Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance
Limmer, Andreas, Ohl, Jutta, Kurts, Christian, Ljunggren, Hans-Gustaf, Reiss, Yuval, Groettrup, Marcus, Momburg, Frank, Arnold, Bernd +1 more·2000·Nature Medicine
DOI 10.1038/82161
Cited by (682)
Items 301–400 of 682
- YAP Orchestrates Heterotypic Endothelial Cell Communication via HGF/c-MET Signaling in Liver TumorigenesisStefan Thomann, Sofia M.E. Weiler, Simone Marquard, Fabian Rose, Claudia R. Ball, Marcell Tóth, Teng Wei, Carsten Sticht, Sarah Fritzsche, Stephanie K. Roessler et al. · 2020 · Cancer Research
- Immunopathogenesis: Role of Innate and Adaptive Immune ResponsesK. Visvanathan, S. Lewin · 2006 · Seminars in liver disease (Print)
- Nanoparticle-Based Drug Delivery Systems for Induction of Tolerance and Treatment of Autoimmune DiseasesHe Li, Yong‐Guang Yang, Tianmeng Sun · 2022 · Frontiers in Bioengineering and Biotechnology
- The response of fenestrations, actin, and caveolin-1 to vascular endothelial growth factor in SK Hep1 cells.V. Cogger, I. Arias, A. Warren, A. Mcmahon, D. L. Kiss, V. Avery, D. Le Couteur · 2008 · American Journal of Physiology - Gastrointestinal and Liver Physiology
- CD8 T Cells Can Reject Major Histocompatibility Complex Class I‐Deficient Skin AllograftsChun-Shui He, P. Heeger · 2004 · American Journal of Transplantation
- Staying local-antigen presentation in the liverKnolle, Percy A · 2016 · Current Opinion in Immunology
- Liver-resident CD103+ dendritic cells prime antiviral CD8+ T cells in situKrueger, Peter D, Kim, Taeg S, Sung, Sun-Sang J, Braciale, Thomas J, Hahn, Young S · 2015 · The Journal of Immunology
- Soluble programmed death-1 levels are associated with disease activity and treatment response in patients with autoimmune hepatitisKristian Aarslev, A. Dige, S. Greisen, M. Kreutzfeldt, N. Jessen, H. Vilstrup, B. Deleuran, H. Grønbæk · 2017 · Scandinavian Journal of Gastroenterology
- Pathogenesis of drug allergy – current concepts and recent insightsB. Schnyder, K. Brockow · 2015 · Clinical and Experimental Allergy
- Analysis of antigen-presenting functionality of cultured rat hepatic stellate cells and transdifferentiated myofibroblasts.Michael Bomble, F. Tacke, L. Rink, E. Kovalenko, R. Weiskirchen · 2010 · Biochemical and Biophysical Research Communications - BBRC
- Early Intrahepatic Accumulation of CD8+ T Cells Provides a Source of Effectors for Nonhepatic Immune ResponsesNoelle Katherine Polakos, Ingo Klein, Martin V. Richter, Dietmar M. W. Zaiss, Matthew Giannandrea, Ian Nicholas Crispe, David J. Topham · 2007 · The Journal of Immunology
- Dectin-1 targeting delivery of TNF-α antisense ODNs complexed with β-1,3-glucan protects mice from LPS-induced hepatitis.S. Mochizuki, K. Sakurai · 2011 · Journal of Controlled Release
- Defective antigen-presenting capacity of murine dendritic cells during starvation.M. Abe, F. Akbar, B. Matsuura, N. Horiike, M. Onji · 2003 · Nutrition (Burbank, Los Angeles County, Calif.)
- Remodeling the hepatic fibrotic microenvironment with emerging nanotherapeutics: a comprehensive reviewXing-Tao Zhao, Felix Kwame Amevor, Xin-Yan Xue, Cheng Wang, Zhifu Cui, Shuang-Hua Dai, Cheng Peng, Yun-Xia Li · 2023 · Journal of Nanobiotechnology
- Inflammation and Fibrogenesis in MAFLD: Role of the Hepatic Immune SystemPietro Torre, Benedetta Maria Motta, Roberta Sciorio, Mario Masarone, Marcello Persico · 2021 · Frontiers in Medicine
- The Hepatic Sinusoid in Chronic Liver Disease: The Optimal Milieu for CancerAlbert Gibert‐Ramos, David Sanfeliu-Redondo, Peio Aristu-Zabalza, Ana Martínez-Alcocer, Jordi Gracia‐Sancho, Sergi Guixé‐Muntet, Anabel Fernández‐Iglesias · 2021 · Cancers
- Dynamic imaging reveals promiscuous crosspresentation of blood-borne antigens to naive CD8+ T cells in the bone marrow.I. Milo, A. Sapoznikov, V. Kalchenko, O. Tal, R. Krauthgamer, N. van Rooijen, D. Dudziak, Steffen Jung, G. Shakhar · 2013 · Blood
- A novel mechanism of liver allograft rejection facilitated by antibodies to liver sinusoidal endothelial cellsS. Sumitran-Holgersson, X. Ge, Azza Karrar, Bo Xu, S. Nava, U. Broomé, G. Nowak, B. Ericzon · 2004 · Hepatology
- Donor bone marrow transplantation: chimerism and tolerance.S. Delis, G. Ciancio, G. Burke, R. Garcia-Morales, J. Miller · 2004 · Transplant Immunology
- Liver tolerance mediated by antigen presenting cells: fact or fiction?Audrey H. Lau, A. de Creus, L. Lu, A. Thomson · 2003 · Gut
- Transplant Tolerance Induction: Insights From the LiverHelong Dai, Yawen Zheng, Angus W. Thomson, Natasha M. Rogers · 2020 · Frontiers in Immunology
- Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens.C. Gottschalk, V. Damuzzo, Janine Gotot, R. Kroczek, H. Yagita, K. Murphy, P. Knolle, I. Ludwig-Portugall, C. Kurts · 2013 · Journal of the American Society of Nephrology
- Human blood outgrowth endothelial cells improve islet survival and function when co-transplanted in a mouse model of diabetesV. Coppens, Y. Heremans, G. Leuckx, K. Suenens, D. Jacobs-Tulleneers-Thevissen, K. Verdonck, T. Lahoutte, A. Luttun, H. Heimberg, N. De Leu · 2013 · Diabetologia
- Cytokines and chronic liver diseaseLeonardo Fainboim, Alejandra Claudia Cherñavsky, Natalia Paladino, Ana Claudia Flores, Lourdes Arruvito · 2007 · Cytokine & Growth Factor Reviews
- Gestational age of recipient determines pattern and level of transgene expression following in utero retroviral gene transfer.C. Porada, Paul J. Park, G. Almeida-Porada, Wansheng Liu, Ferhat Ozturk, H. Glimp, E. Zanjani · 2005 · Molecular Therapy
- CTLA‐4‐dependent mechanisms prevent T cell induced‐liver pathology during the erythrocyte stage of Plasmodium berghei malariaThomas Jacobs, Tanja Plate, Iris Gaworski, Bernhard Fleischer · 2004 · European Journal of Immunology
- Anti‐angiogenic therapy enhances cancer immunotherapy: Mechanism and clinical applicationAn‐Qi Li, Jian‐Hong Fang · 2024 · Interdisciplinary medicine
- Immune Cell Trafficking to the LiverSulemon Chaudhry, Jean C. Emond, Adam D. Griesemer · 2019 · Transplantation
- Autoimmune hepatitis in a murine autoimmune polyendocrine syndrome type 1 model is directed against multiple autoantigensM. Hardtke-Wolenski, R. Taubert, F. Noyan, M. Sievers, Janine Dywicki, J. Schlué, Christine S. Falk, B. Ardesjö-Lundgren, H. Scott, A. Pich et al. · 2015 · Hepatology
- Conventional liver CD4 T cells are functionally distinct and suppressed by environmental factors†Steven C. Katz, Venu Gopal Pillarisetty, Joshua I.S. Bleier, T. Peter Kingham, Umer I. Chaudhry, Alaap B. Shah, Ronald P. DeMatteo · 2005 · Hepatology
- Immune-mediated liver injuryAnsgar Wilhelm Lohse, Christina Weiler‐Normann, Gisa Tiegs · 2009 · Journal of Hepatology
- Liver Sinusoidal Endothelial Cells in the Regulation of Immune Responses and Fibrosis in Metabolic Dysfunction-Associated Fatty Liver DiseaseMunish Puri, Snehal S. Sonawane · 2025 · International Journal of Molecular Sciences
- Cellular effector mechanisms againstPlasmodiumliver stagesUte Frevert, Elizabeth Higgins Nardin · 2008 · Cellular Microbiology
- HBsAg/HLA-A2 transgenic mice: a model for T cell tolerance to hepatitis B surface antigen in chronic hepatitis B virus infection.D. Loirat, M. Mancini-Bourgine, J. Abastado, M. Michel · 2003 · International Immunology
- Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages2020
- Endothelial Dysfunction and Liver Cirrhosis: Unraveling of a Complex RelationshipA. Nesci, Vittorio Ruggieri, Vittoria Manilla, Irene Spinelli, Luca Santoro, A. Di Giorgio, A. Santoliquido, F. Ponziani · 2024 · International Journal of Molecular Sciences
- The Impact of Malaria Parasites on Dendritic Cell–T Cell InteractionRowland Osii, T. Otto, P. Garside, F. Ndungu, J. Brewer · 2020 · Frontiers in Immunology
- The C-type lectin L-SIGN differentially recognizes glycan antigens on egg glycosphingolipids and soluble egg glycoproteins from Schistosoma mansoniS. Meyer, Boris Tefsen, A. Imberty, R. Geyer, I. van Die · 2007 · Glycobiology
- PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cellsJonathan De Smedt, Elise Anne van Os, Irene Talón, Sreya Ghosh, Burak Toprakhisar, Rodrigo Madeiro da Costa, Samantha Zaunz, Marta Aguirre Vázquez, Ruben Boon, Pieter Baatsen et al. · 2021 · Cell Death and Disease
- Amoxicillin haptenates intracellular proteins that can be transported in exosomes to target cellsFrancisco J. Sánchez-Gómez, Juan M. González-Morena, Yolanda Vida, Ezequiel Perez-Inestrosa, M. Blanca, M. J. Torres, D. Pérez-Sala · 2017 · Allergy. European Journal of Allergy and Clinical Immunology
- Direct, help-independent priming of CD8+ T cells by AAV-transduced hepatocytesS. A. Wuensch, J. Spahn, I. N. Crispe · 2010 · Hepatology
- HBV-Specific Adaptive ImmunityAntonio Bertoletti, Anthony Tanoto Tan, Adam J. Gehring · 2009 · Viruses
- Hepatic sinusoidal endothelial cells promote hepatocyte proliferation early after partial hepatectomy in rats.Ping Chen, Xiao-Ling Dong, Jin Zhu, Jia-Hong Dong, Ji-Min Ding, Lin Zhang · 2006 · Archives of Medical Research
- Liver sinusoidal endothelial cells have a capacity for inducing nonresponsiveness of T cells across major histocompatibility complex barriersTakashi Onoe, Hideki Ohdan, Daisuke Tokita, Hidetaka Hara, Yuka Tanaka, Kohei Ishiyama, Toshimasa Asahara · 2005 · Transplant International
- Transplantation of human hepatocytes into tolerized genetically immunocompetent rats.E. Ouyang, Catherine H. Wu, C. Walton, Kittichai Promrat, George Y. Wu · 2001 · World Journal of Gastroenterology
- Antigen-Specific Immunotherapy for Treatment of Autoimmune Liver DiseasesNaomi Richardson, Sky T. H. Ng, David Cameron Wraith · 2020 · Frontiers in Immunology
- Antigen presentation by endothelial cells: what role in the pathophysiology of malaria?Razakandrainibe, Romy, Pelleau, Stéphane, Grau, Georges E., Jambou, Ronan · 2012 · Trends in Parasitology
- Harnessing the liver to induce antigen-specific immune toleranceCornelia Gottwick, Antonella Carambia, Johannes Herkel · 2022 · Seminars in Immunopathology
- The Emerging Jamboree of Transformative Therapies for Autoimmune DiseasesJosé M. Carballido, Camille Regairaz, Céline Rauld, Layla Raad, Damien Picard, Michael E. Kammuller · 2020 · Frontiers in Immunology
- Dendritic cells are required for effective cross‐presentation in the murine liver†George Plitas, Bryan M. Burt, Jennifer A. Stableford, Hoang M. Nguyen, Alexander P. Welles, Ronald P. DeMatteo · 2008 · Hepatology
- A Comparative Perspective on Wnt/β-Catenin Signalling in Cell Fate DeterminationClare L. Garcin, Shukry James Habib · 2017 · Results and problems in cell differentiation
- Shaping of Peripheral T Cell Responses by Lymphatic Endothelial CellsHumbert, Marion, Hugues, Stéphanie, Dubrot, Juan · 2017 · Frontiers in Immunology
- Crosstalk between innate and adaptive immunity in hepatitis B virus infectionLi Wang · 2015 · World Journal of Hepatology
- Pathogen Infection as a Possible Cause for Autoimmune HepatitisUrs Christen, Edith Hintermann · 2014 · International Reviews of Immunology
- Functional Genetic Variants in DC-SIGNR Are Associated with Mother-to-Child Transmission of HIV-1G. Boily-Larouche, A. Iscache, L. Zijenah, J. Humphrey, A. Mouland, B. Ward, M. Roger · 2009 · PLoS ONE
- Levels of peripheral T cell tolerance.B. Arnold · 2002 · Transplant Immunology
- Microvascular Thrombosis and Liver Fibrosis Progression: Mechanisms and Clinical ApplicationsCarlo Airola, Maria Pallozzi, Lucia Cerrito, Francesco Santopaolo, Leonardo Stella, Antonio Gasbarrini, Francesca Romana Ponziani · 2023 · Cells
- Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injuryCarl-Philipp Hackstein, Jasper Spitzer, Konstantinos Symeonidis, Helena Horvatic, Tanja Bedke, Babett Steglich, Sabine Klein, Lisa Mareike Assmus, Alexandru Odainic, Jennifer Szlapa et al. · 2023 · Journal of Hepatology
- The ABCs of Antigen Presentation by Stromal Non-Professional Antigen-Presenting CellsT. J. Harryvan, Sabine de Lange, L. Hawinkels, E. Verdegaal · 2021 · International Journal of Molecular Sciences
- Immunotherapy for Hepatocellular Carcinoma: Current Limits and ProspectsCheng Frank Zhong, Yirun Li, Jing Yang, Shengxi Jin, Guoqiao Chen, Duguang Li, Xiaoxiao Fan, Hui Min Lin · 2021 · Frontiers in Oncology
- Inhibition of In Vivo Growth of Plasmodium berghei by Launaea taraxacifolia and Amaranthus viridis in MiceAdewale Adetutu, Olubukola Sinbad Olorunnisola, Abiodun Olusoji Owoade, Peter Ifeoluwa Adegbola · 2016 · Malaria Research and Treatment
- Tolerance Induction in Response to Liver InflammationA. Erhardt, G. Tiegs · 2010 · Digestive Diseases
- Lung single-cell RNA profiling reveals response of pulmonary capillary to sepsis-induced acute lung injuryRu-Hao Yang, Ting Zheng, Hongyu Xiang, Meng-Lin Liu, Ke Hu · 2024 · Frontiers in Immunology
- The role of the liver in the migration of parasites of global significanceG. Deslyper, D. Doherty, J. Carolan, C. Holland · 2019 · Parasites & Vectors
- Animal models of autoimmune hepatitisUrs Christen · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Acute on Chronic Liver Failure and Immune Dysfunction: A Mimic of SepsisM. Hensley, Jane C. Deng · 2018 · Seminars in Respiratory and Critical Care Medicine
- Mouse Models for Experimental Autoimmune Hepatitis: Limits and ChancesMatthias Hardtke‐Wolenski, Elmar Jaeckel · 2010 · Digestive Diseases
- Vascular targeting and antigen presentationR. Pasqualini, D. McDonald, W. Arap · 2001 · Nature Immunology
- Nanoparticle‐mediated targeting of autoantigen peptide to cross‐presenting liver sinusoidal endothelial cells protects from CD8 T‐cell‐driven autoimmune cholangitisCarambia, Antonella, Gottwick, Cornelia, Schwinge, Dorothee, Stein, Stephanie, Digigow, Reinaldo, Şeleci, Muharrem, Mungalpara, Disha, Heine, Markus, Schuran, Fenja A., Corban, Carlotta et al. · 2021 · Immunology
- Hepatitis mouse models: from acute‐to‐chronic autoimmune hepatitisM. Yüksel, D. Laukens, F. Heindryckx, H. van Vlierberghe, A. Geerts, F. Wong, L. Wen, I. Colle · 2014 · International journal of experimental pathology (Print)
- Balance of inflammatory pathways and interplay of immune cells in the liver during homeostasis and injuryChrister Baeck, Frank Tacke · 2014 · Europe PMC (PubMed Central)
- Matrix adherence of endothelial cells attenuates immune reactivity: induction of hyporesponsiveness in allo‐ and xenogeneic modelsHeiko Methe, Adam Groothuis, Mohamed H. Sayegh, Elazer Reuven Edelman · 2007 · The FASEB Journal
- Study of the Impact of Liver Transplantation on the Outcome of Intestinal Grafts in ChildrenM. Jugie, D. Canioni, C. Le Bihan, S. Sarnacki, Y. Révillon, D. Jan, F. Lacaille, N. Cerf-Bensussan, O. Goulet, N. Brousse et al. · 2006 · Transplantation
- Parenchymal cells in immune and tolerance induction.B. Arnold · 2003 · Immunology Letters
- Liver-resident memory T cells: life in lockdownPallett, Laura J., Maini, Mala K. · 2022 · Seminars in Immunopathology
- The role of liver sinusoidal endothelial cells in liver diseases: Key players in health and pathologyÉric Felli, Yeldos Nulan, Martí Ortega‐Ribera, Anabel Fernández‐Iglesias, Jordi Gracia‐Sancho · 2025 · Journal of Hepatology
- Interorgan communication with the liver: novel mechanisms and therapeutic targetsJiulu Zhao, Xi Zhang, Yuewen Li, Jizhang Yu, Zhang Chen, Yuqing Niu, Shuan Ran, Song Wang, Weicong Ye, Zilong Luo et al. · 2023 · Frontiers in Immunology
- Progress of immune checkpoint inhibitors therapy for non-small cell lung cancer with liver metastasesFanjie Qu, Yi Zhou, Shuang Wu · 2023 · British Journal of Cancer
- Regulatory T-Cell Therapy in Liver Transplantation and Chronic Liver DiseaseAngus Hann, Ye Htun Oo, M. Thamara P. R. Perera · 2021 · Frontiers in Immunology
- Immune responses in liver-directed lentiviral gene therapyAndrea Annoni, Kevin Goudy, Mahzad Akbarpour, Luigi Naldini, Maria Grazia Roncarolo · 2013 · Translational research
- The Efficacy of PD-1/PD-L1 Inhibitors in Patients with Liver Metastasis of Non-Small Cell Lung Cancer: A Real-World StudyMingying Xie, Na Li, Xiaoling Xu, Yanjun Xu, Hui Li, Liang Zhu, Jiamin Sheng, Zichao Zhou, Yun Fan · 2022 · Cancers
- Optimization of Liposomes for Antigen Targeting to Splenic CD169+ MacrophagesMaarten K. Nijen Twilhaar, Lucas Czentner, Joanna Aleksandra Grabowska, Alsya J. Affandi, Chun Yin Jerry Lau, Katarzyna Olesek, Hakan Kalay, Cornelus F. van Nostrum, Yvette van Kooyk, Gert Storm et al. · 2020 · Pharmaceutics
- Liver immunology: How to reconcile tolerance with autoimmunity.C. Grant, R. Liberal · 2017 · Clinics And Research in Hepatology and Gastroenterology
- New Animal Models for Autoimmune HepatitisUrs Christen, Edith Hintermann, Elmar Jaeckel · 2009 · Seminars in Liver Disease
- Traffic of Proteins and Peptides across Membranes for Immunosurveillance by CD8+ T Lymphocytes: A Topological ChallengeCarolina Johnstone, Margarita Del Val · 2007 · Traffic
- Neisserial Immunoglobulin A1 Protease Induces Specific T-Cell Responses in HumansAnastasios Tsirpouchtsidis, R. Hurwitz, V. Brinkmann, T. Meyer, G. Haas · 2002 · Infection and Immunity
- Promises and challenges of mucosal COVID-19 vaccinesAbhay P. S. Rathore, Ashley L. St. John · 2023 · Vaccine
- SCARF-1 promotes adhesion of CD4+ T cells to human hepatic sinusoidal endothelium under conditions of shear stressDaniel A. Patten, Sivesh Kathir Kamarajah, Joanne M. Rose, Joseph Tickle, Emma L. Shepherd, David Adams, Chris J. Weston, Shishir Shetty · 2017 · Scientific Reports
- Measuring antigen presentation in mouse brain endothelial cells ex vivo and in vitroS. Howland, S. Gun, C. Claser, C. Poh, L. Rénia · 2015 · Nature Protocols
- Plasmodium cellular effector mechanisms and the hepatic microenvironmentU. Frevert, U. Krzych · 2015 · Frontiers in Microbiology
- Absorption, Migration and Kinetics in Peripheral Blood of Orally Administered Ovalbumin in a Mouse ModelT. Matsubara, N. Aoki, T. Honjoh, K. Mizumachi, J. Kurisaki, T. Okajima, D. Nadano, T. Matsuda · 2008 · Bioscience, biotechnology and biochemistry
- Protection of Hepatocytes from Cytotoxic T Cell Mediated Killing by Interferon-AlphaC. Willberg, S. Ward, R. Clayton, N. Naoumov, C. McCormick, S. Proto, Mark Harris, Arvind H. Patel, P. Klenerman · 2007 · PLoS ONE
- Autoimmune Hepatitis in Brazil: An OverviewAnna Carla Goldberg, Paulo Lisboa Bittencourt, Léa Campos de Oliveira, Rajendranath Ramasawmy, Maria Lúcia Carnevale Marin, Selma A. Palácios, Jorge Elias Kalil, Gilda Porta · 2007 · Scandinavian Journal of Immunology
- Immunization with a Circumsporozoite Epitope Fused to Bordetella pertussis Adenylate Cyclase in Conjunction with Cytotoxic T-Lymphocyte-Associated Antigen 4 Blockade Confers Protection against Plasmodium berghei Liver-Stage MalariaSusanne Tartz, Jana Kamanová, Marcela Simsova, Peter Šebo, Stefanie Bolte, Volker Theo Heussler, Bernhard Fleischer, Thomas Jacobs · 2006 · Infection and Immunity
- Role of the Liver in Peripheral Tolerance: Induction Through Oral Antigen FeedingWei Li, Sonja T. Chou, Celso Wang, C. S. Kuhr, J. Perkins · 2004 · American Journal of Transplantation
- Liver-Targeting Nanoplatforms for the Induction of Immune ToleranceSydney Kusumoputro, Christian Au, Katie H. Lam, Nathaniel Park, Austin Hyun, Emily Kusumoputro, Xiang Wang, Tian Xia · 2023 · Nanomaterials
- Biomaterial Approaches for Understanding and Overcoming Immunological Barriers to Effective Oral VaccinationsHannah Frizzell, Kim A. Woodrow · 2020 · Advanced Functional Materials
- The role of hepatic immune regulation in systemic immunity to viral infectionPercy Alexander Knolle, Jan P. Böttcher, Li–Rung Huang · 2014 · Medical Microbiology and Immunology
- Association of the cannabinoid receptor 2 (CB2) Gln63Arg polymorphism with indices of liver damage in obese children: An alternative way to highlight the CB2 hepatoprotective propertiesM. Ehrhardt, P. Leidinger, A. Keller, T. Baumert, Juana Díez, E. Meese, A. Meyerhans · 2011 · Hepatology
- Taking off the brakes: T cell immunity in the liverMA Kern, A. Popov, Christian Kurts, Joachim Ludwig Schultze, Percy Alexander Knolle · 2010 · Trends in Immunology