Too many roads not taken
Edwards, Aled M., Isserlin, Ruth, Bader, Gary D., Frye, Stephen V., Willson, Timothy M., Yu, Frank H.·2011·Nature
DOI 10.1038/470163a
Cited by (412)
Items 201–300 of 412
- Exploring regulatory networks of miR-96 in the developing inner earMorag A. Lewis, Annalisa Buniello, Jennifer M. Hilton, Fei Zhu, William I. Zhang, Stephanie K. Evans, Stijn van Dongen, Anton James Enright, Karen P. Steel · 2016 · Scientific Reports
- Parallel Immunizations of Rabbits Using the Same Antigen Yield Antibodies with Similar, but Not Identical, EpitopesBarbara Hjelm, Björn Forsström, John Löfblom, Johan Rockberg, Mathias Uhlén · 2012 · PLoS ONE
- Establishing the role of rare coding variants in known Parkinson's disease risk lociIris E. Jansen, Jesse Raphael Gibbs, Mike A. Nalls, T. Ryan Price, Steven J Lubbe, Jeroen van Rooij, André Gerardus Uitterlinden, Robert Kraaij, Nigel M. Williams, Alexis Brice et al. · 2017 · Neurobiology of Aging
- Plasma Proteomics, The Human Proteome Project, and Cancer-Associated Alternative Splice Variant ProteinsGilbert S. Omenn · 2013 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- Mapping physical interactions within chromatin by proteomic approachesJean‐Philippe Lambert, Tony J. Pawson, Anne‐Claude Gingras · 2012 · PROTEOMICS
- A Multifunctional Mutagenesis System for Analysis of Gene Function in ZebrafishHelen Ngoc Bao Quach, Shijie Tao, Pavle Vrljicak, Adita Joshi, Hua Ruan, Rashmi Sukumaran, Gaurav K. Varshney, Matthew C. LaFave, The Ds Screen Team, Shawn M. Burgess et al. · 2015 · G3 Genes Genomes Genetics
- Question answering systems in biology and medicine—the time is nowJonathan D. Wren · 2011 · Bioinformatics
- Human genes: Time to follow the roads less traveled?Ian Dunham · 2018 · PLoS Biology
- Predictive Factors for Outcome and Quality of Life in HPV-Positive and HPV-Negative HNSCCJochen Heß · 2016 · Recent results in cancer research/Recent Results in Cancer Research
- Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heartYu Han, Silas D. Wood, Julianna M. Wright, Vishantie Dostal, Edward Lau, Maggie P. Y. Lam · 2021 · Journal of Molecular and Cellular Cardiology
- Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data ScienceDarrin D. Stuart, Angel Guzman-Perez, Natasja Brooijmans, Erica L. Jackson, Gregory V. Kryukov, Adam A. Friedman, Axel Hoos · 2023 · Cancer Discovery
- Dynamics of the discovery process of protein-protein interactions from low content studiesZichen Wang, Neil R. Clark, Avi Ma’ayan · 2015 · BMC Systems Biology
- Prioritizing Proteomics Assay Development for Clinical TranslationMaggie P. Y. Lam, Vidya Venkatraman, Quan Cao, Ding Wang, T. Umut Dincer, Edward Lau, Andrew I. Su, Yi Xing, Junbo Ge, Peipei Ping et al. · 2015 · Journal of the American College of Cardiology
- Recent developments in ligands and chemical probes targeting solute carrier transportersAndrea Casiraghi, Ariel Bensimon, Giulio Superti‐Furga · 2021 · Current Opinion in Chemical Biology
- Rapid de novo discovery of peptidomimetic affinity reagents for human angiotensin converting enzyme 2Genwei Zhang, Joseph S. Brown, Anthony J. Quartararo, Chengxi Li, Xuyu Tan, Stephanie Hanna, Sarah Antilla, Amanda E. Cowfer, Andrei Loas, Bradley L. Pentelute · 2022 · Communications Chemistry
- Probing Cellular Processes Using Engineered NanoparticlesMd. Nazir Hossen, Brennah Murphy, Lorena García‐Hevia, Resham Bhattacharya, Priyabrata Mukherjee · 2018 · Bioconjugate Chemistry
- Challenges, Progresses, and Promises for Developing Future NADPH Oxidase TherapeuticsKaren Bedard, Scott Whitehouse, Vincent Jaquet · 2015 · Antioxidants and Redox Signaling
- Superconserved Receptors Expressed in the Brain: Expression, Function, Motifs and Evolution of an Orphan Receptor FamilyClaudia Stäubert, Monika Woźniak, Nadine Dupuis, Céline Laschet, Thanigaimalai Pillaiyar, Julien Hanson · 2022 · Pharmacology & Therapeutics
- Predicting Preterm Birth Using ProteomicsIvana Marić, David K. Stevenson, Nima Aghaeepour, Brice L Gaudilliere, Ronald J. Wong, Martin S. Angst · 2024 · Clinics in Perinatology
- MorPhiC Consortium: towards functional characterization of all human genesMazhar Adli, Laralynne Przybyla, Tony Burdett, Paul W. Burridge, Pilar Cacheiro, Howard Y. Chang, J Engreitz, Luke A. Gilbert, William James Greenleaf, Li Hsu et al. · 2025 · Nature
- Contextualized Protein-Protein InteractionsAnthony N. Federico, Stefano Monti · 2020 · Patterns
- Ligand Similarity Complements Sequence, Physical Interaction, and Co-Expression for Gene Function PredictionMatthew J. O’Meara, Sara Ballouz, Brian K. Shoichet, Jesse Gillis · 2016 · PLoS ONE
- Biomarker time outAxel Petzold, Robert P. Bowser, Paolo Calabresi, Henrik Zetterberg, Bernard M.J. Uitdehaag · 2014 · Multiple Sclerosis Journal
- A Chromosome-Centric Analysis of Antibodies Directed toward the Human Proteome Using AntibodypediaTove Alm, Kalle von Feilitzen, Emma K. Lundberg, Åsa Sivertsson, Mathias Uhlén · 2014 · Journal of Proteome Research
- Drosophila RNAi screening in a postgenomic worldChris Bakal · 2011 · Briefings in Functional Genomics
- New directions in antimalarial target validationFernando de Assis Batista, Benjamin Baffour Gyau, Juliana F. Vilachã, Soraya Soledad Bosch, Sergey Lunev, Carsten Wrenger, Matthew R. Groves · 2020 · Expert Opinion on Drug Discovery
- Metabotropic signaling cascade involved in α4β2 nicotinic acetylcholine receptor-mediated PKCβII activationSrijan Acharya, Dooti Kundu, Hyun Jin Choi, Kyeong‐Man Kim · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Integrating Large-Scale Protein Structure Prediction into Human Genetics ResearchMiguel Correa Marrero, Jürgen Jänes, Delora Baptista, Pedro Beltrão · 2024 · Annual Review of Genomics and Human Genetics
- Influence networks based on coexpression improve drug target discovery for the development of novel cancer therapeuticsNadia M. Penrod, Jason H. Moore · 2014 · BMC Systems Biology
- Genotype–phenotype relationships in light of a modular protein interaction landscapeMatthias Gstaiger, Ruedi H. Aebersold · 2013 · Molecular BioSystems
- The Chromosome-Centric Human Proteome Project: A Call to ActionAndreas F. R. Hühmer, Aran Paulus, LeRoy B. Martin, Kevin K. Millis, Tasha M. Agreste, Julian A. Saba, Jennie Rebecca Lill, Steven M. Fischer, William Dracup, Paddy Lavery · 2012 · Journal of Proteome Research
- Deorphanization strategies for dark chemical matterAnne Mai Wassermann, Matthew Tudor, Meir Glick · 2017 · Drug Discovery Today Technologies
- Structure-guided drug discovery: back to the futureC.H. Arrowsmith · 2024 · Nature Structural & Molecular Biology
- Who talks to whom about what? How interdisciplinary communication and knowledge of expertise distribution improve in integrated R&D labsMareike Heinzen, Eugenia Cacciatori, Frank A. Zoller, Roman Boutellier · 2018 · Ergonomics
- Drug Target Validation Methods in Malaria - Protein Interference Assay (PIA) as a Tool for Highly Specific Drug Target ValidationKamila Anna Meissner, Sergey Lunev, Yuanze Wang, Marleen Linzke, Fernando de Assis Batista, Carsten Wrenger, Matthew R. Groves · 2016 · Current Drug Targets
- Beyond history and “on a roll”: The list of the most well‐studied human protein structures and overall trends in the protein data bankZhenlu Li, Matthias Buck · 2021 · Protein Science
- Integration of Stemness Gene Signatures Reveals Core Functional Modules of Stem Cells and Potential Novel Stemness GenesTânia Barata, Isabel Duarte, Matthias E. Futschik · 2023 · Genes
- Illuminating the druggable genome through patent bioactivity dataMaría Paula Magariños, Anna Gaulton, Eloy Félix, Tevfik Kizilören, Ricardo Arcila, Tudor Ionel Oprea, Andrew R. Leach · 2023 · PeerJ
- Compensating for literature annotation bias when predicting novel drug-disease relationships through Medical Subject Heading Over-representation Profile (MeSHOP) similarityWarren Cheung, B. F. Francis Ouellette, Wyeth W. Wasserman · 2013 · BMC Medical Genomics
- A gene expression resource generated by genome-wide lacZ profiling in the mouseElizabeth J. Tuck, Jeanne Estabel, Anika Oellrich, Anna Karin B. Maguire, Hibret A. Adissu, Luke Souter, Emma J. Siragher, Charlotte Lillistone, Angela L. Green, Hannah Wardle‐Jones et al. · 2015 · Disease Models & Mechanisms
- Precision medicine: Look to the miceK. C. Kent Lloyd, Terrence F. Meehan, Arthur L. Beaudet, Stephen A. Murray, Karen L. Svenson, Colin McKerlie, David West, Iva S. Morse, Helen Parkinson, Steve D. M. Brown et al. · 2015 · Science
- Data-Driven Exploration of Selectivity and Off-Target Activities of Designated Chemical ProbesFilip N. Miljković, Jürgen Bajorath · 2018 · Molecules
- Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)Felipe de Jesus Cortez, Miyuki Suzawa, Sam Irvy, John M. Bruning, Elena P. Sablin, Matthew P. Jacobson, Robert J. Fletterick, Holly A. Ingraham, Pamela M. England · 2016 · PLoS ONE
- Interactome NetworksAnne‐Ruxandra Carvunis, Frederick P. Roth, Michael A. Calderwood, Michael E. Cusick, Giulio Superti‐Furga, Marc Vidal · 2012 · Elsevier eBooks
- Probing cancer with small-molecule tools—Progress and challengesSusanne Müller, Domenico Sanfelice, Paul Workman · 2025 · Cancer Cell
- The Institute for the Study of Non–Model Organisms and other fantasiesWilliam Sullivan · 2015 · Molecular Biology of the Cell
- Chemical biology tools for protein labelling: insights into cell–cell communicationMegan H. Wright · 2023 · Biochemical Journal
- Determination of minimal transcriptional signatures of compounds for target predictionFlorian Nigsch, Janna Hutz, Ben Cornett, Douglas W. Selinger, Gregory McAllister, Somnath Bandyopadhyay, Joseph Loureiro, Jeremy L. Jenkins · 2012 · EURASIP Journal on Bioinformatics and Systems Biology
- Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modelingXiang Li, Yuan Chen, Hong Qi, Liyu Liu, Jianwei Shuai · 2016 · Oncotarget
- Healthcare innovation and patent law’s ‘pharmaceutical privilege’: is there a pharmaceutical privilege? And if so, should we remove it?Graham Dutfield · 2017 · Health Economics Policy and Law
- The expanding world of protein kinase-like families in bacteria: forty families and countingMarcin Gradowski, Bartosz Baranowski, Krzysztof Pawłowski · 2020 · Biochemical Society Transactions
- A Perspective on Extreme Open Science: Companies Sharing Compounds without RestrictionDavid H. Drewry, Carrow I. Wells, William J. Zuercher, Timothy Mark Willson · 2019 · SLAS DISCOVERY
- Harnessing Noncanonical Proteins for Next‐Generation Drug Discovery and DiagnosisNachiket Rajinikanth, Ruchi Chauhan, Sudhakaran Prabakaran · 2025 · WIREs Mechanisms of Disease
- Integrated multiomic analyses: An approach to improve understanding of diabetic kidney diseaseClaire Hill, Amy Jayne McKnight, Laura Jane Smyth · 2024 · Diabetic Medicine
- Predicting Target and Chemical DruggabilityTudor Ionel Oprea, Catrin Hasselgren · 2017 · Elsevier eBooks
- Phosphoproteomic insights into processes influenced by the kinase-like protein DIA1/C3orf58Agnieszka Hareza, Magdalena Bakun, Bianka Świderska, Małgorzata Dudkiewicz, Alicja Koscielny, Anna T. Bajur, Jacek Jaworski, Michał Dadlez, Krzysztof Pawłowski · 2018 · PeerJ
- The characteristics of early-stage research into human genes are substantially different from subsequent researchThomas Stoeger, Luı́s A. Nunes Amaral · 2022 · PLoS Biology
- Protocols for the Design of Kinase‐focused Compound LibrariesEdgar Jacoby, Berthold Wroblowski, Christophe Buyck, Jean‐Marc Neefs, Christophe Meyer, Maxwell D. Cummings, Herman van Vlijmen · 2017 · Molecular Informatics
- Soft windowing application to improve analysis of high-throughput phenotyping dataHamed Haselimashhadi, Jeremy Mason, Violeta Muñoz‐Fuentes, Federico López, Kola Babalola, Elif Fidan Acar, Vivek Kumar, Jacqui K. White, Ann Marie Flenniken, Ruairidh King et al. · 2019 · Bioinformatics
- A conversation on using chemical probes to study protein function in cells and organisms2022 · Nature Communications
- A Critical Analysis of the FDA’s Omics-Driven Pharmacodynamic Biomarkers to Establish BiosimilaritySarfaraz K. Niazi · 2023 · Pharmaceuticals
- Large-scale knowledge graph representations of disease processesMatti Hoch, Shailendra K. Gupta, Olaf Wolkenhauer · 2024 · Current Opinion in Systems Biology
- Mass Spectrometry-Based Approaches to Understand the Molecular Basis of MemoryArthur Henriques Pontes, Marcelo Valle de Sousa · 2016 · Frontiers in Chemistry
- Pleiotropy data resource as a primer for investigating co-morbidities/multi-morbidities and their role in diseaseVioleta Muñoz‐Fuentes, Hamed Haselimashhadi, Luís Santos, Henrik Westerberg, Helen Parkinson, Jeremy Mason · 2021 · Mammalian Genome
- Polarity Directed Appraisal of Pharmacological Potential and HPLC-DAD Based Phytochemical Profiling of Polygonum glabrum WilldTahira Sultana, Madiha Ahmed, Nosheen Akhtar, Mohammad K. Okla, Abdulrahman Al-Hashimi, Wahidah H. Al-Qahtani, Hamada AbdElgawad, Ihsan Ul Haq · 2022 · Molecules
- Intersection of selenoproteins and kinase signallingAnna Lenart, Krzysztof Pawłowski · 2013 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
- Diversity & tractability revisited in collaborative small molecule phenotypic screening library designBrian R. Lahue, Meir Glick, Matthew Tudor, Scott Arne Johnson, Janet Diratsouian, Mary Jo Wildey, Marybeth S. Burton, Robert Mazzola, Anne Mai Wassermann · 2019 · Bioorganic & Medicinal Chemistry
- Research topic choice: Motivations, strategies, and consequencesSidney Xiang, Daniel M. Romero, Misha Teplitskiy · 2025 · Quantitative Science Studies
- A Pharmacochaperone-Based High-Throughput Screening Assay for the Discovery of Chemical Probes of Orphan ReceptorsCamilo J. Morfa, Daniel L. Bassoni, Andras Szabo, Danielle McAnally, Haleli Sharir, Becky L. Hood, Stefan Vasile, Tom S. Wehrman, Jane E. Lamerdin, Layton Harris Smith · 2018 · Assay and Drug Development Technologies
- Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3Martin Schröder, P. Filippakopoulos, Martin P. Schwalm, Carla Alamillo‐Ferrer, David H. Drewry, Stefan Knapp, A. Chaikuad · 2020 · International Journal of Molecular Sciences
- Accelerating target discovery using pre-competitive open science— patients need faster innovation more than anyone elseEric Low, C. Bountra, Wen Hwa Lee · 2016 · ecancermedicalscience
- Development of Ligands for the Super Conserved Orphan G Protein-Coupled Receptor GPR27 with Improved Efficacy and PotencyThanigaimalai Pillaiyar, Monika Woźniak, Dayana Abboud, Alexander Rasch, Aenne‐Dorothea Liebing, Antti Poso, Thales Kronenberger, Claudia Stäubert, Stefan Laufer, Julien Hanson · 2023 · Journal of Medicinal Chemistry
- Identification and Benchmarking of Myokinasib-II as a Selective and Potent Chemical Probe for Exploring MLCK1 InhibitionGautam Kumar, Prema Kumari Agarwala, Aswin T. Srivatsav, Ashok Ravula, G. Ashmitha, Sreenath Balakrishnan, Shobhna Kapoor, Rishikesh Narayan · 2024 · ACS Chemical Biology
- Open drug discovery in Alzheimer's diseaseAlison D. Axtman, Paul E. Brennan, Tristan Frappier‐Brinton, Ranjita S. Betarbet, Gregory W. Carter, Haian Fu, O. Gileadi, Anna K. Greenwood, Karina Leal, Frank M. Longo et al. · 2023 · Alzheimer s & Dementia Translational Research & Clinical Interventions
- Realizing Our Potential in Biobanking: Disease Advocacy Organizations Enliven Translational ResearchKelly A. Edwards, Sharon F. Terry, Dana Gold, Elizabeth J. Horn, Mary E. Schwartz, Molly Stuart, Suzanne D. Vernon · 2016 · Biopreservation and Biobanking
- Studies in Population GeneticsBaron, Byron · 2012 · InTech eBooks
- Expanding chemogenomic space using chemoproteomicsLyn H. Jones · 2019 · Bioorganic & Medicinal Chemistry
- Network-Based Analysis for Biological DiscoveryLokesh P. Tripathi, Y. Ann Chen, Kenji Mizuguchi, Yoichi Murakami · 2018 · Elsevier eBooks
- Commentary: The International Mouse Phenotyping Consortium: high-throughput in vivo functional annotation of the mammalian genomeK. C. Kent Lloyd · 2024 · Mammalian Genome
- Chemical coverage of human biological pathwaysHaejin Angela Kwak, Lihua Liu, Claudia Tredup, Sandra Röhm, Panagiotis Prinos, Jark Böttcher, Matthieu Schapira · 2024 · Drug Discovery Today
- Temporal trends in evidence supporting novel drug target discoveryMaria J. Falaguera, Ellen M. McDonagh, David Ochoa, Polina V. Rusina, Juan María Roldán‐Romero, David G. Hulcoop, Andrew R. Leach, Ian Dunham · 2025 · Nature Communications
- Open innovation in neuroscience research and drug discoveryAnn Jacqueline Hunter, Wen Hwa Lee, C. Bountra · 2018 · Brain and Neuroscience Advances
- Toward a Jurisprudence of Drug RegulationMatthew Herder · 2014 · The Journal of Law Medicine & Ethics
- Development and Analyses of a Database of Antibody – Antigen ComplexesVarun M. Chauhan, Sumaiya Islam, Alexis Vroom, Robert J. Pantazes · 2018 · Computer-aided chemical engineering/Computer aided chemical engineering
- Identification of Fungicide Targets in Pathogenic FungiAndrew J. Foster · 2018 · Springer eBooks
- Dictyostelium discoideum as a Model in Biomedical ResearchSandra Muñoz‐Braceras, Ana Mesquita, Ricardo Escalante · 2013 · Springer eBooks
- Overcoming research bias: The untapped potential of biomedically important but understudied proteinsSteven Grudman, Carlos J. Madrid-Aliste, András Fiser · 2025 · iScience
- Proteome-Wide Identification and Comparison of Drug Pockets for Discovering New Drug Indications and Side EffectsRenxin Zhang, Zhiyuan Chen, Shuhan Li, Haohao Lv, Jinjun Li, Naixue Yang, Shao‐Xing Dai · 2025 · Molecules
- Synteny – a high throughput web tool to streamline causal gene prioritisation and provide insight into protein functionHarry B. Cutler, Jacqueline Stöckli, Søren Madsen, Stewart W. C. Masson, Oliver K Fuller, Tom Buckingham Shum, David Ernest James · 2025 · Scientific Reports
- Priorities and trends in the study of proteins in eye research, 1924–2014Richard D. Semba, Maggie P. Y. Lam, Kai Sun, Pingbo Zhang, Debra Ann Schaumberg, Luigi Ferrucci, Peipei Ping, Jennifer E. Van Eyk · 2015 · PROTEOMICS - CLINICAL APPLICATIONS
- Policies and Practices to Enhance Multi-sectorial Collaborations and Commercialization of Regenerative MedicineTania M. Bubela, Amrita Mishra, Debra Mathews · 2013 · Springer eBooks
- Focusing on shared subpockets – new developments in fragment-based drug discoveryEman M. M. Abdelraheem, Carlos Jaime Camacho, Alexander S. S. Dömling · 2015 · Expert Opinion on Drug Discovery
- Exploring Integrative Analysis Using the BioMedical Evidence GraphAdam J. Struck, Brian Walsh, Alexander Buchanan, Jordan Lee, Ryan K. Spangler, Joshua M. Stuart, Kyle Ellrott · 2020 · JCO Clinical Cancer Informatics
- The Repertoire of Glycan Alterations and Glycoproteins in Human CancersMedi Kori, Büşra Aydın, Gizem Gülfidan, Hande Beklen, Nurdan Kelesoglu, Aysegul Caliskan, Beste Turanlı, Can Erzık, Betul Karademir-Yilmaz, Kazım Yalçın Arğa · 2021 · OMICS A Journal of Integrative Biology
- Primer on Protein–Protein Interaction MapsNora Marín‐de la Rosa, Pascal Falter‐Braun · 2015 · Wiley eBooks
- The dark side of the ribosome life cycleSébastien Ferreira-Cerca · 2022 · RNA Biology
- PCfun: a hybrid computational framework for systematic characterization of protein complex functionVarun Sharma, Andrea Fossati, Rodolfo Ciuffa, Marija Buljan, Evan G. Williams, Zhen Chen, Wenguang Shao, Patrick G. A. Pedrioli, Anthony Wayne Purcell, María Rodríguez Martínez et al. · 2022 · Briefings in Bioinformatics
- Looking Under the Lamppost: The Search for New Cancer Targets in the Human KinomeMireia Sueca-Comes, Elena Cristina Rusu, Anna M. Grabowska, David O. Bates · 2022 · Pharmacological Reviews
- Diastereoselective Synthesis of Camptothecin‐like Scaffolds: Construction of a New Class of Pseudo‐natural ProductsGourishetty Srikanth, Anil Ravi, Anusha Sebastian, Jobi Joseph, Monther A. Khanfar, Mohammed Ibrahim El-Gamal, Raed A. Al‐Qawasmeh, Ihsan A. Shehadi, Scott McN. Sieburth, Imad A. Abu‐Yousef et al. · 2023 · European Journal of Organic Chemistry
- Funding priorities and health outcomes in Danish medical researchEmil Bargmann Madsen, Jens Peter Andersen · 2024 · Social Science & Medicine