Oral Propranolol Decreases Intestinal Permeability in Patients With Cirrhosis: Another Protective Mechanism Against Bleeding?
Abstract
Senzolo, Marco MD, PhD1; Fries, W. MD2; Buda, A. MD, PhD1; Pizzuti, D. MD1; Nadal, E. MD1; Sturniolo, G. C. MD1; Burroughs, A. K. MD3; D'Incà, R. MD1 Author Information
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Nonselective β-adrenergic blockers decrease intestinal transit time and reduce intestinal bacterial overgrowth, intestinal permeability and bacterial translocation in experimental cirrhosis and patients.
“Accordingly, nonselective β-adrenergic blockers decrease intestinal transit time and reduce intestinal bacterial overgrowth, intestinal permeability and bacterial translocation in experimental models of cirrhosis as well as in patients153–157.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [156]
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- Authors
- Senzolo, M., Fries, W., Buda, A., Pizzuti, D., Nadal, E., Sturniolo, G. C., Burroughs, A. K., & DʼIncà, R.
- Affiliations
- University of Padua (IT)
- University of Messina (IT)
- Corresponding author
- Senzolo, Marco
- Venue
- American Journal of Gastroenterology
- Published
- 2009-12
- Volume
- 104
- Issue
- 12
- Pages
- 3115-3116
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W2051446116
- Cited by
- 36
- References
- 7
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Keywords
- propranolol, intestinal permeability, liver cirrhosis, beta-blockers, intestinal barrier, portal hypertension
- MeSH terms
- Adrenergic beta-Antagonists, Clinical Trials as Topic, Esophageal and Gastric Varices, Gastrointestinal Hemorrhage, Humans, Intestinal Absorption, Liver Cirrhosis, Peritonitis, Propranolol, Bacterial Translocation
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