Too many roads not taken

Edwards, Aled M., Isserlin, Ruth, Bader, Gary D., Frye, Stephen V., Willson, Timothy M., Yu, Frank H.·2011·Nature

DOI 10.1038/470163a

Cited by (411)

Items 101–200 of 411

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Albert A. Antolín, Domenico Sanfelice, Alisa Crisp, Eloy D. Villasclaras-Fernández, Ioan L Mica, Yi Chen, Ian Collins, A.M. Edwards, Susanne Müller, Bissan Al‐Lazikani et al. · 2022 · Nucleic Acids Research
Interactome mapping for analysis of complex phenotypes: Insights from benchmarking binary interaction assays
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Safal Shrestha, Dominic P. Byrne, John A. Harris, Natarajan Kannan, Patrick A. Eyers · 2020 · FEBS Journal
Identifying gene function and module connections by the integration of multispecies expression compendia
Hao Li, Daria Rukina, Fabrice P. A. David, Terytty Yang Li, Chang‐Myung Oh, Arwen W. Gao, Elena Katsyuba, Maroun S. Bou Sleiman, Andrea Komljenović, Qingyao Daniel Huang et al. · 2019 · Genome Research
A roadmap for the functional annotation of protein families: a community perspective
Valérie de Crécy‐Lagard, Rocío Amorín, Cecilia N. Arighi, Jill T. Babor, Alex G. Bateman, Ian K. Blaby, Crysten Blaby, Alan James Bridge, Stephen Kevin Burley, Stacey Cleveland et al. · 2022 · Database
Why responsible innovation?
R. von Schomberg · 2019 · International Handbook on Responsible Innovation
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Jonathan Woodsmith, Ulrich Stelzl · 2013 · Current Opinion in Structural Biology
N-Glycoprotein SRMAtlas
Ruth Hüttenhain, Silvia Šurinová, Reto Ossola, Zhi Sun, David S Campbell, Ferdinando Cerciello, Ralph Schiess, Damaris Bausch‐Fluck, George Rosenberger, J. Chen et al. · 2013 · Molecular & Cellular Proteomics
The Atypical Kinase RIOK1 Promotes Tumor Growth and Invasive Behavior
Florian Weinberg, Nadine Reischmann, Lisa Fauth, Sanaz Taromi, Justin Mastroianni, M. Köhler, Sebastian Halbach, Andrea C. Becker, Niantao Deng, Tatjana Schmitz et al. · 2017 · EBioMedicine
De novo coiled-coil peptides as scaffolds for disrupting protein–protein interactions
Jordan M. Fletcher, Katherine A. Horner, Gail J. Bartlett, Guto G. Rhys, Andrew John Wilson, Derek N. Woolfson · 2018 · Chemical Science
Exon Level Transcriptomic Profiling of HIV-1-Infected CD4+ T Cells Reveals Virus-Induced Genes and Host Environment Favorable for Viral Replication
Michaël Imbeault, Katia Giguère, Michel Ouellet, Michel J. Tremblay · 2012 · PLoS Pathogens
Exploring the dark genome: implications for precision medicine
Tudor Ionel Oprea · 2019 · Mammalian Genome
Protection of the human gene research literature from contract cheating organizations known as research paper mills
Byrne, Jennifer A, Park, Yasunori, Richardson, Reese A K, Pathmendra, Pranujan, Sun, Mengyi, Stoeger, Thomas · 2022 · Nucleic Acids Research
An open invitation to the Understudied Proteins Initiative
Georg Kustatscher, Tom Collins, Anne‐Claude Gingras, Tiannan Guo, Henning Hermjakob, Trey Ideker, Kathryn Susan Lilley, Emma K. Lundberg, Edward M. Marcotte, Markus Ralser et al. · 2022 · Nature Biotechnology
Uncertainty and Risk-Taking in Science: Meaning, Measurement and Management
Chiara Franzoni, Paula E. Stephan · 2021 · Research Policy
A compendium of human gene functions derived from evolutionary modelling
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Anushya Muruganujan, Suzanna Lewis, Dustin Ebert, Tremayne Mushayahama, Suzi Aleksander, James P. Balhoff, Seth Carbon et al. · 2025 · Nature
CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression
Linna Li, Chunping Liu, Robert John Amato, Jeffrey T. Chang, Guangwei Du, Wenliang Li · 2014 · Oncotarget
The Resurrection of Phenotypic Drug Discovery
Wayne E. Childers, Khaled M. Elokely, Magid A. Abou-Gharbia · 2020 · ACS Medicinal Chemistry Letters
An End to the Myth: There Is No Drug Development Pipeline
Kristin Kathleen Baxter, Elizabeth J. Horn, Neely Gal‐Edd, Kristi D. Zonno, James C. O'Leary, Patrick F. Terry, Sharon F. Terry · 2013 · Science Translational Medicine
A Novel Predicted Calcium-Regulated Kinase Family Implicated in Neurological Disorders
Małgorzata Dudkiewicz, Anna Lenart, Krzysztof Pawłowski · 2012 · Nature Precedings
How to Illuminate the Druggable Genome Using Pharos
Timothy K. Sheils, Stephen L. Mathias, Vishal B. Siramshetty, Giovanni Bocci, Cristian Bologa, Jeremy J. Yang, Anna Waller, Noel T Southall, Ðắc-Trung Nguyễn, Tudor Ionel Oprea · 2020 · Current Protocols in Bioinformatics
Calling the next generation of affinity reagents
Vivien Marx · 2013 · Nature Methods
The strategy, organization, and progress of the HUPO Human Proteome Project
Gilbert S. Omenn · 2013 · Journal of Proteomics
Reproducible quantitative proteotype data matrices for systems biology
Hannes Luc Röst, Lars Malmström, Ruedi H. Aebersold · 2015 · Molecular Biology of the Cell
Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems
Maggie P. Y. Lam, Vidya Venkatraman, Yi Xing, Edward Lau, Quan Cao, Dominic C. M. Ng, Andrew I. Su, Junbo Ge, Jennifer E. Van Eyk, Peipei Ping · 2016 · Journal of Proteome Research
Structure to function of an α-glucan metabolic pathway that promotes Listeria monocytogenes pathogenesis
Samuel H. Light, Laty A. Cahoon, Andrei S. Halavaty, Nancy Elizabeth Freitag, W.F. Anderson · 2016 · Nature Microbiology
Anthropogenic reaction parameters – the missing link between chemical intuition and the available chemical space
György Miklós Keserű, Tibor Soós, Christian Oliver Kappe · 2014 · Chemical Society Reviews
The Cryptosporidium parvum Kinome
Jennifer D. Artz, Amy K. Wernimont, Abdellah Allali‐Hassani, Yong Zhao, Mehrnaz Amani, Yu‐Hui Lin, Guillermo A. Senisterra, Gregory A. Wasney, O. Fedorov, Oliver D. King et al. · 2011 · BMC Genomics
Handbook of systems biology : concepts and insights
Albertha J.M. Walhout, Marc Vidal, Job Dekker · 2013 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
Contributions of Academic Laboratories to the Discovery and Development of Chemical Biology Tools
Donna M. Huryn, Lynn Resnick, Peter Wipf · 2013 · Journal of Medicinal Chemistry
Antibody characterization is critical to enhance reproducibility in biomedical research
Kahn, Richard A, Virk, Harvinder, Laflamme, Carl, Houston, Douglas W, Polinski, Nicole K, Meijers, Rob, Levey, Allan I, Saper, Clifford B, Errington, Timothy M, Turn, Rachel E et al. · 2024 · eLife
Integration, visualization and analysis of human interactome
Chiara Pastrello, Elisa Pasini, Max Kotlyar, David Otasek, Serene Wong, Waheed Sangrar, Sara Rahmati, Igor Jurišica · 2014 · Biochemical and Biophysical Research Communications
Range of protein detection by selected/multiple reaction monitoring mass spectrometry in an unfractionated human cell culture lysate
Ebhardt, H. Alexander, Sabidó, Eduard, Hüttenhain, Ruth, Collins, Ben, Aebersold, Ruedi · 2012 · PROTEOMICS
Design and synthesis of DNA-encoded libraries based on a benzodiazepine and a pyrazolopyrimidine scaffold
Mateja Klika Škopić, Olivia Bugain, Kathrin Jung, S. Onstein, Sven Brandherm, Tuomo Kalliokoski, Andreas Brunschweiger · 2016 · MedChemComm
Antibody-siRNA conjugates: drugging the undruggable for anti-leukemic therapy
Jogender Tushir‐Singh · 2016 · Expert Opinion on Biological Therapy
Recombinant renewable polyclonal antibodies
Fortunato Ferrara, Sara D’Angelo, Tiziano Gaiotto, Leslie A. Naranjo, Hongzhao Tian, S. Gräslund, E. Dobrovetsky, Peter Hraber, Fridtjof Lund‐Johansen, Silvia Saragozza et al. · 2014 · mAbs
Recalibrating Intellectual Property Rights to Enhance Translational Research Collaborations
Tania M. Bubela, Garret A. FitzGerald, Edward Richard Gold · 2012 · Science Translational Medicine
Illuminating the druggable genome: Pathways to progress
Karlie Roxanne Sharma, Christine M. Colvis, Griffin P. Rodgers, Douglas M. Sheeley · 2023 · Drug Discovery Today
Analytical challenges translating mass spectrometry‐based phosphoproteomics from discovery to clinical applications
Anton B. Iliuk, Justine V. Arrington, W. Andy Tao · 2014 · Electrophoresis
Efficiency of hit generation and structural characterization in fragment-based ligand discovery
Andreas Larsson, Anna Elisabet Jansson, Anders Åberg, Pär Nordlund · 2011 · Current Opinion in Chemical Biology
High-Throughput Assessment of Kinome-Wide Activation States
Thierry Schmidlin, Donna O. Debets, Charlotte A. G. H. van Gelder, Kelly E. Stecker, Stamatia Rontogianni, Bart L. van den Eshof, Kristel Kemper, Esther H. Lips, Maartje van den Biggelaar, Daniel S. Peeper et al. · 2018 · Cell Systems
Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery
Corvin Walter, Adinarayana Marada, Tamara Suhm, Ralf Ernsberger, Vera Muders, Cansu Küçükköse, Pablo Sánchez‐Martín, Zehan Hu, Abhishek Aich, Stefan Loroch et al. · 2021 · Nature Communications
New Approaches to Difficult Drug Targets: The Phosphatase Story
John Stephen Lazo, Kelley E. McQueeney, Elizabeth R. Sharlow · 2017 · SLAS DISCOVERY
Activity-based proteomic and metabolomic approaches for understanding metabolism
Devon M. Hunerdosse, Daniel K. Nomura · 2014 · Current Opinion in Biotechnology
Meta-analysis of transcriptomic datasets identifies genes enriched in the mammalian circadian pacemaker
Laurence A. Brown, John Alexander Williams, Lewis Taylor, Ross J Thomson, Patrick M. Nolan, F. Foster, Stuart N. Peirson · 2017 · Nucleic Acids Research
The Possibility of Systematic Research Fraud Targeting Under-Studied Human Genes: Causes, Consequences, and Potential Solutions
Byrne, Jennifer A, Grima, Natalie, Capes-Davis, Amanda, Labbé, Cyril · 2019 · Biomarker Insights
A Road Map to Personalizing Targeted Cancer Therapies Using Synthetic Lethality
Sreejit Parameswaran, Deeksha Kundapur, Frederick S. Vizeacoumar, Andrew Freywald, Maruti Uppalapati, Franco J. Vizeacoumar · 2018 · Trends in cancer
Open Access Target Validation Is a More Efficient Way to Accelerate Drug Discovery
Wen Hwa Lee · 2015 · PLoS Biology
Probing the epigenome
Andrea Huston, C.H. Arrowsmith, Stefan Knapp, Matthieu Schapira · 2015 · Nature Chemical Biology
MCR synthesis of a tetracyclic tetrazole scaffold
Pravin Patil, Kareem Khoury, Eberhardt Herdtweck, Alexander S. S. Dömling · 2014 · Bioorganic & Medicinal Chemistry
Helix mimetics: Recent developments
Andrew John Wilson · 2015 · Progress in Biophysics and Molecular Biology
The role of the interactome in the maintenance of deleterious variability in human populations
Luz García‐Alonso, Jorge Jimenez-Almazán, José Carbonell‐Caballero, Alicia Vela‐Boza, Javier Santoyo‐López, Guillermo Antiñolo, Joaquı́n Dopazo · 2014 · Molecular Systems Biology
Natural product-informed exploration of chemical space to enable bioactive molecular discovery
Adam S. Nelson, George Karageorgis · 2020 · RSC Medicinal Chemistry
Identification of Genes Important for Cutaneous Function Revealed by a Large Scale Reverse Genetic Screen in the Mouse
Tia DiTommaso, Lynelle K. Jones, Denny L. Cottle, The WTSI Mouse Genetics Program, Anna-Karin Gerdin, Valerie E. Vancollie, Fiona M. Watt, Ramiro Ramírez‐Solis, Allan Bradley, Karen P. Steel et al. · 2014 · PLoS Genetics
ProteomeGenerator: A Framework for Comprehensive Proteomics Based on de Novo Transcriptome Assembly and High-Accuracy Peptide Mass Spectral Matching
Paolo Cifani, Avantika Dhabaria, Zining Chen, Akihide Yoshimi, Emily A. Kawaler, Omar Ibrahim Abdel-Wahab, John Thomas Poirier, Alex Kentsis · 2018 · Journal of Proteome Research
COVID-19 research risks ignoring important host genes due to pre-established research patterns
Stoeger, Thomas, Nunes Amaral, Luís A · 2020 · eLife
Speos: an ensemble graph representation learning framework to predict core gene candidates for complex diseases
Florin Ratajczak, Mitchell Joblin, Marcel E. Hildebrandt, Martin Ringsquandl, Pascal Falter‐Braun, Matthias Heinig · 2023 · Nature Communications
What general conclusions can we draw from kinase profiling data sets?
Jeffrey J. Sutherland, Cen Gao, Suntara Cahya, Michal Vieth · 2013 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Recombinant polypeptide production in E. coli: towards a rational approach to improve the yields of functional proteins
Ario de Marco · 2013 · Microbial Cell Factories
Systems Biochemistry Approaches to Defining Mitochondrial Protein Function
Andrew Y. Sung, Brendan J. Floyd, David J. Pagliarini · 2020 · Cell Metabolism
Digging Deeper into Precision/Personalized Medicine: Cracking the Sugar Code, the Third Alphabet of Life, and Sociomateriality of the Cell
Vural Özdemir, Kazım Yalçın Arğa, Ramy Karam Aziz, Mustafa Bayram, Shannon N. Conley, Collet Dandara, László Endrényi, Erik Fisher, Colin K. Garvey, Nezih Hekim et al. · 2020 · OMICS A Journal of Integrative Biology
Profiling the kinome: Current capabilities and future challenges
James D.R. Knight, Tony J. Pawson, Anne‐Claude Gingras · 2012 · Journal of Proteomics
Unbiased binding assays for discovering small-molecule probes and drugs
Melissa M. Kemp, Michel Weïwer, Angela N. Koehler · 2011 · Bioorganic & Medicinal Chemistry
Applying proteomics to tick vaccine development: where are we?
Margarita Villar, Anabel Marina, José de la Fuente · 2017 · Expert Review of Proteomics
Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species
Gregory J. Tawa, John C. Braisted, David Lee Gerhold, Gurmit S. Grewal, Christina N. Mazcko, Matthew Breen, Gurusingham Sitta Sittampalam, Amy Kathleen LeBlanc · 2021 · PLoS Computational Biology
Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2)
Stefan Gerstenecker, Lisa Haarer, Martin Schröder, Mark Kudolo, Martin P. Schwalm, Valentin R. Wydra, Ricardo A. M. Serafim, A. Chaikuad, Stefan Knapp, Stefan Laufer et al. · 2021 · Cancers
Pseudo Natural Products—Chemical Evolution of Natural Product Structure
George Karageorgis, Daniel J. Foley, Luca Laraia, Susanne Brakmann, Herbert Waldmann · 2021 · Angewandte Chemie
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Marco Giudici, Saioa Goñi, Rongrong Fan, Eckardt Treuter · 2015 · Handbook of experimental pharmacology
Protein–ligand data at scale to support machine learning
A.M. Edwards, Dafydd R. Owen, Leili Zhang, Damian W. Young, Timothy Mark Willson, James Wellnitz, Yanli Wang, Jarrod J. Walsh, Erik Vernet, Alexander Tropsha et al. · 2025 · Nature Reviews Chemistry
KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases
Liang‐Chin Huang, Rahil Taujale, Nathan Gravel, Aarya Venkat, Wayland Yeung, Dominic P. Byrne, Patrick A. Eyers, Natarajan Kannan · 2021 · BMC Bioinformatics
Predicting gene ontology from a global meta-analysis of 1-color microarray experiments
Mikhail G. Dozmorov, Cory B. Giles, Jonathan D. Wren · 2011 · BMC Bioinformatics
A Universal Isocyanide for Diverse Heterocycle Syntheses
Pravin Patil, Kareem Khoury, Eberhardt Herdtweck, Alexander S. S. Dömling · 2014 · Organic Letters
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Jung Nyeo Chun, Jin Muk Lim, Young Ae Kang, Eung Hee Kim, Young-Cheul Shin, Hong‐Gee Kim, Dayk Jang, Dongseop Kwon, Soo-Yong Shin, Insuk So et al. · 2013 · Pflügers Archiv - European Journal of Physiology
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Holger Alexander Ebhardt · 2013 · Methods in molecular biology
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Frederik Gwinner, Adelina E. Acosta‐Martin, Ludovic Boytard, Maggy Chwastyniak, Olivia Beseme, Hervé Drobecq, Sophie Duban‐Deweer, Françis Juthier, Brigitte Jude, Philippe Amouyel et al. · 2013 · PROTEOMICS
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