Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease

Lorenzo, Alfredo, Yuan, Menglan, Zhang, Zhuohua, Paganetti, Paolo A., Sturchler-Pierrat, Christine, Staufenbiel, Matthias, Mautino, Jorge, Vigo, Francisco Sol +2 more·2000·Nature Neuroscience
DOI 10.1038/74833

Cited by (257)

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  6. Genome-wide association study identifies CBFA2T3 affecting the rate of CSF Aβ42 decline in non-demented elders
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  7. Polypeptide and Protein Aggregates with Neurotoxic Properties in Neurodegenerative Disorders: Emphasis on β-Amyloid-Induced Dysfunction of Receptor-Mediated Signal Transduction Pathways
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  8. Retinal cell apoptosis
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  11. Behavioural, genomics and proteomic approach to examine Alzheimer's disease in zebrafish
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  12. The Function of the Amyloid Precursor Protein Family
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  13. Neural cell injury microenvironment induces neural differentiation of human umbilical cord mesenchymal stem cells.
    Jin Lin Zhou, Guo-Ping Tian, Jinge Wang, Xiaoguang Luo, Siyang Zhang, Jianping Li, Li Li, Bing Xu, Feng Zhu, Xia Wang et al. · 2012 · PubMed Central
  14. A mechanistic kinetic model reveals how amyloidogenic hydrophobic patches facilitate the amyloid-β fibril elongation
    Heng-Yi Xie, A. Rojas, G. G. Maisuradze, G. Khelashvili · 2022 · ACS Chemical Neuroscience
  15. Neuroprotective functions of the APPI domain of amyloid precursor protein (APP): Reducing KLK6-mediated APP cleavage and Aβ42 formation and aggregation
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  16. Amyloid-β Protein Precursor Regulates Depolarization-Induced Calcium-Mediated Synaptic Signaling in Brain Slices
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  17. Diffusion and aggregation of Alzheimer’s Aβ1–40 peptide in aqueous trifluoroethanol solutions as studied by pulsed field gradient NMR
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  18. Characterization of the beta amyloid precursor protein-like gene in the central nervous system of the crab Chasmagnathus. Expression during memory consolidation
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  22. New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer’s disease
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  24. Apoptosis in Neurodegeneration: Programmed Cell Death and its Role in Alzheimer’s and Huntington’s Diseases
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  26. APP signaling in Alzheimer’s disease
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  27. β-Secretase (BACE1) Purification by Refolding Method and Complex with Hispidin
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  29. Tumor Necrosis Factor Death Receptor Signaling Cascade Is Required for Amyloid-β Protein-Induced Neuron Death
    Li, Rena, Yang, Libang, Lindholm, Kristina, Konishi, Yoshihiro, Yue, Xu, Hampel, Harald, Zhang, Dai, Shen, Yong · 2004 · The Journal of Neuroscience
  30. Signaling Mechanisms that Mediate Aβ Induced Neuronal Dysfunction
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  31. The Role of Lipoproteins/cholesterol in Genomic Instability and Chromosome Mis-segregation in Alzheimer's and Cardiovascular Disease
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  32. -Secretase-Regulated Signaling Mechanisms: Notch and Amyloid Precursor Protein
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  33. Amyloid precursor protein with the Alzheimer´s disease 670/671 mutation : Animal and cellular models
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  34. Role of Oxidatively Stressed Lipids in Amyloid Formation and Toxicity
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  35. Investigating the Role of the Amyloid Precursor Protein in the Pathogenesis of Alzheimer's Disease
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  36. Transporters in the Blood-Brain Barrier
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  37. Microglia demostrate age-dependent performance and interaction with beta-amyloid peptide
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  38. γ-Secretase — Regulated Signaling and Alzheimer's Disease
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  39. Effects of long-term administration of caffeine in a mouse model for Alzheimer's disease
    William S. Schleif · 2005 · Digital Commons - University of South Florida (University of South Florida)
  40. Role of the 39-kDa receptor-associated protein (RAP) in Alzheimer's disease
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  41. Aβ-Induced Toxicity Mediated by Caspase Cleavage of the Amyloid Precursor Protein (APP)
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  42. Quantitative analysis of streptococcal exoprotein flow to the host receptor — Exact basis for therapy of tumors and alzheimer’s disease
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  43. Alzheimer‘s disease therapy: focus on synapses
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  44. Effects of amyloidogenic peptides on the phosphorylation state of the tau-protein and on the expression of the alpha7 subunit of the nicotinic acetylcholine receptor in vitro
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  46. Review Alzheimer ß-amyloid peptides: normal and abnormal localization
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  47. Study by proteomics of a transgenic mouse model of Alzheimer's disease tau pathology
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  48. Neuro-pathological Implications of β-Amyloid Protein: An Update
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  49. Molecular basis for amyloid precursor protein mediated neuroprotection in traumatic brain injury
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  50. Mechanisms of neurodegeneration and potential rescue effects with respect to synaptic plasticity
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    Christopher Michael Attwood · 2019 · Otago University Research Archive (University of Otago)
  52. A failure of β-amyloid physiological function due to genetic deletion of α7 nicotinic acetylcholine receptors induces an Alzheimer’s disease-like pathology
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  53. Aβ promotes amyloidogenic processing of APP through a Go/Gβγ signaling
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  57. Unraveling the physiopathological actions of the newly discovered Aη peptides in the brain
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