Celiac disease–like abnormalities in a subgroup of patients with irritable bowel syndrome

Wahnschaffe, Ulrich; Ullrich, R.; Riecken, E.O.; Schulzke, J.D.

doi:10.1053/gast.2001.29572

Cited by 280Celiac Disease Research and ManagementGastrointestinal motility and disordersInflammatory Bowel Disease

Celiac disease–like abnormalities in a subgroup of patients with irritable bowel syndrome

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Wahnschaffe, Ulrich, Ullrich, R., Riecken, E.O., Schulzke, J.D.·2001·Gastroenterology

DOI 10.1053/gast.2001.29572

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Abstract

Background & aims Abdominal symptoms in the absence of mucosal abnormalities are features of both the irritable bowel syndrome (IBS) and latent/potential celiac disease (cd). To identify a possible subgroup of IBS patients with latent/potential cd, surrogate markers of cd were investigated in IBS patients.Methods IBS patients suffering from diarrhea (n = 102), and patients with active cd (n = 10), treated cd (n = 26), and latent cd (n = 5) were included in the study. We measured serum immunoglobulin (Ig) A against gliadin and tissue-transglutaminase, and IgA and IgM against gliadin, tissue-transglutaminase (intestinal cd-associated antibodies), and the dietary proteins beta-lactoglobulin and ovalbumin in duodenal aspirate by enzyme-linked immunosorbent assay. Intraepithelial lymphocytes (IELs) were counted in histology sections, and the expression of HLA-DQ2 (A1*0501/B1*0201) was investigated by polymerase chain reaction. In 26 IBS patients, the effect of 6 months of gluten withdrawal was examined.Results Most cd patients expressed HLA-DQ2 and had increased intestinal cd-associated antibodies, whereas cd-associated serum IgA and IEL counts were increased in active cd in contrast to treated or latent cd. In IBS patients, 35% were HLA-DQ2-positive, 23% had increased IEL counts, and 0% and 30% had increased cd-associated antibodies in serum and duodenal aspirate, respectively. Furthermore, stool frequency and intestinal IgA decreased significantly under a gluten-free diet in the subgroups of HLA-DQ2-positive and intestinal antibody-positive IBS patients when compared with IBS patients without these markers.Conclusions HLA-DQ2 expression and increased intestinal cd-associated antibodies are markers that can identify latent/potential cd in a subgroup of IBS patients who consequently appear to profit from a gluten-free diet.

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Some patients with IBS lack tissue transglutaminase antibodies or histological markers of coeliac disease yet still respond symptomatically to a gluten-free diet.
“Some patients with IBS lack tissue transglutaminase antibodies or histological markers of coeliac disease yet still respond symptomatically to a gluten-free diet.”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [157]
Gluten causes coeliac disease in genetically susceptible people and causes gut dysfunction in mice and can generate IBS symptoms in the absence of coeliac disease.
“Gluten causes coeliac disease in genetically susceptible people and causes gut dysfunction in mice and can generate IBS symptoms in the absence of coeliac disease.157”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [157]

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Identification of tissue transglutaminase as the autoantigen of celiac disease
Dieterich, W., Ehnis, T., Bauer, M., Donner, P., Volta, U., Riecken, E. O., & Schuppan, D. (1997) · Nature Medicine · doi:10.1038/nm0797-797 · Cited by 2,021 · see citing works
Self-citation
Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.
Sollid, L. M., Markussen, G., Ek, J., Gjerde, H., Vartdal, F., & Thorsby, E. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.1.345 · Cited by 929 · see citing works
Functional bowel disorders in apparently healthy people
Thompson, W., & Heaton, K. W. (1980) · Gastroenterology · doi:10.1016/0016-5085(80)90142-0 · Cited by 665 · see citing works
Tissue transglutaminase autoantibody enzyme-linked immunosorbent assay in detecting celiac disease
Sulkanen, S., Halttunen, T., Laurila, K., Kolho, K., Korponay-Szabo, I. R., Sarnesto, A., Savilahti, E., Collin, P., & Mäki, M. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70008-3 · Cited by 589 · see citing works
HLA‐DQB1 and ‐DQA1 typing by PCR amplification with sequence‐specific primers (PCR‐SSP) in 2 hours
Olerup, O., Aldener, A., & Fogdell, A. (1993) · Tissue Antigens · doi:10.1111/j.1399-0039.1993.tb01991.x · Cited by 555 · see citing works
Medical costs in community subjects with irritable bowel syndrome
Talley, N. J., Gabriel, S. E., Harmsen, W. S., Zinsmeister, A. R., & Evans, R. W. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90738-6 · Cited by 460 · see citing works
Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction.
Whitehead, W. E., Crowell, M. D., Robinson, J. C., Heller, B. R., & Schuster, M. M. (1992) · Gut · doi:10.1136/gut.33.6.825 · Cited by 432 · see citing works
Quantitation of intraepithelial lymphocytes in human jejunum
Ferguson, A., & Murray, D. J. (1971) · Gut · doi:10.1136/gut.12.12.988 · Cited by 409 · see citing works
Clinical and pathological spectrum of coeliac disease--active, silent, latent, potential.
Ferguson, A., Arranz, E. M., & O'Mahony, S. (1993) · Gut · doi:10.1136/gut.34.2.150 · Cited by 404 · see citing works
FOOD INTOLERANCE: A MAJOR FACTOR IN THE PATHOGENESIS OF IRRITABLE BOWEL SYNDROME
Jones, V. A., Shorthouse, M., McLaughlan, P., Workman, E., & Hunter, J. O. (1982) · The Lancet · doi:10.1016/s0140-6736(82)92782-9 · Cited by 333 · see citing works
ORGANIC AND FUNCTIONAL DISORDERS IN 2000 GASTROENTEROLOGY OUTPATIENTS
Harvey, R., Salih, S., & Read, A. E. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91802-0 · Cited by 331 · see citing works
Irritable Bowel Syndrome in a Community: Symptom Subgroups, Risk Factors, and Health Care Utilization
Talley, N. J., Zinsmeister, A. R., & Melton, L. J. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117548 · Cited by 327 · see citing works
Food intolerance and the irritable bowel syndrome.
Nanda, R., James, R., Smith, H., Dudley, C. R., & Jewell, D. P. (1989) · Gut · doi:10.1136/gut.30.8.1099 · Cited by 307 · see citing works
Survey of the AGA Membership Relating to Patients With Functional Gastrointestinal Disorders
Mitchell, C. M., & Drossman, D. A. (1987) · Gastroenterology · doi:10.1016/s0016-5085(87)91099-7 · Cited by 292 · see citing works
Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome
Lembo, T., Munakata, J., Mertz, H., Niazi, N., Kodner, A., Nikas, V., & Mayer, E. A. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90809-5 · Cited by 290 · see citing works
Irritable bowel-type symptoms in HMO examinees
Longstreth, G. F., & Wolde-Tsadik, G. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303163 · Cited by 279 · see citing works
Colonic Myoelectric Activity in the Irritable Bowel Syndrome
Snape, W. J., Carlson, G. M., & Cohen, S. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80141-2 · Cited by 262 · see citing works
Gluten-sensitive diarrhea without evidence of celiac disease
Cooper, B. T., Holmes, G. K. T., Ferguson, R., Thompson, R. A., Allan, R. N., & Cooke, W. T. (1980) · Gastroenterology · doi:10.1016/0016-5085(80)90432-1 · Cited by 218 · see citing works
PROGNOSIS IN THE IRRITABLE BOWEL SYNDROME: A 5-YEAR PROSPECTIVE STUDY
Harvey, R. F., Mauad, E. C., & Brown, A. M. (1987) · The Lancet · doi:10.1016/s0140-6736(87)90304-7 · Cited by 212 · see citing works
Antibodies to Tissue Transglutaminase as Serologic Markers in Patients with Dermatitis Herpetiformis
Dieterich, W., Schuppan, D., Laag, E., Bruckner-Tuderman, L., Reunala, T. L., Kárpáti, S., Zágoni, T., & Riecken, E. O. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00627.x · Cited by 205 · see citing works
Self-citation
Immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies.
Cerf–Bensussan, N., Schneeberger, E. E., & Bhan, A. K. (1983) · The Journal of Immunology · doi:10.4049/jimmunol.130.6.2615 · Cited by 189 · see citing works
Increase in gamma/delta T cell receptor bearing lymphocytes in normal small bowel mucosa in latent coeliac disease.
Mäki, M., Holm, K., Collin, P., & Savilahti, E. (1991) · Gut · doi:10.1136/gut.32.11.1412 · Cited by 177 · see citing works
Discrepancies Between Reported Food Intolerance and Sensitization Test Findings in Irritable Bowel Syndrome Patients
Dainese, R., Galliani, E., Lazzari, F. D., Leo, V. D., & Naccarato, R. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01226.x · Cited by 143 · see citing works
Latent and potential coeliac disease
Troncone, R., Greco, L., Mayer, M., Paparo, F., Caputo, N., Micillo, M., Mugìone, P., & Auricchio, S. (1996) · Acta Paediatrica · doi:10.1111/j.1651-2227.1996.tb14240.x · Cited by 121 · see citing works
Intestinal antibody pattern of celiac disease: Occurrence in patients with normal jejunal biopsy histology
Arranz, E. M., & Ferguson, A. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90333-8 · Cited by 101 · see citing works
Irritable bowel syndrome--a safe diagnosis?
Holmes, K. M., & Salter, R. H. (1982) · BMJ · doi:10.1136/bmj.285.6354.1533 · Cited by 82 · see citing works
Intestinal antibody pattern of coeliac disease: association with gamma/delta T cell receptor expression by intraepithelial lymphocytes, and other indices of potential coeliac disease.
Arranz, E. M., Bode, J., Kingstone, K., & Ferguson, A. (1994) · Gut · doi:10.1136/gut.35.4.476 · Cited by 74 · see citing works
Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease
O'Mahony, S., Ferguson, A., & VESTEY, J. P. (1990) · The Lancet · doi:10.1016/0140-6736(90)93029-o · Cited by 73 · see citing works
Susceptibility to develop celiac disease is primarily associated with HLA-DQ alleles
Spurkland, A., Sollid, L. M., Rønningen, K. S., Bosnes, V., Ek, J., Vartdal, F., & Thorsby, E. (1990) · Human Immunology · doi:10.1016/0198-8859(90)90111-2 · Cited by 72 · see citing works
[Epidemiology of intestinal functional disorders in an apparently healthy population].
Bommelaer, G., Rouch, M., Dapoigny, M. C., Pais, D., Loisy, P., Gualino, M., & Tournut, R. (1986) · PubMed · Cited by 50 · see citing works
Colonic myoelectrical activity in IBS painless diarrhoea.
Frexinos, J., Fioramonti, J., & Buéno, L. (1987) · Gut · doi:10.1136/gut.28.12.1613 · Cited by 31 · see citing works
Molecular biology and coeliac disease.
Howdle, P. D., & Blair, G. E. (1992) · Gut · doi:10.1136/gut.33.5.573 · Cited by 19 · see citing works
Intraepithelial lymphocyte mitosis in a jejunal biopsy correlates with intraepithelial lymphocyte count, irrespective of diagnosis.
Ferguson, A., & Ziegler, K. (1986) · Gut · doi:10.1136/gut.27.6.675 · Cited by 18 · see citing works
New perspectives of the pathogenesis of coeliac disease: evolution of a working clinical definition
Ferguson, A. (1996) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1996.41875000.x · Cited by 16 · see citing works
Immunoglobulin A Antigliadin Antibodies in Jejunal Juice: Markers of Severe Intestinal Damage in Coeliac Children
Volta, U., Bonazzi, C., Lazzari, R., Baldoni, A. M., Collina, A., Bianchi, F. B., & Pisi, E. (2009) · Digestion · doi:10.1159/000199605 · Cited by 8 · see citing works

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Functional Bowel Disorders
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856 · see citing works
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384 · see citing works
Spectrum of gluten-related disorders: consensus on new nomenclature and classification
Sapone, A., Bai, J. C., Ciacci, C., Dolinšek, J., Green, P. H. R., Hadjivassiliou, M., Kaukinen, K., Rostami, K., Sanders, D. S., Schümann, M., et al. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-13 · Cited by 1,139 · see citing works
Self-citation
Irritable bowel syndrome
Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M. D., Schemann, M., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.14 · Cited by 1,057 · see citing works
Intestinal microbiota in functional bowel disorders: a Rome foundation report
Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939 · see citing works
No Effects of Gluten in Patients With Self-Reported Non-Celiac Gluten Sensitivity After Dietary Reduction of Fermentable, Poorly Absorbed, Short-Chain Carbohydrates
Biesiekierski, J. R., Peters, S., Newnham, E., Rosella, O., Muir, J. G., & Gibson, P. R. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.051 · Cited by 794 · see citing works
Irritable Bowel Syndrome
(2011) · Springer eBooks · doi:10.1007/springerreference_44317 · Cited by 549 · see citing works
Full-thickness biopsy of the jejunum reveals inflammation and enteric neuropathy in irritable bowel syndrome
Törnblom, H., Lindberg, G., Nyberg, B., & Veress, B. (2002) · Gastroenterology · doi:10.1053/gast.2002.37059 · Cited by 516 · see citing works
Endocrinological Disorders and Celiac Disease
Collin, P., Kaukinen, K., Välimäki, M. J., & Salmi, J. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0035 · Cited by 315 · see citing works
Irritable bowel syndrome: a little understood organic bowel disease?
Talley, N. J., & Spiller, R. E. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09712-x · Cited by 304 · see citing works
Between Celiac Disease and Irritable Bowel Syndrome: The “No Man's Land” of Gluten Sensitivity
Verdu, E. F., Armstrong, D., & Murray, J. A. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.188 · Cited by 281 · see citing works
Serological Tests in Gluten Sensitivity (Nonceliac Gluten Intolerance)
Volta, U., Tovoli, F., Cicola, R., Parisi, C., Fabbri, A., Piscaglia, M., Fiorini, E., & Caio, G. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3182372541 · Cited by 248 · see citing works
Yield of Diagnostic Tests for Celiac Disease in Individuals With Symptoms Suggestive of Irritable Bowel Syndrome
Ford, A. C., Chey, W. D., Talley, N. J., Malhotra, A., Spiegel, B. M. R., & Moayyedi, P. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.22 · Cited by 240 · see citing works
Predictors of Clinical Response to Gluten-Free Diet in Patients Diagnosed With Diarrhea-Predominant Irritable Bowel Syndrome
Wahnschaffe, U., Schulzke, J., Zeitz, M., & Ullrich, R. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.03.021 · Cited by 240 · see citing works
Self-citation
The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update
Catassi, C., Alaedini, A., Bojarski, C., Bonaz, B. L., Bouma, G., Carroccio, A., Castillejo, G., de Magistris, L., Dieterich, W., Liberto, D. D., et al. (2017) · Nutrients · doi:10.3390/nu9111268 · Cited by 240 · see citing works
The utility of diagnostic tests in irritable bowel syndrome patients: a systematic review
Cash, B. D., Schoenfeld, P., & Chey, W. D. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.07027.x · Cited by 242 · see citing works
Irritable bowel syndrome: Diagnosis and pathogenesis
El‐Salhy, M. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i37.5151 · Cited by 214 · see citing works
Health Benefits and Adverse Effects of a Gluten-Free Diet in Non-Celiac Disease Patients.
Niland, B. R., & Cash, B. D. (2018) · Europe PMC (PubMed Central) · Cited by 203 · see citing works
The Gluten-Free Diet for Celiac Disease and Beyond
Aljada, B., Zohni, A., & El‐Matary, W. (2021) · Nutrients · doi:10.3390/nu13113993 · Cited by 238 · see citing works
Intraepithelial Lymphocytosis in Architecturally Preserved Proximal Small Intestinal Mucosa: An Increasing Diagnostic Problem With a Wide Differential Diagnosis
Brown, I., Mino-Kenudson, M. A., Deshpande, V., & Lauwers, G. Y. (2006) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2006-130-1020-iliapp · Cited by 192 · see citing works
Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction?
GIORGIO, R. D., Volta, U., & Gibson, P. R. (2015) · Gut · doi:10.1136/gutjnl-2015-309757 · Cited by 190 · see citing works
Food Choice as a Key Management Strategy for Functional Gastrointestinal Symptoms
Gibson, P. R., & Shepherd, S. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.49 · Cited by 188 · see citing works
Irritable bowel syndrome: Emerging paradigm in pathophysiology
Lee, Y. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2456 · Cited by 186 · see citing works
Screening for Celiac Disease in Irritable Bowel Syndrome: An Updated Systematic Review and Meta-analysis
Irvine, A. J., Chey, W. D., & Ford, A. C. (2017) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.466 · Cited by 172 · see citing works
Prevalence of Irritable Bowel Syndrome–type Symptoms in Patients With Celiac Disease: A Meta-analysis
Sainsbury, A., Sanders, D. S., & Ford, A. C. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.11.033 · Cited by 174 · see citing works
Pathophysiology, Evaluation, and Management of Chronic Watery Diarrhea
Camilleri, M., Sellin, J. H., & Barrett, K. E. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.014 · Cited by 163 · see citing works
Irritable bowel syndrome: the role of food in pathogenesis and management.
Hayes, P. A., Fraher, M., & Quigley, E. M. M. (2014) · Europe PMC (PubMed Central) · Cited by 158 · see citing works
Diagnosis of coeliac disease
Green, P. H. R., Rostami, K., & Marsh, M. N. (2005) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2005.02.006 · Cited by 157 · see citing works
Food: The Forgotten Factor in the Irritable Bowel Syndrome
Eswaran, S. L., Tack, J. F., & Chey, W. D. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.012 · Cited by 154 · see citing works
Small-bowel mucosal transglutaminase 2-specific IgA deposits in coeliac disease without villous atrophy: A prospective and randomized clinical study
Kaukinen, K., Peräaho, M., Collin, P., Partanen, J., Woolley, N., Kaartinen, T., Nuutinen, T., Halttunen, T., Mäki, M., & Korponay-Szabo, I. R. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510023422 · Cited by 152 · see citing works
New insights into the pathogenesis and pathophysiology of irritable bowel syndrome
Öhman, L., & Simrén, M. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2006.10.014 · Cited by 155 · see citing works
Impaired Uptake of Serotonin by Platelets From Patients With Irritable Bowel Syndrome Correlates With Duodenal Immune Activation
Foley, S., Garsed, K. C., Singh, G., Duroudier, N. P., Swan, C., Hall, I. P., Zaitoun, A. M., Bennett, A. J., Marsden, C. A., Holmes, G. K. T., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.052 · Cited by 141 · see citing works
Chronic Functional Bowel Syndrome Enhances Gut-Brain Axis Dysfunction, Neuroinflammation, Cognitive Impairment, and Vulnerability to Dementia
Daulatzai, M. A. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1266-6 · Cited by 141 · see citing works
Lactobacilli Degrade Wheat Amylase Trypsin Inhibitors to Reduce Intestinal Dysfunction Induced by Immunogenic Wheat Proteins
Caminero, A., McCarville, J. L., Zevallos, V. F., Pigrau, M., Yu, X. B., Jury, J., Galipeau, H. J., Clarizio, A. V., Casqueiro, J., Murray, J. A., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.02.028 · Cited by 136 · see citing works
Non coeliac gluten sensitivity – A new disease with gluten intolerance
Czaja‐Bulsa, G. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.08.012 · Cited by 134 · see citing works
Systematic Evaluation of the Causes of Chronic Watery Diarrhea With Functional Characteristics
Fernández‐Bañares, F., Esteve, M., Salas, A., Alsina, M., Farré, C., González, C., Buxeda, M., Forné, M., Rosinach, M., Espinós, J. C., et al. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01438.x · Cited by 133 · see citing works
Coeliac disease presenting with symptoms of irritable bowel syndrome
Shahbazkhani, B., Forootan, M., Merat, S., Akbari, M. R., Nasseri‐Moghaddam, S., Vahedi, H., & Malekzadeh, R. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01666.x · Cited by 132 · see citing works
Spectrum of gluten-sensitive enteropathy in first-degree relatives of patients with coeliac disease: clinical relevance of lymphocytic enteritis
Esteve, M., Rosinach, M., Fernández‐Bañares, F., Farre, C., Salas, A., Alsina, M., Vilar, P., Abad-Lacruz, A., Forné, M., Mariné, M., et al. (2006) · Gut · doi:10.1136/gut.2006.095299 · Cited by 125 · see citing works
Gliadin-dependent neuromuscular and epithelial secretory responses in gluten-sensitive HLA-DQ8 transgenic mice
Verdu, E. F., Huang, X., Natividad, J. M., Lu, J., Blennerhassett, P. A., David, C. S., McKay, D. M., & Murray, J. A. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00225.2007 · Cited by 125 · see citing works
Randomised clinical trial: gluten may cause depression in subjects with non‐coeliac gluten sensitivity – an exploratory clinical study
Peters, S., Biesiekierski, J. R., Yelland, G. W., Muir, J. G., & Gibson, P. R. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12730 · Cited by 118 · see citing works
Food and Food Groups in Inflammatory Bowel Disease (IBD): The Design of the Groningen Anti-Inflammatory Diet (GrAID)
Campmans-Kuijpers, M. J. E., & Dijkstra, G. D. H. (2021) · Nutrients · doi:10.3390/nu13041067 · Cited by 116 · see citing works
A Grounded Guide to Gluten: How Modern Genotypes and Processing Impact Wheat Sensitivity
Kucek, L. K., Veenstra, L. D., Amnuaycheewa, P., & Sorrells, M. E. (2015) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12129 · Cited by 114 · see citing works
Non-Celiac Gluten Sensitivity: Literature Review
Mansueto, P., Seidita, A., D’Alcamo, A., & Carroccio, A. (2014) · Journal of the American College of Nutrition · doi:10.1080/07315724.2014.869996 · Cited by 112 · see citing works
Systematic review: noncoeliac gluten sensitivity
Molina‐Infante, J., Santolaria, S., Sanders, D. S., & Fernández‐Bañares, F. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13155 · Cited by 111 · see citing works
A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways
Anderson, R. P., Henry, M. J., Taylor, R., Duncan, E. L., Danoy, P., Costa, M., Addison, K., Tye–Din, J. A., Kotowicz, M. A., Knight, R. E., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-188 · Cited by 107 · see citing works
Celiac Disease Serology in Irritable Bowel Syndrome and Dyspepsia: A Population-Based Case-Control Study
Locke, G. R., Murray, J. A., Zinsmeister, A. R., Melton, L. J., & Talley, N. J. (2004) · Mayo Clinic Proceedings · doi:10.4065/79.4.476 · Cited by 104 · see citing works
A prospective study into the aetiology of lymphocytic duodenosis
Aziz, I., Evans, K., Hopper, A. D., Smillie, D., & Sanders, D. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04477.x · Cited by 101 · see citing works
Symptom overlap and comorbidity of irritable bowel syndrome with other conditions
Frissora, C. L., & Koch, K. L. (2005) · Current Gastroenterology Reports · doi:10.1007/s11894-005-0018-9 · Cited by 100 · see citing works
Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm
Losurdo, G., Principi, M., Iannone, A., Amoruso, A., Ierardi, E., Leo, A. D., & Barone, M. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i14.1521 · Cited by 102 · see citing works
Fecal Clostridiales distribution and short‐chain fatty acids reflect bowel habits in irritable bowel syndrome
Gargari, G., Taverniti, V., Gardana, C., Cremon, C., Canducci, F., Pagano, I., Barbaro, M. R., Bellacosa, L., Castellazzi, A. M., Valsecchi, C., et al. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14271 · Cited by 98 · see citing works
Celiac Disease With Mild Enteropathy Is Not Mild Disease
Zanini, B., Caselani, F., Magni, A., Turini, D., Ferraresi, A., Lanzarotto, F., Villanacci, V., Carabellese, N., Ricci, C., & Lanzini, A. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.09.027 · Cited by 96 · see citing works
Non‐coeliac gluten sensitivity: piecing the puzzle together
Biesiekierski, J. R., & Iven, J. (2015) · United European Gastroenterology Journal · doi:10.1177/2050640615578388 · Cited by 90 · see citing works
In Vitro–Deranged Intestinal Immune Response to Gliadin in Type 1 Diabetes
Auricchio, R., Paparo, F., Maglio, M. A., Franzese, A., Lombardi, F., Valerio, G., Nardone, G., Percopo, S., Greco, L., & Troncone, R. (2004) · Diabetes · doi:10.2337/diabetes.53.7.1680 · Cited by 90 · see citing works
Enteroendocrine cell counts correlate with visceral hypersensitivity in patients with diarrhoea‐predominant irritable bowel syndrome
Park, J. H., Rhee, P., Kim, G., Lee, J. H., Kim, Y., Kim, J. J., Rhee, J. C., & Song, S. Y. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00771.x · Cited by 89 · see citing works
Impact of diet on symptoms of the irritable bowel syndrome
Spiller, R. (2021) · Nutrients · doi:10.3390/nu13020575 · Cited by 86 · see citing works
Frequency of Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome and Chronic Non-Specific Diarrhea
Ghoshal, U. C., Kumar, S., Mehrotra, M., Lakshmi, C., & Misra, A. (2010) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2010.16.1.40 · Cited by 85 · see citing works
The spectrum of noncoeliac gluten sensitivity
Aziz, I., Hadjivassiliou, M., & Sanders, D. S. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.107 · Cited by 82 · see citing works
Clinical, Serologic, and Histologic Features of Gluten Sensitivity in Children
Francavilla, R., Cristofori, F., Castellaneta, S. P., Polloni, C., Albano, V., Dellatte, S., Indrio, F., Cavallo, L., & Catassi, C. (2013) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2013.10.007 · Cited by 81 · see citing works
Irritable bowel syndrome: Role of food in pathogenesis and management
Morcos, A. I., Dinan, T. G., & Quigley, E. M. M. (2009) · Journal of Digestive Diseases · doi:10.1111/j.1751-2980.2009.00392.x · Cited by 81 · see citing works
A case for an immunological basis for irritable bowel syndrome
Collins, S. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.34097 · Cited by 79 · see citing works
Lymphocytic Duodenosis and the Spectrum of Celiac Disease
Voort, J. L. V., Murray, J. A., Lahr, B. D., Dyke, C. T. V., Kroning, C. M., Moore, S. B., & Wu, T. (2008) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.7 · Cited by 77 · see citing works
Review article: small intestinal bacterial overgrowth, bile acid malabsorption and gluten intolerance as possible causes of chronic watery diarrhoea
Fan, X., & Sellin, J. H. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.03970.x · Cited by 74 · see citing works
Buried Barrett's Epithelium Following Photodynamic Therapy Shows Reduced Crypt Proliferation and Absence of DNA Content Abnormalities
Hornick, J. L., Mino-Kenudson, M. A., Lauwers, G. Y., Liu, W., Goyal, R. K., & Odze, R. D. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01560.x · Cited by 72 · see citing works
Dietary Proteins and Functional Gastrointestinal Disorders
Boettcher, E., & Crowe, S. E. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.97 · Cited by 71 · see citing works
Celiac Disease: A Progress Report
Antonioli, D. A. (2003) · Modern Pathology · doi:10.1097/01.mp.0000062997.16339.47 · Cited by 70 · see citing works
Predisposing HLA-DQ2 and HLA-DQ8 haplotypes of coeliac disease and associated enteropathy in microscopic colitis
Fernández‐Bañares, F., Esteve, M., Farr??, C., Salas, A., Alsina, M., Casalots, J., s, J. E., Forn, M., & Viver, J. M. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200512000-00011 · Cited by 70 · see citing works
Celiac disease
Holtmeier, W., & Caspary, W. F. (2006) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-1-3 · Cited by 70 · see citing works
Dietary Triggers in Irritable Bowel Syndrome: Is There a Role for Gluten?
Volta, U., Pinto-Sánchez, M. I., Boschetti, E., Caio, G., GIORGIO, R. D., & Verdu, E. F. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16069 · Cited by 69 · see citing works
Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome
Barmeyer, C., Schümann, M., Meyer, T., Zielinski, C. E., Zuberbier, T., Siegmund, B., Schulzke, J., Daum, S., & Ullrich, R. (2016) · International Journal of Colorectal Disease · doi:10.1007/s00384-016-2663-x · Cited by 68 · see citing works
Self-citation
Enterocyte Actin Autoantibody Detection: A New Diagnostic Tool in Celiac Disease Diagnosis: Results of a Multicenter Study
Clemente, M. G., Musu, M. P., Troncone, R., Volta, U., Congia, M., Ciacci, C., Neri, E., Not, T., Maggiore, G., Strisciuglio, P., et al. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.30296.x · Cited by 66 · see citing works
The Role of Food Intolerance in Irritable Bowel Syndrome
Lea, R., & Whorwell, P. J. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.005 · Cited by 64 · see citing works
Irritable bowel syndrome and inflammatory bowel disease: interrelated diseases?
Quigley, E. M. M. (2005) · Chinese Journal of Digestive Diseases · doi:10.1111/j.1443-9573.2005.00202.x · Cited by 64 · see citing works
Treating irritable bowel syndrome: overview, perspective and future therapies
Camilleri, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705741 · Cited by 64 · see citing works
Prevalence and factors associated with gluten sensitivity in inflammatory bowel disease
Limketkai, B. N., Sepulveda, R., Hing, T. C., Shah, N. D., Choe, M. Y., Limsui, D., & Shah, S. B. (2017) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2017.1409364 · Cited by 63 · see citing works
Is Gluten a Cause of Gastrointestinal Symptoms in People Without Celiac Disease?
Biesiekierski, J. R., Muir, J. G., & Gibson, P. R. (2013) · Current Allergy and Asthma Reports · doi:10.1007/s11882-013-0386-4 · Cited by 62 · see citing works
Dynamics of Non-conventional Intraepithelial Lymphocytes—NK, NKT, and γδ T—in Celiac Disease: Relationship with Age, Diet, and Histopathology
Calleja, S., Vivas, S., Santiuste, M., Arias, L., Hernando, M., Nistal, E., Casqueiro, J., & Ruiz de Morales, J. G. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1534-5 · Cited by 60 · see citing works
Changing face of irritable bowel syndrome
Quigley, E. M. M. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i1.1 · Cited by 60 · see citing works
Gluten-free and low-FODMAP sourdoughs for patients with coeliac disease and irritable bowel syndrome: A clinical perspective
Muir, J. G., Varney, J. E., Ajamian, M., & Gibson, P. R. (2018) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2018.10.016 · Cited by 60 · see citing works
Absence of somatization in non-coeliac gluten sensitivity
Brottveit, M., Vandvik, P. O., Wojniusz, S., Løvik, A., Lundin, K. E. A., & Boye, B. (2012) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2012.679685 · Cited by 56 · see citing works
Gluten‐Free Diet in Nonceliac Disease
El‐Chammas, K. I., & Danner, E. (2011) · Nutrition in Clinical Practice · doi:10.1177/0884533611405538 · Cited by 57 · see citing works
Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A
Rauhavirta, T., Qiao, S.-W., Jiang, Z., Myrsky, E., Loponen, J., Korponay-Szabo, I. R., Salovaara, H. O., Garcia-Horsman, A., Venäläinen, J. I., Männistö, P. T., et al. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04317.x · Cited by 55 · see citing works
Non-coeliac gluten/wheat sensitivity: advances in knowledge and relevant questions
Volta, U., Caio, G., Karunaratne, T. B., Alaedini, A., & GIORGIO, R. D. (2016) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2017.1260003 · Cited by 54 · see citing works
Immunopathogenesis of celiac disease
Tye–Din, J. A., & Anderson, R. P. (2008) · Current Gastroenterology Reports · doi:10.1007/s11894-008-0085-9 · Cited by 53 · see citing works
Duodenal lymphocytosis with no or minimal enteropathy: much ado about nothing?
Lauwers, G. Y., Fasano, A., & Brown, I. (2015) · Modern Pathology · doi:10.1038/modpathol.2014.135 · Cited by 52 · see citing works
Current and emerging therapies in irritable bowel syndrome: from pathophysiology to treatment
CHANG, J. Y., & Talley, N. J. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.04.008 · Cited by 53 · see citing works
Effect of gluten-free diet and co-morbidity of irritable bowel syndrome-type symptoms on health-related quality of life in adult coeliac patients
Usai, P., Manca, R., Cuomo, R., Lai, M., & Mf, B. (2007) · Digestive and Liver Disease · doi:10.1016/j.dld.2007.05.017 · Cited by 52 · see citing works
Disturbances of Motility and Visceral Hypersensitivity in Irritable Bowel Syndrome: Biological Markers or Epiphenomenon
Quigley, E. M. M. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.010 · Cited by 51 · see citing works
Patients with serum IgA endomysial antibodies and intact duodenal villi: Clinical characteristics and management options
Dickey, W., Hughes, D. F., & McMillan, S. A. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510023747 · Cited by 51 · see citing works
The Bowel and Migraine: Update on Celiac Disease and Irritable Bowel Syndrome
Cady, R. K., Farmer, K. U., Dexter, J., & Hall, J. (2012) · Current Pain and Headache Reports · doi:10.1007/s11916-012-0258-y · Cited by 49 · see citing works
Irritable bowel syndrome and chronic gastritis, hemorrhoid, urolithiasis.
Helvacı, M. R., Algın, M. C., & Kaya, H. (2009) · PubMed Central · Cited by 48 · see citing works
Non-celiac gluten sensitivity. Is it in the gluten or the grain?
Nijeboer, P., Bontkes, H. J., Mulder, C. J. J., & Bouma, G. (2013) · PubMed · Cited by 47 · see citing works
Current Concepts of the Irritable Bowel Syndrome
Quigley, E. M. M. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00855910310001403 · Cited by 46 · see citing works
Celiac disease: clinical, endoscopic, and histopathologic review
Harris, L. A., Park, J. Y., Voltaggio, L., & Lam-Himlin, D. M. (2012) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2012.04.473 · Cited by 46 · see citing works
Neurologic Complications of Celiac Disease
Chin, R. L., Latov, N., Green, P. H. R., Brannagan, T. H., Alaedini, A., & Sander, H. W. (2004) · Journal of Clinical Neuromuscular Disease · doi:10.1097/00131402-200403000-00004 · Cited by 46 · see citing works
Small bowel bacterial overgrowth, celiac disease, and IBS: what are the real associations?
O’Leary, C., & Quigley, E. M. M. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07395.x · Cited by 46 · see citing works
Food Allergies and Intolerances: A Clinical Approach to the Diagnosis and Management of Adverse Reactions to Food
Onyimba, F. U., Crowe, S. E., Johnson, S., & Leung, J. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.01.025 · Cited by 48 · see citing works
Issues related to gluten-free diet in coeliac disease
Troncone, R., Auricchio, R., & Granata, V. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f795f8 · Cited by 44 · see citing works
A Physiologic Events' Cascade, Irritable Bowel Syndrome, may Even Terminate with Urolithiasis
Helvacı, M. R., Kabay, Ş., & Gülcan, E. (2006) · Eisei kagaku · doi:10.1248/jhs.52.478 · Cited by 43 · see citing works
Testing for Gluten-Related Disorders in Clinical Practice: The Role of Serology in Managing the Spectrum of Gluten Sensitivity
Armstrong, D., Don-Wauchope, A., & Verdu, E. F. (2011) · Canadian Journal of Gastroenterology · doi:10.1155/2011/642452 · Cited by 43 · see citing works
Diet in the Irritable Bowel Syndrome
Floch, M. H., & Narayan, R. (2002) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200207001-00009 · Cited by 42 · see citing works

Predictors of Clinical Response to Gluten-Free Diet in Patients Diagnosed With Diarrhea-Predominant Irritable Bowel Syndrome
Wahnschaffe, U., Schulzke, J., Zeitz, M., & Ullrich, R. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.03.021 · Cited by 240 · see citing works
Self-citation
The prevalence of celiac disease in patients with irritable bowel syndrome and its subtypes
Domżał-Magrowska, D., Kowalski, M. K., Szcześniak, P., Bulska, M., Orszulak–Michalak, D., & Malecka-Panas, E. I. (2016) · Gastroenterology Review · doi:10.5114/pg.2016.57941 · Cited by 18 · see citing works
Long-term response to gluten-free diet as evidence for non-celiac wheat sensitivity in one third of patients with diarrhea-dominant and mixed-type irritable bowel syndrome
Barmeyer, C., Schümann, M., Meyer, T., Zielinski, C. E., Zuberbier, T., Siegmund, B., Schulzke, J., Daum, S., & Ullrich, R. (2016) · International Journal of Colorectal Disease · doi:10.1007/s00384-016-2663-x · Cited by 68 · see citing works
Self-citation
Is it reasonable to perform serological tests for celiac disease in patients with irritable bowel syndrome?
Respondek, W., Tomasiuk, R., Jarosz, M. J., Traczyk, I., & Mekus, M. (2013) · Gastroenterology Review · doi:10.5114/pg.2013.36333 · Cited by 4 · see citing works
The seroprevalence of celiac disease in patients with symptoms of irritable bowel syndrome: A cross-sectional study in the north of Iran
Joukar, F., Yeganeh, S., Shafaghi, A., Mahjoub-Jalali, M. R., Hassanipour, S., Santacroce, L., Mavaddati, S., & Mansour‐Ghanaei, F. (2022) · Human Antibodies · doi:10.3233/hab-211516 · Cited by 6 · see citing works

Authors: Wahnschaffe, U., Ullrich, R., Riecken, E. O., & Schulzke, J. D.
Affiliations: Freie Universität Berlin (DE)
ORCID: Schulzke, J.D.
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 2001-12
Volume: 121
Issue: 6
Pages: 1329-1338
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1053/gast.2001.29572
OpenAlex: W2169133758
Cited by: 280
References: 35
Citations by year: 2025: 2 · 2024: 1 · 2023: 23 · 2022: 5 · 2021: 10 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 5 · 2016: 9 · 2015: 13 · 2014: 16 · 2013: 17 · 2012: 15
FWCI: 13.18
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords: irritable bowel syndrome, celiac disease, latent celiac disease, HLA-DQ2, intraepithelial lymphocytes, anti-tissue transglutaminase antibodies, anti-gliadin antibodies, duodenal aspirate, gluten-free diet, gluten withdrawal, intestinal IgA, β-lactoglobulin, ovalbumin, diarrhea, surrogate markers
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Antigens, Celiac Disease, Colonic Diseases, Functional, Diet, Duodenum, Female, Gliadin, Humans, Immunoglobulin A, Immunoglobulin M, Lactoglobulins, Male, Middle Aged, Ovalbumin, Transglutaminases, Reticulin

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Celiac disease–like abnormalities in a subgroup of patients with irritable bowel syndrome

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