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Grand challenges in global mental health
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“In LMICs, as in much of the world, mental health is consistently relegated to a secondary or even tertiary concern [1, 100, 101]”
From Barriers and facilitators to implementation of evidence-based task-sharing mental health interventions in low- and middle-income countries: a systematic review using implementation science frameworks (2022) · cites this paper as [1]
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“the integration of mental health into primary health care, and the related idea of task-shifting, were quickly identified as one of the five 'grand challenges' in global mental health in the field's early years (Collins et al. 2011)”
From Throwing therapy at the problem mental health and humanitarian intervention in Palabek refugee settlement, northern Uganda (2023) · cites this paper as Collins et al. 2011
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“In 2011, the Grand Challenges in Global Mental Health Initiative (GCMHI) defined a set of 25 urgent research priorities 237 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [237]
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“The treatment of central nervous system (CNS) diseases, such as neurodegenerative disorders, brain tumors, brain infections, and stroke, is severely constrained by the blood-brain barrier (BBB) because it prevents the transfer of most of small-molecule drugs and macromolecules (e.g., peptides, gene drugs, and protein drugs) into the brain (1–6).”
From Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection (2020) · cites this paper as [3]
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“it prevents the transfer of most of small-molecule drugs and macromolecules (e.g., peptides, gene drugs, and protein drugs) into the brain (1–6).”
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Metadata
- Authors
- Collins, P. Y., Patel, V., Joestl, S. S., March, D., Insel, T. R., Daar, A. S., Bordin, I. A., Costello, E. J., Durkin, M., Fairburn, C., Glass, R. I., Hall, W., Huang, Y., Hyman, S. E., Jamison, K., Kaaya, S., Kapur, S., Kleinman, A., Ogunniyi, A., Otero-Ojeda, A., Poo, M.-M., Ravindranath, V., Sahakian, B. J., Saxena, S., Singer, P. A., Stein, D. J., Anderson, W., Dhansay, M. A., Ewart, W., Phillips, A., Shurin, S., & Walport, M.
- Affiliations
- National Institute of Mental Health (US)
- London School of Hygiene & Tropical Medicine (GB)
- University of Toronto (CA)
- Universidade Federal de São Paulo (BR)
- Duke University (US)
- University of Oxford (GB)
- Fogarty International Center (US)
- The University of Queensland (AU)
- Chinese Center For Disease Control and Prevention (CN)
- Harvard University (US)
- Johns Hopkins University (US)
- Muhimbili University of Health and Allied Sciences (TZ)
- King's College London (GB)
- University of Ibadan (NG)
- Universidad Peruana Cayetano Heredia (PE)
- University of California, Berkeley (US)
- Indian Institute of Science Bangalore (IN)
- University of Cambridge (GB)
- World Health Organization (CH)
- University of Cape Town (ZA)
- National Health and Medical Research Council (AU)
- Medical Research Council (GB)
- Canadian Institutes of Health Research (CA)
- National Heart, Lung, and Blood Institute (US)
- Wellcome Trust (GB)
- Corresponding author
- Collins, Pamela Y.
- Daar, Abdallah S.
- ORCID
- Collins, Pamela Y.
- Patel, Vikram
- Insel, Thomas R.
- Daar, Abdallah S.
- Bordin, Isabel A.
- Costello, E. Jane
- Durkin, Maureen
- Glass, Roger I.
- Hall, Wayne
- Huang, Yueqin
- Hyman, Steven E.
- Kaaya, Sylvia
- Kapur, Shitij
- Kleinman, Arthur
- Ogunniyi, Adesola
- Poo, Mu-Ming
- Ravindranath, Vijayalakshmi
- Sahakian, Barbara J.
- Saxena, Shekhar
- Stein, Dan J.
- Anderson, Warwick
- Dhansay, Muhammad A.
- Phillips, Anthony
- Walport, Mark
- Venue
- Nature
- Published
- 2011-07-06
- Volume
- 475
- Issue
- 7354
- Pages
- 27-30
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3173804
- OpenAlex
- W2148602524
- Cited by
- 2,043
- References
- 15
- Citations by year
- 2026: 58 · 2025: 82 · 2024: 87 · 2023: 129 · 2022: 141 · 2021: 182 · 2020: 152 · 2019: 133 · 2018: 142 · 2017: 155 · 2016: 180 · 2015: 176 · 2014: 165 · 2013: 140 · 2012: 96
- FWCI
- 171.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Wellcome Trust (079113, 079113/Z/06/Z, 091834)
- University of Toronto
- National Institutes of Health (Z99 MH999999)
- National Institute of Mental Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD003352)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- global mental health, mental illness, research priorities, research funding, mental health advocacy, mental health policy
- MeSH terms
- Mental Disorders, Humans, Mental Health, Global Health, World Health Organization, Substance-Related Disorders
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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