Hematological changes during androgen deprivation therapy
Open accessAbstract
Androgen deprivation therapy (ADT) has been associated with a plethora of adverse effects, consistent with the androgen dependency of multiple reproductive and somatic tissues. One such tissue is the hemopoietic system, and one of the most predictable consequences of ADT is the development of anemia. Although anemia caused by ADT is rarely severe, ADT is often given to frail, elderly men with increased susceptibility to anemia due to multiple other causes. ADT-associated anemia may contribute to fatigue and reduced quality of life (QoL) in such men, although this requires further study. While anemia is an independent risk factor of mortality in men with prostate cancer, it is not known whether treatment of ADT-associated anemia alters clinically important outcomes, or whether treatment affects mortality. Awareness of the phenomenon of ADT-induced anemia should avoid unnecessary work-up in mild cases of normocytic normochromic anemia. However, assessment and treatment of more severe anemia may be required. This should be determined on an individual basis. In contrast to the well-described actions of ADT on erythropoiesis, its effect on other hemopoietic lineages has been less well elucidated. While preclinical studies have found roles for androgens in maturation and differentiated function of neutrophils, lymphocytes and platelets, the implications of these findings for men with prostate cancer receiving ADT require further studies.
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The sex difference in circulating hemoglobin levels is likely due to the sex difference in average circulating testosterone concentrations.
“The proposition that the sex difference in circulating hemoglobin levels is likely to be due to the sex difference in average circulating testosterone concentrations is supported by the fact that male castration (e.g., for advanced prostate cancer) (126) and androgen deficiency due to reproductive system disorders (127) reduce circulating hemoglobin in men, eliminating the sex difference, whereas”
From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [126]
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- Authors
- Grossmann, M., & Zajac, J. D.
- Affiliations
- The University of Melbourne (AU)
- Venue
- Asian Journal of Andrology
- Publisher
- Medknow
- Published
- 2012-01-09
- Volume
- 14
- Issue
- 2
- Pages
- 187-192
- ISSN
- 1008-682X (ISSN-L)
- 1745-7262
- PMC
- PMC3735076
- OpenAlex
- W2085387385
- Cited by
- 62
- References
- 71
- Citations by year
- 2025: 6 · 2024: 3 · 2023: 9 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 6 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 4 · 2012: 1
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Asian Journal of Andrology (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royal Australasian College of Physicians
- Medical Research Council
- National Health and Medical Research Council (1006407, 1024139)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Keywords
- androgen deprivation therapy, anemia, hematological changes, prostate cancer, erythropoiesis, neutrophils, lymphocytes, platelets, quality of life, fatigue, older men, normocytic normochromic anemia
- MeSH terms
- Androgen Antagonists, Anemia, Erythropoiesis, Hematopoiesis, Humans, Male, Prostatic Neoplasms, Incidence
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