The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Between Celiac Disease and Irritable Bowel Syndrome: The “No Man's Land” of Gluten Sensitivity
Open accessAbstract
The repertoire of gastrointestinal (GI) symptoms is finite; however, the etiologies and mechanisms underlying symptom generation and perception are diverse and, in many cases, unknown. This review examines the clinical and experimental evidence exploring the putative relationship between gluten sensitivity (GS) and the generation of GI symptoms. It explores the hypothesis that, in a proportion of patients, GS causes functional bowel disorder (FBD)-like symptoms. We propose a model for investigating and understanding the induction of GI symptoms and dysfunction by gluten in FBD and organic disease. We hypothesize that, even in the absence of fully developed celiac disease, gluten can induce symptoms similar to FBD. We discuss the hypothesis that GS and post-infectious irritable bowel syndrome (IBS) provide two triggers that can explain at least part of the spectrum that constitutes IBS, further advancing an understanding of the role of mucosal responses to luminal factors in FBDs. We propose that the animal model of GS in human leukocyte antigen (HLA)- DQ8 mice allows investigation of mucosal pathophysiological changes that occur before the onset of full-blown inflammation in a GS host. A better understanding of how gluten can cause symptoms in sensitive individuals will illuminate the interaction between host genotype, diet, and intestinal microbiota in generating one of the most common GI conditions.
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Terminal ileal mucosal mast cells in irritable bowel syndrome
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Cited by
Sapone, A., Lammers, K. M., Casolaro, V., Cammarota, M., Giuliano, M. T., De Rosa, M., Stefanile, R., Mazzarella, G., Tolone, C., Russo, M. I., et al. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-23 · Cited by 452
Carroccio, A., Mansueto, P., Iacono, G., Soresi, M., D'Alcamo, A., Cavataio, F., Brusca, I., Florena, A. M., Ambrosiano, G., Seidita, A., et al. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.236 · Cited by 406
Camilleri, M., Lasch, K., & Zhou, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00155.2012 · Cited by 396
Dionne, J., Ford, A. C., Yuan, Y., Chey, W. D., Lacy, B. E., Saito, Y. A., Quigley, E. M. M., & Moayyedi, P. (2018) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0195-4 · Cited by 379
Review article: the diagnosis and management of food allergy and food intolerances
Turnbull, J. L., Adams, H. N., & Gorard, D. A. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12984 · Cited by 306
Metadata
- Authors
- Verdu, E. F., Armstrong, D., & Murray, J. A.
- Venue
- The American Journal of Gastroenterology
- Published
- 2009-05-19
- Volume
- 104
- Issue
- 6
- Pages
- 1587-1594
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2012505724
- Cited by
- 283
- References
- 10
- FWCI
- 22.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Verdu, E. F., Armstrong, D., & Murray, J. A. (2009). Between Celiac Disease and Irritable Bowel Syndrome: The “No Man's Land” of Gluten Sensitivity. The American Journal of Gastroenterology. https://doi.org/10.1038/ajg.2009.188
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
