Evidence for the role of corticotropin-releasing factor in major depressive disorder

Waters, R. Parrish; Rivalan, Marion; Bangasser, D.A.; Deussing, J.M.; Ising, M.; Wood, S.K.; Holsboer, F.; Summers, Cliff H.

doi:10.1016/j.neubiorev.2015.07.011

Cited by 93Stress Responses and CortisolNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Evidence for the role of corticotropin-releasing factor in major depressive disorder

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Waters, R. Parrish, Rivalan, Marion, Bangasser, D.A., Deussing, J.M., Ising, M., Wood, S.K., Holsboer, F., Summers, Cliff H.·2015·Neuroscience & Biobehavioral Reviews

DOI 10.1016/j.neubiorev.2015.07.011PMC PMC4828243

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Abstract

Major depressive disorder (MDD) is a devastating disease affecting over 300 million people worldwide, and costing an estimated 380 billion Euros in lost productivity and health care in the European Union alone. Although a wealth of research has been directed toward understanding and treating MDD, still no therapy has proved to be consistently and reliably effective in interrupting the symptoms of this disease. Recent clinical and preclinical studies, using genetic screening and transgenic rodents, respectively, suggest a major role of the CRF1 gene, and the central expression of CRF1 receptor protein in determining an individual's risk of developing MDD. This gene is widely expressed in brain tissue, and regulates an organism's immediate and long-term responses to social and environmental stressors, which are primary contributors to MDD. This review presents the current state of knowledge on CRF physiology, and how it may influence the occurrence of symptoms associated with MDD. Additionally, this review presents findings from multiple laboratories that were presented as part of a symposium on this topic at the annual 2014 meeting of the International Behavioral Neuroscience Society (IBNS). The ideas and data presented in this review demonstrate the great progress that has been made over the past few decades in our understanding of MDD, and provide a pathway forward toward developing novel treatments and detection methods for this disorder.

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Findings in mood disorders reveal alterations at the levels of intracellular signaling, gene expression, neurotrophic factors, neurogenesis, neuroinflammation, excitatory and inhibitory neurotransmission, and synaptic number and function in several brain regions implicated in depression.
“These findings reveal alterations at the levels of intracellular signaling, gene expression, neurotrophic factors, neurogenesis, neuroinflammation, excitatory and inhibitory neurotransmission, and synaptic number and function, and have been described in several brain regions implicated in depression 13-22 .”
From Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model (2020) · cites this paper as [15]
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Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model
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Hypothalamic-pituitary-adrenal (HPA) axis functioning as predictor of antidepressant response - meta-analysis
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Authors: Waters, R. P., Rivalan, M., Bangasser, D. A., Deussing, J. M., Ising, M., Wood, S. K., Holsboer, F., & Summers, C. H.
Affiliations: University of Mary Washington (US)
Charité – Universitätsmedizin Berlin (DE)
Temple University (US)
Max Planck Institute of Psychiatry (DE)
University of South Carolina (US)
HolsboerMaschmeyer NeuroChemie (Germany) (DE)
University of South Dakota (US)
Corresponding author: Waters, R. Parrish
Rivalan, Marion
Summers, Cliff H.
ORCID: Waters, R. Parrish
Rivalan, Marion
Bangasser, D.A.
Deussing, J.M.
Ising, M.
Wood, S.K.
Summers, Cliff H.
Venue: Neuroscience & Biobehavioral Reviews
Publisher: Elsevier BV
Published: 2015-11
Volume: 58
Pages: 63-78
ISSN: 0149-7634 (ISSN-L)
DOI: 10.1016/j.neubiorev.2015.07.011
PMC: PMC4828243
OpenAlex: W1133363097
Cited by: 93
References: 268
Citations by year: 2026: 8 · 2025: 5 · 2024: 9 · 2023: 9 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 15 · 2017: 14 · 2016: 8
FWCI: 0.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience & Biobehavioral Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: National Institute of Mental Health (R15MH104485)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: major depressive disorder, corticotropin-releasing factor, CRF1 receptor, genetic risk, stress response, transgenic rodent models, depression treatment, depression detection
MeSH terms: CRF Receptor, Type 1, Corticotropin-Releasing Hormone, Major Depressive Disorder, Humans, Receptors, Corticotropin-Releasing Hormone

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Evidence for the role of corticotropin-releasing factor in major depressive disorder

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