The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons
Abstract
Most mammalian central neurons receive synaptic input over complicated dendritic arbors. Therefore, timing of synaptic information should vary with synapse location. However, I report that temporal summation at CA1 pyramidal somata does not depend on the location of synaptic input. This spatial normalization of temporal integration requires a dendritic hyperpolarization-activated current (lh). Shaping of synaptic activity by deactivating a nonuniform lh could counterbalance filtering by dendrites and effectively remove location-dependent variability in temporal integration, thus enhancing synchronization of neuronal populations and functional capabilities of the hippocampal CA1 region.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Second, distal EPSPs in CA1 neurons are locally attenuated by the active properties of the dendrites, including the presence of a very high density of HCN1 channels in the distal dendrites, which act as a depolarizing shunt conductance (George et al., 2009; Magee, 1999).”
From Strong CA2 Pyramidal Neuron Synapses Define a Powerful Disynaptic Cortico-Hippocampal Loop (2010) · cites this paper as Magee, 1999
Citations
Cites
Phase relationship between hippocampal place units and the EEG theta rhythm
O'Keefe, J. M., & Recce, M. L. (1993) · Hippocampus · doi:10.1002/hipo.450030307 · Cited by 2,643
K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons
Hoffman, D. A., Magee, J. C., Colbert, C. M., & Johnston, D. (1997) · Nature · doi:10.1038/43119 · Cited by 1,392
Self-citationQueer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in Neurons
Pape, H.-C. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.001503 · Cited by 1,152
Magee, J. C. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07613.1998 · Cited by 981
Self-citationTemporal structure in spatially organized neuronal ensembles: a role for interneuronal networks
Buzsáki, G., & Chrobak, J. J. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80012-3 · Cited by 878
Action potential initiation and backpropagation in neurons of the mammalian CNS
Stuart, G., Spruston, N., Sakmann, B., & Häusser, M. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10075-8 · Cited by 768
Active Properties of Neuronal Dendrites
Johnston, D., Magee, J. C., Colbert, C. M., & Christie, B. R. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001121 · Cited by 608
Self-citationDendritic location of synapses and possible mechanisms for the monosynaptic EPSP in motoneurons.
Rall, W., Burke, R. E., Smith, T., Nelson, P. G., & Frank, K. (1967) · Journal of Neurophysiology · doi:10.1152/jn.1967.30.5.1169 · Cited by 607
Determinants of Voltage Attenuation in Neocortical Pyramidal Neuron Dendrites
Stuart, G. J., & Spruston, N. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03501.1998 · Cited by 527
Maccaferri, G., & McBain, C. J. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021754 · Cited by 503
Flagged first, then by citations
Research works printed but not linked: 1
- Rall, W. in Neural Theory and Modeling (ed. Reiss, R. F.) 5– 30 (Stanford Univ. Press, Palo Alto, 1964).
Cited by
Sorted by citations
Items 501–600 of 617
Spatiotemporal Regulation of Transcript Isoform Expression in the Hippocampus
Park, J., & Farris, S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.694234 · Cited by 5
Ramos, M., Bharadwaj, V., Sotillo, B., Gholipour, B., Giakoumaki, A. N., Ramponi, R., Eaton, S. M., & Soci, C. (2021) · Applied Physics Letters · doi:10.1063/5.0055067 · Cited by 5
Tanabe, M. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.025 · Cited by 5
Effects of SKF83959 on the excitability of hippocampal CA1 pyramidal neurons: a modeling study
Zhou, S., Chu, H., Jin, G.-Z., Cui, J., & Zhen, X.-C. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.23 · Cited by 5
Walters, J. M., Noblet, H. A., & Chung, H. J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106641 · Cited by 5
Hewitt, L. T., Marron, A. M., & Brager, D. H. (2025) · Journal of Neurophysiology · doi:10.1152/jn.00510.2024 · Cited by 5
Reevaluation of McCulloch–Pitts–von Neumann’s clock
Ohta, H. (2014) · Biosystems · doi:10.1016/j.biosystems.2014.10.003 · Cited by 5
Lee, C. H., Park, J. H., & Won, M. (2019) · PubMed Central · doi:10.22038/ijbms.2019.35760.8520 · Cited by 4
Hung, T., Wu, S., & Huang, C. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1159067 · Cited by 4
Chancey, J. H., Ahmed, A. A., Guillén, F. I., Ghatpande, V., & Howard, M. A. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0786-23.2023 · Cited by 4
DESIGN OF DETERMINISTIC MODEL OF SIGNAL TRANSDUCTION BETWEEN NEURONAL CELLS
Hliatsevich, M. A., Bulai, P. M., Pitlik, T. N., Denisov, A. A., & Cherenkevich, S. N. (2015) · Mathematical Modelling and Analysis · doi:10.3846/13926292.2015.1002823 · Cited by 4
Wynne, P. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3852-06.2006 · Cited by 4
Choi, I. S., Kim, J., Choi, J. H., Kim, E.-M., Choi, J.-W., & Rah, J. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102761 · Cited by 3
Implementing feature binding through dendritic networks of a single neuron
Tang, Y., Jia, S., Huang, T., Yu, Z., & Liu, J. K. (2025) · Neural Networks · doi:10.1016/j.neunet.2025.107555 · Cited by 4
Longden, K. D., & Willshaw, D. J. (2007) · Network Computation in Neural Systems · doi:10.1080/09548980701587100 · Cited by 3
Heys, J. G., Shay, C. F., MacLeod, K. M., Witter, M. P., Moss, C. F., & Hasselmo, M. E. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1791-15.2016 · Cited by 3
Miao, B., Mao, G., Wu, J., Zhao, B., Shi, H., & Fei, S. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147538 · Cited by 3
Modeling Dendrites and Spatially-Distributed Neuronal Membrane Properties
Chavlis, S., & Poirazi, P. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-89439-9_2 · Cited by 3
Initial Variability and Time-Dependent Changes of Neuronal Response Features Are Cell-Type-Specific
Scherer, J.-S., Riedesel, O. E., Arkhypchuk, I., Meiser, S., & Kretzberg, J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.858221 · Cited by 3
Ceballos, C. C., Pena, R. F. O., Roque, A. C., & Leão, R. M. (2018) · Channels · doi:10.1080/19336950.2018.1433940 · Cited by 3
‘Hidden’ HCN channels permit pathway-specific synaptic amplification in L2/3 pyramidal neurons
Oláh, V. J., Wu, J., Kaczmarek, L. K., & Rowan, M. J. (2024) · doi:10.7554/elife.96002.1 · Cited by 2
So, T. W., Choi, H. Y., Xu, H., Zhu, J., Shi, L., & Ip, J. P. K. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.03.008 · Cited by 3
Licheri, V., Talani, G., Biggio, G., & Sanna, E. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109423 · Cited by 2
Distinct Modulation of I h by Synaptic Potentiation in Excitatory and Inhibitory Neurons
Herstel, L. J., & Wierenga, C. J. (2024) · eNeuro · doi:10.1523/eneuro.0185-24.2024 · Cited by 2
Chapter 17 Dendritic action potentials in magnocellular neurons
Bains, J. S. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)39019-8 · Cited by 2
Gradwohl, G., & Grossman, Y. R. (2004) · Neurocomputing · doi:10.1016/j.neucom.2004.01.075 · Cited by 2
Learning by structural remodeling in a class of single cell models
Kelleher, K. J., Hajdik, V., Colbert, C. M., & Josić́, K. (2008) · Journal of Computational Neuroscience · doi:10.1007/s10827-008-0078-6 · Cited by 2
Characterization of hyperpolarization-activated cyclic nucleotide-gated channels in oligodendrocytes
Lyman, K. A., Han, Y. S., Robinson, A. P., Weinberg, S. E., Fisher, D. W., Heuermann, R. J., Lyman, R. E., Kim, D., Ludwig, A., Chandel, N. S., et al. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1321682 · Cited by 3
Channeling a 'funny' side of memory
Johnston, D. (2005) · Nature Neuroscience · doi:10.1038/nn0205-134 · Cited by 2
Goz, R. U., Silas, A., Buzel, S., & LoTurco, J. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/544973 · Cited by 1
Mertens, E. J., Leibner, Y., Pie, J. L., Galakhova, A. A., Waleboer, F., Meijer, J., Heistek, T. S., Wilbers, R., Heyer, D. B., Goriounova, N. A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.05.561029 · Cited by 2
Input-specific gating of NMDA amplification via HCN channels in mouse L2/3 pyramidal neuronsPreprint
Oláh, V. J., Wu, J., Kaczmarek, L. K., & Rowan, M. J. (2025) · eLife · doi:10.7554/elife.96002.2 · Cited by 2
Dudek, F. E. (2004) · Epiliepsy currents/Epilepsy currents · doi:10.1111/j.1535-7597.2004.42011.x · Cited by 1
Hormones and the Regulation of Neuronal Voltage-Sensing Ion Channels
Lyons, D. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00011-0 · Cited by 1
Alshehri, M. A., Alghamdi, A., Binshaya, A. S., Juraybi, T. N., Abalkhail, A., & Alissa, M. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103520 · Cited by 1
Binding of NRSF to the HCN1 Gene Represses Expression after Seizures
Petrosyan, R. (2013) · Cureus · doi:10.7759/cureus.86 · Cited by 1
Parab, V., & Manchanda, R. (2009) · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany · doi:10.1007/978-3-642-03882-2_238 · Cited by 1
Energy-Efficient Neuronal Computation via Quantal
Levy, W. B., & Baxter, R. A. (2002) · Cited by 1
The Role of Cardiac Pacemaker Currents in Antiarrhythmic Drug Discovery
Saint, D. A. (2003) · Humana Press eBooks · doi:10.1385/1-59259-404-2:27 · Cited by 1
Localising Receptors and Channels Across the Dendritic Arbour
Bikbaev, A. F., Duménieu, M., Lopez‐Rojas, J., & Heine, M. (2016) · Springer eBooks · doi:10.1007/978-4-431-56050-0_16 · Cited by 1
Dubé, C. M., & Baram, T. Z. (2009) · Blue books of neurology · doi:10.1016/b978-1-4160-6171-7.00002-9 · Cited by 1
Hippocampal synchronization in a realistic CA1 neuron model
Fiasconaro, A., & Migliore, M. (2024) · Physical review. E · doi:10.1103/physreve.110.044406 · Cited by 1
Biophysical Mechanisms of Computation in a Looming Sensitive Neuron
Peron, S. (2013) · Springer series in computational neuroscience · doi:10.1007/978-1-4614-8094-5_17 · Cited by 1
Computing Temporal Sequence with Dendrites
Branco, T. (2013) · Springer series in computational neuroscience · doi:10.1007/978-1-4614-8094-5_15 · Cited by 1
Towards Deterministic and Stochastic Computations with the Izhikevich Spiking-Neuron Model
Hasani, R., Wang, G., & Grosu, R. (2017) · Lecture notes in computer science · doi:10.1007/978-3-319-59147-6_34 · Cited by 1
Hyperpolarization-activated Cyclic Nucleotide-gated Channels
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_2290 · Cited by 1
Kim, N., Bahn, S., Choi, J. H., Kim, J. S., & Rah, J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.08.363200 · Cited by 1
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Nolan, M. F. (2014) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-4614-7320-6_231-2 · Cited by 1
Bock, T., Buss, E. W., Lofaro, O. M., Leroy, F., Santoro, B., & Siegelbaum, S. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.11.516205 · Cited by 1
HCN Channels: Biophysics and Functional Relevance
Baruscotti, M., Piantoni, C., Bertoli, G., Barbuti, A., & Bucchi, A. (2022) · Springer eBooks · doi:10.1007/978-3-642-35943-9_652-1 · Cited by 1
Input-specific gating of NMDA amplification via HCN channels in mouse L2/3 pyramidal neuronsPreprint
Oláh, V. J., Wu, J., Kaczmarek, L. K., & Rowan, M. J. (2024) · eLife · doi:10.7554/elife.96002 · Cited by 2
Klimmt, H., Kappel, D., Ulivi, A. F., Argunşah, A. Ö., Murthy, B., Somatakis, S., Huettl, R.-E., Remy, S., & Attardo, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.04.641429 · Cited by 1
NMDAR-mediated shift of neuronal gain across the cortical hierarchyPreprint
Lenninger, M., Herman, P. A., Skoglund, M., & Kumar, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.04.709528 · Cited by 1
GABA signaling in the thalamus
Frère, S. G. A. (2004) · edoc (University of Basel) · doi:10.5451/unibas-003611223
Course 1 Experimenting with theory
Marder, E. E. (2005) · Les Houches/Les Houches · doi:10.1016/s0924-8099(05)80007-1
Dendritic Dynamic Clamp – A Tool to Study Single Neuron Computation
Williams, S. R. (2009) · Springer eBooks · doi:10.1007/978-0-387-89279-5_2
Khurana, S. (2009) · Texas ScholarWorks (Texas Digital Library)
Wierschke, S. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-4313
ACTIVITY-DEPENDENT CHANGES IN A NEURONAL CIRCUIT IMPORTANT FOR SOUND LOCALIZATION
Haßfurth, B. (2010) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.12045
Computational investigation of effects of UP state on EPSP in striatal Medium Spiny Neurons
Rane, M., Shah, A. H., Sheth, S., & Manchanda, R. (2012) · doi:10.1109/icobe.2012.6178980
5HT neuromodulation of hippocampal pyramidal cells: effects of increased Ihon cell excitability
Lippert, A., & Booth, V. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-s2-p118
Immunohistochemical localization of Ih channel HCN3 in the rat brain
Liersch, J., Rader, C. M., Görcs, T. J., Scholten, A., Kremmer, E., Plum, J., Pöggel, S., & Zilles, K. (2006) · Anatomy and Embryology · doi:10.1007/s00429-006-0108-y
Synchrony and the single neuron
Williams, S. R. (2013) · Nature Neuroscience · doi:10.1038/nn.3586
Determinants of Synaptic Integration in Cerebellar Neurons
Engbers, J. D. T. (2013) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/25604
Synaptic integration and dendritic excitability in cerebellar Purkinje neurons
Christensen, S. R. (2002) · OpenGrey (Institut de l'Information Scientifique et Technique)
Perception Timing-Dependent Plasticity: From Synapse to
Dan, Y., & Poo, M. (2006)
h-Ströme in epilepsiechirurgischen Resektaten
Wierschke, S. (2013) · Clinical Epileptology · doi:10.1007/s10309-013-0333-3
Network Activity Synaptic Integration in Rat Frontal Cortex Shaped by
Stern, E. A., Heck, D. H., Boucsein, C., Fucke, T., Nawrot, M. P., Seamari, Y., Rossant, C., Fontaine, B., Magnusson, A., Brette, R., et al. (2015)
The cellular basis of rhythmic activity patterns occurring in the CA1 region of the hippocampus
Zemankovics, R., & Szentágothai, J. (2011) · Semmelweis University Repository (Semmelweis University) · doi:10.14753/se.2012.1696
by HCN channels Regulation of epileptiform discharges in rat neocortex
Williams, S. B., & Hablitz, J. J. (2015)
Coward, L. A. (2013) · Springer eBooks · doi:10.1007/978-94-007-7107-9_5
Gurkiewicz, M., & Korngreen, A. (2006)
Spatiotemporal Effects of Synaptic Current
Graziane, N., & Dong, Y. (2015) · Neuromethods · doi:10.1007/978-1-4939-3274-0_6
Hammond, C., Debanne, D., & Goaillard, J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-397032-9.00015-7
Sparks, D. W. (2016) · Spectrum Research Repository (Concordia University)
Klar, M., Surges, R., & Feuerstein, T. J. (2003)
Angelo, K., London, M., Christensen, S. R., Häusser, M., Carr, D. B., Andrews, G. D., Glen, W. B., Lavı́n, A., Barth, A. M., Vizi, E. S., et al. (2008)
Potassium Changing from Pro- to Anti-convulsant in the Epileptic Juvenile Rat Hippocampus
Yu, W. (2009) · TSpace (University of Toronto)
Storage of spatiotemporal input sequences in dendrites of pyramidal neurons
Macak, M. (2016) · UCL Discovery (University College London)
Hua, F. S., Lia, G., Lianga, Z., Yanga, Y., & Zhoua, Y. (2008)
Dendritic biophysics and evolution
Beaulieu-Laroche, L. (2020) · DSpace@MIT (Massachusetts Institute of Technology)
On the Auditory System: genes, DNA repair and ion channels
Nagtegaal, A. P. (2013)
Meeuwissen, A. (2022) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9058
Hyperpolarization-Activated Cyclic Nucleotide Gated Channels
Nolan, M. F. (2015) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-4614-6675-8_231
de Deus, J. L. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2019.tde-08052019-143657
(2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-04-00001.2002
HCN Channels: Biophysics and Functional Relevance
DiFrancesco, D., & Baruscotti, M. (2012) · Springer eBooks · doi:10.1007/978-3-642-16712-6_652
Spatiotemporal Effects of Synaptic Current
Graziane, N., & Dong, Y. (2022) · Neuromethods · doi:10.1007/978-1-0716-2589-7_6
Hyperpolarization-Activated Cyclic Nucleotide Gated Channels
Nolan, M. F. (2022) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-0716-1006-0_231
Saponaro, A., Vallese, F., Porro, A., & Clarke, O. B. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.998176
Poluição sonora e perda auditiva podem levar a prejuízo cognitivo e quadros de demência?
Filho, D. M. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2022.tde-08092022-152535
Metadata
- Authors
- Magee, J. C.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Magee, Jeffrey C.
- ORCID
- Magee, Jeffrey C.
- Venue
- Nature Neuroscience
- Published
- 1999-06
- Volume
- 2
- Issue
- 6
- Pages
- 508-514
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- DOI
- 10.1038/9158
- OpenAlex
- W2020505352
- Cited by
- 617
- References
- 30
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 18 · 2023: 14 · 2022: 19 · 2021: 21 · 2020: 26 · 2019: 14 · 2018: 26 · 2017: 15 · 2016: 22 · 2015: 31 · 2014: 18 · 2013: 33 · 2012: 29
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Update notices
- erratum (1999-09-01)
- Open access
- closed
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS35865)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- hyperpolarization-activated current, dendritic integration, temporal summation, CA1 pyramidal neurons, neuronal synchronization
- MeSH terms
- Animals, Dendrites, Electric Conductivity, Electric Stimulation, Hippocampus, Neurons, Synapses, Time Factors, Rats, Sprague-Dawley, Excitatory Postsynaptic Potentials, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review