Too many roads not taken

Edwards, Aled M., Isserlin, Ruth, Bader, Gary D., Frye, Stephen V., Willson, Timothy M., Yu, Frank H.·2011·Nature

Cited by (412)

Items 201–300 of 412

  1. Exploring regulatory networks of miR-96 in the developing inner ear
    Morag A. Lewis, Annalisa Buniello, Jennifer M. Hilton, Fei Zhu, William I. Zhang, Stephanie K. Evans, Stijn van Dongen, Anton James Enright, Karen P. Steel · 2016 · Scientific Reports
  2. Parallel Immunizations of Rabbits Using the Same Antigen Yield Antibodies with Similar, but Not Identical, Epitopes
    Barbara Hjelm, Björn Forsström, John Löfblom, Johan Rockberg, Mathias Uhlén · 2012 · PLoS ONE
  3. Establishing the role of rare coding variants in known Parkinson's disease risk loci
    Iris E. Jansen, Jesse Raphael Gibbs, Mike A. Nalls, T. Ryan Price, Steven J Lubbe, Jeroen van Rooij, André Gerardus Uitterlinden, Robert Kraaij, Nigel M. Williams, Alexis Brice et al. · 2017 · Neurobiology of Aging
  4. Plasma Proteomics, The Human Proteome Project, and Cancer-Associated Alternative Splice Variant Proteins
    Gilbert S. Omenn · 2013 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  5. Mapping physical interactions within chromatin by proteomic approaches
    Jean‐Philippe Lambert, Tony J. Pawson, Anne‐Claude Gingras · 2012 · PROTEOMICS
  6. A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish
    Helen Ngoc Bao Quach, Shijie Tao, Pavle Vrljicak, Adita Joshi, Hua Ruan, Rashmi Sukumaran, Gaurav K. Varshney, Matthew C. LaFave, The Ds Screen Team, Shawn M. Burgess et al. · 2015 · G3 Genes Genomes Genetics
  7. Question answering systems in biology and medicine—the time is now
    Jonathan D. Wren · 2011 · Bioinformatics
  8. Human genes: Time to follow the roads less traveled?
    Ian Dunham · 2018 · PLoS Biology
  9. Predictive Factors for Outcome and Quality of Life in HPV-Positive and HPV-Negative HNSCC
    Jochen Heß · 2016 · Recent results in cancer research/Recent Results in Cancer Research
  10. Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heart
    Yu Han, Silas D. Wood, Julianna M. Wright, Vishantie Dostal, Edward Lau, Maggie P. Y. Lam · 2021 · Journal of Molecular and Cellular Cardiology
  11. Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science
    Darrin D. Stuart, Angel Guzman-Perez, Natasja Brooijmans, Erica L. Jackson, Gregory V. Kryukov, Adam A. Friedman, Axel Hoos · 2023 · Cancer Discovery
  12. Dynamics of the discovery process of protein-protein interactions from low content studies
    Zichen Wang, Neil R. Clark, Avi Ma’ayan · 2015 · BMC Systems Biology
  13. Prioritizing Proteomics Assay Development for Clinical Translation
    Maggie P. Y. Lam, Vidya Venkatraman, Quan Cao, Ding Wang, T. Umut Dincer, Edward Lau, Andrew I. Su, Yi Xing, Junbo Ge, Peipei Ping et al. · 2015 · Journal of the American College of Cardiology
  14. Recent developments in ligands and chemical probes targeting solute carrier transporters
    Andrea Casiraghi, Ariel Bensimon, Giulio Superti‐Furga · 2021 · Current Opinion in Chemical Biology
  15. Rapid de novo discovery of peptidomimetic affinity reagents for human angiotensin converting enzyme 2
    Genwei Zhang, Joseph S. Brown, Anthony J. Quartararo, Chengxi Li, Xuyu Tan, Stephanie Hanna, Sarah Antilla, Amanda E. Cowfer, Andrei Loas, Bradley L. Pentelute · 2022 · Communications Chemistry
  16. Probing Cellular Processes Using Engineered Nanoparticles
    Md. Nazir Hossen, Brennah Murphy, Lorena García‐Hevia, Resham Bhattacharya, Priyabrata Mukherjee · 2018 · Bioconjugate Chemistry
  17. Challenges, Progresses, and Promises for Developing Future NADPH Oxidase Therapeutics
    Karen Bedard, Scott Whitehouse, Vincent Jaquet · 2015 · Antioxidants and Redox Signaling
  18. Superconserved Receptors Expressed in the Brain: Expression, Function, Motifs and Evolution of an Orphan Receptor Family
    Claudia Stäubert, Monika Woźniak, Nadine Dupuis, Céline Laschet, Thanigaimalai Pillaiyar, Julien Hanson · 2022 · Pharmacology & Therapeutics
  19. Predicting Preterm Birth Using Proteomics
    Ivana Marić, David K. Stevenson, Nima Aghaeepour, Brice L Gaudilliere, Ronald J. Wong, Martin S. Angst · 2024 · Clinics in Perinatology
  20. MorPhiC Consortium: towards functional characterization of all human genes
    Mazhar Adli, Laralynne Przybyla, Tony Burdett, Paul W. Burridge, Pilar Cacheiro, Howard Y. Chang, J Engreitz, Luke A. Gilbert, William James Greenleaf, Li Hsu et al. · 2025 · Nature
  21. Contextualized Protein-Protein Interactions
    Anthony N. Federico, Stefano Monti · 2020 · Patterns
  22. Ligand Similarity Complements Sequence, Physical Interaction, and Co-Expression for Gene Function Prediction
    Matthew J. O’Meara, Sara Ballouz, Brian K. Shoichet, Jesse Gillis · 2016 · PLoS ONE
  23. Biomarker time out
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  24. A Chromosome-Centric Analysis of Antibodies Directed toward the Human Proteome Using Antibodypedia
    Tove Alm, Kalle von Feilitzen, Emma K. Lundberg, Åsa Sivertsson, Mathias Uhlén · 2014 · Journal of Proteome Research
  25. Drosophila RNAi screening in a postgenomic world
    Chris Bakal · 2011 · Briefings in Functional Genomics
  26. New directions in antimalarial target validation
    Fernando de Assis Batista, Benjamin Baffour Gyau, Juliana F. Vilachã, Soraya Soledad Bosch, Sergey Lunev, Carsten Wrenger, Matthew R. Groves · 2020 · Expert Opinion on Drug Discovery
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    Srijan Acharya, Dooti Kundu, Hyun Jin Choi, Kyeong‐Man Kim · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  28. Integrating Large-Scale Protein Structure Prediction into Human Genetics Research
    Miguel Correa Marrero, Jürgen Jänes, Delora Baptista, Pedro Beltrão · 2024 · Annual Review of Genomics and Human Genetics
  29. Influence networks based on coexpression improve drug target discovery for the development of novel cancer therapeutics
    Nadia M. Penrod, Jason H. Moore · 2014 · BMC Systems Biology
  30. Genotype–phenotype relationships in light of a modular protein interaction landscape
    Matthias Gstaiger, Ruedi H. Aebersold · 2013 · Molecular BioSystems
  31. The Chromosome-Centric Human Proteome Project: A Call to Action
    Andreas F. R. Hühmer, Aran Paulus, LeRoy B. Martin, Kevin K. Millis, Tasha M. Agreste, Julian A. Saba, Jennie Rebecca Lill, Steven M. Fischer, William Dracup, Paddy Lavery · 2012 · Journal of Proteome Research
  32. Deorphanization strategies for dark chemical matter
    Anne Mai Wassermann, Matthew Tudor, Meir Glick · 2017 · Drug Discovery Today Technologies
  33. Structure-guided drug discovery: back to the future
    C.H. Arrowsmith · 2024 · Nature Structural & Molecular Biology
  34. Who talks to whom about what? How interdisciplinary communication and knowledge of expertise distribution improve in integrated R&D labs
    Mareike Heinzen, Eugenia Cacciatori, Frank A. Zoller, Roman Boutellier · 2018 · Ergonomics
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    Kamila Anna Meissner, Sergey Lunev, Yuanze Wang, Marleen Linzke, Fernando de Assis Batista, Carsten Wrenger, Matthew R. Groves · 2016 · Current Drug Targets
  36. Beyond history and “on a roll”: The list of the most well‐studied human protein structures and overall trends in the protein data bank
    Zhenlu Li, Matthias Buck · 2021 · Protein Science
  37. Integration of Stemness Gene Signatures Reveals Core Functional Modules of Stem Cells and Potential Novel Stemness Genes
    Tânia Barata, Isabel Duarte, Matthias E. Futschik · 2023 · Genes
  38. Illuminating the druggable genome through patent bioactivity data
    María Paula Magariños, Anna Gaulton, Eloy Félix, Tevfik Kizilören, Ricardo Arcila, Tudor Ionel Oprea, Andrew R. Leach · 2023 · PeerJ
  39. Compensating for literature annotation bias when predicting novel drug-disease relationships through Medical Subject Heading Over-representation Profile (MeSHOP) similarity
    Warren Cheung, B. F. Francis Ouellette, Wyeth W. Wasserman · 2013 · BMC Medical Genomics
  40. A gene expression resource generated by genome-wide lacZ profiling in the mouse
    Elizabeth J. Tuck, Jeanne Estabel, Anika Oellrich, Anna Karin B. Maguire, Hibret A. Adissu, Luke Souter, Emma J. Siragher, Charlotte Lillistone, Angela L. Green, Hannah Wardle‐Jones et al. · 2015 · Disease Models & Mechanisms
  41. Precision medicine: Look to the mice
    K. C. Kent Lloyd, Terrence F. Meehan, Arthur L. Beaudet, Stephen A. Murray, Karen L. Svenson, Colin McKerlie, David West, Iva S. Morse, Helen Parkinson, Steve D. M. Brown et al. · 2015 · Science
  42. Data-Driven Exploration of Selectivity and Off-Target Activities of Designated Chemical Probes
    Filip N. Miljković, Jürgen Bajorath · 2018 · Molecules
  43. Disulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)
    Felipe de Jesus Cortez, Miyuki Suzawa, Sam Irvy, John M. Bruning, Elena P. Sablin, Matthew P. Jacobson, Robert J. Fletterick, Holly A. Ingraham, Pamela M. England · 2016 · PLoS ONE
  44. Interactome Networks
    Anne‐Ruxandra Carvunis, Frederick P. Roth, Michael A. Calderwood, Michael E. Cusick, Giulio Superti‐Furga, Marc Vidal · 2012 · Elsevier eBooks
  45. Probing cancer with small-molecule tools—Progress and challenges
    Susanne Müller, Domenico Sanfelice, Paul Workman · 2025 · Cancer Cell
  46. The Institute for the Study of Non–Model Organisms and other fantasies
    William Sullivan · 2015 · Molecular Biology of the Cell
  47. Chemical biology tools for protein labelling: insights into cell–cell communication
    Megan H. Wright · 2023 · Biochemical Journal
  48. Determination of minimal transcriptional signatures of compounds for target prediction
    Florian Nigsch, Janna Hutz, Ben Cornett, Douglas W. Selinger, Gregory McAllister, Somnath Bandyopadhyay, Joseph Loureiro, Jeremy L. Jenkins · 2012 · EURASIP Journal on Bioinformatics and Systems Biology
  49. Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling
    Xiang Li, Yuan Chen, Hong Qi, Liyu Liu, Jianwei Shuai · 2016 · Oncotarget
  50. Healthcare innovation and patent law’s ‘pharmaceutical privilege’: is there a pharmaceutical privilege? And if so, should we remove it?
    Graham Dutfield · 2017 · Health Economics Policy and Law
  51. The expanding world of protein kinase-like families in bacteria: forty families and counting
    Marcin Gradowski, Bartosz Baranowski, Krzysztof Pawłowski · 2020 · Biochemical Society Transactions
  52. A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction
    David H. Drewry, Carrow I. Wells, William J. Zuercher, Timothy Mark Willson · 2019 · SLAS DISCOVERY
  53. Harnessing Noncanonical Proteins for Next‐Generation Drug Discovery and Diagnosis
    Nachiket Rajinikanth, Ruchi Chauhan, Sudhakaran Prabakaran · 2025 · WIREs Mechanisms of Disease
  54. Integrated multiomic analyses: An approach to improve understanding of diabetic kidney disease
    Claire Hill, Amy Jayne McKnight, Laura Jane Smyth · 2024 · Diabetic Medicine
  55. Predicting Target and Chemical Druggability
    Tudor Ionel Oprea, Catrin Hasselgren · 2017 · Elsevier eBooks
  56. Phosphoproteomic insights into processes influenced by the kinase-like protein DIA1/C3orf58
    Agnieszka Hareza, Magdalena Bakun, Bianka Świderska, Małgorzata Dudkiewicz, Alicja Koscielny, Anna T. Bajur, Jacek Jaworski, Michał Dadlez, Krzysztof Pawłowski · 2018 · PeerJ
  57. The characteristics of early-stage research into human genes are substantially different from subsequent research
    Thomas Stoeger, Luı́s A. Nunes Amaral · 2022 · PLoS Biology
  58. Protocols for the Design of Kinase‐focused Compound Libraries
    Edgar Jacoby, Berthold Wroblowski, Christophe Buyck, Jean‐Marc Neefs, Christophe Meyer, Maxwell D. Cummings, Herman van Vlijmen · 2017 · Molecular Informatics
  59. Soft windowing application to improve analysis of high-throughput phenotyping data
    Hamed Haselimashhadi, Jeremy Mason, Violeta Muñoz‐Fuentes, Federico López, Kola Babalola, Elif Fidan Acar, Vivek Kumar, Jacqui K. White, Ann Marie Flenniken, Ruairidh King et al. · 2019 · Bioinformatics
  60. A conversation on using chemical probes to study protein function in cells and organisms
    2022 · Nature Communications
  61. A Critical Analysis of the FDA’s Omics-Driven Pharmacodynamic Biomarkers to Establish Biosimilarity
    Sarfaraz K. Niazi · 2023 · Pharmaceuticals
  62. Large-scale knowledge graph representations of disease processes
    Matti Hoch, Shailendra K. Gupta, Olaf Wolkenhauer · 2024 · Current Opinion in Systems Biology
  63. Mass Spectrometry-Based Approaches to Understand the Molecular Basis of Memory
    Arthur Henriques Pontes, Marcelo Valle de Sousa · 2016 · Frontiers in Chemistry
  64. Pleiotropy data resource as a primer for investigating co-morbidities/multi-morbidities and their role in disease
    Violeta Muñoz‐Fuentes, Hamed Haselimashhadi, Luís Santos, Henrik Westerberg, Helen Parkinson, Jeremy Mason · 2021 · Mammalian Genome
  65. Polarity Directed Appraisal of Pharmacological Potential and HPLC-DAD Based Phytochemical Profiling of Polygonum glabrum Willd
    Tahira Sultana, Madiha Ahmed, Nosheen Akhtar, Mohammad K. Okla, Abdulrahman Al-Hashimi, Wahidah H. Al-Qahtani, Hamada AbdElgawad, Ihsan Ul Haq · 2022 · Molecules
  66. Intersection of selenoproteins and kinase signalling
    Anna Lenart, Krzysztof Pawłowski · 2013 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  67. Diversity & tractability revisited in collaborative small molecule phenotypic screening library design
    Brian R. Lahue, Meir Glick, Matthew Tudor, Scott Arne Johnson, Janet Diratsouian, Mary Jo Wildey, Marybeth S. Burton, Robert Mazzola, Anne Mai Wassermann · 2019 · Bioorganic & Medicinal Chemistry
  68. Research topic choice: Motivations, strategies, and consequences
    Sidney Xiang, Daniel M. Romero, Misha Teplitskiy · 2025 · Quantitative Science Studies
  69. A Pharmacochaperone-Based High-Throughput Screening Assay for the Discovery of Chemical Probes of Orphan Receptors
    Camilo J. Morfa, Daniel L. Bassoni, Andras Szabo, Danielle McAnally, Haleli Sharir, Becky L. Hood, Stefan Vasile, Tom S. Wehrman, Jane E. Lamerdin, Layton Harris Smith · 2018 · Assay and Drug Development Technologies
  70. Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3
    Martin Schröder, P. Filippakopoulos, Martin P. Schwalm, Carla Alamillo‐Ferrer, David H. Drewry, Stefan Knapp, A. Chaikuad · 2020 · International Journal of Molecular Sciences
  71. Accelerating target discovery using pre-competitive open science— patients need faster innovation more than anyone else
    Eric Low, C. Bountra, Wen Hwa Lee · 2016 · ecancermedicalscience
  72. Development of Ligands for the Super Conserved Orphan G Protein-Coupled Receptor GPR27 with Improved Efficacy and Potency
    Thanigaimalai Pillaiyar, Monika Woźniak, Dayana Abboud, Alexander Rasch, Aenne‐Dorothea Liebing, Antti Poso, Thales Kronenberger, Claudia Stäubert, Stefan Laufer, Julien Hanson · 2023 · Journal of Medicinal Chemistry
  73. Identification and Benchmarking of Myokinasib-II as a Selective and Potent Chemical Probe for Exploring MLCK1 Inhibition
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  74. Open drug discovery in Alzheimer's disease
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  75. Realizing Our Potential in Biobanking: Disease Advocacy Organizations Enliven Translational Research
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  76. Studies in Population Genetics
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  77. Expanding chemogenomic space using chemoproteomics
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  78. Network-Based Analysis for Biological Discovery
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  79. Commentary: The International Mouse Phenotyping Consortium: high-throughput in vivo functional annotation of the mammalian genome
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  80. Chemical coverage of human biological pathways
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  81. Temporal trends in evidence supporting novel drug target discovery
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  82. Open innovation in neuroscience research and drug discovery
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  83. Toward a Jurisprudence of Drug Regulation
    Matthew Herder · 2014 · The Journal of Law Medicine & Ethics
  84. Development and Analyses of a Database of Antibody – Antigen Complexes
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  85. Identification of Fungicide Targets in Pathogenic Fungi
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  86. Dictyostelium discoideum as a Model in Biomedical Research
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  87. Overcoming research bias: The untapped potential of biomedically important but understudied proteins
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