The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
Open accessAbstract
We measured endogenous cannabinoid release in dorsal striatum of freely moving rats by microdialysis and gas chromatography/mass spectrometry. Neural activity stimulated the release of anandamide, but not of other endogenous cannabinoids such as 2-arachidonylglycerol. Moreover, anandamide release was increased eightfold over baseline after local administration of the D2-like (D2, D3, D4) dopamine receptor agonist quinpirole, a response that was prevented by the D2-like receptor antagonist raclopride. Administration of the D1-like (D1, D5) receptor agonist SKF38393 had no such effect. These results suggest that functional interactions between endocannabinoid and dopaminergic systems may contribute to striatal signaling. In agreement with this hypothesis, pretreatment with the cannabinoid antagonist SR141716A enhanced the stimulation of motor behavior elicited by systemic administration of quinpirole. The endocannabinoid system therefore may act as an inhibitory feedback mechanism countering dopamine-induced facilitation of motor activity.
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Cited by
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Self-citationThe reinstatement model of drug relapse: history, methodology and major findings
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Metadata
- Authors
- Giuffrida, A., Parsons, L. H., Kerr, T. M., de Fonseca, F. R., Navarro, M., & Piomelli, D.
- Venue
- Nature Neuroscience
- Published
- 1999-04
- Volume
- 2
- Issue
- 4
- Pages
- 358-363
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- DOI
- 10.1038/7268
- OpenAlex
- W1513230591
- Cited by
- 775
- References
- 8
- FWCI
- 23.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Giuffrida, A., Parsons, L. H., Kerr, T. M., de Fonseca, F. R., Navarro, M., & Piomelli, D. (1999). Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. Nature Neuroscience. https://doi.org/10.1038/7268
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
