CoChat
Sign Up
Cited by 23Sexual Differentiation and DisordersHormonal and reproductive studiesAdrenal Hormones and Disorders

Androgens correlate with increased erythropoiesis in women with congenital adrenal hyperplasia

Open access
Karunasena, Nayananjani, Han, Thang S., Mallappa, Ashwini, Elman, Meredith, Merke, Deborah P., Ross, Richard J.M., Daniel, Eleni·2017·Clinical Endocrinology
DOI 10.1111/cen.13148PMC PMC5161698
Open this paper in CoChat — free accountOpen PDF

Abstract

OBJECTIVE: Hyperandrogenism in congenital adrenal hyperplasia (CAH) provides an in vivo model for exploring the effect of androgens on erythropoiesis in women. We investigated the association of androgens with haemoglobin (Hb) and haematocrit (Hct) in women with CAH. DESIGN: Cross-validation study. PATIENTS: Women with CAH from Sheffield Teaching Hospitals, UK (cohort 1, the training set: n = 23) and National Institutes of Health, USA (cohort 2, the validation set: n = 53). MEASUREMENTS: Androgens, full blood count and basic biochemistry, all measured on the same day. Demographic and anthropometric data. RESULTS: Significant age-adjusted correlations (P < 0·001) were observed for Ln testosterone with Hb and Hct in cohorts 1 and 2 (Hb r = 0·712 & 0·524 and Hct r = 0·705 & 0·466), which remained significant after adjustments for CAH status, glucocorticoid treatment dose and serum creatinine. In the combined cohorts, Hb correlated with androstenedione (P = 0·002) and 17-hydroxyprogesterone (P = 0·008). Hb and Hct were significantly higher in cohort 1 than those in cohort 2, while there were no group differences in androgen levels, glucocorticoid treatment dose or body mass index. In both cohorts, women with Hb and Hct in the highest tertile had significantly higher testosterone levels than women with Hb and Hct in the lowest tertile. CONCLUSIONS: In women with CAH, erythropoiesis may be driven by androgens and could be considered a biomarker for disease control.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/cen.13148

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Interpolating from the dose-response regression, increases in circulating testosterone from 0.9 nmol/L to 5, 7, 10, and 19 nmol/L were associated with increases in circulating hemoglobin of 6.5%, 7.8%, 8.9%, and 11%, respectively, establishing a strong dose-response relationship.

    “Interpolating from the dose-response regression, increases in circulating testosterone measured by LC-MS from 0.9 nmol/L to 5 nmol/L, 7 nmol/L, 10 nmol/L, and 19 nmol/L were associated with increases in circulating hemoglobin of 6.5%, 7.8%, 8.9%, and 11%, respectively, establishing a strong dose-response relationship.”

    From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [92]

  • In women with CAH, the degree of poor hormonal control is associated with increasing circulating testosterone ranging from normal female concentrations up to 36 nmol/L, and these levels correlate closely (r = 0.56) with circulating hemoglobin.

    “The degree of poor control is associated with increasing levels of circulating testosterone ranging from normal female concentrations up to 36 nmol/L, and these levels correlate closely (r = 0.56) with levels of circulating hemoglobin (Fig. 5).”

    From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [92]

  • According to the Karunasena et al. study, reducing circulating testosterone concentration to 7 nmol/L would still deliver 7.8% more circulating hemoglobin than the normal female mean value.

    “Similarly, according to the Karunasena et al. (92) study, reducing circulating testosterone concentration to 7 nmol/L would still deliver 7.8% more circulating hemoglobin than the normal female mean value.”

    From Circulating Testosterone as the Hormonal Basis of Sex Differences in Athletic Performance (2018) · cites this paper as [92]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Karunasena, N., Han, T. S., Mallappa, A., Elman, M., Merke, D. P., Ross, R. J. M., & Daniel, E.
Affiliations
  • University of Sheffield (GB)
  • Royal Holloway University of London (GB)
  • National Institutes of Health (US)
Corresponding author
Daniel, Eleni
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2016-07-25
Volume
86
Issue
1
Pages
19-25
ISSN
0300-0664 (ISSN-L)
DOI
10.1111/cen.13148
PMC
PMC5161698
OpenAlex
W2463676804
Cited by
23
References
37
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 3 · 2019: 3 · 2018: 2 · 2017: 2
FWCI
1.21
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Endocrinology (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
Funders
  • National Institutes of Health
  • Sri Lankan Government
  • European Commission (281654)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
congenital adrenal hyperplasia, hyperandrogenism, erythropoiesis, testosterone, hemoglobin, hematocrit, androstenedione, 17-hydroxyprogesterone, glucocorticoid therapy, women
MeSH terms
Adrenal Hyperplasia, Congenital, Adult, Erythropoiesis, Female, Hematocrit, Hemoglobins, Humans, Middle Aged, Retrospective Studies, Testosterone, Hyperandrogenism, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review