The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Inflammatory bowel disease, irritable bowel syndrome, or what: a challenge to the functional-organic dichotomy.
Abstract
Many patients with inflammatory bowel disease (IBD) in clinical remission continue to have symptoms of pain and diarrhea despite minimal or no ongoing inflammation. These patients may be considered to have an overlap of IBD and irritable bowel syndrome (IBD-IBS). In this month's Journal, a proposal is made that continued symptoms in patients with elevated calprotectin, a marker of inflammation, is related to IBD. We propose an alternate biopsychosocial model whereby mutual effects of peripheral and central factors influence symptom generation in both IBD and IBS. Understanding this model has important implications for treatment of patients with IBD-IBS.
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“Given this prevalence, it is unlikely that IBD patients are protected from IBS.2”
From Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease (2014) · cites this paper as [2]
Citations
Cites
Physiology of the Gastrointestinal Tract
Johnson, L. R. (2006) · Elsevier eBooks · doi:10.1016/b978-0-12-088394-3.x5000-4 · Cited by 4,616
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome
Barbara, G., Wang, B., Stanghellini, V., de Giorgio, R., Cremon, C., Di Nardo, G., Trevisani, M., Campi, B., Geppetti, P., Tonini, M., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.039 · Cited by 783
Dinan, T. G., Quigley, E. M. M., Ahmed, S. M. M., Scully, P., O’Brien, S., O’Mahony, L., O’Mahony, S., Shanahan, F., & Keeling, P. W. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.033 · Cited by 636
(2006) · Cited by 534
Self-citationStress and Exacerbation in Ulcerative Colitis: A Prospective Study of Patients Enrolled in Remission
Levenstein, S., Prantera, C., Varvo, V., Scribano, M. L., Andreoli, A., Luzi, C., Arcà, M., Berto, E., Milite, G., & Marcheggiano, A. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02012.x · Cited by 451
Gastrointestinal Illness and the Biopsychosocial Model
Drossman, D. A. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199805000-00007 · Cited by 388
Self-citationKeohane, J., O’Mahony, C., O’Mahony, L., O’Mahony, S. M., Quigley, E. M. M., & Shanahan, F. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.156 · Cited by 260
Minderhoud, I. M., Oldenburg, B., Wismeijer, J. A., Henegouwen, G. P. V. B., & Smout, A. J. P. M. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000020506.84248.f9 · Cited by 243
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Pappas, A., & David, J. G. (2026) · Current Sleep Medicine Reports · doi:10.1007/s40675-026-00375-x
Metadata
- Authors
- Long, M. D., & Drossman, D. A.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Drossman, Douglas A
- Venue
- American Journal of Gastroenterology
- Published
- 2010-08
- Volume
- 105
- Issue
- 8
- Pages
- 1796-1798
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W47476788
- Cited by
- 101
- References
- 22
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 6 · 2021: 7 · 2020: 6 · 2019: 10 · 2018: 8 · 2017: 9 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 8 · 2012: 9
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Keywords
- inflammatory bowel disease, irritable bowel syndrome, calprotectin, biopsychosocial model, chronic pain, diarrhea, clinical remission, symptom generation
- MeSH terms
- Colitis, Ulcerative, Crohn Disease, Diagnosis, Differential, Feces, Humans, Quality of Life, Risk Factors, Stress, Psychological, Biomarkers, Cytokines, Leukocyte L1 Antigen Complex, Irritable Bowel Syndrome
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