Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

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1. Common genetic variants on chromosome 9p21 are associated with myocardial infarction and type 2 diabetes in an Italian population
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2. Mammalian Interphase Cdks: Dispensable Master Regulators of the Cell Cycle
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3. Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion
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4. BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA
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5. Recombinant Reg3β protein protects against streptozotocin-induced β-cell damage and diabetes
   Chen Luo, Luting Yu, Mengqi Yang, Xiang Li, Zhiyuan Zhang, Martin Omondi Alfred, Jun‐Li Liu, Min Wang · 2016 · Scientific Reports
6. GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1)
   Jeffrey M. Stein, Wieslawa M. Milewski, Manami Hara, Donald F. Steiner, Arunangsu Dey · 2011 · Islets
7. Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic beta cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice
   Xiaodan Wang, Yimeng Liu, Z. Yang, Z. Zhang, Wenping Zhou, Ziliang Ye, W. Zhang, Si Zhang, Z. Yang, Xu Feng et al. · 2011 · Diabetologia
8. Transgenic Overexpression of the Transcription Factor Nkx6.1 in β-Cells of Mice Does Not Increase β-Cell Proliferation, β-Cell Mass, or Improve Glucose Clearance
   Ashleigh E. Schaffer, Almira Yang, Fabrizio Thorel, Pedro Luis Herrera, Maike Sander · 2011 · Molecular Endocrinology
9. Synergistic effects of activin and FSH on hyperphosphorylation of Rb and G1/S transition in rat primary granulosa cells
   Takuya Ogawa, Keiichiro Yogo, Norihiro Ishida, Tatsuo Takeya · 2003 · Molecular and Cellular Endocrinology
10. In vivo proliferation of differentiated pancreatic islet beta cells in transgenic mice expressing mutated cyclin-dependent kinase 4
    Satoshi Hino, Takashi Yamaoka, Y. Yamashita, Taketo Yamada, Junichi Hata, Mitsuo Itakura · 2004 · Diabetologia
11. Cell cycle regulators control mesoderm specification in human pluripotent stem cells
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12. Positive association of free triiodothyronine with pancreatic β‐cell function in people with prediabetes
    Tomoyasu Oda, Haruhito Taneichi, Kazuhiro Takahashi, Hirobumi Togashi, Mari Hangai, Riyuki Nakagawa, Mikiko Ono, Mizue Matsui, Takayoshi Sasai, Kan Nagasawa et al. · 2014 · Diabetic Medicine
13. p19Ink4d Is a Tumor Suppressor and Controls Pituitary Anterior Lobe Cell Proliferation
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14. Emerging innovative treatment strategies for advanced clear cell renal cell carcinoma
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15. RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK–cyclin D1/CDK4 pathway
    Suihai Wang, Xiaobo Wang, Yanjun Gao, Peng Yingxia, Ningning Dong, Qian Reuben Xie, Xian Zhang, Yingsong Wu, Ming Li, Jiliang Li · 2019 · The Journal of Pathology
16. Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells
    Seung‐Hee Lee, Ergeng Hao, Fred Levine, Pamela Itkin‐Ansari · 2011 · Islets
17. A Defect of the INK4-Cdk4 Checkpoint and Myc Collaborate in Blastoid Mantle Cell Lymphoma–Like Lymphoma Formation in Mice
    Christelle Vincent‐Fabert, Rémi Fiancette, Pauline Rouaud, Christel Baudet, Véronique Truffinet, Virginie Magnone, Angélique Guillaudeau, Michel Cogné, Pierre R. Dubus, Yves Denizot · 2012 · American Journal Of Pathology
18. PAQR4 has a tumorigenic effect in human breast cancers in association with reduced CDK4 degradation
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19. Common Polymorphisms Linked to Obesity and Cardiovascular Disease in Europeans and Asians are Associated with Type 2 Diabetes in Mexican Mestizos
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20. Hypomorphic mutation in an essential cell‐cycle kinase causes growth retardation and impaired spermatogenesis
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21. CDC123/CAMK1D gene rs12779790 polymorphism and rs10811661 polymorphism upstream of the CDKN2A/2B gene in women with gestational diabetes
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22. CDK4/6 Inhibition on Glucose and Pancreatic Beta Cell Homeostasis in Young and Aged Rats
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23. DLX3 promotes bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis
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24. Chemokine signaling links cell-cycle progression and cilia formation for left–right symmetry breaking
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25. CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells
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26. Role of the Mammalian Target of Rapamycin (mTOR) Complexes in Pancreatic β-Cell Mass Regulation
    Alberto Bartolomé, Carlos Guillén · 2014 · Vitamins and hormones
27. Promiscuity Rules? The Dispensability of Cyclin E and Cdk2
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28. Novel Potent Pharmacological Cyclin-Dependent Kinase Inhibitors
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29. Mouse Models of Cell Cycle Regulators: New Paradigms
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30. Absence of Caspase-3 Protects Pancreatic β-Cells from c-Myc-induced Apoptosis without Leading to Tumor Formation
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31. Cyclin-Dependent Kinase 4 (CDK4) Expression in Pancreatic Endocrine Tumors
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32. Cyclin-dependent kinase 4 may be expressed as multiple proteins and have functions that are independent of binding to CCND and RB and occur at the S and G2/M phases of the cell cycle
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33. Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies
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34. Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4‐activated invasive melanomas
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35. Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21 Cip
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36. Gene Expression Profiling of a Mouse Model of Pancreatic Islet Dysmorphogenesis
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37. Cardiac Progenitors and the Embryonic Cell Cycle
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38. Insulin Receptor Substrate-2 in β-Cells Decreases Diabetes in Nonobese Diabetic Mice
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39. A New Way to Treat Brain Tumors: Targeting Proteins Coded by Microcephaly Genes?
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40. Activating point mutations in cyclin-dependent kinase 4 are not seen in sporadic pituitary adenomas, insulinomas or Leydig cell tumours
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41. Docking-Dependent Regulation of the Rb Tumor Suppressor Protein by Cdk4
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42. CDK4, pRB and E2F1: connected to insulin
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43. Mantle cell lymphoma-like lymphomas in c-myc-3'RR/p53+/− mice and c-myc-3'RR/Cdk4R24C mice: differential oncogenic mechanisms but similar cellular origin
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44. Hypophosphorylated pRb knock‐in mice exhibit hallmarks of aging and vitamin C‐preventable diabetes
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46. AP4 is required for mitogen- and c-MYC-induced cell cycle progression
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47. Cdk3, a conjugation-specific cyclin-dependent kinase, is essential for the initiation of meiosis in Tetrahymena thermophila
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48. The New Generation of Beta-Cells: Replication, Stem Cell Differentiation, and the Role of Small Molecules
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49. Association between type 2 diabetes and rs10811661 polymorphism upstream of CDKN2A/B: a meta-analysis
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50. Increased angiogenesis in Cdk4 R24C/R24C :Apc +/Min intestinal tumors
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51. Cyclin-Dependent Kinase Inhibitors Block Leukocyte Adhesion and Migration
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53. Cell cycle regulators and bone: development and regeneration
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54. Angiotensin II regulates activation of Bim via Rb/E2F1 during apoptosis: involvement of interaction between AMPKβ1/2 and Cdk4
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55. Malignant Melanoma–a Genetic Overview
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56. MYCL-mediated reprogramming expands pancreatic insulin-producing cells
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57. KLF10 affects pancreatic function via the SEI-1/p21Cip1 pathway
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58. Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells
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59. Expression of CDK4 or CDK2 in Mouse Oral Cavity Is Retained in Adult Pituitary with Distinct Effects on Tumorigenesis
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60. Insights into regulation of the mammalian cell cycle from studies on spermatogenesis using genetic approaches in animal models
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61. A Novel Class of Cyclin-dependent Kinase Inhibitors Identified by Molecular Docking Act through a Unique Mechanism
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62. Interaction of type 2 diabetes mellitus with Chromosome 9p21 rs10757274 polymorphism on the risk of myocardial infarction: a case–control study in Chinese population
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63. CDK4-E2F3 signals enhance oxidative skeletal muscle fiber numbers and function to affect myogenesis and metabolism
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64. Okamoto model for necrosis and its expansions, CD38-cyclic ADP-ribose signal system for intracellular Ca2+ mobilization and Reg (Regenerating gene protein)-Reg receptor system for cell regeneration
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65. Requirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C Mutation
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66. CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis
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67. Directed overexpression of insulin in Leydig cells causes a progressive loss of germ cells
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68. Implication of the INK4a/ARF Locus in Gastroenteropancreatic Neuroendocrine Tumorigenesis
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69. Deregulation of anti-Mullerian hormone/BMP and transforming growth factor- pathways in Leydig cell lesions developed in male heterozygous multiple endocrine neoplasia type 1 mutant mice
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70. TLS-ERG Leukemia Fusion Protein Deregulates Cyclin-Dependent Kinase 1 and Blocks Terminal Differentiation of Myeloid Progenitor Cells
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71. Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells
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72. Role of Cdk4 in lymphocyte function and allergen response
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73. Cyclin D1 is required for proliferation of olig2‐expressing progenitor cells in the injured cerebral cortex
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78. Differential expression of cell cycle proteins during ageing of pancreatic islet cells
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79. Ferrata Storti Foundation
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97. Genetic models of Insulin Resistance:Alterations in β-cell biology
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