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Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

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Micropatterning neural cell cultures in 3D with a multi-layered scaffold

Kunze, A., Giugliano, M., Valero, A., & Renaud, P. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.11.047 · Cited by 153 · see citing works

Characterization of neuronal dystrophy induced by fibrillar amyloid β: implications for Alzheimer’s disease

Grace, E. A., Rabiner, C. A., & Busciglio, J. A. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00241-5 · Cited by 151 · see citing works

Role of p75 Neurotrophin Receptor in the Neurotoxicity by β-amyloid Peptides and Synergistic Effect of Inflammatory Cytokines

Perini, G., Bianca, V. D., Politi, V., Valle, G. D., Prà, I. D., Rossi, F., & Armato, U. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011797 · Cited by 152 · see citing works

APP Homodimers Transduce an Amyloid-β-Mediated Increase in Release Probability at Excitatory Synapses

Fogel, H., Frere, S., Segev, O., Bharill, S., Shapira, I., Gazit, N., O’Malley, T., Slomowitz, E., Berdichevsky, Y., Walsh, D. M., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.024 · Cited by 138 · see citing works

Collagen VI protects neurons against Aβ toxicity

Cheng, J. S., Dubal, D. B., Kim, D. H., Legleiter, J. A., Cheng, I. H.-J., Yu, G.-Q., Tesseur, I. C., Wyss‐Coray, T., Bonaldo, P., & Mucke, L. (2009) · Nature Neuroscience · doi:10.1038/nn.2240 · Cited by 134 · see citing works

Magnetic resonance imaging shows delayed ischemic striatal neurodegeneration

Fujioka, M., Taoka, T., Matsuo, Y., Mishima, K., Ogoshi, K., Kondo, Y., Tsuda, M., Fujiwara, M., Asano, T., Sakaki, T., et al. (2003) · Annals of Neurology · doi:10.1002/ana.10751 · Cited by 138 · see citing works

Lipoprotein Receptor-Related Protein-1 Mediates Amyloid-β-Mediated Cell Death of Cerebrovascular Cells

Wilhelmus, M. M. M., Otte-Höller, I., van Triel, J. J. J., Veerhuis, R., Maat-Schieman, M. L. C., Bu, G., de Waal, R. M. W., & Verbeek, M. M. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070050 · Cited by 138 · see citing works

Deficits in Synaptic Transmission and Learning in Amyloid Precursor Protein (APP) Transgenic Mice Require C-Terminal Cleavage of APP

Saganich, M. J., Schroeder, B. E., Galván, V., Bredesen, D. E., Koo, E. H., & Heinemann, S. F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4180-06.2006 · Cited by 135 · see citing works

A Role for Calcineurin in Alzheimers Disease

Reese, L. C., & Taglialatela, G. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376316 · Cited by 131 · see citing works

Aβ induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597–624)

Shaked, G. M., Kummer, M. P., Lu, D. C., Galvan, V., Bredesen, D. E., Koo, E. H., Shaked, G. M., Kummer, M. P., Lu, D. C., Galvan, V., et al. (2006) · The FASEB Journal · doi:10.1096/fj.05-5032fje · Cited by 132 · see citing works

Synaptic Activity Reduces Intraneuronal Aβ, Promotes APP Transport to Synapses, and Protects against Aβ-Related Synaptic Alterations

Tampellini, D., Rahman, N., Gallo, E. F., Huang, Z., Dumont, M., Capetillo-Zarate, E., Ma, T., Zheng, R., Lu, B., Nanus, D. M., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2292-09.2009 · Cited by 127 · see citing works

Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease

Schwab, C., Hosokawa, M., & McGeer, P. L. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.03.016 · Cited by 121 · see citing works

Intracellular Accumulation of Amyloid- (A ) Protein Plays a Major Role in A -Induced Alterations of Glutamatergic Synaptic Transmission and Plasticity

Ripoli, C., Cocco, S., Puma, D. D. L., Piacentini, R., Mastrodonato, A., Scala, F., Puzzo, D., D’Ascenzo, M., & Grassi, C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1201-14.2014 · Cited by 122 · see citing works

Tauroursodeoxycholic Acid Prevents Amyloid-β Peptide-Induced Neuronal Death Via a Phosphatidylinositol 3-Kinase-Dependent Signaling Pathway

Solá, S., Castro, R. E., Laires, P. A., Steer, C. J., & Rodrigues, C. M. P. (2003) · Molecular Medicine · doi:10.2119/2003-00042.rodrigues · Cited by 119 · see citing works

Internalized Antibodies to the Aβ Domain of APP Reduce Neuronal Aβ and Protect against Synaptic Alterations

Tampellini, D., Magrané, J., Takahashi, R. H., Li, F., Lin, M. T., Almeida, C. G., & Gouras, G. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700373200 · Cited by 118 · see citing works

Complex formation of APP with GABAB receptors links axonal trafficking to amyloidogenic processing

Dinamarca, M. C., Raveh, A., Schneider, A., Fritzius, T., Früh, S., Rem, P. D., Stawarski, M., Lalanne, T., Tureček, R., Choo, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09164-3 · Cited by 113 · see citing works

Aberrant Activation of Focal Adhesion Proteins Mediates Fibrillar Amyloid β-Induced Neuronal Dystrophy

Grace, E. A., & Busciglio, J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00493.2003 · Cited by 113 · see citing works

APP Receptor? To Be or Not To Be

Deyts, C., Thinakaran, G., & Parent, A. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.01.005 · Cited by 109 · see citing works

Caspase cleavage of the amyloid precursor protein modulates amyloid β‐protein toxicity

Lu, D. C.-T., Soriano, S., Bredesen, D. E., & Koo, E. H. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02059.x · Cited by 110 · see citing works

Common features between diabetes mellitus and Alzheimer’s disease

Götz, J., Ittner, L. M., & Lim, Y.-A. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-9070-1 · Cited by 109 · see citing works

Pharmacogenomics in Alzheimer's Disease

Cacabelos, R. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-205-2_10 · Cited by 109 · see citing works

Molecules that Target beta‐Amyloid

Stains, C. I., Mondal, K., & Ghosh, I. (2007) · ChemMedChem · doi:10.1002/cmdc.200700140 · Cited by 108 · see citing works

Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning

Sénéchal, Y., Kelly, P. H., & Dev, K. K. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.08.003 · Cited by 105 · see citing works

Single Transmembrane Spanning Heterotrimeric G Protein-Coupled Receptors and Their Signaling Cascades

Patel, T. B. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.3.4 · Cited by 104 · see citing works

The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system

Sosa, L. J., Cáceres, A., Dupraz, S., Oksdath, M., Quiroga, S., & Lorenzo, A. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14122 · Cited by 105 · see citing works

Glucocorticoids Trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau

Sotiropoulos, I., Catania, C., Riedemann, T., Fry, J. P., Breen, K. C., Michaelidis, T. M., & Almeida, O. F. X. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05613.x · Cited by 97 · see citing works

Neuromodulatory Action of Picomolar Extracellular Aβ42 Oligomers on Presynaptic and Postsynaptic Mechanisms Underlying Synaptic Function and Memory

Gulisano, W., Melone, M., Ripoli, C., Tropea, M. R., Li Puma, D. D., Giunta, S., Cocco, S., Marcotulli, D., Origlia, N., Palmeri, A., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0163-19.2019 · Cited by 100 · see citing works

Aβ Oligomers and Fibrillar Aggregates Induce Different Apoptotic Pathways in LAN5 Neuroblastoma Cell Cultures

Picone, P., Carrotta, R., Montana, G., Nobile, M. R., Biagio, P. L. S., & Carlo, M. D. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.11.056 · Cited by 97 · see citing works

Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer’s Disease

Dinamarca, M. C., Ríos, J. A., & Inestrosa, N. C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00464 · Cited by 98 · see citing works

Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer’s disease

Canobbio, I., Abubaker, A. A., Visconte, C., Torti, M., & Pula, G. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00065 · Cited by 101 · see citing works

Mechanism of Fiber Assembly: Treatment of Aβ Peptide Aggregation with a Coarse-Grained United-Residue Force Field

Rojas, A. V., Liwo, A., Browne, D. A., & Scheraga, H. A. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.09.057 · Cited by 93 · see citing works

Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells

Brunholz, S., Sisodia, S., Lorenzo, A., Deyts, C., Kins, S., & Morfini, G. (2012) · Experimental Brain Research · doi:10.1007/s00221-011-2870-1 · Cited by 92 · see citing works

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer’s Disease

Park, G., Nhan, H. S., Tyan, S.-H., Kawakatsu, Y., Zhang, C., Navarro, M., & Koo, E. H. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107839 · Cited by 92 · see citing works

Amyloid β protein toxicity mediated by the formation of amyloid‐β protein precursor complexes

Lu, D. C.-T., Shaked, G. M., Masliah, E., Bredesen, D. E., & Koo, E. H. (2003) · Annals of Neurology · doi:10.1002/ana.10761 · Cited by 91 · see citing works

Amyloid-beta Alzheimer targets - protein processing, lipid rafts, and amyloid-beta pores.

Arbor, S., LaFontaine, M., & Cumbay, M. G. (2016) · Europe PMC (PubMed Central) · Cited by 92 · see citing works

Aβ Internalization by Neurons and Glia

Mohamed, A., & Chaves, E. (2011) · International Journal of Alzheimer s Disease · doi:10.4061/2011/127984 · Cited by 91 · see citing works

Amyloid-β-induced Synapse Damage Is Mediated via Cross-linkage of Cellular Prion Proteins

Bate, C., & Williams, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.248724 · Cited by 89 · see citing works

Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons

Riudavets, M. A., Iacono, D., Resnick, S. M., O’Brien, R., Zonderman, A. B., Martin, L. J., Rudow, G., Pletnikova, O., & Troncoso, J. C. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.05.005 · Cited by 106 · see citing works

Multivariate Analyses of Amyloid-Beta Oligomer Populations Indicate a Connection between Pore Formation and Cytotoxicity

Prangkio, P., Yusko, E. C., Sept, D., Yang, J., & Mayer, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047261 · Cited by 86 · see citing works

Characterization of the toxic mechanism triggered by Alzheimer's amyloid‐β peptides via p75 neurotrophin receptor in neuronal hybrid cells

Tsukamoto, E., Hashimoto, Y., Kanekura, K., Niikura, T., Aiso, S., & Nishimoto, I. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10703 · Cited by 86 · see citing works

Localization and Trafficking of Amyloid-β Protein Precursor and Secretases: Impact on Alzheimer's Disease

Agostinho, P., Pliássova, A., Oliveira, C., & Cunha, R. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142730 · Cited by 78 · see citing works

Normal cognition in transgenic BRI2-Aβ mice

Kim, J., Chakrabarty, P., Hanna, A., March, A., Dickson, D. W., Borchelt, D. R., Golde, T., & Janus, C. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-15 · Cited by 83 · see citing works

Effects of the monomeric, oligomeric, and fibrillar Aβ42 peptides on the proliferation and differentiation of adult neural stem cells from subventricular zone

Heo, C., Chang, K., Choi, H. S., Kim, H., Kim, S., Liew, H., Kim, J. A., Yu, E., Ma, J., & Suh, Y. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04499.x · Cited by 83 · see citing works

Alzheimer Aβ Peptide Induces Chromosome Mis-Segregation and Aneuploidy, Including Trisomy 21: Requirement for Tau and APP

Granic, A., Padmanabhan, J., Norden, M., & Potter, H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-10-0850 · Cited by 82 · see citing works

Amyloid precursor protein (APP) and amyloid β (Aβ) interact with cell adhesion molecules: Implications in Alzheimer’s disease and normal physiology

Pfundstein, G., Nikonenko, A. G., & Sytnyk, V. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.969547 · Cited by 83 · see citing works

Signal transduction in Alzheimer disease: p21‐activated kinase signaling requires C‐terminal cleavage of APP at Asp664

Nguyen, T. V., Galván, V., Huang, W., Banwait, S., Tang, H., Zhang, J., & Bredesen, D. E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05031.x · Cited by 76 · see citing works

Characterization of the Signaling Pathway Downstream p75 Neurotrophin Receptor Involved in β-Amyloid Peptide-Dependent Cell Death

Costantini, C., Rossi, F., Formaggio, E., Bernardoni, R., Cecconi, D., & Bianca, V. D. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:25:2:141 · Cited by 74 · see citing works

Endogenous Aβ causes cell death via early tau hyperphosphorylation

Amadoro, G., Corsetti, V., Ciotti, M. T., Florenzano, F., Capsoni, S., Amato, G., & Calissano, P. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.06.005 · Cited by 73 · see citing works

Metallothionein-III Antagonizes the Neurotoxic and Neurotrophic Effects of Amyloid β Peptides

Irie, Y., & Keung, W. M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4594 · Cited by 69 · see citing works

Astrocyte modulation of in vitro β‐amyloid neurotoxicity

Paradisi, S., Sacchetti, B., Balduzzi, M., Gaudi, S., & Malchiodi‐Albedi, F. (2004) · Glia · doi:10.1002/glia.20005 · Cited by 68 · see citing works

Amyloid β-interacting partners in Alzheimer's disease: From accomplices to possible therapeutic targets

Han, S.-H., Park, J.-C., & Mook-Jung, I. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.12.004 · Cited by 67 · see citing works

Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

Acquarone, E., Argyrousi, E. K., van den Berg, M., Gulisano, W., Fà, M., Staniszewski, A., Calcagno, E., Zuccarello, E., D'adamio, L., Deng, S.-X., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0326-4 · Cited by 68 · see citing works

Intracellular Trafficking Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease

Perdigão, C., Barata, M. A., Araújo, M. N., Mirfakhar, F., Castanheira, J., & Almeida, C. G. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00072 · Cited by 56 · see citing works

APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease

Manocha, G. D., Floden, A. M., Rausch, K., Kulas, J. A., McGregor, B. A., Rojanathammanee, L., Puig, K. L., Puig, K. L., Karki, S., Nichols, M. R., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4654-15.2016 · Cited by 64 · see citing works

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression

Ruiz‐Riquelme, A., Lau, H. H. C., Stuart, E., Goczi, A. N., Wang, Z., Schmitt‐Ulms, G., & Watts, J. C. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0529-x · Cited by 65 · see citing works

Amyloid Beta Peptide-Induced Cerebral Neuronal Loss Is Mediated By Caspase-3 In Vivo

Takuma, H., Tomiyama, T., Kuida, K., & Mori, H. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.3.255 · Cited by 63 · see citing works

PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2

Pellegrini, L., Passer, B. J., Cañelles, M., Lefterov, I. M., Ganjei, J. K., Fowlkes, B. J., Koonin, E. V., & D'adamio, L. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3203 · Cited by 65 · see citing works

Amyloid-β 42 Activates the Expression of BACE1 Through the JNK Pathway

Guglielmotto, M., Monteleone, D., Giliberto, L., Fornaro, M., Borghi, R., Tamagno, E., & Tabaton, M. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110884 · Cited by 63 · see citing works

Molecular characterization of neurohybrid cell death induced by Alzheimer's amyloid‐β peptides via p75NTR/PLAIDD

Hashimoto, Y., Kaneko, Y., Tsukamoto, E., Frankowski, H., Kouyama, K., Kita, Y. A., Niikura, T., Aiso, S., Bredesen, D. E., Matsuoka, M., et al. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02513.x · Cited by 63 · see citing works

μ-Amyloid Peptide-induced Apoptosis Regulated by a Novel Protein Containing a G Protein Activation Module

Kajkowski, E. M., Lo, C. F., Ning, X., Walker, S., Sofia, H. J., Wang, W., Edris, W., Chanda, P., Wagner, E., Vile, S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011161200 · Cited by 63 · see citing works

A Study of the α-Helical Intermediate Preceding the Aggregation of the Amino-Terminal Fragment of the β Amyloid Peptide (Aβ1–28)

Rojas, A. V., Liwo, A., & Scheraga, H. A. (2011) · The Journal of Physical Chemistry B · doi:10.1021/jp2050993 · Cited by 60 · see citing works

The existence of Aβ strains and their potential for driving phenotypic heterogeneity in Alzheimer’s disease

Lau, H. H. C., Ingelsson, M., & Watts, J. C. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02201-2 · Cited by 57 · see citing works

Coordinated Expression of Caspase 8, 3 and 7 mRNA in Temporal Cortex of Alzheimer Disease: Relationship to Formic Acid Extractable Aβ42 Levels

Matsui, T., Ramasamy, K., Ingelsson, M., Fukumoto, H., Conrad, C., Frosch, M. P., Irizarry, M. C., Yuan, J., & Hyman, B. T. (2006) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000229238.05748.12 · Cited by 58 · see citing works

Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit

Angulo, S. L., Orman, R., Neymotin, S. A., Liu, L., Buitrago, L., Cepeda-Prado, E., Stefanov, D. G., Lytton, W. W., Stewart, M., Small, S. A., et al. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.015 · Cited by 56 · see citing works

Research News

Aamodt, S. M., Farlane, J. M., & Novak, K. D. (2000) · Nature Medicine · doi:10.1038/74991

Secreted amyloid precursor protein and holo‐APP bind amyloid β through distinct domains eliciting different toxic responses on hippocampal neurons

Kedikian, G., Heredia, F., Rozés‐Salvador, V., Raimunda, D., Isoardi, N. A., Heredia, L., & Lorenzo, A. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22347 · Cited by 16 · see citing works

Amyloid-β precursor protein mediates neuronal toxicity of amyloid β through Go protein activation

Vigo, F. S., Kedikian, G., Heredia, L., Heredia, F., Añel, A. D., Rosa, A. L., & Lorenzo, A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.017 · Cited by 41 · see citing works

Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid β precursor protein

Heredia, L., Lin, R., Vigo, F. S., Kedikian, G., Busciglio, J. A., & Lorenzo, A. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.04.015 · Cited by 27 · see citing works

P4‐213: Stereospecific interactions are necessary for Alzheimer's disease amyloid‐beta toxicity

Ciccotosto, G. D., Tew, D. J., Drew, S. C., Smith, D. G., Johanssen, T., Lal, V., Lau, T., Perez, K. A., Curtain, C. C., Wade, J. D., et al. (2009) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.04.679 · Cited by 4 · see citing works