited by 33 · see citing works

Global DNA Methylation and Histone Posttranslational Modifications in Human and Nonhuman Primate Brain in Association with Prenatal Alcohol Exposure

Jarmasz, J. S., Stirton, H., Basalah, D. A., Davie, J., Clarren, S. K., Astley, S. J., & Bigio, M. R. D. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14052 · Cited by 33 · see citing works

Sex and Brain: The Role of Sex Chromosomes and Hormones in Brain Development and Parkinson’s Disease

Terrin, F., Tesoriere, A., Plotegher, N., & Valle, L. D. (2023) · Cells · doi:10.3390/cells12111486 · Cited by 31 · see citing works

Transgenerational transmission of neurodevelopmental disorders induced by maternal exposure to PM2.5

Zhou, Y., Zhang, M., Liu, W. Y., Li, Y., Qin, Y., & Xu, Y. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126920 · Cited by 30 · see citing works

Prenatal loss of father during World War One is predictive of a reduced lifespan in adulthood

Todd, N., Valleron, A., & Bougneres, P. F. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617911114 · Cited by 29 · see citing works

The Prenatal Hormone Milieu in Autism Spectrum Disorder

Worsham, W., Dalton, S., & Bilder, D. A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.655438 · Cited by 29 · see citing works

Sexual Differentiation and Sex Differences in Neural Development

Turano, A., Osborne, B. F., & Schwarz, J. M. (2018) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_56 · Cited by 29 · see citing works

Inhibition of DNA Methylation in the Developing Rat Brain Disrupts Sexually Dimorphic Neurobehavioral Phenotypes in Adulthood

Li, Y., Ma, Q., Dasgupta, C., Halavi, S., Hartman, R. E., Xiao, D., & Zhang, L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9957-4 · Cited by 28 · see citing works

A paternal methyl donor depleted diet leads to increased anxiety- and depression-like behavior in adult rat offspring

McCoy, C. R., Jackson, N. L., Brewer, R. L., Moughnyeh, M., Smith, D. L., & Clinton, S. M. (2018) · Bioscience Reports · doi:10.1042/bsr20180730 · Cited by 26 · see citing works

Down, But Not Out: Partial Elimination of Androgen Receptors in the Male Mouse Brain Does Not Affect Androgenic Regulation of Anxiety or HPA Activity

Chen, C. V., Brummet, J. L., Jordan, C. L., & Breedlove, S. M. (2015) · Endocrinology · doi:10.1210/en.2015-1417 · Cited by 21 · see citing works

Minding the Gap: Exploring Neuroinflammatory and Microglial Sex Differences in Alzheimer’s Disease

Reed-Geaghan, E. G., & Keller-Norrell, P. R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417377 · Cited by 19 · see citing works

Exposure to dexamethasone during late gestation causes female-specific decreases in core body temperature and prepro-thyrotropin-releasing hormone expression in the paraventricular nucleus of the hypothalamus in rats

Carbone, D. L., Zuloaga, D. G., Lacagnina, A. F., McGivern, R. F., & Handa, R. J. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.07.010 · Cited by 18 · see citing works

Low levels of Methyl-CpG binding protein 2 are accompanied by an increased vulnerability to the negative outcomes of stress exposure during childhood in healthy women

Cosentino, L., Zidda, F., Dukal, H., Witt, S. H., Filippis, B. D., & Flor, H. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02259-4 · Cited by 18 · see citing works

The noncoding human genome and the future of personalised medicine

Cowie, P., Hay, E. A., & MacKenzie, A. (2015) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2014.23 · Cited by 14 · see citing works

Sex-Specific Epigenetics: Implications for Environmental Studies of Brain and Behavior

Kundaković, M. (2017) · Current Environmental Health Reports · doi:10.1007/s40572-017-0172-x · Cited by 14 · see citing works

Prenatal Programming of Psychopathology: The Role of Epigenetic Mechanisms / PRENATALNO PROGRAMIRANJE PSIHIJATRIJSKIH POREMEĆAJA: ULOGA EPIGENETSKIH MEHANIZAMA

Kundaković, M. (2013) · Journal of Medical Biochemistry · doi:10.2478/jomb-2013-0047 · Cited by 11 · see citing works

Epigenetic regulation of Progesterone Receptor isoforms: From classical models to the sexual brain

Vázquez-Martínez, E. R., Mendoza‐Garcés, L., Vergara, E., & Cerbón, M. A. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.05.011 · Cited by 12 · see citing works

Modeling heritability of temperamental differences, stress reactivity, and risk for anxiety and depression: Relevance to research domain criteria (RDoC)

Clinton, S. M., Shupe, E. A., Glover, M. E., Unroe, K. A., McCoy, C. R., Cohen, J. L., & Kerman, I. A. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15158 · Cited by 13 · see citing works

21st Century Neo-Androgyny: What Is Androgyny Anymore and Why We Should Still Care

Woodhill, B. M., & Samuels, C. A. (2022) · Psychological Reports · doi:10.1177/00332941221076759 · Cited by 11 · see citing works

Resilience to Stress: Lessons from Rodents about Nature versus Nurture

Clinton, S. M., Unroe, K. A., Shupe, E. A., McCoy, C. R., & Glover, M. E. (2021) · The Neuroscientist · doi:10.1177/1073858421989357 · Cited by 10 · see citing works

Genetic Aspects of Gender Identity Development and Gender Dysphoria

Klink, D. T., & den Heijer, M. (2013) · Focus on sexuality research · doi:10.1007/978-1-4614-7441-8_2 · Cited by 12 · see citing works

The impact of sex and gender on heart–brain axis dysfunction: current concepts and novel perspectives

Baroni, C., & Lionetti, V. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2020-0391 · Cited by 10 · see citing works

Testosterone works through androgen receptors to modulate neuronal response to anxiogenic stimuli

Chen, C. V., Jordan, C. L., & Breedlove, S. M. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135852 · Cited by 10 · see citing works

Decoding the epigenetic mechanism of mammalian sex determination

Kumar, C., & Roy, J. K. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114011 · Cited by 10 · see citing works

Epigenetics of Reproduction

McCarthy, M. M., & Rissman, E. F. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00052-1 · Cited by 9 · see citing works

Fetal intracranial structures: differences in size according to sex

Kavak, E. Ç., Kavak, S. B., Şanlı, C., Batmaz, I., Özden, S., & Sapmaz, E. (2021) · Journal of Perinatal Medicine · doi:10.1515/jpm-2020-0419 · Cited by 9 · see citing works

Developmental programming of the adrenocortical stress response by yolk testosterone depends on sex and life history stage

Schwabl, H. G., & Partecke, J. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.220152 · Cited by 8 · see citing works

Neonatal fluoxetine exposure delays reflex ontogeny, somatic development, and food intake similarly in male and female rats

Campos, R. D. M. M., Toscano, A. E., Gouveia, H. J. C. B., Lacerda, D. C., Pereira, S. D. C., Paz, I. A. A. D. S. G., Alves, J. S. D., & Manhães‐de‐Castro, R. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2020-0261 · Cited by 7 · see citing works

Sexual dimorphism in brain transcriptomes of Amami spiny rats (Tokudaia osimensis): a rodent species where males lack the Y chromosome

Ortega, M. T., Bivens, N. J., Jogahara, T., Kuroiwa, A., Givan, S. A., & Rosenfeld, C. S. (2019) · BMC Genomics · doi:10.1186/s12864-019-5426-6 · Cited by 6 · see citing works

No Sex Differences in the Frequencies of Common Single Nucleotide Polymorphisms Associated with Age-Related Macular Degeneration

Popp, N. A., Agrón, E., Hageman, G. S., Tuo, J., Chew, E. Y., & Chan, C. (2016) · Current Eye Research · doi:10.1080/02713683.2016.1196708 · Cited by 3 · see citing works

The Origins of Gender, not Sex: Evolution and the Reproductive AxisPreprint

Woodhill, B. M., Samuels, C. A., & Jamieson, G. A. (2024) · doi:10.33774/coe-2020-k7gt1-v10 · Cited by 2 · see citing works

GENETIC BASIS OF GENDER DYSPHORIA

Прилепа, С. А., & Медведева, Е. В. (2017) · Fundamental and Clinical Medicine · doi:10.23946/2500-0764-2017-2-1-75-83 · Cited by 2 · see citing works

Sex vs Gender: A Biological Location for Gender, not Sex.Preprint

Woodhill, B. M., & Samuels, C. A. (2021) · doi:10.33774/coe-2020-k7gt1-v4 · Cited by 3 · see citing works

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Čater, M., Dušek, A., Bartelik, A., Mandillo, S., Golini, E., Rigamonti, M., Bains, R. S., Forrest, H., Rivalan, M., Long, M., et al. (2026) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1002/brv.70184 · Cited by 1 · see citing works

Chapter 5 – Perinatal Neurohormonal Programming and Endocrine Disruption

Rosenfeld, C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801383-0.00005-0 · Cited by 1 · see citing works

Sex vs Gender: A Biological Location for Gender, not Sex.Preprint

Woodhill, B. M., & Samuels, C. A. (2021) · doi:10.33774/coe-2020-k7gt1-v3 · Cited by 1 · see citing works

Shades of pink and blue: Unidimensional spectra of identity within a multidimensional model of diversity.Preprint

Woodhill, B. M., & Samuels, C. A. (2021) · doi:10.33774/coe-2021-bcw4j · Cited by 2 · see citing works

The Biological Origins of Gender, not Sex: A Review of Psychobiological Evidence - Evolution and the Reproductive AxisPreprint

Woodhill, B. M., Samuels, C. A., & Jamieson, G. A. (2023) · doi:10.33774/coe-2020-k7gt1-v9

Epigenetic Mechanisms in Blast-Induced Neurotrauma

Bailey, Z. S. (2017) · VTechWorks (Virginia Tech)

Sex Differences in Drug Effects

Pöğün, Ş., & Yararbaş, G. (2015) · Springer eBooks · doi:10.1007/978-3-642-36172-2_209

Sex Differences in Drug Effects

Pöğün, Ş., & Yararbaş, G. (2014) · Springer eBooks · doi:10.1007/978-3-642-27772-6_209-2

Biologizing Gender: The canalized reproductive axis of gender, not sex.Preprint

Woodhill, B. M., Samuels, C. A., & Jamieson, G. A. (2023) · doi:10.33774/coe-2020-k7gt1-v8

Additional file 2 of Sex-specific DNA methylation differences in Alzheimer’s disease pathology

Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Figshare · doi:10.6084/m9.figshare.14490464

Early-life Exposure to Arsenic Primes the Offspring to Increased Asthma Risk: Transcriptome and Epigenome AnalysisPreprint

Sun, Y., Watfa, M., Sun, Q., Rajasundaram, D., Schlegel, B., Yeung, H.-Y., Pulczinski, J., Park, B. S., Barchowsky, A., Mitzner, W., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.01.668223

Additional file 1 of Sex-specific DNA methylation differences in Alzheimer’s disease pathology

Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Figshare · doi:10.6084/m9.figshare.14490461

Additional file 3 of Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring

Schrott, R., Modliszewski, J. L., Hawkey, A. B., Grenier, C., Holloway, Z., Evans, J., Pippen, E., Corcoran, D. L., Levin, E. D., & Murphy, S. K. (2022) · Figshare · doi:10.6084/m9.figshare.21077552

Additional file 1 of Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring

Schrott, R., Modliszewski, J. L., Hawkey, A. B., Grenier, C., Holloway, Z., Evans, J., Pippen, E., Corcoran, D. L., Levin, E. D., & Murphy, S. K. (2022) · Figshare · doi:10.6084/m9.figshare.21077546

Additional file 4 of Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring

Schrott, R., Modliszewski, J. L., Hawkey, A. B., Grenier, C., Holloway, Z., Evans, J., Pippen, E., Corcoran, D. L., Levin, E. D., & Murphy, S. K. (2022) · Figshare · doi:10.6084/m9.figshare.21077555

Additional file 2 of Sperm DNA methylation alterations from cannabis extract exposure are evident in offspring

Schrott, R., Modliszewski, J. L., Hawkey, A. B., Grenier, C., Holloway, Z., Evans, J., Pippen, E., Corcoran, D. L., Levin, E. D., & Murphy, S. K. (2022) · Figshare · doi:10.6084/m9.figshare.21077549

Trichostatin A Modulates Ethanol Consumption and Reveals Dose- and Sex-Specific Transcriptomic Signatures in the Nucleus Accumbens Shell

Zou, Y., Hauser, S. R., Raba, T. J., Bell, R. L., Lai, Z., & Liang, T. (2026) · Cells · doi:10.3390/cells15161494

Epigenetic mechanisms underlying sex differences in the brain and behavior

Kundaković, M., & Tickerhoof, M. C. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.09.007 · Cited by 85 · see citing works

Sex Differences in the Epigenome: A Cause or Consequence of Sexual Differentiation of the Brain?

Gegenhuber, B., & Tollkühn, J. (2019) · Genes · doi:10.3390/genes10060432 · Cited by 40 · see citing works

Epigenetic Sex: Gene–Environment Contributions to Brain Sex Differences and their Impact on Mental Health Risk

Auger, A. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-802114-9.00015-9 · Cited by 1 · see citing works

Epigenetic Underpinnings of Developmental Sex Differences in the Brain

Nugent, B. M., & McCarthy, M. M. (2011) · Neuroendocrinology · doi:10.1159/000325264 · Cited by 142 · see citing works

Sex-Specific Epigenetics: Implications for Environmental Studies of Brain and Behavior

Kundaković, M. (2017) · Current Environmental Health Reports · doi:10.1007/s40572-017-0172-x · Cited by 14 · see citing works