Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance
Limmer, Andreas, Ohl, Jutta, Kurts, Christian, Ljunggren, Hans-Gustaf, Reiss, Yuval, Groettrup, Marcus, Momburg, Frank, Arnold, Bernd +1 more·2000·Nature Medicine
DOI 10.1038/82161
Cited by (682)
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- Reply:S. Lotersztajn, F. Teixeira-Clerc, V. Deveaux, S. Manin, A. Mallat · 2011
- ReplyM. Kowalik, G. Ledda-columbano, S. Giordano, A. Columbano · 2011 · Hepatology
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- Untitled workKalina · 2002 · 10.1002/1521-4141(200209)32:9