Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease

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2. Amyloid-β neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity
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3. Early Synergy between Aβ42 and Oxidatively Damaged Membranes in Promoting Amyloid Fibril Formation by Aβ40
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4. The last neuronal division: a unifying hypothesis for the pathogenesis of Alzheimer's disease
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5. Alzheimer's Aβ interacts with cellular prion protein inducing neuronal membrane damage and synaptotoxicity
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6. The Molecular Assembly of Amyloid Aβ Controls Its Neurotoxicity and Binding to Cellular Proteins
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7. Synapses, synaptic activity and intraneuronal Aβ in Alzheimer’s disease
   Davide Tampellini · 2010 · Frontiers in Aging Neuroscience
8. Molecular Mechanisms for Neuronal Cell Death by Alzheimer’s Amyloid Precursor Protein-Relevant Insults
   Masaoki Kawasumi, Yuichi Hashimoto, Tomohiro Chiba, Kohsuke Kanekura, Yohichi Yamagishi, Miho Ishizaka, Hirohisa Tajima, Takako Niikura, Ikuo Nishimoto · 2002 · Neurosignals
9. Effects of tumor necrosis factor‐alpha central administration on hippocampal damage in rat induced by amyloid beta‐peptide (25–35)
   M. Yu. Stepanichev, Irina M. Zdobnova, Alexander A. Yakovlev, Mikhail V. Onufriev, Н. А. Лазарева, Irina I. Zarubenko, Natalia V. Gulyaeva · 2002 · Journal of Neuroscience Research
10. Tau is not necessary for amyloid-β–induced synaptic and memory impairments
    Daniela Puzzo, Elentina K. Argyrousi, Agnieszka Staniszewski, Hong Zhang, Elisa Calcagno, Elisa Zuccarello, Erica Acquarone, Mauro Fà, Domenica Donatella Li Puma, Claudio Grassi et al. · 2020 · Journal of Clinical Investigation
11. Impaired migration signaling in the hippocampus following prenatal hypoxia
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12. Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice
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13. Bacterial Extracellular DNA Promotes β-Amyloid Aggregation
    George V. Tetz, Victor Tetz · 2021 · Microorganisms
14. Assemblies of Alzheimer’s peptides Aβ25–35 and Aβ31–35: reverse-turn conformation and side-chain interactions revealed by X-ray diffraction
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15. Localization of a Fibrillar Amyloid β-Protein Binding Domain on Its Precursor
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16. Amyloid β precursor protein as a molecular target for amyloid β–induced neuronal degeneration in Alzheimer's disease
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17. Mouse models of Alzheimer's disease: The long and filamentous road
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18. C-Terminal Cleavage of the Amyloid-β Protein Precursor at Asp664: A Switch Associated with Alzheimer's Disease
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19. Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
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20. Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers
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21. Morphological and Molecular Profiling of Amyloid-β Species in Alzheimer’s Pathogenesis
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22. Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664
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23. RIG-1 receptor expression in the pathology of Alzheimer’s disease
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24. Glimepiride protects neurons against amyloid-β-induced synapse damage
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25. Amyloid-β precursor protein mediates neuronal toxicity of amyloid β through Go protein activation
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26. Association of amyloid-β peptide with membrane surfaces monitored by solid state NMR
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27. Regulation of global gene expression and cell proliferation by APP
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28. Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions
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29. Mitotic Spindle Defects and Chromosome Mis-Segregation Induced by LDL/Cholesterol—Implications for Niemann-Pick C1, Alzheimer’s Disease, and Atherosclerosis
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30. Amyloid Precursor Protein Mediates a Tyrosine Kinase-Dependent Activation Response in Endothelial Cells
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31. Immobilized amyloid Aβ peptides support platelet adhesion and activation
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32. Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer’s disease-like pathology
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33. Effect of Aβ Oligomers on Neuronal APP Triggers a Vicious Cycle Leading to the Propagation of Synaptic Plasticity Alterations to Healthy Neurons
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34. Amyloid precursor protein cross‐linking stimulates beta amyloid production and pro‐inflammatory cytokine release in monocytic lineage cells
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35. Potential role of PCTAIRE-2, PCTAIRE-3 and P-Histone H4 in amyloid precursor protein-dependent Alzheimer pathology
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36. Highly Efficient Destruction of Amyloid-β Fibrils by Femtosecond Laser-Induced Nanoexplosion of Gold Nanorods
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37. Elucidating Important Sites and the Mechanism for Amyloid Fibril Formation by Coarse-Grained Molecular Dynamics
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38. Role of APP Interactions with Heterotrimeric G Proteins: Physiological Functions and Pathological Consequences
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39. Physiological and pathological effects of amyloid-β species in neural stem cell biology
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40. Transcriptomic Analysis of the Effects of a Fish Oil Enriched Diet on Murine Brains
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41. Glycines from the APP GXXXG/GXXXA Transmembrane Motifs Promote Formation of Pathogenic Aβ Oligomers in Cells
    Marie Decock, Serena Stanga, Jean‐Noël Octave, Ilse Dewachter, Steven O. Smith, Stefan N. Constantinescu, Pascal Kienlen‐Campard · 2016 · Frontiers in Aging Neuroscience
42. Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis
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43. In vitro cultured neurons for molecular studies correlating apoptosis with events related to Alzheimer disease
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44. Identification of synaptic plasma membrane proteins co‐precipitated with fibrillar β‐amyloid peptide
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45. Amyloid beta1-42 peptide regulates microtubule stability independently of tau
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46. Alzheimer's disease proteins in cerebellar and hippocampal synapses during postnatal development and aging of the rat
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47. Diverse fibrillar peptides directly bind the Alzheimer’s amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation
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48. Heterogeneous Association of Alzheimer’s Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses
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49. Contributions of polyunsaturated fatty acids (PUFA) on cerebral neurobiology: an integrated omics approach with epigenomic focus
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51. Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid β precursor protein
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52. Amyloid metabolism and secretases in Alzheimer’s disease
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53. Characterization of the interaction between Aβ 1–42 and glyceraldehyde phosphodehydrogenase
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55. Pentapeptides derived from Aβ1–42 protect neurons from the modulatory effect of Aβ fibrils—an in vitro and in vivo electrophysiological study
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56. Rab35 and glucocorticoids regulate APP and BACE1 trafficking to modulate Aβ production
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57. Interactions between the amyloid precursor protein C‐terminal domain and G proteins mediate calcium dysregulation and amyloid β toxicity in Alzheimer’s disease
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58. β-Amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome
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59. Aβ Assemblies Promote Amyloidogenic Processing of APP and Intracellular Accumulation of Aβ42 Through Go/Gβγ Signaling
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60. Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: A role for early experience
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61. Chemical imaging delineates Aβ plaque polymorphism across the Alzheimer’s disease spectrum
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62. The expression of CD36 in vessels with blood–brain barrier impairment in a stroke‐prone hypertensive model
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63. Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE−/− mice
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64. Present and prospective clinical therapeutic regimens for Alzheimer’s disease
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65. An overview of disease models for NLRP3 inflammasome over-activation
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66. Amyloidogenesis: What Do We Know So Far?
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67. Tomoregulin (TMEFF2) Binds Alzheimer’s Disease Amyloid-β (Aβ) Oligomer and AβPP and Protects Neurons from Aβ-Induced Toxicity
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68. Interaction of ASK1 and the β-amyloid precursor protein in a stress-signaling complex
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69. APP/Go protein Gβγ-complex signaling mediates Aβ degeneration and cognitive impairment in Alzheimer's disease models
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70. The sea urchin embryo: A model to study Alzheimer’s beta amyloid induced toxicity
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71. γ-Secretase-Regulated Mechanisms Similar to Notch Signaling May Play a Role in Signaling Events, Including APP Signaling, Which Leads to Alzheimer’s Disease
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72. Association of microbiota-derived propionic acid and Alzheimer’s disease; bioinformatics analysis
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73. Accumulation of Cerebrospinal Fluid Glycerophospholipids and Sphingolipids in Cognitively Healthy Participants With Alzheimer’s Biomarkers Precedes Lipolysis in the Dementia Stage
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74. Amyloid Oligomer Structures and Toxicity
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75. Secreted amyloid precursor protein and holo‐APP bind amyloid β through distinct domains eliciting different toxic responses on hippocampal neurons
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76. The expression of LDL receptor in vessels with blood–brain barrier impairment in a stroke-prone hypertensive model
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77. Secretases as therapeutic targets in Alzheimer’s disease: patents 2000 – 2004
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78. The Level of NMDA Receptor in the Membrane Modulates Amyloid-β Association and Perforation
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79. Deciphering an interplay of proteins associated with amyloid β 1-42 peptide and molecular mechanisms of Alzheimer’s disease
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80. Antibody binding to cell surface amyloid precursor protein induces neuronal injury by deregulating the phosphorylation of focal adhesion signaling related proteins
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81. Selective Vulnerability of Neurons in Primary Cultures and in Neurodegenerative Diseases
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82. Amyloid β and Amyloid Precursor Protein Synergistically Suppress Large-Conductance Calcium-Activated Potassium Channel in Cortical Neurons
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83. Role of Drosophila Amyloid Precursor Protein in Memory Formation
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84. Amyloid-β Peptide Exacerbates the Memory Deficit Caused by Amyloid Precursor Protein Loss-of-Function in Drosophila
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85. Platelets in Neurological Disorders
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86. Amyloid Metabolism and Amyloid-Targeting Blood-Based Biomarkers of Alzheimer’s Disease
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89. Tracking the Mechanism of Fibril Assembly by Simulated Two-Dimensional Ultraviolet Spectroscopy
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90. RAGE, LDL receptor, and LRP1 expression in the brains of SAMP8
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91. Oligomer β-amyloid Induces Hyperactivation of Ras to Impede NMDA Receptor-Dependent Long-Term Potentiation in Hippocampal CA1 of Mice
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92. Protofibrillar and Fibrillar Amyloid-β Binding Proteins in Cerebrospinal Fluid
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93. The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function
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95. Effect of Selenium Treatment on Central Insulin Sensitivity: A Proteomic Analysis in β-Amyloid Precursor Protein/Presenilin-1 Transgenic Mice
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96. The presymptomatic treatment with 3HFWC nanosubstance decreased plaque load in 5XFAD mouse model of Alzheimer's disease
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97. Re-Arranging the Puzzle between the Amyloid-Beta and Tau Pathology: An APP-Centric Approach
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98. Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP
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99. Effects of Aβ1−42 fibrils and of the tetrapeptide Pr‐IIGL on the phosphorylation state of the τ‐protein and on the α7 nicotinic acetylcholine receptor in vitro
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100. Detection of the Presenilin 1 COOH-Terminal Fragment in the Extracellular Compartment: A Release Enhanced by Apoptosis
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