Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance
Limmer, Andreas, Ohl, Jutta, Kurts, Christian, Ljunggren, Hans-Gustaf, Reiss, Yuval, Groettrup, Marcus, Momburg, Frank, Arnold, Bernd +1 more·2000·Nature Medicine
DOI 10.1038/82161
Cited by (682)
Items 501–600 of 682
- Liver Sinusoidal Endothelial Cell-Mediated CD8 T Cell Priming Depends on Co-Inhibitory Signal Integration over TimeJ. Kaczmarek, Yahya Homsi, J. V. van Uum, C. Metzger, P. Knolle, W. Kolanus, T. Lang, L. Diehl · 2014 · PLoS ONE
- Virological breakthrough and resistance in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practiceE. Ridruejo, R. Adrover, Marcelo O. Silva · 2011 · Hepatology
- Cytotoxic T cells – Stroma interactionsMuhammad Zaeem Noman, Houssem Benlalam, Meriem Hasmim, Salem Chouaı̈b · 2011 · Bulletin du Cancer
- Genetic Modification of Donor Hepatocytes Improves Therapeutic Efficacy for Hemophilia B in MiceYao-Ming Wu, C. Kao, Yu-Jen Huang, I-Shing Yu, Hsuan-Shu Lee, H. Lai, Po-Huang Lee, Chia-Ni Lin, Shu-Wha Lin · 2010 · Cell Transplantation
- Different mechanisms regulate CD4+ T cell independent induction of oral and nasal tolerance of CD8+ T cellsHendrik van den Berg, Mascha Greuter, Georg Kraal, Joke M. M. den Haan · 2009 · Immunobiology
- Coaxing the liver into preventing autoimmune disease in the brain.Brad E. Hoffman, R. Herzog · 2008 · Journal of Clinical Investigation
- Molecular mechanisms of portal vein toleranceTomohiro Watanabe, Masatoshi Kudo, Tsutomu Chiba, Yoshio Wakatsuki · 2007 · Hepatology Research
- Impaired function of dendritic cells translocating the liver sinusoids: A veto effect contributing to intrahepatic tolerance?Patrick Bertolino · 2008 · European Journal of Immunology
- Cross‐priming with an epicutaneously introduced soluble protein antigen generates Tc1 cellsLi-Fang Wang, Chih‐Jung Hsu, S. Miaw, H.-C. Chiu, Ching-Yi Liu, H.-S. Yu · 2006 · European Journal of Immunology
- Cognate Interaction Between Endothelial Cells and T CellsPercy Alexander Knolle · 2006 · Springer eBooks
- Anti-PD-1 alone or in combination with anti-CTLA-4 for advanced melanoma patients with liver metastasesInês Pires da Silva, Isabel Li, Selma Ugurel, Patricio Serra-Bellver, Avanti Andhale, Hannah Burnette, Francisco Aya, Jordan W. Conway, Jorja Braden, Matteo Salvatore Carlino et al. · 2024 · European Journal of Cancer
- Development and Validation of a Prognostic Risk Model for Patients with Advanced Melanoma Treated with Immune Checkpoint InhibitorsIgor Stukalin, Vishal Navani, Mehul Gupta, Yibing Ruan, Devon J. Boyne, Dylan Edmund O'Sullivan, Daniel E. Meyers, Siddhartha Goutam, Michael Sander, Benjamin W. Ewanchuk et al. · 2023 · The Oncologist
- Mimicking Pathogens to Augment the Potency of Liposomal Cancer VaccinesMaarten K. Nijen Twilhaar, Lucas Czentner, Cornelus F. van Nostrum, Gert Storm, Joke M. M. den Haan · 2021 · Pharmaceutics
- Stellate Cells in Hepatic Immunological ToleranceChandrashekhar R. Gandhi · 2015 · Elsevier eBooks
- Role and Function of Liver Sinusoidal Endothelial CellsPercy Alexander Knolle · 2008 · Humana Press eBooks
- Hepatitis Prevention and TreatmentJ. Colacino, B. Heinz · 2004 · Milestones in Drug Therapy
- Induction Phase of Spontaneous Liver Transplant ToleranceG. Mccaughan, D. Bowen, P. Bertolino · 2020 · Frontiers in Immunology
- Role of sterile inflammation in fatty liver diseasesYonglin Chen, Muhammad Nadeem Yousaf, Wajahat Zafar Mehal · 2018 · Liver Research
- A novel vascular targeting strategy for brain-derived endothelial cells using a TCR mimic antibodyR. Bhattacharya, Yan Xu, Md Ashequr Rahman, P. Couraud, I. A. Romero, Babette B. Weksler, J. Weidanz, U. Bickel · 2010 · Journal of Cellular Physiology
- Toward a molecular explanation for cross-presentation of antigens to the immune system.B. Khor, R. Makar · 2008 · Transfusion Medicine Reviews
- Kupffer cells: Another player in liver tolerance inductionM. Everett, Bradley H. Collins, W. Parker · 2003 · Liver transplantation
- Animal Models of Autoimmune HepatitisE. Jaeckel · 2002 · Seminars in liver disease (Print)
- Infection, Immune Homeostasis and Immune PrivilegeJ. Stein-Streilein · 2012 · Birkhäuser Advances in Infectious Diseases
- Non-hematopoietic Control of Peripheral Tissue T Cell Responses: Implications for Solid TumorsRyan S. Lane, Amanda W. Lund · 2018 · Frontiers in Immunology
- Liver-Specific Allergen Gene Transfer by Adeno-Associated Virus Suppresses Allergic Airway Inflammation in MiceCheng-Chi Chan, Chin‐Wen Lai, Chia-Jen Wu, Li‐Chen Chen, Mi‐Hua Tao, Ming‐Ling Kuo · 2016 · Human Gene Therapy
- Correction: The Brain Microvascular Endothelium Supports T Cell Proliferation and Has Potential for Alloantigen PresentationJulie Wheway, Stephanie Obeid, P. Couraud, V. Combes, G. Grau · 2013 · PLoS ONE
- Requirements and Challenges of a Preclinical Autoimmune Hepatitis Mouse ModelMatthias Hardtke‐Wolenski, Fatih Noyan, Elmar Jaeckel · 2011 · Digestive Diseases
- Liver sinusoidal endothelial cell function in rejected and spontaneously accepted rat liver allograftsX. Ge, G. Nowak, B. Ericzon, S. Sumitran-Holgersson · 2007 · Transplant International
- T cells in the liver: There is life beyond the graveyardP. Bertolino, D. Bowen, V. Benseler · 2007 · Hepatology
- T‐Helper Cell Tolerance to Ubiquitous Nuclear AntigensBritt Nakken, K. E. Davis, Zijian Pan, Michael Philipp Bachmann, Amy Darise Farris · 2003 · Scandinavian Journal of Immunology
- Hepatitis B Virus Infection: Molecular Virology to Antiviral DrugsHong Tang · 2020 · Advances in Experimental Medicine and Biology
- Heterogeneity of human nasal vascular and sinusoidal endothelial cells from the inferior turbinate.C. Holmén, P. Stjärne, S. Sumitran-Holgersson · 2005 · American Journal of Respiratory Cell and Molecular Biology
- Single-cell RNA sequencing of terminal ileal biopsies identifies signatures of Crohn’s disease pathogenesisMonika Krzak, Tobi Alegbe, D. Leland Taylor, Gareth‐Rhys Jones, Mennatallah Ghouraba, Michelle Strickland, Bradley T. Harris, Reem Satti, Kenneth Arestang, Lucia Ramirez-Navarro et al. · 2026 · Nature Genetics
- Τ cell-mediated adaptive immunity in the transition from metabolic dysfunction-associated steatohepatitis to hepatocellular carcinomaGrigorios Papadopoulos, Eirini Giannousi, A. Avdi, Rallia-Iliana Velliou, P. Nikolakopoulou, Antonios Chatzigeorgiou · 2024 · Frontiers in Cell and Developmental Biology
- Insights gained from single-cell RNA analysis of murine endothelial cells in aging heartsZhong Liu, Ya-Lin Huang, Dongliang Wang, Mengke Li, Qi-Kai Zhang, Caineng Pan, Yuheng Lin, Yuanting Luo, Zhuoxing Shi, Ping Zhang et al. · 2023 · Heliyon
- The Immunomodulatory Properties of Mesenchymal Stem Cells Play a Critical Role in Inducing Immune Tolerance after Liver TransplantationShao-wei Li, Yue Cai, Xin‐Li Mao, Sai-qin He, Yahong Chen, Lingling Yan, Jingjing Zhou, Ya-qi Song, Liping Ye, Xian-Bin Zhou · 2021 · Stem Cells International
- Zone defence – the gut microbiota position macrophages for optimal liver protectionKieran English, D. Bowen, P. Bertolino · 2021 · Immunology and Cell Biology
- Targeting Lymphoid Tissues to Promote Immune ToleranceXiao Yan Chen, Guang Sheng Du, Xun Sun · 2021 · Advanced Therapeutics
- Recent advances regarding tumor microenvironment and immunotherapy in hepatocellular carcinomaWei Qin, Zhenyu Cao, Siyuan Liu, Xun-Di Xu · 2020 · Hepatoma Research
- Cell Therapy as a Tool for Induction of Immunological Tolerance after Liver TransplantationI. Kholodenko, R. Kholodenko, A. Lupatov, K. N. Yarygin · 2018 · Bulletin of experimental biology and medicine
- Intrahepatic T cell survival versus death: which one prevails and why?Wajahat Zafar Mehal · 2003 · Journal of Hepatology
- Nanotherapy targeting liver sinusoidal endothelial cells in liver fibrosisLingfeng Zhang, Jia-Wen Ru, Su-Qing Liang, Meng-Meng Zhang, Chun-Yu Zhang, Jia-Qi Liu, Yi Wang, Tian‐Jiao Zhou, Xian Wu Cheng, Lei Xing et al. · 2026 · Journal of Controlled Release
- Prognostic Value of the C-PLAN Index in Metastatic Renal Cell Carcinoma Treated with NivolumabGökhan Şahin, Caner Acar, Haydar Çağatay Yüksel, Salih Tünbekici, Fatma Pınar Açar, Erhan Gökmen, Burçak Karaca · 2025 · Journal of Clinical Medicine
- Deciphering the tumour immune microenvironment of hepatocellular carcinomaSha Liu, Man Jia, Rongyang Dai · 2023 · Scandinavian Journal of Immunology
- Immunotherapy and tumor mutational burden in cancer patients with liver metastases: A meta and real word cohort analysisRui-Yan Wu, Bi-Cheng Wang, Kun Wang, F. Xia, Zhi-Yuan Zhang, J. Wan, Zhen Zhang · 2023 · Frontiers in Oncology
- The Liver Sinusoidal Endothelial CellKaren Kristine Sørensen, Bård H. Smedsrød · 2020 · Liver
- Impact of post‐transplant flow cytometric panel‐reactive antibodies on late‐onset hepatic venous outflow obstruction following pediatric living donor liver transplantationT. Urahashi, K. Mizuta, Y. Ihara, Y. Sanada, T. Wakiya, N. Yamada, N. Okada · 2014 · Transplant International
- Human hepatic stellate cells are liver-resident antigen-presenting cellsAnna Alisi, Paolo Romania, Valério Nobili, Franco Locatelli, Doriana Fruci · 2011 · Hepatology
- Gap Junction Communication between Autologous Endothelial and Tumor Cells Induce Cross-Recognition and Elimination by Specific CTL1Houssem Benlalam, Abdelali Jalil, M. Hasmim, B. Pang, Ryad Tamouza, M. Mitterrand, Y. Godet, Nathalie Lamerant, Caroline Robert, M. Avril et al. · 2009 · Journal of Immunology
- Alternatives to immunosuppressive drugs in human islet transplantationA. Cotterell, N. Kenyon · 2002 · Current Diabetes Reports
- Antigen Processing and Presentation in the LiverMasanori Abe, Angus W. Thomson · 2008 · Humana Press eBooks
- Clinical applications of immunogenomics in hepatocellular carcinomaJames K. Carter, Daniel C. Cameron, Augusto Villanueva · 2026 · Clinical and Molecular Hepatology
- Liver metastasis affects progression pattern during immune checkpoint inhibitors monotherapy in gastric cancerIori Motoo, Takayuki Ando, Takeru Hamashima, Shinya Kajiura, Miho Sakumura, Yuko Ueda, Aiko Murayama, Kohei Ogawa, Kenichiro Tsukada, Akira Ueda et al. · 2023 · Frontiers in Oncology
- Immune response to foreign materials in spinal fusion surgeryJia Cai, Wengang Wang, Peng Cai, Bo Cao · 2023 · Heliyon
- The influence of baseline characteristics on the efficacy of immune checkpoint inhibitors for advanced lung cancer: A systematic review and meta-analysisQionghua Xiao, Xiaolin Yu, Zhihao Shuai, Ting Shan Yao, Xiaohua Yang, Yanxia Zhang · 2022 · Frontiers in Pharmacology
- Improved function and balance in T cell modulation by endothelial cells in young peopleShu-Qian Tang, Weili Yao, Yazhe Wang, Yuanyuan Zhang, Hongyan Zhao, Qi Wen, Yu Wang, Lan‐Ping Xu, Xiaohui Zhang, Xiao‐Jun Huang et al. · 2021 · Clinical & Experimental Immunology
- Unexpected enhancement of FVIII immunogenicity by endothelial expression in lentivirus-transduced and transgenic miceQizhen Shi, Christopher V. Carman, Yingyu Chen, Peter T. Sage, Feng Xue, Xin M. Liang, Gary E. Gilbert · 2020 · Blood Advances
- Stem cells or macrophages: Which contribute to bone marrow cell therapy for liver cirrhosis?Tao Liu, Yingjie Wang, Chen-Ting Wen, Shi-Chang Zhang, Chun-Mei Zhang · 2011 · Hepatology
- Rapid and preferential distribution of blood‐borne αCD3εAb to the liver is followed by local stimulation of T cells and natural killer T cellsGerhard Wingender, Beatrix Schumak, Anna Schurich, J. Engelbert Gessner, Elmar Endl, Andreas Limmer, Percy Alexander Knolle · 2005 · Immunology
- Hepatitis C virus–specific CD8 + T cells restricted by donor HLA alleles following liver transplantationGeorg M. Lauer · 2005 · Liver Transplantation
- Genetic manipulation of sinusoidal endothelial cellsY. Takei, A. Maruyama, K. Ikejima, N. Enomoto, S. Yamashina, John J. Lemasters, N. Sato · 2001 · Journal of Gastroenterology and Hepatology
- Molecular and Immunological Responses to FoodV. Turcanu, G. Lack · 2006 · ASM Press eBooks
- Immunologic Tolerance as Taught by AllograftsW. Burlingham, J. Torrealba · 2004
- Immune Responses in Gene Transfer for Genetic DisordersD. Sabatino, K. High · 2003 · Springer eBooks
- Cancer-associated fibroblast-derived exosomes in cancer progression: a focus on hepatocellular carcinoma.Chou-Yi Hsu, A. T. Ahmed, S. O. Rab, S. Uthirapathy, S. Ballal, Rishiv Kalia, Renu Arya, Deepak Nathiya, Muthena Kariem, Abed J. Kadhim · 2025 · Experimental Cell Research
- Advancing immunosuppression in liver transplantation: the role of regulatory T cells in immune modulation and graft toleranceJi Won Han, Su‐Hyung Park · 2024 · Clinical Transplantation and Research
- HBVsvp-Pulsed Dendritic Cell Immunotherapy Induces Th1 Polarization and Hepatitis B Virus-Specific Cytotoxic T Lymphocytes ProductionM. Farag, Reda A. Suef, Ghada M. Al-Toukhy, M. Selim, Mostafa A. Elbahnasawy, N. Elsharkawy, S. Ezzat, N. Shebl, M. Mansour · 2020 · Infection and Drug Resistance
- Postoperative Portal Hypertension Enhances Alloimmune Responses after Living-Donor Liver Transplantation in Patients and in a Mouse ModelShinji Hashimoto, Takashi Onoe, Masataka Banshodani, Kazuhiro Taguchi, Yuka Tanaka, Hideki Ohdan · 2019 · The Journal of Immunology
- The Role of Liver Sinusoidal Endothelial Cells in Induction of Carbohydrate Reactive B Cells Tolerance Through the Programmed Death 1/Programmed Death Ligand 1 PathwayYuka Igarashi, Takashi Onoe, Hideki Ohdan · 2015 · Transplantation
- Cytotoxic T-Cell Response Following Mouse Liver Transplantation Is Independent of the Initial Site of T-Cell PrimingIngo Klein, HJ Gassel, Ian Nicholas Crispe · 2006 · Transplantation Proceedings
- The Liver as an Immune-Privileged SiteDirk Wohlleber, Percy Alexander Knolle · 2012 · Springer eBooks
- Biomarker-guided strategies for tumor vasculature: From imaging advances to novel therapeutic interventionsConnor Purcell, Dinara Ryspayeva, Jay Gopal, Andrea Schmidt, Philippa C. Vaughn-Beaucaire, Audrey Y. Su, Sean Edward Lawler, William MacDonald, Maximillian Pinho-Schwerrman, Wafik S. El‐Deiry et al. · 2026 · Cancer Letters
- Hepatic Viral Reservoirs in Concurrent HIV and HBV: From Mechanistic Insight to Integrated Cure StrategiesRenato Bobadilla, Finn MacLean, Shravan Dave, Jason T. Blackard, Sara Gianella · 2026 · Infection and Drug Resistance
- Liver sinusoidal endothelial cells: Central mediators of MASLD pathogenesis and sepsis susceptibilityYanying Wu, Wenyi Le, Huali Zhang, Yaxi Zhu · 2025 · Life Sciences
- Transcriptome wide functional analysis of HBx expressing human hepatocytes stimulated with endothelial cell cross-talkShaikh M. Ghufran, Prachi Sharma, B. Roy, Shivani Jaiswal, Mehreen Aftab, Shinjinee Sengupta, S. Ghose, Subhrajit Biswas · 2023 · Genomics
- Identification of HLA‐A2‐restricted immunogenic peptides derived from a xenogenic porcine major histocompatibility complexChan-Su Park, Sun-A Im, Sukgil Song, Kyungjae Kim, C. Lee · 2014 · Xenotransplantation
- Future Perspective: Immunomodulatory Therapy for Autoimmune HepatitisM. Sebode, A. Lohse · 2014 · Digestive Diseases
- Organtransplantation in der EndokrinologieElmar Jaeckel, Thomas Becker, M.P. Manns · 2004 · Der Internist
- Scavenger endothelial cells alleviate tissue damage by engulfing toxic molecules derived from hemolysisYimei Dai, Yunyun Jiang, Canran Cao, Yongtai Xu, Siting Lai, Wenchao Zhu, Meng Gao, Feifei Li, Sicong He, Jin Xu · 2025 · Proceedings of the National Academy of Sciences
- RASGRF2 as a potential pathogenic gene mediating the progression of alcoholic hepatitis to alcohol-related cirrhosis and hepatocellular carcinomaZhengyuan Chen, Danfeng Fan, Tianyi Hang, Xiaoqing Yue · 2025 · Discover Oncology
- The necessary role of an efficient tumor immunotherapy by MHC II expression on amateur APCsJiaxin Zhong, Xiaorong Lin, Hai Hu · 2024 · Malignancy Spectrum
- Single-cell RNA sequencing reveals dysregulated cellular programmes in the inflamed epithelium of Crohn's disease patients.M. Krzak, T. Alegbe, D. Taylor, M. Ghouraba, M. Strickland, R. Satti, T. Thompson, K. Arestang, M. Przybilla, L. Ramirez-Navarro et al. · 2023 · medRxiv
- Perspectives for novel therapeutic concepts in hepatocellular carcinoma targeting the stromal and innate immune microenvironmentCharlotte Rennert, Julia Lang‐Meli, Mikhail Gromak, Maike Hofmann, Robert Thimme, Natascha Roehlen · 2022 · Liver Cancer International
- Deciphering the Dynamic Complexities of the Liver Microenvironment — Toward a Better Understanding of Immune-Mediated liver Injury Caused by Immune Checkpoint Inhibitors (ILICI)Tao Wang, Matthew M. Yeh, M. Avigan, L. Pelosof, G. Feldman · 2021 · AAPS Journal
- Fetal Hepatic Response to Bovine Viral Diarrhea Virus Infection in UteroS. E. Morarie, Natalia P. Smirnova, Thomas Ross Hansen, Jessica Mediger, Lyle J. Braun, Christopher C. L. Chase · 2018 · Pathogens
- Gut microbiome in liver diseaseYu-Xin Chen, Han Shen · 2016
- The liver’s imprint on CD8+ T cell primingPercy Alexander Knolle · 2012 · Journal of Hepatology
- Outcome of patients suffering from a spontaneous reactivation of hepatitis B presenting as acute‐on‐chronic liver failure and treated with antiviralsC. Dai, Ming-Lun Yeh, Chung-Feng Huang, Jee-Fu Huang, Ming-Lung Yu, Wan-Long Chuang · 2011 · Hepatology
- Lack of an association between an apolipoprotein C3 genetic variant and the liver fat content in patients with type 2 diabetesJ. Petit, B. Guiu, D. Masson, J. Cercueil, P. Hillon, B. Vergès · 2011 · Hepatology
- Role of Invariant Natural Killer T Cells in Liver Sinusoidal Endothelial Cell-Induced Immunosuppression Among T Cells with Indirect AllospecificityMasayuki Shishida, Hideki Ohdan, Takashi Onoe, Yuka Tanaka, Yuka Igarashi, Masataka Banshodani, Toshimasa Asahara · 2008 · Transplantation
- Evaluation of the role of the endocytic receptor L-SIGN for cytoadhesion of Plasmodium falciparum-infected erythrocytesN. Viebig, K. Andrews, Y. van Kooyk, M. Lanzer, P. Knolle · 2005 · Parasitology Research
- Can Combined Therapy Benefit Immune Checkpoint Blockade Response in Hepatocellular Carcinoma?Zhong-Hong Fan, Xiao-Dong Sun, Yu-Guo Chen, Guo-Yue Lv · 2018 · Anti-Cancer Agents in Medicinal Chemistry
- Pseudocapillarization and the Aging LiverD. Svistounov, S. Zykova, V. Cogger, A. Warren, R. Fraser, B. Smedsrød, R. Mccuskey, D. Le Couteur · 2011 · Springer eBooks
- Relations entre foie et immunitéJean‐Charles Duclos‐Vallée, Éric. Ballot, Catherine Johanet · 2003 · EMC - Hépatologie
- 8 Immunopathogenesis of hepatitis CB. Rehermann · 2000 · Biomedical research reports
- Dissecting the Cellular Heterogeneity Underlying Liver Diseases Through the Integration of GWASs and Single-Cell RNA SequencingMiao Zhou, Meng Liu, Chao Xue · 2025 · Biology
- Comprehensive review of the vascular niche in regulating liver regeneration, fibrosis, and hepatocellular carcinomaYutian Chen, Yangfan Zhou, Peipei Li, Bi-Sen Ding · 2025 · EngMedicine
- Publication characteristics and visualized analysis of research about liver sinusoidal endothelial cellsShanshan Zhao, Lan Zhang, Junzhe Zhao, Farah Tasnim, Hanry Yu · 2023 · iLiver
- Exploring the Molecular and Developmental Dynamics of Endothelial Cell DifferentiationYu Jung Shin, Jung Hyun Lee · 2023 · International Journal of Stem Cells
- Short-term cyclosporine therapy and cotransplantation of donor splenocytes: effects on graft rejection and survival rates in pigs subjected to renal transplantation.M. Maestri, J. Rademacher, A. Gaspari, L. Lenti, S. Crespi, L. Cansolino, G. Novelli, D. Agoglitta, F. Maffeis, Antonjacopo Ferrario di Tor Vajana et al. · 2008 · Journal of Surgical Research