Cited by 617Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionIon channel regulation and function

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Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons

Magee, Jeffrey C.·1999·Nature Neuroscience

DOI 10.1038/9158

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Abstract

Most mammalian central neurons receive synaptic input over complicated dendritic arbors. Therefore, timing of synaptic information should vary with synapse location. However, I report that temporal summation at CA1 pyramidal somata does not depend on the location of synaptic input. This spatial normalization of temporal integration requires a dendritic hyperpolarization-activated current (lh). Shaping of synaptic activity by deactivating a nonuniform lh could counterbalance filtering by dendrites and effectively remove location-dependent variability in temporal integration, thus enhancing synchronization of neuronal populations and functional capabilities of the hippocampal CA1 region.

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Authors: Magee, J. C.
Affiliations: Louisiana State University (US)
Corresponding author: Magee, Jeffrey C.
ORCID: Magee, Jeffrey C.
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 1999-06
Volume: 2
Issue: 6
Pages: 508-514
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/9158
OpenAlex: W2020505352
Cited by: 617
References: 30
Citations by year: 2026: 6 · 2025: 9 · 2024: 18 · 2023: 14 · 2022: 19 · 2021: 21 · 2020: 26 · 2019: 14 · 2018: 26 · 2017: 15 · 2016: 22 · 2015: 31 · 2014: 18 · 2013: 33 · 2012: 29
FWCI: 7.17
Type: journal article
Language: en
Update notices: erratum (1999-09-01)
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
www.springer.com/tdm (unspecified)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (NS35865)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: hyperpolarization-activated current, dendritic integration, temporal summation, CA1 pyramidal neurons, neuronal synchronization
MeSH terms: Animals, Dendrites, Electric Conductivity, Electric Stimulation, Hippocampus, Neurons, Synapses, Time Factors, Rats, Sprague-Dawley, Excitatory Postsynaptic Potentials, Rats

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Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons

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